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[191964_at] guanylate cyclase

Description C17F4.6 /REP_DB=WormBase Gene ID /WP=CE08279 /GEN=gcy-19 /TR=O16544 /GB=AAK31438.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=guanylate cyclase
Cluster 6grp_total > 16      4grp_total > 38      6grp_cgc > 22      6grp_cgc_sub > De      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 151
1 2 3 4 range
A 179.4
(3)
P 		121.6
(0.4)
P 		46.4
(-3)
A 		94.2
(-0.8)
A 		133
B 197.2
(3)
A 		71.6
(-2.8)
A 		66.6
(-3)
A 		93.6
(-1.8)
A 		131
C 180.5
(3)
P 		98.8
(-0.8)
A 		51.2
(-3)
A 		119.3
(0.2)
M 		129
avr 185.7
(3) 		97.3
(-1) 		54.7
(-3) 		102.4
(-0.8) 		131

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 93
1 2 3 4 5 6 range
A 114.2
(3)
A 		110.9
(2.8)
A 		73.5
(0.1)
A 		29.7
(-3)
A 		77.6
(0.4)
A 		38.7
(-2.4)
A 		85
B 117.4
(3)
P 		88.9
(0.8)
P 		69.7
(-0.7)
A 		45.3
(-2.6)
A 		57.3
(-1.6)
M 		39.7
(-3)
A 		78
C 95.5
(3)
P 		81.9
(1.9)
P 		73.6
(1.1)
A 		24.5
(-3)
A 		78.1
(1.5)
A 		80.7
(1.7)
A 		71
avr 109
(3) 		93.9
(1.8) 		72.3
(0.1) 		33.2
(-3) 		71
(-0) 		53
(-1.4) 		76
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 53
1 2 3 4 range
A 65.3
(3)
P 		26.4
(-1.4)
P 		12.1
(-3)
A 		13.8
(-2.8)
A 		53
B 62.9
(3)
A 		17.7
(-2.7)
A 		15.4
(-3)
A 		20
(-2.4)
A 		48
C 59.7
(3)
P 		28.4
(-1.5)
A 		17.8
(-3)
A 		20.1
(-2.7)
M 		42
avr 62.6
(3) 		24.2
(-1.9) 		15.1
(-3) 		18
(-2.6) 		48

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 36
1 2 3 4 5 6 range
A 21
(-0.5)
A 		39.4
(3)
A 		16
(-1.4)
A 		7.5
(-3)
A 		23.4
(-0)
A 		9.4
(-2.6)
A 		32
B 40.8
(3)
P 		29.6
(0.7)
P 		16.9
(-2)
A 		12
(-3)
A 		23.3
(-0.6)
M 		14.8
(-2.4)
A 		29
C 35.4
(3)
P 		25
(1)
P 		18.7
(-0.3)
A 		4.9
(-3)
A 		25.3
(1)
A 		27
(1.3)
A 		31
avr 32.4
(3) 		31.3
(2.7) 		17.2
(-0.8) 		8.1
(-3) 		24
(0.9) 		17.1
(-0.8) 		24
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 191964_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.4112
Sequence Type Exemplar sequence
Representative Public ID C17F4.6 NCBI
Target Description C17F4.6 /REP_DB=WormBase Gene ID /WP=CE08279 /GEN=gcy-19 /TR=O16544 /GB=AAK31438.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=guanylate cyclase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_062090(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_062090 NCBI Caenorhabditis elegans Guanylyl CYclase family member (gcy-19) (gcy-19) mRNA, complete cds. 11/11 None
SNAP00000021560 ENSEMBL cdna:SNAP chromosome:CEL140:II:3251078:3260183:-1 11/11 None
GENEFINDER00000021583 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:3251078:3258874:-1 11/11 None
C17F4.6 ENSEMBL cdna:known chromosome:CEL140:II:3251078:3258817:-1 gene:C17F4.6 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:3251076-3259294(-) 97.49 100.0
Public Domain and Genome References
Gene Title guanylate cyclase
Gene Symbol gcy-19
Ensembl C17F4.6
Entrez Gene 191650 Entrez gene
SwissProt O16544 EMBL-EBI
WormBase CE36790 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4383 guanylate cyclase activity inferred from electronic annotation QuickGO AmiGO
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAK31438 Guanylyl cyclase protein 19 [Caenorhabditis elegans] ref|NP_494491.3| Guanylyl CYclase family member (gcy-19) [Caenorhabditis elegans] 0.0
blast T31927 hypothetical protein C17F4.6 - Caenorhabditis elegans 0.0
blast CAE70463 Hypothetical protein CBG17049 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 3.1E-17
Pfam IPR001054 EMBL-EBI Guanylate cyclase 1.9E-88
Pfam IPR001828 EMBL-EBI Extracellular ligand-binding receptor 7.1E-58
Pfam IPR000719 EMBL-EBI Protein kinase 3.1E-17
Pfam IPR001054 EMBL-EBI Guanylate cyclase 7.7E-93
Pfam IPR001828 EMBL-EBI Extracellular ligand-binding receptor 6.3E-53
Pfam IPR000719 EMBL-EBI Protein kinase 3.1E-17
Pfam IPR001054 EMBL-EBI Guanylate cyclase 7.7E-93
Pfam IPR001828 EMBL-EBI Extracellular ligand-binding receptor 9.8E-61
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_494491.3 1 461-483
C17F4.6 1 461-483
SNAP00000021560 1 458-480
GENEFINDER00000021583 1 465-487
Sequence
Target Sequence 
>C. ELEGANS:191964_AT
catttaaaataccccatttgccacgtgaaaaggttgagctcaggattggagtgaacagtg
ggccttgtgtggcgggagttgtgggcttgagtatgcctagatattgtctgtttggagata
cggtgaacactgcgtcgagaatggagtctaatggaaaaggtaggcaaatggctttaaaaa
gctcatcccatatccacctcagcgccgcttcttacacacttctaatgaagcattatccga
atcaatacaacactgcctccagaggagatgttattattaaaggaaaaggcgtgatggaga
ctttctgggtattcgaacgaaataatcaatttatgggagtatcctctaacagtggatatc
aaagtgacaaaaaggccacaaataacggtagcagtccggaatccacgcctccaagtaccc
cgccgatgcatgaagtaaaagccaacagtccggtccgtcatcgtaagccgccatctccgt
cctcaccaacactttccaagcggtctgtaagcccaataatggaggcaaaagcccgagata
ttcacaatgaggagaccgaggctttgtaccggcagtt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CATTTAAAATACCCCATTTGCCACG 245 213 3143 Antisense
GAACAGTGGGCCTTGTGTGGCGGGA 422 349 3195 Antisense
GTGGCGGGAGTTGTGGGCTTGAGTA 554 477 3211 Antisense
CCGCTTCTTACACACTTCTAATGAA 375 263 3347 Antisense
TCAATACAACACTGCCTCCAGAGGA 351 633 3384 Antisense
GGAGACTTTCTGGGTATTCGAACGA 346 515 3438 Antisense
AACGGTAGCAGTCCGGAATCCACGC 321 143 3526 Antisense
TACCCCGCCGATGCATGAAGTAAAA 628 649 3558 Antisense
CCAACACTTTCCAAGCGGTCTGTAA 600 275 3628 Antisense
AAGCGGTCTGTAAGCCCAATAATGG 407 147 3640 Antisense
AGACCGAGGCTTTGTACCGGCAGTT 159 69 3695 Antisense
Sequence Source Affymetrix Proprietary Database