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[191906_at] guanylate cyclase

Description ZC239.7 /REP_DB=WormBase Gene ID /WP=CE26332 /GEN=gcy-15 /TR=P91550 /GB=AAB37946.2 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=guanylate cyclase
Cluster 6grp_total > 08      4grp_total > 63      6grp_cgc > 10      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 48
1 2 3 4 range
A 24.8
(2.7)
A 		12.6
(-1.3)
A 		25.8
(3)
A 		7.2
(-3)
A 		19
B 9.8
(-2.3)
A 		6.9
(-2.8)
A 		40.9
(3)
A 		5.7
(-3)
A 		35
C 53.7
(3)
A 		8.9
(-3)
A 		28.4
(-0.4)
A 		35.9
(0.6)
A 		45
avr 29.4
(2.4) 		9.5
(-3) 		31.7
(3) 		16.3
(-1.2) 		22

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 38
1 2 3 4 5 6 range
A 38.8
(3)
A 		23.8
(-0)
A 		14.9
(-1.8)
A 		33.9
(2)
A 		8.9
(-3)
A 		20.3
(-0.7)
A 		30
B 27.1
(2.1)
A 		8.6
(-2.2)
A 		31
(3)
A 		25.8
(1.8)
A 		5
(-3)
A 		5.4
(-2.9)
A 		26
C 16.5
(-1.2)
A 		20.8
(-0.5)
A 		28.1
(0.6)
A 		5.1
(-3)
A 		43.4
(3)
A 		33.5
(1.4)
A 		38
avr 27.5
(3) 		17.7
(-3) 		24.7
(1.3) 		21.6
(-0.6) 		19.1
(-2.1) 		19.7
(-1.8) 		10
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 17
1 2 3 4 range
A 9
(3)
A 		2.7
(-1.8)
A 		6.7
(1.3)
A 		1.1
(-3)
A 		8
B 3.1
(-1.6)
A 		1.7
(-2.6)
A 		9.5
(3)
A 		1.2
(-3)
A 		8
C 17.8
(3)
A 		2.5
(-3)
A 		9.9
(-0.1)
A 		6
(-1.6)
A 		15
avr 10
(3) 		2.3
(-3) 		8.7
(2) 		2.8
(-2.6) 		8

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 13
1 2 3 4 5 6 range
A 7.2
(1.6)
A 		8.5
(2.9)
A 		3.3
(-2.4)
A 		8.6
(3)
A 		2.7
(-3)
A 		4.9
(-0.8)
A 		6
B 9.4
(3)
A 		2.8
(-2.4)
A 		7.5
(1.5)
A 		6.8
(0.9)
A 		2
(-3)
A 		2
(-3)
A 		7
C 6.1
(-0.7)
A 		6.3
(-0.6)
A 		7.2
(-0.2)
A 		1
(-3)
A 		14.1
(3)
A 		11.2
(1.7)
A 		13
avr 7.6
(3) 		5.9
(-1.9) 		6
(-1.6) 		5.5
(-3) 		6.3
(-0.7) 		6
(-1.6) 		2
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 191906_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.5070
Sequence Type Exemplar sequence
Representative Public ID ZC239.7 NCBI
Target Description ZC239.7 /REP_DB=WormBase Gene ID /WP=CE26332 /GEN=gcy-15 /TR=P91550 /GB=AAB37946.2 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=guanylate cyclase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_062067(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_062067 NCBI Caenorhabditis elegans Guanylyl CYclase family member (gcy-15) (gcy-15) mRNA, complete cds. 11/11 A 
SNAP00000024287 ENSEMBL cdna:SNAP chromosome:CEL140:II:3192415:3198111:-1 9/11 None
GENEFINDER00000024303 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:3192419:3200901:-1 9/11 None
ZC239.7 ENSEMBL cdna:known chromosome:CEL140:II:3192415:3196870:-1 gene:ZC239.7 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:2660091-2664615(+) 94.84 94.84
chrII:3192413-3196869(-) 100.0 100.0
Public Domain and Genome References
Gene Title guanylate cyclase
Gene Symbol gcy-15
Ensembl ZC239.7
Entrez Gene 191648 Entrez gene
SwissProt P91550 EMBL-EBI
WormBase CE26332 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4383 guanylate cyclase activity inferred from electronic annotation QuickGO AmiGO
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAB37946 Guanylyl cyclase protein 15 [Caenorhabditis elegans] ref|NP_494468.1| Guanylyl CYclase family member (gcy-15) [Caenorhabditis elegans] 0.0
blast NP_494324 Guanylyl CYclase family member (gcy-21) [Caenorhabditis elegans] gb|AAB66169.1| Guanylyl cyclase protein 21 [Caenorhabditis elegans] 0.0
blast CAE72387 Hypothetical protein CBG19543 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 3.6E-8
Pfam IPR000719 EMBL-EBI Protein kinase 6.2E-5
Pfam IPR001054 EMBL-EBI Guanylate cyclase 1.3E-77
Pfam IPR000719 EMBL-EBI Protein kinase 3.6E-8
Pfam IPR000719 EMBL-EBI Protein kinase 6.2E-5
Pfam IPR001054 EMBL-EBI Guanylate cyclase 4.3E-85
Pfam IPR003003 EMBL-EBI 7TM chemoreceptor, subfamily 2 1.0E-80
Pfam IPR003003 EMBL-EBI 7TM chemoreceptor, subfamily 2 4.4E-70
Pfam IPR000719 EMBL-EBI Protein kinase 3.6E-8
Pfam IPR000719 EMBL-EBI Protein kinase 6.2E-5
Pfam IPR001054 EMBL-EBI Guanylate cyclase 4.3E-85
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_494468.1 1 317-339
ZC239.7 1 317-339
SNAP00000024287 3 7-29,64-86,501-523
GENEFINDER00000024303 16 10-32,45-64,91-113,134-156,189-211,241-263,273-295,363-385,395-413,420-439,444-463,484-506,539-561,596-618,623-645,1128-1150
Sequence
Target Sequence 
>C. ELEGANS:191906_AT
gatattgtccaattcctaaacgatttatacacggtcttcgatcgaatcattgatcaattc
gacgtctacaaagtggagacaattgcagacgcttatatggtcgcctcgggattgcctgtc
ccaaatggaaaccatcacgccggggagatcgcttctctcgggcttgctctgctgaaagct
gttgagagcttcaaaatccgtcacctaccaaatgagaaggtccgtctaagaattggtatg
aactcgggaccttgtgtagcaggggttgttgggttgaagatgccgcgatattgcttgttc
ggggacactgtgaacacggcaagtcgcatggagagtaatggaattcgtaagtttttttgg
gtggcagaacctgtgagttctctccg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GATATTGTCCAATTCCTAAACGATT 480 395 2407 Antisense
TTGTCCAATTCCTAAACGATTTATA 202 705 2411 Antisense
TCCTAAACGATTTATACACGGTCTT 116 593 2420 Antisense
CGGGCTTGCTCTGCTGAAAGCTGTT 672 243 2565 Antisense
GAAAGCTGTTGAGAGCTTCAAAATC 227 359 2580 Antisense
TTCAAAATCCGTCACCTACCAAATG 209 641 2596 Antisense
AATCCGTCACCTACCAAATGAGAAG 306 167 2601 Antisense
ACCAAATGAGAAGGTCCGTCTAAGA 179 75 2613 Antisense
GAAGGTCCGTCTAAGAATTGGTATG 186 321 2622 Antisense
GTTTTTTTGGGTGGCAGAACCTGTG 593 447 2757 Antisense
TGGCAGAACCTGTGAGTTCTCTCCG 356 545 2768 Antisense
Sequence Source Affymetrix Proprietary Database