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[191885_at] guanylate cyclase

Description ZC412.2 /REP_DB=WormBase Gene ID /WP=CE15213 /GEN=gcy-14 /TR=Q23310 /GB=CAB01533.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=guanylate cyclase
Cluster 6grp_total > 35      4grp_total > 13      6grp_cgc > 34      6grp_cgc_sub > Cu      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 122
1 2 3 4 range
A 69.5
(0.6)
P 		41.4
(-1.6)
A 		23.3
(-3)
A 		99.9
(3)
P 		77
B 67.1
(3)
P 		47.1
(-3)
A 		66.6
(2.9)
A 		58.7
(0.5)
P 		20
C 90.1
(0.2)
P 		53.7
(-1.7)
A 		28.3
(-3)
A 		145
(3)
P 		117
avr 75.6
(0.5) 		47.4
(-2.2) 		39.4
(-3) 		101.2
(3) 		62

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 66
1 2 3 4 5 6 range
A 46.5
(0.4)
A 		50.3
(0.9)
P 		65.8
(3)
A 		20.9
(-3)
A 		26.9
(-2.2)
A 		26.4
(-2.3)
A 		45
B 79.3
(3)
P 		64.8
(1.3)
P 		59.3
(0.7)
A 		27.1
(-3)
A 		45.5
(-0.9)
P 		37.6
(-1.8)
P 		52
C 40
(0.4)
A 		61
(3)
P 		35.5
(-0.2)
A 		47.3
(1.3)
A 		13.1
(-3)
A 		61
(3)
P 		48
avr 55.3
(2.3) 		58.7
(3) 		53.5
(2) 		31.8
(-2.3) 		28.5
(-3) 		41.7
(-0.4) 		30
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 24
1 2 3 4 range
A 25.3
(3)
P 		9
(-2.1)
A 		6.1
(-3)
A 		14.6
(-0.3)
P 		19
B 21.4
(3)
P 		11.6
(-3)
A 		15.4
(-0.7)
A 		12.5
(-2.4)
P 		10
C 29.8
(3)
P 		15.4
(-1.3)
A 		9.8
(-3)
A 		24.4
(1.4)
P 		20
avr 25.5
(3) 		12
(-2.4) 		10.4
(-3) 		17.2
(-0.3) 		15

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 23
1 2 3 4 5 6 range
A 8.6
(-1.4)
A 		17.9
(3)
P 		14.3
(1.3)
A 		5.3
(-3)
A 		8.1
(-1.7)
A 		6.4
(-2.5)
A 		13
B 27.6
(3)
P 		21.6
(1.2)
P 		14.4
(-0.9)
A 		7.2
(-3)
A 		18.5
(0.3)
P 		14
(-1)
P 		20
C 14.8
(0.9)
A 		18.6
(2.3)
P 		9
(-1.2)
A 		9.5
(-1.1)
A 		4.3
(-3)
A 		20.4
(3)
P 		16
avr 17
(1.8) 		19.4
(3) 		12.6
(-0.4) 		7.3
(-3) 		10.3
(-1.5) 		13.6
(0.1) 		12
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 191885_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.12715
Sequence Type Exemplar sequence
Representative Public ID ZC412.2 NCBI
Target Description ZC412.2 /REP_DB=WormBase Gene ID /WP=CE15213 /GEN=gcy-14 /TR=Q23310 /GB=CAB01533.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=guanylate cyclase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_074259(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_074259 NCBI Caenorhabditis elegans Guanylyl CYclase family member (gcy-14) (gcy-14) mRNA, complete cds. 11/11 None
SNAP00000018092 ENSEMBL cdna:SNAP chromosome:CEL140:V:14865757:14870494:-1 11/11 None
GENEFINDER00000018104 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:14865008:14870395:-1 11/11 None
ZC412.2 ENSEMBL cdna:known chromosome:CEL140:V:14865757:14870494:-1 gene:ZC412.2 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:14865756-14870494(-) 100.0 100.0
Public Domain and Genome References
Gene Title guanylate cyclase
Gene Symbol gcy-14
Ensembl ZC412.2
Entrez Gene 191647 Entrez gene
SwissProt Q23310 EMBL-EBI
WormBase CE15213 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4383 guanylate cyclase activity inferred from electronic annotation QuickGO AmiGO
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB01533 Hypothetical protein ZC412.2 [Caenorhabditis elegans] ref|NP_506660.1| Guanylyl CYclase family member (gcy-14) [Caenorhabditis elegans] 0.0
blast CAE60828 Hypothetical protein CBG04537 [Caenorhabditis briggsae] 0.0
blast CAE62465 Hypothetical protein CBG06559 [Caenorhabditis briggsae] 0.0
blast CAB07591 Hypothetical protein F21H7.9 [Caenorhabditis elegans] ref|NP_507101.1| Guanylyl CYclase family member (gcy-20) [Caenorhabditis elegans] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 7.9E-13
Pfam IPR001054 EMBL-EBI Guanylate cyclase 1.4E-88
Pfam IPR001828 EMBL-EBI Extracellular ligand-binding receptor 1.4E-53
Pfam IPR000719 EMBL-EBI Protein kinase 7.9E-13
Pfam IPR001054 EMBL-EBI Guanylate cyclase 9.6E-81
Pfam IPR000719 EMBL-EBI Protein kinase 7.9E-13
Pfam IPR001054 EMBL-EBI Guanylate cyclase 1.4E-88
Pfam IPR001828 EMBL-EBI Extracellular ligand-binding receptor 1.4E-53
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_506660.1 2 408-430,475-497
ZC412.2 2 408-430,475-497
SNAP00000018092 2 408-430,475-497
GENEFINDER00000018104 2 375-397,442-464
Sequence
Target Sequence 
>C. ELEGANS:191885_AT
tgaacatattcgtcacattgctcgaatgtctcttggattcttgtccagcttggagttctt
ccgagttcagcatttaccatctgagcgtatcaatctaagaatcggaattaattgtggttc
cgtggttgccggagtcgttggtttaacaatgccacgatactgtctatttggagatgcagt
taacacagcaagccggatggagagtaatgggaaacccggaaaaatccacgtgactgctga
agcgaatcaaatgttaactcaagtcgttggtggattcaggacagaatctcgaggagaagt
tataattaaagggaaaggagttatggagacatattggcttctaggagaacaatctagaat
tagtgtttctgctcaggcaccgcgagaaaagacaccagaaccgcctcgtcggcaatctgt
tcggagcatatc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TGAACATATTCGTCACATTGCTCGA 648 573 3003 Antisense
GTCTCTTGGATTCTTGTCCAGCTTG 461 469 3030 Antisense
TCCAGCTTGGAGTTCTTCCGAGTTC 681 587 3046 Antisense
GTTCTTCCGAGTTCAGCATTTACCA 593 443 3057 Antisense
GCATTTACCATCTGAGCGTATCAAT 555 307 3072 Antisense
ATTAATTGTGGTTCCGTGGTTGCCG 164 11 3109 Antisense
GAGTCGTTGGTTTAACAATGCCACG 112 399 3134 Antisense
GAAAAATCCACGTGACTGCTGAAGC 180 355 3221 Antisense
GAATTAGTGTTTCTGCTCAGGCACC 262 325 3359 Antisense
GAGAAAAGACACCAGAACCGCCTCG 138 391 3386 Antisense
GTCGGCAATCTGTTCGGAGCATATC 112 473 3410 Antisense
Sequence Source Affymetrix Proprietary Database