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[191796_s_at] guanylate cyclase

Description B0240.3 /REP_DB=WormBase Gene ID /WP=CE05174 /GEN=daf-11 /TR=Q17462 /GB=CAA98417.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=guanylate cyclase
Cluster 6grp_total > 34      4grp_total > 06      6grp_cgc > 34      6grp_cgc_sub > Cu      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 44
1 2 3 4 range
A 29.8
(1.9)
A 		3.2
(-3)
A 		14.3
(-1)
A 		35.9
(3)
A 		33
B 18.8
(3)
A 		4.5
(-2)
A 		1.5
(-3)
A 		17.9
(2.7)
A 		17
C 10.3
(-2)
A 		2.9
(-3)
A 		8.6
(-2.2)
A 		45.2
(3)
P 		42
avr 19.6
(0.3) 		3.5
(-3) 		8.1
(-2.1) 		33
(3) 		30

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 32
1 2 3 4 5 6 range
A 29.3
(3)
A 		24.1
(1.9)
A 		1.6
(-2.9)
A 		3.5
(-2.5)
A 		1.5
(-3)
A 		1.3
(-3)
A 		28
B 2.2
(-2.5)
A 		2.4
(-2.4)
A 		15.7
(3)
A 		0.9
(-3)
A 		2.6
(-2.3)
A 		15.1
(2.8)
A 		15
C 14
(-0.5)
A 		15.7
(-0.1)
A 		32.4
(3)
A 		1.3
(-2.8)
A 		1.5
(-2.8)
A 		0.5
(-3)
A 		32
avr 15.2
(2.4) 		14.1
(2) 		16.6
(3) 		1.9
(-3) 		1.9
(-3) 		5.6
(-1.5) 		15
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 11
1 2 3 4 range
A 10.9
(3)
A 		0.7
(-3)
A 		3.7
(-1.2)
A 		5.2
(-0.4)
A 		10
B 6
(3)
A 		1.1
(-2.3)
A 		0.4
(-3)
A 		3.8
(0.6)
A 		6
C 3.4
(-0.7)
A 		0.8
(-3)
A 		3
(-1.1)
A 		7.6
(3)
P 		7
avr 6.8
(3) 		0.9
(-3) 		2.4
(-1.5) 		5.5
(1.7) 		6

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 8
1 2 3 4 5 6 range
A 5.4
(0.7)
A 		8.6
(3)
A 		0.3
(-3)
A 		0.9
(-2.6)
A 		0.4
(-2.9)
A 		0.3
(-3)
A 		8
B 0.8
(-2.3)
A 		0.8
(-2.3)
A 		3.8
(1)
A 		0.2
(-3)
A 		1.1
(-2)
A 		5.6
(3)
A 		5
C 5.2
(0.7)
A 		4.8
(0.4)
A 		8.3
(3)
A 		0.3
(-2.9)
A 		0.5
(-2.8)
A 		0.2
(-3)
A 		8
avr 3.8
(1.7) 		4.7
(3) 		4.1
(2.1) 		0.5
(-3) 		0.7
(-2.7) 		2
(-0.9) 		4
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 191796_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.13953
Sequence Type Exemplar sequence
Representative Public ID B0240.3 NCBI
Target Description B0240.3 /REP_DB=WormBase Gene ID /WP=CE05174 /GEN=daf-11 /TR=Q17462 /GB=CAA98417.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=guanylate cyclase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_073559(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_073559 NCBI Caenorhabditis elegans abnormal DAuer Formation family member (daf-11) (daf-11) mRNA, complete cds. 11/11 None
SNAP00000008959 ENSEMBL cdna:SNAP chromosome:CEL140:V:11721261:11726998:-1 11/11 None
GENEFINDER00000008969 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:11721261:11732748:-1 11/11 None
B0240.3 ENSEMBL cdna:known chromosome:CEL140:V:11720678:11728241:-1 gene:B0240.3 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:11721260-11728241(-) 100.0 100.0
Public Domain and Genome References
Gene Title guanylate cyclase
Gene Symbol daf-11
Ensembl B0240.3
Entrez Gene 179605 Entrez gene
SwissProt Q8I4N4 EMBL-EBI
WormBase CE05174 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4383 guanylate cyclase activity inferred from electronic annotation QuickGO AmiGO
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAD56284 Hypothetical protein B0240.3 [Caenorhabditis elegans] ref|NP_505960.1| abnormal DAuer Formation family member (daf-11) [Caenorhabditis elegans] 0.0
blast CAE75310 Hypothetical protein CBG23280 [Caenorhabditis briggsae] 0.0
blast CAA98418 Hypothetical protein B0240.1 [Caenorhabditis elegans] ref|NP_505961.1| RH (Rhesus) antigen Related family member (rhr-2) [Caenorhabditis elegans] 0.0
blast CAE75310 Hypothetical protein CBG23280 [Caenorhabditis briggsae] 1.0E-142
blast CAB05325 Hypothetical protein ZK896.8 [Caenorhabditis elegans] ref|NP_502449.1| Guanylyl CYclase family member (gcy-18) [Caenorhabditis elegans] 3.0E-94
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 0.21
Pfam IPR000719 EMBL-EBI Protein kinase 8.4E-4
Pfam IPR001054 EMBL-EBI Guanylate cyclase 7.0E-53
Pfam IPR001054 EMBL-EBI Guanylate cyclase 1.3E-56
Pfam IPR000719 EMBL-EBI Protein kinase 0.21
Pfam IPR000719 EMBL-EBI Protein kinase 8.4E-4
Pfam IPR001054 EMBL-EBI Guanylate cyclase 1.3E-56
Pfam IPR010256 EMBL-EBI Rh-like protein/ammonium transporter 1.0E-126
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_505960.1 2 224-243,346-368
B0240.3 2 224-243,346-368
SNAP00000008959 1 118-140
GENEFINDER00000008969 11 12-29,49-68,75-97,137-159,171-188,208-227,240-259,292-314,327-349,384-406,880-902
Sequence
Target Sequence 
>C. ELEGANS:191796_S_AT
gctggtgttattgggcaaaaggctccaagatatgcttgtttcggagaagctgttatatta
gcttcaaaaatggaaagctctggagtggaggatagaattcaaatgacattggcaagccaa
caattgctagaagaaaattttcctcaatttgtgtgtagtaacagaggaggccgtactatt
gaaggaattggtcgtattttaacgtattggctggaaggagtaaatgcaggagaacaagtt
aaagttgttgaattccaaaatgatttgaacgacgaactttcaagaataatgaaaaaagat
ggagagcttttagctgcagcaacagcattaaaaccaaaagacaaaatgacgttggcgaaa
gaaaaagtgatagctgaacgaaaaaatgaagaagaacgactccaacgacagcagacatta
caggaagcattggaagaacatgaagaagagatagaaatgaatgaagtactggtggatgag
gatgaaggtgaaggaaaaccaaaagaagttgatctgacaagtattgtaagtacccaaatg
gaagagctagaagatgaaccagcaggtcgaacaattggac

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GCTGGTGTTATTGGGCAAAAGGCTC 700 293 2671 Antisense
GATATGCTTGTTTCGGAGAAGCTGT 608 425 2699 Antisense
CATTGGCAAGCCAACAATTGCTAGA 645 215 2777 Antisense
ATTTTCCTCAATTTGTGTGTAGTAA 72 15 2807 Antisense
GTGTAGTAACAGAGGAGGCCGTACT 488 483 2823 Antisense
CGTATTTTAACGTATTGGCTGGAAG 283 247 2863 Antisense
GGAGAGCTTTTAGCTGCAGCAACAG 246 519 2971 Antisense
GCAGCAACAGCATTAAAACCAAAAG 532 313 2986 Antisense
GAAGAAGAACGACTCCAACGACAGC 609 339 3058 Antisense
GACTCCAACGACAGCAGACATTACA 212 375 3068 Antisense
GAACCAGCAGGTCGAACAATTGGAC 76 345 3226 Antisense
Sequence Source Affymetrix Proprietary Database