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[191782_s_at] Na/Ca,K exchanger

Description F35C12.2 /REP_DB=WormBase Gene ID /WP=CE28020 /GEN=ncx-4 /TR=P90858 /GB=CAB03047.2 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=Na-Ca,K exchanger
Cluster 6grp_highest_10_10 > 50      6grp_high1_10_10 > 16      4grp_highest_8_8 > 53      4grp_high_8_8 > 17      6grp_highest_nonorm > 40      6grp_total > 16      4grp_total > 31      6grp_highest_sub > De      6grp_cgc > 23      6grp_high1_sub > De      6grp_cgc_sub > De      6grp_total_sub > Decrease      6grp_rule_based > S1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1050
1 2 3 4 range
A 1250.9
(3)
P 		349.1
(-2.8)
P 		319.4
(-3)
P 		812.3
(0.2)
P 		932
B 1253.8
(3)
P 		517.8
(-1.9)
P 		344.5
(-3)
P 		903.7
(0.7)
P 		909
C 1354.8
(3)
P 		421.8
(-2.3)
P 		304.8
(-3)
P 		878.4
(0.3)
P 		1050
avr 1286.5
(3) 		429.6
(-2.3) 		322.9
(-3) 		864.8
(0.4) 		964

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 786
1 2 3 4 5 6 range
A 989.6
(3)
P 		661.7
(0)
P 		549.5
(-1)
P 		403.7
(-2.3)
P 		392.7
(-2.4)
P 		325.6
(-3)
P 		664
B 1111.4
(3)
P 		800.8
(0.5)
P 		578.6
(-1.3)
P 		451.3
(-2.3)
P 		370.3
(-3)
P 		444.2
(-2.4)
P 		741
C 758
(3)
P 		725
(2.5)
P 		436
(-1.9)
P 		505.3
(-0.9)
P 		364.7
(-3)
P 		456.7
(-1.6)
P 		393
avr 953
(3) 		729.2
(0.7) 		521.4
(-1.5) 		453.4
(-2.2) 		375.9
(-3) 		408.8
(-2.7) 		577
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 380
1 2 3 4 range
A 455.5
(3)
P 		75.8
(-3)
P 		83.5
(-2.9)
P 		118.9
(-2.3)
P 		380
B 399.8
(3)
P 		127.9
(-2.1)
P 		79.8
(-3)
P 		192.6
(-0.9)
P 		320
C 448.5
(3)
P 		121.3
(-2.7)
P 		106.2
(-3)
P 		148.1
(-2.3)
P 		342
avr 434.6
(3) 		108.3
(-2.7) 		89.8
(-3) 		153.2
(-1.9) 		345

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 307
1 2 3 4 5 6 range
A 182.4
(1)
P 		235.3
(3)
P 		119.7
(-1.4)
P 		102.4
(-2.1)
P 		118.5
(-1.5)
P 		79.3
(-3)
P 		156
B 386.7
(3)
P 		266.6
(0.3)
P 		140.5
(-2.5)
P 		119.5
(-3)
P 		150.4
(-2.3)
P 		165.6
(-2)
P 		267
C 280.9
(3)
P 		221.2
(1)
P 		111
(-2.7)
P 		101.6
(-3)
P 		118
(-2.5)
P 		152.9
(-1.3)
P 		179
avr 283.3
(3) 		241
(1.6) 		123.7
(-2.5) 		107.8
(-3) 		129
(-2.3) 		132.6
(-2.2) 		176
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 191782_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.1136
Sequence Type Exemplar sequence
Representative Public ID F35C12.2 NCBI
Target Description F35C12.2 /REP_DB=WormBase Gene ID /WP=CE28020 /GEN=ncx-4 /TR=P90858 /GB=CAB03047.2 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=Na-Ca,K exchanger
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_060203(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_060203 NCBI Caenorhabditis elegans Na/Ca eXchangers family member (ncx-4) (ncx-4) mRNA, complete cds. 11/11 None
SNAP00000022597 ENSEMBL cdna:SNAP chromosome:CEL140:I:9817025:9820793:1 9/11 None
GENEFINDER00000022600 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:9817025:9820933:1 11/11 None
F35C12.2 ENSEMBL cdna:known chromosome:CEL140:I:9817025:9821196:1 gene:F35C12.2 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:9816955-9820864(+) 100.0 100.0
Public Domain and Genome References
Gene Title Na/Ca,K exchanger
Gene Symbol ncx-4
Ensembl F35C12.2
Entrez Gene 172834 Entrez gene
SwissProt P90858 EMBL-EBI
WormBase CE28020 Wormbase
Functional Annotations
Ortholog
ID Title Organism
HG-U95AV2:38538_AT solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 hs
HG-U133_PLUS_2:210421_S_AT solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 hs
HG-U133A:210421_S_AT solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 hs
HG-U133A_2:210421_S_AT solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 hs
HG-U133_PLUS_2:210420_AT solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 hs
HG-U133A:210420_AT solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 hs
HG-U133A_2:210420_AT solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 hs
HG-U133_PLUS_2:211842_S_AT solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 hs
HG-U133A:211842_S_AT solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 hs
HG-U133A_2:211842_S_AT solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 hs
HG-U133_PLUS_2:206081_AT solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 hs
HG-U133A:206081_AT solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 hs
HG-FOCUS:206081_AT solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 hs
HG-U133A_2:206081_AT solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 hs
HU35KSUBB:RC_AA015999_AT solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 hs
HU35KSUBB:RC_W02204_AT solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 hs
U133_X3P:G4759127_3P_AT solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 hs
U133_X3P:G3327217_3P_A_AT solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 hs
HG-U95AV2:38539_AT solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 hs
MOUSE430_2:1451647_AT solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 mm
MOE430A:1451647_AT solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 mm
MOUSE430A_2:1451647_AT solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 mm
Gene Ontology
GO Cellular Component (view graph)
ID Description Evidence Links
16021 integral to membrane inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB03047 Hypothetical protein F35C12.2 [Caenorhabditis elegans] ref|NP_492604.1| Na/Ca eXchangers family member (ncx-4) [Caenorhabditis elegans] 0.0
blast CAA06686 Na/Ca,K-exchanger [Caenorhabditis elegans] 0.0
blast CAE60285 Hypothetical protein CBG03868 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR004837 EMBL-EBI Sodium/calcium exchanger membrane region 8.9E-33
Pfam IPR004837 EMBL-EBI Sodium/calcium exchanger membrane region 4.9E-32
Pfam IPR004837 EMBL-EBI Sodium/calcium exchanger membrane region 8.9E-33
Pfam IPR004837 EMBL-EBI Sodium/calcium exchanger membrane region 7.0E-39
Pfam IPR004837 EMBL-EBI Sodium/calcium exchanger membrane region 7.0E-39
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_492604.1 10 15-34,101-123,143-165,172-194,209-243,423-445,460-482,495-517,537-559,564-583
F35C12.2 10 15-34,101-123,143-165,172-194,209-243,423-445,460-482,495-517,537-559,564-583
SNAP00000022597 9 15-34,101-123,143-165,172-194,209-243,419-441,456-478,490-512,532-554
GENEFINDER00000022600 12 15-34,116-138,158-180,187-209,224-258,412-429,476-498,503-525,540-562,575-597,617-639,644-663
Sequence
Target Sequence 
>C. ELEGANS:191782_S_AT
gttagcacctgttgtaatacccatgtgggtcactattccggatgttagaaaatctcataa
ccgtggtctctaccccgcgacattcataatctccatcttgtggatcgcatttttctcgta
tctcatggtttggtgggcaaatacaattggagagacatttgtgattccaactgaaattat
tggattgactattctagctgctggaacaagtattcctgatcttatcactagtgttattgt
ggctcgaaaaggtttgggtgatatggcagtgtccagttcagttggttcaaatattttcga
tgtctgtgttggtctaccgattccgtggcttttatattttctaatagaatatatcaagca
tccaaatgaacctttatcaccaatttctgtgagttcaaaaggattattatgctctgttgg
aatgcttttcatcatgctcattgtattggtctttgctattttcttatcgggatggaagat
gaacaagattttcggaatcctgatgatcgtttcctacgttttcttctgcgtatt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GTTAGCACCTGTTGTAATACCCATG 383 445 1260 Antisense
TACCCATGTGGGTCACTATTCCGGA 278 649 1277 Antisense
GCGACATTCATAATCTCCATCTTGT 294 289 1336 Antisense
ATCTTGTGGATCGCATTTTTCTCGT 587 29 1354 Antisense
GGCAGTGTCCAGTTCAGTTGGTTCA 171 537 1524 Antisense
CGATGTCTGTGTTGGTCTACCGATT 271 249 1557 Antisense
TCTACCGATTCCGTGGCTTTTATAT 325 613 1572 Antisense
GTTGGAATGCTTTTCATCATGCTCA 122 437 1675 Antisense
ATTGGTCTTTGCTATTTTCTTATCG 132 5 1704 Antisense
GAATCCTGATGATCGTTTCCTACGT 576 329 1754 Antisense
TTTCCTACGTTTTCTTCTGCGTATT 646 669 1769 Antisense
Sequence Source Affymetrix Proprietary Database