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[191753_at] Zinc-binding metalloprotease

Description F54F11.2 /REP_DB=WormBase Gene ID /WP=CE11095 /TR=O45569 /GB=CAB05739.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=Zinc-binding metalloprotease
Cluster 6grp_highest_10_10 > 62      6grp_high1_10_10 > 26      4grp_highest_8_8 > 41      4grp_high_8_8 > 50      6grp_highest_nonorm > 02      6grp_total > 16      4grp_total > 61      6grp_highest_sub > Cu      6grp_high1_sub > De      6grp_total_sub > Decrease      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 4025
1 2 3 4 range
A 6282.5
(3)
P 		4876.2
(0.8)
P 		4170.5
(-0.3)
P 		2443.3
(-3)
P 		3839
B 5520.5
(3)
P 		4133.8
(0)
P 		4232.3
(0.2)
P 		2728.4
(-3)
P 		2792
C 5775.1
(3)
P 		4847.9
(1.4)
P 		5314
(2.2)
P 		2257.3
(-3)
P 		3518
avr 5859.4
(3) 		4619.3
(0.8) 		4572.3
(0.7) 		2476.3
(-3) 		3383

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 3380
1 2 3 4 5 6 range
A 3388.1
(3)
P 		3069.6
(2.2)
P 		1747
(-1.3)
P 		1143.4
(-2.9)
P 		1087.2
(-3)
P 		2078.7
(-0.4)
P 		2301
B 3069.8
(3)
P 		2435.4
(1.2)
P 		2300.2
(0.8)
P 		1277.6
(-2.1)
P 		949.6
(-3)
P 		1550.1
(-1.3)
P 		2120
C 4202.6
(3)
P 		2447
(-0.1)
P 		2224.1
(-0.5)
P 		823.1
(-3)
P 		1576.4
(-1.7)
P 		1706.7
(-1.4)
P 		3380
avr 3553.5
(3) 		2650.7
(0.8) 		2090.4
(-0.6) 		1081.4
(-3) 		1204.4
(-2.7) 		1778.5
(-1.3) 		2472
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1930
1 2 3 4 range
A 2287.4
(3)
P 		1058.5
(-0.8)
P 		1090.2
(-0.7)
P 		357.6
(-3)
P 		1930
B 1760.4
(3)
P 		1021
(-0.8)
P 		980.7
(-1)
P 		581.4
(-3)
P 		1179
C 1911.7
(3)
P 		1393.8
(1)
P 		1852.1
(2.8)
P 		380.6
(-3)
P 		1531
avr 1986.5
(3) 		1157.8
(-0.2) 		1307.7
(0.4) 		439.9
(-3) 		1547

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1392
1 2 3 4 5 6 range
A 624.6
(-0.5)
P 		1091.7
(3)
P 		380.4
(-2.3)
P 		290
(-3)
P 		328.1
(-2.7)
P 		506.1
(-1.4)
P 		802
B 1068.1
(3)
P 		810.6
(0.9)
P 		558.6
(-1.2)
P 		338.4
(-3)
P 		385.8
(-2.6)
P 		578
(-1)
P 		730
C 1557.7
(3)
P 		746.6
(-0.5)
P 		566.1
(-1.3)
P 		165.5
(-3)
P 		510.1
(-1.5)
P 		571.3
(-1.3)
P 		1392
avr 1083.5
(3) 		883
(1.5) 		501.7
(-1.3) 		264.6
(-3) 		408
(-1.9) 		551.8
(-0.9) 		819
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 191753_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.3539
Sequence Type Exemplar sequence
Representative Public ID F54F11.2 NCBI
Target Description F54F11.2 /REP_DB=WormBase Gene ID /WP=CE11095 /TR=O45569 /GB=CAB05739.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=Zinc-binding metalloprotease
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_064441(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_064441 NCBI Caenorhabditis elegans F54F11.2 (F54F11.2) mRNA, complete cds. 11/11 None
SNAP00000024040 ENSEMBL cdna:SNAP chromosome:CEL140:II:13508722:13521009:1 10/11 None
GENEFINDER00000024046 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:13507727:13516265:1 11/11 None
F54F11.2 ENSEMBL cdna:known chromosome:CEL140:II:13507715:13516371:1 gene:F54F11.2 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:13507723-13516262(+) 100.0 100.0
Public Domain and Genome References
Gene Title Zinc-binding metalloprotease
Ensembl F54F11.2
Entrez Gene 174996 Entrez gene
SwissProt O45569 EMBL-EBI
WormBase CE11095 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4245 neprilysin activity inferred from electronic annotation QuickGO AmiGO
8237 metallopeptidase activity inferred from electronic annotation QuickGO AmiGO
8270 zinc ion binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB05739 Hypothetical protein F54F11.2 [Caenorhabditis elegans] ref|NP_496842.1| F54F11.2 [Caenorhabditis elegans] 0.0
blast CAE73337 Hypothetical protein CBG20766 [Caenorhabditis briggsae] 0.0
blast AAG29105 zinc metallopeptidase 2 MEP2 [Ancylostoma caninum] 1.0E-168
Protein Domains
Database ID Description E-Value
Pfam IPR008753 EMBL-EBI Peptidase M13 3.7E-7
Pfam IPR008753 EMBL-EBI Peptidase M13 1.4E-5
Pfam IPR008753 EMBL-EBI Peptidase M13 3.3E-8
Pfam IPR000718 EMBL-EBI Peptidase M13, neprilysin 2.1E-77
Pfam IPR000718 EMBL-EBI Peptidase M13, neprilysin 9.1E-113
Pfam IPR004151 EMBL-EBI C. elegans Sre G protein-coupled chemoreceptor 6.0E-19
Pfam IPR008753 EMBL-EBI Peptidase M13 3.7E-7
Pfam IPR008753 EMBL-EBI Peptidase M13 1.4E-5
Pfam IPR008753 EMBL-EBI Peptidase M13 3.3E-8
Pfam IPR000718 EMBL-EBI Peptidase M13, neprilysin 2.1E-77
Pfam IPR000718 EMBL-EBI Peptidase M13, neprilysin 4.9E-62
Pfam IPR000718 EMBL-EBI Peptidase M13, neprilysin 8.4E-42
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_496842.1 1 12-34
F54F11.2 1 12-34
SNAP00000024040 1 1623-1645
GENEFINDER00000024046 1 12-34
Sequence
Target Sequence 
>C. ELEGANS:191753_AT
cccgccatacttcaatccaaactggccaccaagcatcaattacggaggaatgggattggt
cgccggacacgagttgactcacggatttgacgatcagggagttcaatggggaccgactgg
aaacctggccagatggatggatgataattctatggccggattcaaaaacatgtcacagtg
tgttatcaatgagtacagtggattctgtccattgaatgcgacgaactactcgccaaattg
tgtcaaggggccgcagactcaaggagagaatattgctgataacggaggtgtccacgccgc
gttcaacgcctacaagacccatcaatccctcgacggacccgatccacgacttcccgatcg
tctcttcggccagttcacccacgatcagctcttcttcatgagcttcgcccaggtttggtg
tgaagtccgacggaccgatgacgcgttgtacactcaaattatggtcgacccacactcacc
gtcaatgtacagagtttatggaacgattcagaacttcccagcgttccaaacggcgttcaa
ctgcccacttggctcgaagagtgctccggaac

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CCCGCCATACTTCAATCCAAACTGG 186 259 4173 Antisense
AACTGGCCACCAAGCATCAATTACG 22 143 4192 Antisense
ATTGGTCGCCGGACACGAGTTGACT 225 3 4227 Antisense
ACGAACTACTCGCCAAATTGTGTCA 293 91 4393 Antisense
TCAAGGGGCCGCAGACTCAAGGAGA 279 627 4415 Antisense
CTGATAACGGAGGTGTCCACGCCGC 435 239 4448 Antisense
TCAGCTCTTCTTCATGAGCTTCGCC 228 625 4557 Antisense
AAGTCCGACGGACCGATGACGCGTT 212 157 4595 Antisense
AACGATTCAGAACTTCCCAGCGTTC 485 143 4674 Antisense
GCGTTCCAAACGGCGTTCAACTGCC 663 273 4693 Antisense
CTTGGCTCGAAGAGTGCTCCGGAAC 166 217 4720 Antisense
Sequence Source Affymetrix Proprietary Database