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[191744_at] guanylate cyclase

Description AH6.1 /REP_DB=WormBase Gene ID /WP=CE01450 /GEN=gcy-1 /TR=SW:Q09435 /GB=CAA88089.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=guanylate cyclase
Cluster 6grp_total > 47      4grp_total > 02      6grp_cgc > 07      6grp_total_sub > Cup      4grp_rule_based > L4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 103
1 2 3 4 range
A 24.6
(-1.2)
A 		4.2
(-3)
A 		7.2
(-2.7)
A 		70.8
(3)
A 		67
B 3.2
(-3)
A 		6.7
(-2.5)
A 		9.6
(-2.1)
A 		46.2
(3)
A 		43
C 3.7
(-2.9)
A 		6.7
(-2.7)
A 		2.3
(-3)
A 		105.3
(3)
A 		103
avr 10.5
(-2.6) 		5.9
(-3) 		6.4
(-3) 		74.1
(3) 		68

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 17
1 2 3 4 5 6 range
A 19.1
(3)
A 		3.3
(-2.5)
A 		7
(-1.2)
A 		3.1
(-2.6)
A 		4.3
(-2.2)
A 		1.9
(-3)
A 		17
B 6.7
(1.1)
A 		5.5
(-0)
A 		5.5
(-0)
A 		3.7
(-1.8)
A 		2.5
(-3)
A 		8.6
(3)
A 		6
C 2.2
(-3)
A 		6.4
(-1)
A 		4.3
(-2)
A 		4.7
(-1.8)
A 		6.2
(-1.1)
A 		15.1
(3)
A 		13
avr 9.3
(3) 		5.1
(-1.6) 		5.6
(-1) 		3.8
(-3) 		4.3
(-2.5) 		8.5
(2.1) 		6
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 17
1 2 3 4 range
A 9
(2.1)
A 		0.9
(-3)
A 		1.9
(-2.4)
A 		10.4
(3)
A 		10
B 1
(-3)
A 		1.7
(-2.5)
A 		2.2
(-2.2)
A 		9.8
(3)
A 		9
C 1.2
(-2.9)
A 		1.9
(-2.6)
A 		0.8
(-3)
A 		17.8
(3)
A 		17
avr 3.7
(-1.8) 		1.5
(-3) 		1.6
(-2.9) 		12.7
(3) 		11

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 5
1 2 3 4 5 6 range
A 3.5
(3)
A 		1.2
(-1.6)
A 		1.5
(-1)
A 		0.8
(-2.4)
A 		1.3
(-1.4)
A 		0.5
(-3)
A 		3
B 2.3
(0.5)
A 		1.8
(-0.8)
A 		1.3
(-2.2)
A 		1
(-3)
A 		1
(-3)
A 		3.2
(3)
A 		2
C 0.8
(-3)
A 		1.9
(-1.4)
A 		1.1
(-2.6)
A 		0.9
(-2.9)
A 		2
(-1.3)
A 		5
(3)
A 		4
avr 2.2
(0.9) 		1.6
(-0.9) 		1.3
(-1.8) 		0.9
(-3) 		1.4
(-1.5) 		2.9
(3) 		2
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 191744_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.2747
Sequence Type Exemplar sequence
Representative Public ID AH6.1 NCBI
Target Description AH6.1 /REP_DB=WormBase Gene ID /WP=CE01450 /GEN=gcy-1 /TR=SW:Q09435 /GB=CAA88089.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=guanylate cyclase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_063638(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_063638 NCBI Caenorhabditis elegans Guanylyl CYclase family member (gcy-1) (gcy-1) mRNA, complete cds. 11/11 None
AH6.1 ENSEMBL cdna:known chromosome:CEL140:II:9512401:9516847:-1 gene:AH6.1 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000033429 6/11 Cross Hyb Matching Probes None
GENEFINDER00000033439 4/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:9512397-9516844(-) 100.0 100.0
Public Domain and Genome References
Gene Title guanylate cyclase
Gene Symbol gcy-1
Ensembl AH6.1
Entrez Gene 191639 Entrez gene
SwissProt Q09435 EMBL-EBI
WormBase CE01450 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4383 guanylate cyclase activity inferred from electronic annotation QuickGO AmiGO
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA88089 Hypothetical protein AH6.1 [Caenorhabditis elegans] emb|CAA88054.1| Hypothetical protein AH6.1 [Caenorhabditis elegans] ref|NP_496039.1| Guanylyl CYclase family member (gcy-1) [Caenorhabditis elegans] sp|Q09435|GCY1_CAEEL Guanylate cyclase receptor-type gcy-1 precursor 0.0
blast CAA88053 Hypothetical protein R134.2 [Caenorhabditis elegans] ref|NP_496038.1| Guanylyl CYclase family member (gcy-2) [Caenorhabditis elegans] 0.0
blast CAA88052 Hypothetical protein R134.1 [Caenorhabditis elegans] ref|NP_496037.1| Guanylyl CYclase family member (gcy-3) [Caenorhabditis elegans] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 6.4E-20
Pfam IPR001054 EMBL-EBI Guanylate cyclase 4.7E-102
Pfam IPR001828 EMBL-EBI Extracellular ligand-binding receptor 1.9E-68
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_496039.1 1 497-519
AH6.1 1 497-519
Sequence
Target Sequence 
>C. ELEGANS:191744_AT
gaaaaccatcccttatacatctaacaaacgatgctcattctcttctaaccactcattatc
caaatcaatacgaaacgagttcccgaggagaagtaattataaaaggaaaaggagttatgg
aaacattttgggtgcacggcagatttggtgaaatggaaccaaccgagttaagaagcatta
gtaatcggtcaacaccaccagtaaccaacgatagatggattccaaatccatcaagctctc
atggatcacgtccttcgagtgtatatgatccattacagggacatcagaaat

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAAAACCATCCCTTATACATCTAAC 185 355 3104 Antisense
CAAACGATGCTCATTCTCTTCTAAC 363 191 3128 Antisense
CTCTTCTAACCACTCATTATCCAAA 621 229 3143 Antisense
TCAATACGAAACGAGTTCCCGAGGA 138 621 3168 Antisense
TTGGGTGCACGGCAGATTTGGTGAA 561 707 3231 Antisense
GGAACCAACCGAGTTAAGAAGCATT 374 527 3258 Antisense
AGCATTAGTAATCGGTCAACACCAC 335 77 3277 Antisense
TCAACACCACCAGTAACCAACGATA 345 629 3292 Antisense
CATGGATCACGTCCTTCGAGTGTAT 681 209 3343 Antisense
GTCCTTCGAGTGTATATGATCCATT 219 477 3353 Antisense
GATCCATTACAGGGACATCAGAAAT 631 415 3370 Antisense
Sequence Source Affymetrix Proprietary Database