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[191736_s_at] Methylmalonyl-coA mutase

Description ZK1058.1 /REP_DB=WormBase Gene ID /WP=CE01101 /TR=SW:Q23381 /GB=CAA84676.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=Methylmalonyl-coA mutase
Cluster 6grp_highest_10_10 > 46      6grp_high1_10_10 > 63      4grp_highest_8_8 > 51      4grp_high_8_8 > 32      6grp_highest_nonorm > 47      6grp_total > 64      4grp_total > 47      6grp_high1_sub > 03      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 2128
1 2 3 4 range
A 4119.8
(3)
P 		2814.4
(-1.6)
P 		2401.8
(-3)
P 		2642.3
(-2.2)
P 		1718
B 4457.2
(3)
P 		2349.8
(-2.9)
P 		2329.6
(-3)
P 		2669.2
(-2)
P 		2128
C 4124
(3)
P 		2397.2
(-2.8)
P 		2421
(-2.7)
P 		2330.3
(-3)
P 		1794
avr 4233.7
(3) 		2520.5
(-2.6) 		2384.1
(-3) 		2547.3
(-2.5) 		1850

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1796
1 2 3 4 5 6 range
A 2933.2
(-2.4)
P 		2953.7
(-2.3)
P 		3695.2
(3)
P 		3349.2
(0.5)
P 		2854.3
(-3)
P 		3381.3
(0.8)
P 		841
B 2637.8
(-3)
P 		3011.1
(-1.8)
P 		4434.1
(3)
P 		3630.6
(0.3)
P 		2908
(-2.1)
P 		3392.9
(-0.5)
P 		1796
C 2723.7
(-3)
P 		2864.5
(-2.4)
P 		4255.5
(3)
P 		3347.4
(-0.6)
P 		3113.4
(-1.5)
P 		3648.4
(0.6)
P 		1532
avr 2764.9
(-3) 		2943.1
(-2.2) 		4128.3
(3) 		3442.4
(-0) 		2958.6
(-2.1) 		3474.2
(0.1) 		1363
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1113
1 2 3 4 range
A 1500
(3)
P 		610.9
(-1.8)
P 		627.9
(-1.7)
P 		386.8
(-3)
P 		1113
B 1421.4
(3)
P 		580.3
(-2.7)
P 		539.8
(-3)
P 		568.8
(-2.8)
P 		882
C 1365.1
(3)
P 		689.2
(-1.2)
P 		843.8
(-0.2)
P 		392.9
(-3)
P 		972
avr 1428.8
(3) 		626.8
(-1.9) 		670.5
(-1.6) 		449.5
(-3) 		979

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 725
1 2 3 4 5 6 range
A 540.7
(-3)
P 		1050.5
(3)
P 		804.7
(0.1)
P 		849.4
(0.6)
P 		861.3
(0.8)
P 		823.2
(0.3)
P 		510
B 917.8
(-3)
P 		1002.3
(-1.5)
P 		1076.7
(-0.3)
P 		961.6
(-2.2)
P 		1181.5
(1.6)
P 		1265.2
(3)
P 		347
C 1009.6
(0.7)
P 		874
(-0.8)
P 		1083.1
(1.5)
P 		673.2
(-3)
P 		1007.5
(0.7)
P 		1221.3
(3)
P 		548
avr 822.7
(-3) 		975.6
(0.3) 		988.2
(0.5) 		828.1
(-2.9) 		1016.8
(1.2) 		1103.2
(3) 		281
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 191736_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.6845
Sequence Type Exemplar sequence
Representative Public ID ZK1058.1 NCBI
Target Description ZK1058.1 /REP_DB=WormBase Gene ID /WP=CE01101 /TR=SW:Q23381 /GB=CAA84676.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=Methylmalonyl-coA mutase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_065385(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_065385 NCBI Caenorhabditis elegans ZK1058.1 (ZK1058.1) mRNA, complete cds. 11/11 None
SNAP00000000029 ENSEMBL cdna:SNAP chromosome:CEL140:III:3903373:3907634:-1 11/11 None
GENEFINDER00000000042 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:3903373:3907634:-1 10/11 None
ZK1058.1.1 ENSEMBL cdna:known chromosome:CEL140:III:3903089:3907664:-1 gene:ZK1058.1 11/11 None
ZK1058.1.2 ENSEMBL cdna:known chromosome:CEL140:III:3903089:3907662:-1 gene:ZK1058.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:3903372-3907634(-) 99.87 99.87
Public Domain and Genome References
Gene Title Methylmalonyl-coA mutase
Ensembl ZK1058.1
Entrez Gene 175503 Entrez gene
SwissProt Q23381 EMBL-EBI
WormBase CE30404 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1584821_AT similar to Methylmalonyl-CoA mutase, mitochondrial precursor (MCM) (Methylmalonyl-CoA isomerase) cfa
CANINE_2:CFA.19060.1.S1_S_AT similar to Methylmalonyl-CoA mutase, mitochondrial precursor (MCM) (Methylmalonyl-CoA isomerase) cfa
CANINE_2:CFA.19576.1.S1_S_AT similar to Methylmalonyl-CoA mutase, mitochondrial precursor (MCM) (Methylmalonyl-CoA isomerase) cfa
CANINE_2:CFA.2432.1.A1_AT similar to Methylmalonyl-CoA mutase, mitochondrial precursor (MCM) (Methylmalonyl-CoA isomerase) cfa
CANINE_2:CFAAFFX.4089.1.S1_S_AT similar to Methylmalonyl-CoA mutase, mitochondrial precursor (MCM) (Methylmalonyl-CoA isomerase) cfa
CHICKEN:GGAAFFX.10684.1.S1_AT similar to methylmalonyl-CoA mutase gga
CHICKEN:GGAAFFX.10684.2.S1_AT similar to methylmalonyl-CoA mutase gga
HG-U133A:202960_S_AT methylmalonyl Coenzyme A mutase hs
HG-U133_PLUS_2:202960_S_AT methylmalonyl Coenzyme A mutase hs
HG-U133A_2:202960_S_AT methylmalonyl Coenzyme A mutase hs
HUGENEFL:M65131_RNA1_AT methylmalonyl Coenzyme A mutase hs
U133_X3P:G4557766_3P_A_AT methylmalonyl Coenzyme A mutase hs
U133_X3P:HS.155212.0.A2_3P_AT methylmalonyl Coenzyme A mutase hs
HG-U133A_2:202959_AT methylmalonyl Coenzyme A mutase hs
HG-FOCUS:202959_AT methylmalonyl Coenzyme A mutase hs
HG-U133_PLUS_2:202959_AT methylmalonyl Coenzyme A mutase hs
HG-U133A:202959_AT methylmalonyl Coenzyme A mutase hs
HG-U95AV2:40105_AT methylmalonyl Coenzyme A mutase hs
HG-U95C:62961_AT methylmalonyl Coenzyme A mutase hs
HU35KSUBB:RC_AA034030_AT Methylmalonyl Coenzyme A mutase hs
HU35KSUBD:RC_T32417_S_AT Methylmalonyl Coenzyme A mutase hs
HU35KSUBB:RC_Z39790_AT Methylmalonyl Coenzyme A mutase hs
MU11KSUBB:X51941_S_AT methylmalonyl-Coenzyme A mutase mm
MG-U74AV2:99613_AT methylmalonyl-Coenzyme A mutase mm
MOE430A:1416839_AT methylmalonyl-Coenzyme A mutase mm
MOUSE430A_2:1416839_AT methylmalonyl-Coenzyme A mutase mm
MOUSE430_2:1416839_AT methylmalonyl-Coenzyme A mutase mm
MOE430A:1448486_AT methylmalonyl-Coenzyme A mutase mm
MOUSE430A_2:1448486_AT methylmalonyl-Coenzyme A mutase mm
MOUSE430_2:1448486_AT methylmalonyl-Coenzyme A mutase mm
MOE430A:1416838_AT methylmalonyl-Coenzyme A mutase mm
MOUSE430A_2:1416838_AT methylmalonyl-Coenzyme A mutase mm
MOUSE430_2:1416838_AT methylmalonyl-Coenzyme A mutase mm
MU19KSUBA:TC24025_AT Methylmalonyl-Coenzyme A mutase, mRNA (cDNA clone MGC:29139 IMAGE:5007694) mm
MU19KSUBA:TC24025_G_AT Methylmalonyl-Coenzyme A mutase, mRNA (cDNA clone MGC:29139 IMAGE:5007694) mm
MU19KSUBC:TC35659_AT Methylmalonyl-Coenzyme A mutase, mRNA (cDNA clone MGC:29139 IMAGE:5007694) mm
MU19KSUBC:TC35659_G_AT Methylmalonyl-Coenzyme A mutase, mRNA (cDNA clone MGC:29139 IMAGE:5007694) mm
RAE230B:1385690_AT similar to Mut protein rn
RAT230_2:1385690_AT similar to Mut protein rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
8152 metabolism inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4494 methylmalonyl-CoA mutase activity inferred from electronic annotation QuickGO AmiGO
16853 isomerase activity inferred from electronic annotation QuickGO AmiGO
50897 cobalt ion binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA84676 Hypothetical protein ZK1058.1 [Caenorhabditis elegans] ref|NP_497786.2| ZK1058.1 [Caenorhabditis elegans] sp|Q23381|MUTA_CAEEL Probable methylmalonyl-CoA mutase, mitochondrial precursor (MCM) 0.0
blast T27674 hypothetical protein ZK1058.1 - Caenorhabditis elegans 0.0
blast CAE60083 Hypothetical protein CBG03603 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR006099 EMBL-EBI Methylmalonyl-CoA mutase 1.0E-126
Pfam IPR006158 EMBL-EBI Coenzyme B12-binding 1.4E-28
Pfam IPR006158 EMBL-EBI Coenzyme B12-binding 1.4E-28
Sequence
Target Sequence 
>C. ELEGANS:191736_S_AT
atggaacttgccattgaagccgcccgtgctcgttgtacagttggagagatttctgatgca
atggagaaagtattcaatcgacacgcagctgttaatcgtttggtttctggtgcatataaa
tcagaatttggagagacttctgaaatgtcacaggtgcttgaacgtgttaaatcgttcgct
gatcgtgatggtcgtcaaccacgtattatggtggcaaagatgggacaagatggacatgat
cgtggagcaaaagtcattgcaacaggattcgctgatcttggattcgatgttgatgttgga
ccactcttccagactccattagaagctgctcaacaagctgtcgatgctgatgttcatgtt
attggagcatccagtttggccgccggacacttgacactcattccacagcttattggagaa
ctcaagaaattgggaagaccagacatcctcgtcgtcgccggaggagtcattccaccacaa
gactacaaggaactctatgatgctggggtcgccctcgtcttcggtccaggaacccgcctt
ccagcttgtgccaaccaaattctcg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
ATGGAACTTGCCATTGAAGCCGCCC 527 51 1630 Antisense
GTATTCAATCGACACGCAGCTGTTA 242 453 1699 Antisense
AGCTGTTAATCGTTTGGTTTCTGGT 137 81 1716 Antisense
GTTCGCTGATCGTGATGGTCGTCAA 180 441 1803 Antisense
ACAGGATTCGCTGATCTTGGATTCG 454 107 1891 Antisense
GTTGATGTTGGACCACTCTTCCAGA 570 437 1918 Antisense
AGACTCCATTAGAAGCTGCTCAACA 307 69 1940 Antisense
TATTGGAGCATCCAGTTTGGCCGCC 537 665 1989 Antisense
TGACACTCATTCCACAGCTTATTGG 276 571 2021 Antisense
GGAACTCTATGATGCTGGGGTCGCC 483 529 2118 Antisense
CCAGCTTGTGCCAACCAAATTCTCG 224 273 2170 Antisense
Sequence Source Affymetrix Proprietary Database