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[191724_at] ribosomal protein S6 kinase

Description Y47D3A.16 /REP_DB=WormBase Gene ID /WP=CE22045 /TR=Q9NAH6 /GB=CAB55075.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=ribosomal protein S6 kinase
Cluster 6grp_total > 48      4grp_total > 12      6grp_cgc > 17      6grp_cgc_sub > Cu      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 177
1 2 3 4 range
A 274
(-1.2)
A 		272.2
(-1.3)
A 		245.6
(-3)
A 		338.5
(3)
P 		93
B 294.1
(-0.4)
M 		219.8
(-3)
A 		238
(-2.4)
A 		392.5
(3)
P 		173
C 299
(0.5)
A 		296.9
(0.4)
A 		216
(-3)
A 		357.6
(3)
P 		142
avr 289
(-0.4) 		263
(-1.6) 		233.2
(-3) 		362.9
(3) 		130

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 175
1 2 3 4 5 6 range
A 247.4
(2.5)
A 		202.9
(0.4)
A 		133.6
(-2.8)
A 		128.8
(-3)
A 		172.4
(-1)
A 		259.2
(3)
A 		130
B 187.8
(2.5)
A 		133.2
(-1.3)
A 		108.7
(-3)
A 		144.1
(-0.5)
A 		122.4
(-2)
A 		194.8
(3)
M 		86
C 273.5
(3)
M 		160.9
(-0.9)
A 		182.1
(-0.1)
A 		180.8
(-0.2)
A 		98.9
(-3)
A 		226.1
(1.4)
A 		175
avr 236.2
(3) 		165.7
(-1) 		141.5
(-2.4) 		151.2
(-1.9) 		131.2
(-3) 		226.7
(2.5) 		105
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 50
1 2 3 4 range
A 99.8
(3)
A 		59.1
(-1.9)
A 		64.2
(-1.3)
A 		49.6
(-3)
P 		50
B 93.8
(3)
M 		54.3
(-3)
A 		55.2
(-2.9)
A 		83.6
(1.5)
P 		40
C 99
(3)
A 		85.4
(0.9)
A 		75.3
(-0.7)
A 		60.3
(-3)
P 		39
avr 97.5
(3) 		66.3
(-2.7) 		64.9
(-2.9) 		64.5
(-3) 		33

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 75
1 2 3 4 5 6 range
A 45.6
(-0.7)
A 		72.2
(3)
A 		29.1
(-3)
A 		32.7
(-2.5)
A 		52
(0.2)
A 		63.1
(1.7)
A 		43
B 65.3
(2.1)
A 		44.3
(-0.7)
A 		26.4
(-3)
A 		38.2
(-1.5)
A 		49.7
(0)
A 		72.6
(3)
M 		46
C 101.4
(3)
M 		49.1
(-1.5)
A 		46.3
(-1.8)
A 		36.4
(-2.6)
A 		32
(-3)
A 		75.7
(0.8)
A 		69
avr 70.8
(3) 		55.2
(0.5) 		33.9
(-3) 		35.8
(-2.7) 		44.6
(-1.3) 		70.5
(3) 		37
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 191724_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.7085
Sequence Type Exemplar sequence
Representative Public ID Y47D3A.16 NCBI
Target Description Y47D3A.16 /REP_DB=WormBase Gene ID /WP=CE22045 /TR=Q9NAH6 /GB=CAB55075.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=ribosomal protein S6 kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_067046(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_067046 NCBI Caenorhabditis elegans RSK-pSeventy (RSK-p70 kinase) homolog family member (rsks-1) (rsks-1) mRNA, complete cds. 11/11 None
SNAP00000007213 ENSEMBL cdna:SNAP chromosome:CEL140:III:11237028:11260141:1 10/11 None
GENEFINDER00000007295 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:11245188:11251062:1 11/11 None
Y47D3A.16 ENSEMBL cdna:known chromosome:CEL140:III:11245066:11251062:1 gene:Y47D3A.16 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:11245183-11251058(+) 100.0 100.0
Public Domain and Genome References
Gene Title ribosomal protein S6 kinase
Gene Symbol rsks-1
Ensembl Y47D3A.16
Entrez Gene 176554 Entrez gene
SwissProt Q9NAH6 EMBL-EBI
WormBase CE22045 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:16087_S_AT serine/threonine protein kinase (PK1) (PK6) at
ATH1-121501:258677_AT serine/threonine protein kinase (PK1) (PK6) at
CANINE:1601215_AT similar to ribosomal protein S6 kinase, 70kDa, polypeptide 1 cfa
CANINE:1588026_AT similar to ribosomal protein S6 kinase, 70kDa, polypeptide 1 cfa
CANINE_2:CFA.13383.1.A1_S_AT similar to ribosomal protein S6 kinase, 70kDa, polypeptide 1 cfa
CANINE_2:CFAAFFX.27069.1.S1_AT similar to ribosomal protein S6 kinase, 70kDa, polypeptide 1 cfa
DROSOPHILA_2:1624244_AT RPS6-p70-protein kinase dm
DROSGENOME1:143848_AT RPS6-p70-protein kinase dm
CHICKEN:GGAAFFX.11722.1.S1_S_AT ribosomal protein S6 kinase, 70kDa, polypeptide 1 gga
HG-U133_PLUS_2:211578_S_AT ribosomal protein S6 kinase, 70kDa, polypeptide 1 hs
HG-U133A:211578_S_AT ribosomal protein S6 kinase, 70kDa, polypeptide 1 hs
HG-U133A_2:211578_S_AT ribosomal protein S6 kinase, 70kDa, polypeptide 1 hs
HG-U95AV2:238_AT ribosomal protein S6 kinase, 70kDa, polypeptide 1 hs
HC-G110:238_AT ribosomal protein S6 kinase, 70kDa, polypeptide 1 hs
HG-U133_PLUS_2:204171_AT ribosomal protein S6 kinase, 70kDa, polypeptide 1 hs
HG-U133A_2:204171_AT ribosomal protein S6 kinase, 70kDa, polypeptide 1 hs
HG-U133A:204171_AT ribosomal protein S6 kinase, 70kDa, polypeptide 1 hs
HG-FOCUS:204171_AT ribosomal protein S6 kinase, 70kDa, polypeptide 1 hs
HG-U133_PLUS_2:226660_AT ribosomal protein S6 kinase, 70kDa, polypeptide 1 hs
HG-U133B:226660_AT ribosomal protein S6 kinase, 70kDa, polypeptide 1 hs
HU35KSUBA:M60725_S_AT ribosomal protein S6 kinase, 70kDa, polypeptide 1 hs
HG-U95AV2:2037_S_AT ribosomal protein S6 kinase, 70kDa, polypeptide 1 hs
HC-G110:2037_S_AT ribosomal protein S6 kinase, 70kDa, polypeptide 1 hs
HUGENEFL:M60724_AT ribosomal protein S6 kinase, 70kDa, polypeptide 1 hs
U133_X3P:G4506736_3P_AT ribosomal protein S6 kinase, 70kDa, polypeptide 1 hs
U133_X3P:G189509_3P_A_AT ribosomal protein S6 kinase, 70kDa, polypeptide 1 hs
U133_X3P:HS.146217.0.S1_3P_AT ribosomal protein S6 kinase, 70kDa, polypeptide 1 hs
HG-U95AV2:37946_AT ribosomal protein S6 kinase, 70kDa, polypeptide 1 hs
HG-U95E:82929_AT ribosomal protein S6 kinase, 70kDa, polypeptide 1 hs
HG-U95E:90022_AT ribosomal protein S6 kinase, 70kDa, polypeptide 1 hs
RT-U34:M57428_S_AT ribosomal protein S6 kinase, polypeptide 1 rn
RG-U34A:M57428_S_AT ribosomal protein S6 kinase, polypeptide 1 rn
RG-U34A:M58340_AT ribosomal protein S6 kinase, polypeptide 1 rn
RG-U34C:RC_AI071422_AT ribosomal protein S6 kinase, polypeptide 1 rn
RAE230A:1368116_A_AT ribosomal protein S6 kinase, polypeptide 1 rn
RAT230_2:1368116_A_AT ribosomal protein S6 kinase, polypeptide 1 rn
RG-U34C:RC_AA817917_AT Ribosomal protein S6 kinase, polypeptide 1 rn
RG-U34C:RC_AA819014_AT Ribosomal protein S6 kinase, polypeptide 1 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB55075 Hypothetical protein Y47D3A.16 [Caenorhabditis elegans] ref|NP_499447.1| RSK-pSeventy (RSK-p70 kinase) homolog family member (rsks-1) [Caenorhabditis elegans] 0.0
blast CAE67653 Hypothetical protein CBG13216 [Caenorhabditis briggsae] 0.0
blast CAB55074 Hypothetical protein Y47D3A.15 [Caenorhabditis elegans] ref|NP_499446.1| Y47D3A.15 [Caenorhabditis elegans] 1.0E-160
blast AAG48248 p70 ribosomal protein S6 kinase [Artemia franciscana] 1.0E-140
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 4.0E-69
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 2.0E-60
hanks 1.6.1 AGC group; AGC VI phosphorylate ribosomal protein S6; S6K 1.0E-113
hanks 1.6.1 AGC group; AGC VI phosphorylate ribosomal protein S6; S6K 1.0E-119
Protein Domains
Database ID Description E-Value
Pfam IPR006828 EMBL-EBI 5-AMP-activated protein kinase, beta subunit, complex-interacting region 5.7E-54
Pfam IPR000719 EMBL-EBI Protein kinase 9.3E-72
Pfam IPR000961 EMBL-EBI Protein kinase C-terminal domain 3.4E-21
Pfam IPR000719 EMBL-EBI Protein kinase 3.3E-81
Pfam IPR000961 EMBL-EBI Protein kinase C-terminal domain 3.4E-21
Sequence
Target Sequence 
>C. ELEGANS:191724_AT
aaaaatgacgccggtcgattcgccgtgtgagacgaatttcagtttgaatggtgataatcc
gtttgtgggattcacctatgtcgcaccgtctgtgttggaaatgatgaataagggaggaca
tggtggaatttcggtggcacatttggcttcgtctatgtcgagagctggtgctgcgaagag
cccgagaaagccaggagacccagaaacggcgagcattcttcacggtggtcactcgaattt
gttcggtcacggaccaaatagtgaagccccacaggcttttggatacggaattggtagtca
aatgactactactactgctggaggagcaggaattcaacagccatatcaatcatttagtgg
tggatatccagaagatgatgcaatggatacatctacaccacgtgctagtgaaagtcgtga
aactactactggaaatggatctactacgacgacaagaccatcaaatgttggaagttctgc
gtcaacacctattccattgccgaaaagggtgataaaattgccacacacacacacctctac
acaaaatgctcaatattcattcatgcttcttctcct

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AAAAATGACGCCGGTCGATTCGCCG 249 129 1149 Antisense
TTGTGGGATTCACCTATGTCGCACC 277 707 1211 Antisense
TATGTCGCACCGTCTGTGTTGGAAA 373 653 1225 Antisense
GCACATTTGGCTTCGTCTATGTCGA 570 315 1285 Antisense
GAGCCCGAGAAAGCCAGGAGACCCA 633 383 1326 Antisense
CACGGTGGTCACTCGAATTTGTTCG 585 153 1369 Antisense
AGCCCCACAGGCTTTTGGATACGGA 13 83 1413 Antisense
TGACTACTACTACTGCTGGAGGAGC 508 571 1451 Antisense
GATACATCTACACCACGTGCTAGTG 415 423 1534 Antisense
TCAACACCTATTCCATTGCCGAAAA 225 629 1630 Antisense
AATATTCATTCATGCTTCTTCTCCT 126 175 1700 Antisense
Sequence Source Affymetrix Proprietary Database