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[191615_at] guanylate cyclase

Description ZK970.5 /REP_DB=WormBase Gene ID /WP=CE02405 /GEN=gcy-4 /TR=Q23681 /GB=CAA88889.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=guanylate cyclase
Cluster 6grp_total > 21      4grp_total > 44      6grp_cgc > 81      6grp_cgc_sub > 03      6grp_total_sub > Hat      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 34
1 2 3 4 range
A 31.3
(3)
A 		20.1
(0)
A 		10.6
(-2.5)
A 		8.8
(-3)
A 		23
B 19.1
(-0.5)
A 		36.3
(3)
A 		6.8
(-3)
A 		7.1
(-2.9)
A 		30
C 24.9
(-2.6)
A 		41
(3)
A 		32.3
(-0)
A 		23.7
(-3)
A 		17
avr 25.1
(0.7) 		32.5
(3) 		16.6
(-1.9) 		13.2
(-3) 		19

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 58
1 2 3 4 5 6 range
A 12.5
(-1.7)
A 		41.5
(3)
A 		33.9
(1.8)
A 		8
(-2.4)
A 		9.4
(-2.2)
A 		4.3
(-3)
A 		37
B 7
(-2.4)
A 		5.5
(-3)
A 		9.6
(-1.3)
A 		20.1
(3)
A 		7.8
(-2.1)
A 		14.4
(0.7)
A 		15
C 28.1
(-0.3)
A 		39.4
(0.8)
A 		60.2
(3)
A 		11.6
(-2)
A 		28.5
(-0.3)
A 		2.3
(-3)
A 		58
avr 15.9
(-1.1) 		28.8
(1.7) 		34.6
(3) 		13.2
(-1.7) 		15.2
(-1.2) 		7
(-3) 		28
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 11
1 2 3 4 range
A 11.4
(3)
A 		4.4
(-1.2)
A 		2.8
(-2.1)
A 		1.3
(-3)
A 		10
B 6.1
(0.7)
A 		9
(3)
A 		1.6
(-2.9)
A 		1.5
(-3)
A 		8
C 8.2
(0.2)
A 		11.8
(3)
A 		11.2
(2.5)
A 		4
(-3)
A 		8
avr 8.6
(3) 		8.4
(2.8) 		5.2
(-0.2) 		2.3
(-3) 		6

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 15
1 2 3 4 5 6 range
A 2.3
(-2.4)
A 		14.8
(3)
A 		7.4
(-0.2)
A 		2
(-2.6)
A 		2.8
(-2.2)
A 		1
(-3)
A 		14
B 2.4
(-2)
A 		1.8
(-3)
A 		2.3
(-2.2)
A 		5.3
(2.8)
A 		3.2
(-0.7)
A 		5.4
(3)
A 		4
C 10.4
(1)
A 		12
(1.6)
A 		15.3
(3)
A 		2.3
(-2.4)
A 		9.2
(0.5)
A 		0.8
(-3)
A 		15
avr 5
(-0.8) 		9.5
(3) 		8.3
(2) 		3.2
(-2.3) 		5.1
(-0.7) 		2.4
(-3) 		7
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 191615_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.3024
Sequence Type Exemplar sequence
Representative Public ID ZK970.5 NCBI
Target Description ZK970.5 /REP_DB=WormBase Gene ID /WP=CE02405 /GEN=gcy-4 /TR=Q23681 /GB=CAA88889.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=guanylate cyclase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_063817(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_063817 NCBI Caenorhabditis elegans Guanylyl CYclase family member (gcy-4) (gcy-4) mRNA, complete cds. 11/11 None
GENEFINDER00000004327 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:10304049:10308736:-1 11/11 None
ZK970.5 ENSEMBL cdna:known chromosome:CEL140:II:10304049:10308766:-1 gene:ZK970.5 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000004312 6/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:10304045-10308763(-) 100.0 100.0
Public Domain and Genome References
Gene Title guanylate cyclase
Gene Symbol gcy-4
Ensembl ZK970.5
Entrez Gene 191642 Entrez gene
SwissProt Q23681 EMBL-EBI
WormBase CE02405 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4383 guanylate cyclase activity inferred from electronic annotation QuickGO AmiGO
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA88889 Hypothetical protein ZK970.5 [Caenorhabditis elegans] ref|NP_496218.1| Guanylyl CYclase family member (gcy-4) [Caenorhabditis elegans] 0.0
blast CAE57826 Hypothetical protein CBG00851 [Caenorhabditis briggsae] 0.0
blast CAA88052 Hypothetical protein R134.1 [Caenorhabditis elegans] ref|NP_496037.1| Guanylyl CYclase family member (gcy-3) [Caenorhabditis elegans] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001828 EMBL-EBI Extracellular ligand-binding receptor 1.5E-65
Pfam IPR000719 EMBL-EBI Protein kinase 3.7E-16
Pfam IPR001054 EMBL-EBI Guanylate cyclase 1.6E-32
Pfam IPR001054 EMBL-EBI Guanylate cyclase 8.9E-52
Pfam IPR000719 EMBL-EBI Protein kinase 1.1E-17
Pfam IPR001054 EMBL-EBI Guanylate cyclase 1.6E-95
Pfam IPR001828 EMBL-EBI Extracellular ligand-binding receptor 1.5E-65
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_496218.1 1 496-518
ZK970.5 1 496-518
GENEFINDER00000004327 1 484-506
Sequence
Target Sequence 
>C. ELEGANS:191615_AT
gaaattttagaatccctcacttgccacgggaacgagtagaattaagagttggcatcaata
gtggtccttgtgtagctggagtcgtaggtctatccatgccacgttattgcctatttgggg
atactgtaaatactgcgtcgagaatggaaagtaatggaaaaccatcaatgattcatatgt
cagaagctgcacacagtctacttgtaaacaattatccttatcaatttgaaacgaattccc
gaggagaagtgataattaaaggaaaaggggttatggaaacttattggcttttgggaaaaa
tgagtttgagcaaccagtcaactccgcccattacaaaagtaaatcacaagccgaggaaga
ttgcaagctttacagattctgagctaaccaattattcttttcgatcggtgagcccgt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAAATTTTAGAATCCCTCACTTGCC 644 359 2948 Antisense
CCTCACTTGCCACGGGAACGAGTAG 327 267 2962 Antisense
GAGTTGGCATCAATAGTGGTCCTTG 102 397 2993 Antisense
GTGGTCCTTGTGTAGCTGGAGTCGT 423 489 3008 Antisense
TCGTAGGTCTATCCATGCCACGTTA 604 597 3029 Antisense
GAAGCTGCACACAGTCTACTTGTAA 471 343 3130 Antisense
AGTTTGAGCAACCAGTCAACTCCGC 266 63 3250 Antisense
TCAACTCCGCCCATTACAAAAGTAA 108 629 3265 Antisense
GATTGCAAGCTTTACAGATTCTGAG 665 429 3306 Antisense
GATTCTGAGCTAACCAATTATTCTT 109 431 3322 Antisense
TATTCTTTTCGATCGGTGAGCCCGT 523 651 3340 Antisense
Sequence Source Affymetrix Proprietary Database