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[191609_at] guanylate cyclase

Description ZK970.6 /REP_DB=WormBase Gene ID /WP=CE02406 /GEN=gcy-5 /TR=Q23682 /GB=CAA88890.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=guanylate cyclase
Cluster 6grp_total > 07      4grp_total > 21      6grp_cgc > 06      6grp_cgc_sub > Cu      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 229
1 2 3 4 range
A 39.8
(1.4)
A 		49.9
(3)
A 		11.4
(-3)
A 		21.8
(-1.4)
A 		39
B 70.5
(3)
A 		28.6
(-1.3)
A 		23.6
(-1.8)
A 		11.6
(-3)
A 		59
C 70.7
(-1.8)
A 		50.5
(-2.4)
A 		29.6
(-3)
A 		240.8
(3)
P 		211
avr 60.3
(0.3) 		43
(-1.2) 		21.5
(-3) 		91.4
(3) 		70

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 135
1 2 3 4 5 6 range
A 143.1
(3)
P 		12.1
(-3)
A 		93.7
(0.7)
A 		110.8
(1.5)
M 		48.1
(-1.4)
A 		81.2
(0.2)
A 		131
B 89.6
(1.3)
P 		121.7
(3)
A 		69.3
(0.2)
A 		7.7
(-3)
A 		11.2
(-2.8)
A 		34.5
(-1.6)
A 		114
C 116.3
(3)
P 		49.4
(-1.2)
A 		64.9
(-0.2)
A 		27.4
(-2.6)
A 		21.2
(-3)
A 		58
(-0.7)
M 		95
avr 116.3
(3) 		61.1
(-0.7) 		76
(0.3) 		48.6
(-1.5) 		26.8
(-3) 		57.9
(-0.9) 		90
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 38
1 2 3 4 range
A 14.5
(3)
A 		10.8
(1.1)
A 		3
(-3)
A 		3.2
(-2.9)
A 		12
B 22.5
(3)
A 		7.1
(-1.6)
A 		5.5
(-2.1)
A 		2.5
(-3)
A 		20
C 23.4
(-0.4)
A 		14.5
(-2.2)
A 		10.3
(-3)
A 		40.6
(3)
P 		30
avr 20.1
(3) 		10.8
(-1) 		6.3
(-3) 		15.4
(1) 		14

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 41
1 2 3 4 5 6 range
A 26.4
(2.6)
P 		4.3
(-3)
A 		20.4
(1.1)
A 		28.1
(3)
M 		14.5
(-0.4)
A 		19.8
(0.9)
A 		24
B 31.2
(1.6)
P 		40.5
(3)
A 		16.8
(-0.7)
A 		2
(-3)
A 		4.5
(-2.6)
A 		12.9
(-1.3)
A 		39
C 43.1
(3)
P 		15.1
(-1.5)
A 		16.5
(-1.2)
A 		5.5
(-3)
A 		6.8
(-2.8)
A 		19.4
(-0.8)
M 		38
avr 33.6
(3) 		20
(-0.3) 		17.9
(-0.8) 		11.9
(-2.2) 		8.6
(-3) 		17.4
(-0.9) 		25
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 191609_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.3166
Sequence Type Exemplar sequence
Representative Public ID ZK970.6 NCBI
Target Description ZK970.6 /REP_DB=WormBase Gene ID /WP=CE02406 /GEN=gcy-5 /TR=Q23682 /GB=CAA88890.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=guanylate cyclase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_063818(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_063818 NCBI Caenorhabditis elegans Guanylyl CYclase family member (gcy-5) (gcy-5) mRNA, complete cds. 11/11 None
SNAP00000004315 ENSEMBL cdna:SNAP chromosome:CEL140:II:10310310:10311882:-1 11/11 None
GENEFINDER00000004325 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:10310310:10311893:-1 11/11 None
ZK970.6 ENSEMBL cdna:known chromosome:CEL140:II:10310310:10316129:-1 gene:ZK970.6 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:10310306-10316126(-) 100.0 100.0
Public Domain and Genome References
Gene Title guanylate cyclase
Gene Symbol gcy-5
Ensembl ZK970.6
Entrez Gene 191643 Entrez gene
SwissProt Q23682 EMBL-EBI
WormBase CE02406 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4383 guanylate cyclase activity inferred from electronic annotation QuickGO AmiGO
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA88890 Hypothetical protein ZK970.6 [Caenorhabditis elegans] ref|NP_496219.1| Guanylyl CYclase family member (gcy-5) [Caenorhabditis elegans] 0.0
blast CAE57825 Hypothetical protein CBG00850 [Caenorhabditis briggsae] 0.0
blast CAA88052 Hypothetical protein R134.1 [Caenorhabditis elegans] ref|NP_496037.1| Guanylyl CYclase family member (gcy-3) [Caenorhabditis elegans] 0.0
blast CAE57825 Hypothetical protein CBG00850 [Caenorhabditis briggsae] 1.0E-170
blast CAA88089 Hypothetical protein AH6.1 [Caenorhabditis elegans] emb|CAA88054.1| Hypothetical protein AH6.1 [Caenorhabditis elegans] ref|NP_496039.1| Guanylyl CYclase family member (gcy-1) [Caenorhabditis elegans] sp|Q09435|GCY1_CAEEL Guanylate cyclase receptor-type gcy-1 precursor 1.0E-146
Protein Domains
Database ID Description E-Value
Pfam IPR001054 EMBL-EBI Guanylate cyclase 1.7E-100
Pfam IPR000719 EMBL-EBI Protein kinase 3.1E-18
Pfam IPR001054 EMBL-EBI Guanylate cyclase 1.7E-100
Pfam IPR001828 EMBL-EBI Extracellular ligand-binding receptor 1.3E-64
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_496219.1 2 489-511,638-660
ZK970.6 2 489-511,638-660
GENEFINDER00000004325 1 239-261
Sequence
Target Sequence 
>C. ELEGANS:191609_AT
tctttgtgtttctgggttaccgacaaaaaatggatatgcccatattaagcaaatagttga
tatgtcactcaagtttatggattactgtaagagcttcaaggttcctcacctaccaagaga
aaaagttgaactaagaattggaattaatagtgggccttgtgttgccggtgtcgttggtct
atccatgccccgttattgcctatttggggatacagtgaacactgcgtcgagaatggaaag
taatggaaaaccatcaatgattcatatgtcagaagctgcacattctctgctcacagatca
ttatcctcatcaatatgaaacaagttcaagaggagaagtgattataaaaggaaaaggtgt
aatggaaacattttgggttctcggaaaaactgacagtgacacaaaatcattgagcactcg
aacaacgccacctatcactgatgagaattggcctccacaaatgaaagaagatttaaagaa
gcgagcagtgacaccttatcca

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TCTTTGTGTTTCTGGGTTACCGACA 607 265 2829 Antisense
GTTCCTCACCTACCAAGAGAAAAAG 338 439 2929 Antisense
TAATAGTGGGCCTTGTGTTGCCGGT 507 631 2973 Antisense
GTCAGAAGCTGCACATTCTCTGCTC 39 467 3096 Antisense
TGCACATTCTCTGCTCACAGATCAT 638 577 3105 Antisense
GCTCACAGATCATTATCCTCATCAA 665 301 3117 Antisense
TGGGTTCTCGGAAAAACTGACAGTG 615 551 3202 Antisense
GACACAAAATCATTGAGCACTCGAA 473 365 3226 Antisense
CAACGCCACCTATCACTGATGAGAA 293 187 3251 Antisense
ATGAGAATTGGCCTCCACAAATGAA 138 45 3269 Antisense
GAAGCGAGCAGTGACACCTTATCCA 710 341 3306 Antisense
Sequence Source Affymetrix Proprietary Database