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[191607_s_at] aspartyl protease

Description R12H7.2 /REP_DB=WormBase Gene ID /WP=CE03567 /GEN=asp-4 /TR=Q21966 /GB=CAA90633.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=aspartyl protease
Cluster 6grp_highest_10_10 > 28      6grp_high1_10_10 > 71      4grp_highest_8_8 > 12      4grp_high_8_8 > 30      6grp_highest_nonorm > 27      6grp_total > 71      4grp_total > 33      6grp_highest_sub > 04      6grp_cgc > 85      6grp_high1_sub > 04      6grp_cgc_sub > 04      6grp_total_sub > Hat      6grp_rule_based > S4      4grp_rule_based > L4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 2521
1 2 3 4 range
A 3866.1
(-3)
P 		6386.9
(3)
P 		6297.3
(2.8)
P 		5722.6
(1.4)
P 		2521
B 3965
(-3)
P 		5695.2
(1.8)
P 		6018.8
(2.7)
P 		6133.3
(3)
P 		2168
C 4092.9
(-3)
P 		4849.1
(-1)
P 		5288.3
(0.1)
P 		6374.4
(3)
P 		2282
avr 3974.7
(-3) 		5643.7
(1.8) 		5868.1
(2.4) 		6076.8
(3) 		2102

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 6786
1 2 3 4 5 6 range
A 5269.9
(-2.7)
P 		5674.2
(-2.3)
P 		7565.7
(-0.5)
P 		11135.3
(3)
P 		6144.9
(-1.9)
P 		4994.6
(-3)
P 		6141
B 4481.5
(-2.8)
P 		4878.5
(-2.2)
P 		6450.4
(0.1)
P 		8478.4
(3)
P 		5888.2
(-0.8)
P 		4349.6
(-3)
P 		4129
C 4769.8
(-2.7)
P 		4495
(-3)
P 		9237.2
(1.6)
P 		10674.3
(3)
P 		7814.3
(0.2)
P 		4450.4
(-3)
P 		6224
avr 4840.4
(-2.7) 		5015.9
(-2.5) 		7751.1
(0.4) 		10096
(3) 		6615.8
(-0.8) 		4598.2
(-3) 		5498
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1005
1 2 3 4 range
A 1407.6
(1.2)
P 		1386.4
(1.1)
P 		1646.2
(3)
P 		837.7
(-3)
P 		809
B 1264.4
(-3)
P 		1406.6
(3)
P 		1394.7
(2.5)
P 		1307
(-1.2)
P 		142
C 1354.9
(-0.8)
P 		1394.2
(-0.5)
P 		1843.1
(3)
P 		1074.8
(-3)
P 		768
avr 1342.3
(-0.1) 		1395.7
(0.5) 		1628
(3) 		1073.2
(-3) 		555

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1853
1 2 3 4 5 6 range
A 971.5
(-3)
P 		2018
(0.4)
P 		1647.6
(-0.8)
P 		2824.2
(3)
P 		1854.3
(-0.1)
P 		1216
(-2.2)
P 		1853
B 1559.4
(-3)
P 		1623.8
(-2.5)
P 		1566.4
(-2.9)
P 		2245.6
(1.9)
P 		2392.3
(3)
P 		1621.9
(-2.5)
P 		833
C 1767.9
(-0.9)
P 		1371.5
(-3)
P 		2351
(2.1)
P 		2146.6
(1)
P 		2528.6
(3)
P 		1489.8
(-2.4)
P 		1157
avr 1432.9
(-3) 		1671.1
(-1.5) 		1855
(-0.4) 		2405.5
(3) 		2258.4
(2.1) 		1442.6
(-2.9) 		973
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 191607_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.17681
Sequence Type Exemplar sequence
Representative Public ID R12H7.2 NCBI
Target Description R12H7.2 /REP_DB=WormBase Gene ID /WP=CE03567 /GEN=asp-4 /TR=Q21966 /GB=CAA90633.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=aspartyl protease
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077790(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077790 NCBI Caenorhabditis elegans ASpartyl Protease family member (asp-4) (asp-4) mRNA, complete cds. 11/11 A 
SNAP00000017895 ENSEMBL cdna:SNAP chromosome:CEL140:X:13218995:13220803:-1 11/11 None
GENEFINDER00000017899 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:13218995:13221347:-1 11/11 None
R12H7.2 ENSEMBL cdna:known chromosome:CEL140:X:13218897:13221389:-1 gene:R12H7.2 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:13218994-13221347(-) 100.0 100.0
Public Domain and Genome References
Gene Title aspartyl protease
Gene Symbol asp-4
Ensembl R12H7.2
Entrez Gene 181444 Entrez gene
SwissProt Q21966 EMBL-EBI
WormBase CE03567 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:18903_AT aspartyl protease family protein at
ATH1-121501:255345_AT aspartyl protease family protein at
CANINE_2:CFA.17547.1.S1_AT cathepsin D (lysosomal aspartyl peptidase) cfa
CANINE_2:CFAAFFX.15770.1.S1_S_AT cathepsin D (lysosomal aspartyl peptidase) cfa
DROSOPHILA_2:1631493_AT dm
DROSGENOME1:141682_AT dm
CHICKEN:GGA.1094.1.S1_AT cathepsin D (lysosomal aspartyl peptidase) gga
HG-U95AV2:239_AT cathepsin D (lysosomal aspartyl peptidase) hs
HC-G110:239_AT cathepsin D (lysosomal aspartyl peptidase) hs
HG-U133_PLUS_2:200766_AT cathepsin D (lysosomal aspartyl peptidase) hs
HG-FOCUS:200766_AT cathepsin D (lysosomal aspartyl peptidase) hs
HG-U133A_2:200766_AT cathepsin D (lysosomal aspartyl peptidase) hs
HG-U133A:200766_AT cathepsin D (lysosomal aspartyl peptidase) hs
HUGENEFL:M63138_AT cathepsin D (lysosomal aspartyl peptidase) hs
HG-U133_PLUS_2:227886_AT cathepsin D (lysosomal aspartyl peptidase) hs
HG-U133B:227886_AT cathepsin D (lysosomal aspartyl peptidase) hs
U133_X3P:G4503142_3P_X_AT cathepsin D (lysosomal aspartyl peptidase) hs
U133_X3P:G4503142_3P_AT cathepsin D (lysosomal aspartyl peptidase) hs
U133_X3P:HS.121575.0.S2_3P_AT cathepsin D (lysosomal aspartyl peptidase) hs
U133_X3P:HS.121575.0.S1_3P_X_AT cathepsin D (lysosomal aspartyl peptidase) hs
U133_X3P:HS.121575.0.S1_3P_AT cathepsin D (lysosomal aspartyl peptidase) hs
U133_X3P:227863_3P_AT cathepsin D (lysosomal aspartyl peptidase) hs
U133_X3P:200766_3P_AT cathepsin D (lysosomal aspartyl peptidase) hs
HG-U133_PLUS_2:227863_AT cathepsin D (lysosomal aspartyl peptidase) hs
HG-U133B:227863_AT cathepsin D (lysosomal aspartyl peptidase) hs
HG-U95E:88716_AT cathepsin D (lysosomal aspartyl peptidase) hs
MOE430A:1448118_A_AT cathepsin D mm
MOUSE430A_2:1448118_A_AT cathepsin D mm
MOUSE430_2:1448118_A_AT cathepsin D mm
MU11KSUBB:MSA.32346.0_S_AT cathepsin D mm
MU11KSUBB:X52886_S_AT cathepsin D mm
MG-U74AV2:93810_AT cathepsin D mm
MU11KSUBB:MSA.28694.0_F_AT Cathepsin D, mRNA (cDNA clone IMAGE:4500905) mm
MU19KSUBC:TC38887_AT Cathepsin D, mRNA (cDNA clone IMAGE:4500905) mm
RG-U34A:RC_AI235585_S_AT cathepsin D rn
RG-U34A:X54467_AT cathepsin D rn
RAE230A:1367651_AT cathepsin D rn
RAT230_2:1367651_AT cathepsin D rn
YEAST_2:1769365_AT Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; synthesized as a zymogen, self-activates Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4190 aspartic-type endopeptidase activity inferred from electronic annotation QuickGO AmiGO
4194 pepsin A activity inferred from electronic annotation QuickGO AmiGO
4190 aspartic-type endopeptidase activity inferred from sequence similarity QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA90633 Hypothetical protein R12H7.2 [Caenorhabditis elegans] ref|NP_510191.1| ASpartyl Protease family member (asp-4) [Caenorhabditis elegans] 0.0
blast CAE61399 Hypothetical protein CBG05258 [Caenorhabditis briggsae] 0.0
blast AAO22152 cathepsin D-like aspartic protease [Ancylostoma ceylanicum] 1.0E-179
Protein Domains
Database ID Description E-Value
Pfam IPR001461 EMBL-EBI Peptidase A1, pepsin 1.0E-126
Pfam IPR001461 EMBL-EBI Peptidase A1, pepsin 1.0E-126
Sequence
Target Sequence 
>C. ELEGANS:191607_S_AT
tcaaccgtaacccagactctgaaattggaggagaaatcacttttggaggaattgactcaa
gaagatatgttgagccaatcacctatgttccagtcaccagaaagggatactggcaattca
agatggacaaggttgttggatctggagttcttggatgctccaatggatgccaagcaattg
ctgataccggtacttctctcatagccggaccaaaggctcaaatcgaagccatccaaaatt
tcattggagctgagcctctcatcaagggagagtacatgatcagctgcgacaaggttccaa
cacttccaccagtctcttttgtgatc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TCAACCGTAACCCAGACTCTGAAAT 310 629 722 Antisense
TGTTGAGCCAATCACCTATGTTCCA 4 563 789 Antisense
CACCTATGTTCCAGTCACCAGAAAG 567 201 801 Antisense
GTTGGATCTGGAGTTCTTGGATGCT 160 437 856 Antisense
TGGATGCTCCAATGGATGCCAAGCA 66 551 873 Antisense
GCAATTGCTGATACCGGTACTTCTC 509 323 895 Antisense
ACCGGTACTTCTCTCATAGCCGGAC 464 83 907 Antisense
TTTCATTGGAGCTGAGCCTCTCATC 135 673 960 Antisense
GGGAGAGTACATGATCAGCTGCGAC 535 495 987 Antisense
TGCGACAAGGTTCCAACACTTCCAC 669 583 1006 Antisense
ACTTCCACCAGTCTCTTTTGTGATC 35 105 1023 Antisense
Sequence Source Affymetrix Proprietary Database