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[191592_s_at] 2-oxoglutarate dehydrogenase

Description ZK836.2 /REP_DB=WormBase Gene ID /WP=CE23468 /TR=Q23629 /GB=CAB01590.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=2-oxoglutarate dehydrogenase
Cluster 6grp_highest_10_10 > 32      6grp_high1_10_10 > 03      4grp_highest_8_8 > 35      4grp_high_8_8 > 56      6grp_highest_nonorm > 20      6grp_total > 24      4grp_total > 63      6grp_highest_sub > De      6grp_high1_sub > De      6grp_total_sub > Decrease      6grp_rule_based > S1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 586
1 2 3 4 range
A 1481.3
(3)
P 		964.9
(-3)
P 		1396.5
(2)
P 		1100.5
(-1.4)
P 		516
B 1433.9
(3)
P 		923.2
(-3)
P 		1335.5
(1.8)
P 		1026.6
(-1.8)
P 		511
C 1509.4
(3)
P 		999
(-3)
P 		1391
(1.6)
P 		1030.3
(-2.6)
P 		510
avr 1474.9
(3) 		962.4
(-3) 		1374.3
(1.8) 		1052.5
(-1.9) 		513

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 954
1 2 3 4 5 6 range
A 1547
(2.6)
P 		1603.4
(3)
P 		860.2
(-1.8)
P 		876.7
(-1.7)
P 		673.2
(-3)
P 		945.3
(-1.2)
P 		930
B 1167.1
(1.7)
P 		1308.9
(3)
P 		1274.1
(2.7)
P 		909.7
(-0.8)
P 		702.8
(-2.7)
P 		670.3
(-3)
P 		639
C 1445.1
(3)
P 		1209
(1.2)
P 		1278.2
(1.7)
P 		775.6
(-2)
P 		843.3
(-1.5)
P 		649.3
(-3)
P 		796
avr 1386.4
(3) 		1373.8
(2.9) 		1137.5
(0.7) 		854
(-1.9) 		739.8
(-3) 		755
(-2.9) 		647
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 378
1 2 3 4 range
A 539.4
(3)
P 		209.4
(-2.2)
P 		365.1
(0.2)
P 		161.1
(-3)
P 		378
B 457.3
(3)
P 		228
(-2.8)
P 		309.5
(-0.7)
P 		218.8
(-3)
P 		239
C 499.6
(3)
P 		287.2
(-0.9)
P 		484.8
(2.7)
P 		173.7
(-3)
P 		326
avr 498.8
(3) 		241.5
(-1.9) 		386.5
(0.9) 		184.5
(-3) 		314

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 414
1 2 3 4 5 6 range
A 285.2
(-1.5)
P 		570.3
(3)
P 		187.3
(-3)
P 		222.4
(-2.5)
P 		203.1
(-2.8)
P 		230.1
(-2.3)
P 		383
B 406.1
(2.1)
P 		435.7
(3)
P 		309.4
(-0.9)
P 		240.9
(-3)
P 		285.6
(-1.6)
P 		249.9
(-2.7)
P 		195
C 535.6
(3)
P 		368.9
(0.4)
P 		325.3
(-0.3)
P 		156
(-3)
P 		272.9
(-1.2)
P 		217.4
(-2)
P 		380
avr 409
(1.8) 		458.3
(3) 		274
(-1.4) 		206.4
(-3) 		253.9
(-1.9) 		232.5
(-2.4) 		252
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 191592_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.14224
Sequence Type Exemplar sequence
Representative Public ID ZK836.2 NCBI
Target Description ZK836.2 /REP_DB=WormBase Gene ID /WP=CE23468 /TR=Q23629 /GB=CAB01590.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=2-oxoglutarate dehydrogenase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_073659(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_073659 NCBI Caenorhabditis elegans ZK836.2 (ZK836.2) mRNA, complete cds. 11/11 None
SNAP00000005775 ENSEMBL cdna:SNAP chromosome:CEL140:V:12203285:12206399:1 10/11 None
GENEFINDER00000005779 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:12203285:12207806:1 11/11 None
ZK836.2.2 ENSEMBL cdna:known chromosome:CEL140:V:12197066:12208073:1 gene:ZK836.2 11/11 A 
ZK836.2.1 ENSEMBL cdna:known chromosome:CEL140:V:12197095:12208089:1 gene:ZK836.2 11/11 A 
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000005776 1/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:12199567-12207806(+) 100.0 100.0
Public Domain and Genome References
Gene Title 2-oxoglutarate dehydrogenase
Ensembl ZK836.2
Entrez Gene 179674 Entrez gene
SwissProt Q23629 EMBL-EBI
WormBase CE35706 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1594103_AT similar to dehydrogenase E1 and transketolase domain containing protein 1 cfa
CANINE:1591872_S_AT similar to dehydrogenase E1 and transketolase domain containing protein 1 cfa
CANINE_2:CFA.2905.1.A1_S_AT similar to dehydrogenase E1 and transketolase domain containing protein 1 cfa
DROSOPHILA_2:1641199_A_AT dm
DROSGENOME1:152172_AT dm
HG-U133A:209916_AT dehydrogenase E1 and transketolase domain containing 1 hs
HG-U133_PLUS_2:209916_AT dehydrogenase E1 and transketolase domain containing 1 hs
HG-U133A_2:209916_AT dehydrogenase E1 and transketolase domain containing 1 hs
HU35KSUBA:HUM_ALU_AT dehydrogenase E1 and transketolase domain containing 1 hs
HU35KSUBB:HUM_ALU_AT dehydrogenase E1 and transketolase domain containing 1 hs
HU35KSUBC:HUM_ALU_AT dehydrogenase E1 and transketolase domain containing 1 hs
HU35KSUBD:HUM_ALU_AT dehydrogenase E1 and transketolase domain containing 1 hs
HUGENEFL:HUM_ALU_AT dehydrogenase E1 and transketolase domain containing 1 hs
HC-G110:HUM_ALU_AT dehydrogenase E1 and transketolase domain containing 1 hs
HU35KSUBB:RC_W92713_AT dehydrogenase E1 and transketolase domain containing 1 hs
U133_X3P:G12803318_3P_X_AT dehydrogenase E1 and transketolase domain containing 1 hs
U133_X3P:HS.11732.0.A1_3P_AT dehydrogenase E1 and transketolase domain containing 1 hs
U133_X3P:209916_3P_AT dehydrogenase E1 and transketolase domain containing 1 hs
HG-U133_PLUS_2:227094_AT dehydrogenase E1 and transketolase domain containing 1 hs
HG-U133B:227094_AT dehydrogenase E1 and transketolase domain containing 1 hs
HG-U95B:52934_AT dehydrogenase E1 and transketolase domain containing 1 hs
HG-U95B:46796_R_AT Dehydrogenase E1 and transketolase domain containing 1 hs
HU35KSUBD:RC_AA447970_AT Dehydrogenase E1 and transketolase domain containing 1 hs
MOUSE430_2:1457027_AT dehydrogenase E1 and transketolase domain containing 1 mm
MOE430B:1457027_AT dehydrogenase E1 and transketolase domain containing 1 mm
MG-U74BV2:106120_AT dehydrogenase E1 and transketolase domain containing 1 mm
RG-U34C:RC_AI169947_AT dehydrogenase E1 and transketolase domain containing 1 (predicted) rn
RAE230A:1390172_AT dehydrogenase E1 and transketolase domain containing 1 (predicted) rn
RAT230_2:1390172_AT dehydrogenase E1 and transketolase domain containing 1 (predicted) rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
8152 metabolism inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
16624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB01590 Hypothetical protein ZK836.2 [Caenorhabditis elegans] emb|CAE46691.1| Hypothetical protein ZK836.2 [Caenorhabditis elegans] ref|NP_506060.2| ZK836.2 [Caenorhabditis elegans] 0.0
blast CAE75416 Hypothetical protein CBG23406 [Caenorhabditis briggsae] 0.0
blast XP_535192 PREDICTED: similar to dehydrogenase E1 and transketolase domain containing protein 1 [Canis familiaris] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR005475 EMBL-EBI Transketolase, central region 1.1E-60
Pfam IPR001017 EMBL-EBI Dehydrogenase, E1 component 1.2E-33
Pfam IPR005475 EMBL-EBI Transketolase, central region 1.1E-60
Pfam IPR001017 EMBL-EBI Dehydrogenase, E1 component 1.2E-33
Sequence
Target Sequence 
>C. ELEGANS:191592_S_AT
ttcacgcgaagatcagacacctgtagatggtgagaatgtgaatatgagagttgctaatcc
aacaacaagtgctcaatatttccatttgttgagaagacaggtcgttcccaactaccgaaa
acctctgatcgtagtcggcccaaagatattgctacgtcatccgaaggccgcctccacaat
taacgagttcggaccaggaaccacttatcaaaatgtgatctcggaagagcatgcaacatc
atctcaaaaaattaagaaagtgatatttgtatctggaaaacattggattaacgtagaaaa
ggctcgtgatgagagaggactcaaggattctgttgcaattgtacgagttgaaatgttatg
tccattccctgttgtagatttgcaagctgttctcaaaaaatatcctggagcacaagactt
cgtgtggtcacaagaagagccaagaaatgccggagcgtggtcgttt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TTCACGCGAAGATCAGACACCTGTA 217 687 2130 Antisense
GAGAAGACAGGTCGTTCCCAACTAC 634 387 2220 Antisense
TCCCAACTACCGAAAACCTCTGATC 190 595 2235 Antisense
TCTGATCGTAGTCGGCCCAAAGATA 340 607 2253 Antisense
AGATATTGCTACGTCATCCGAAGGC 111 67 2273 Antisense
GCCGCCTCCACAATTAACGAGTTCG 9 287 2296 Antisense
TAACGAGTTCGGACCAGGAACCACT 115 639 2310 Antisense
GAGGACTCAAGGATTCTGTTGCAAT 144 405 2444 Antisense
GAAATGTTATGTCCATTCCCTGTTG 367 361 2479 Antisense
GTCCATTCCCTGTTGTAGATTTGCA 236 477 2489 Antisense
AAGAAATGCCGGAGCGTGGTCGTTT 361 153 2571 Antisense
Sequence Source Affymetrix Proprietary Database