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[191432_at] ser/thr kinases

Description B0218.3 /REP_DB=WormBase Gene ID /WP=CE06686 /GEN=pmk-1 /TR=Q17446 /GB=AAB00664.1 /SUBMIT=ST.LOUIS /CHR=4 /FEA=Sanger Annotation /DEF=ser-thr kinases
Cluster 6grp_highest_10_10 > 56      6grp_high1_10_10 > 55      4grp_highest_8_8 > 50      4grp_high_8_8 > 40      6grp_highest_nonorm > 73      6grp_total > 55      4grp_total > 54      6grp_cgc > 36      4grp_rule_based > L1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1230
1 2 3 4 range
A 1607.9
(3)
P 		1049
(-0.2)
P 		851.1
(-1.4)
P 		570
(-3)
P 		1038
B 1800.2
(3)
P 		888.1
(-2.7)
P 		892.4
(-2.7)
P 		838.6
(-3)
P 		962
C 1631.5
(3)
P 		810.4
(-2.2)
P 		934.8
(-1.4)
P 		683.3
(-3)
P 		948
avr 1679.9
(3) 		915.8
(-1.7) 		892.8
(-1.8) 		697.3
(-3) 		983

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 662
1 2 3 4 5 6 range
A 720.9
(3)
P 		311.6
(-2.7)
P 		685.1
(2.5)
P 		450.4
(-0.8)
P 		288.6
(-3)
P 		501.8
(-0)
P 		432
B 808.4
(3)
P 		380.7
(-0.9)
P 		767.3
(2.6)
P 		558.3
(0.7)
P 		146.5
(-3)
P 		769
(2.6)
P 		662
C 310.5
(-1.6)
P 		490.8
(0.5)
P 		681.4
(2.7)
P 		524.9
(0.9)
P 		189.1
(-3)
P 		704.2
(3)
P 		515
avr 613.3
(1.8) 		394.4
(-0.8) 		711.3
(3) 		511.2
(0.6) 		208.1
(-3) 		658.3
(2.4) 		503
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 502
1 2 3 4 range
A 585.4
(3)
P 		227.7
(-1.3)
P 		222.5
(-1.3)
P 		83.4
(-3)
P 		502
B 574.1
(3)
P 		219.3
(-2.4)
P 		206.8
(-2.6)
P 		178.7
(-3)
P 		395
C 540.1
(3)
P 		233
(-1.3)
P 		325.8
(-0)
P 		115.2
(-3)
P 		425
avr 566.5
(3) 		226.7
(-1.6) 		251.7
(-1.3) 		125.8
(-3) 		441

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 227
1 2 3 4 5 6 range
A 132.9
(1.4)
P 		110.8
(-0.7)
P 		149.2
(3)
P 		114.2
(-0.4)
P 		87.1
(-3)
P 		122.2
(0.4)
P 		62
B 281.3
(2.9)
P 		126.7
(-1.2)
P 		186.3
(0.3)
P 		147.9
(-0.7)
P 		59.5
(-3)
P 		286.8
(3)
P 		227
C 115.1
(-1.1)
P 		149.7
(0)
P 		173.4
(0.9)
P 		105.6
(-1.5)
P 		61.2
(-3)
P 		235.7
(3)
P 		175
avr 176.4
(1.4) 		129.1
(-0.5) 		169.6
(1.1) 		122.6
(-0.8) 		69.3
(-3) 		214.9
(3) 		146
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 191432_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.9014
Sequence Type Exemplar sequence
Representative Public ID B0218.3 NCBI
Target Description B0218.3 /REP_DB=WormBase Gene ID /WP=CE06686 /GEN=pmk-1 /TR=Q17446 /GB=AAB00664.1 /SUBMIT=ST.LOUIS /CHR=4 /FEA=Sanger Annotation /DEF=ser-thr kinases
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_068964(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_068964 NCBI Caenorhabditis elegans P38 Map Kinase family member (pmk-1) (pmk-1) mRNA, complete cds. 11/11 None
SNAP00000005552 ENSEMBL cdna:SNAP chromosome:CEL140:IV:8147034:8150722:1 11/11 None
GENEFINDER00000005564 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:8146744:8151149:1 11/11 None
B0218.3 ENSEMBL cdna:known chromosome:CEL140:IV:8148775:8151227:1 gene:B0218.3 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:8148792-8150728(+) 100.0 100.0
Public Domain and Genome References
Gene Title ser/thr kinases
Gene Symbol pmk-1
Ensembl B0218.3
Entrez Gene 191743 Entrez gene
SwissProt Q17446 EMBL-EBI
WormBase CE06686 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:252592_AT mitogen-activated protein kinase, putative / MAPK, putative (MPK3) at
CANINE:1582639_AT mitogen-activated protein kinase 14 cfa
CANINE_2:CFA.1239.1.S1_S_AT mitogen-activated protein kinase 14 cfa
DROSOPHILA_2:1636173_S_AT heat shock construct of Han dm
DROSGENOME1:143839_AT heat shock construct of Han dm
CHICKEN:GGA.5529.1.S1_AT mitogen-activated protein kinase 14 gga
CHICKEN:GGAAFFX.11847.1.S1_S_AT mitogen-activated protein kinase 14 gga
CHICKEN:GGAAFFX.549.1.S1_AT mitogen-activated protein kinase 14 gga
CHICKEN:GGAAFFX.549.2.S1_AT mitogen-activated protein kinase 14 gga
CHICKEN:GGAAFFX.549.3.S1_AT mitogen-activated protein kinase 14 gga
HG-FOCUS:202530_AT mitogen-activated protein kinase 14 hs
HG-U133A:202530_AT mitogen-activated protein kinase 14 hs
HG-U133_PLUS_2:202530_AT mitogen-activated protein kinase 14 hs
HG-U133A_2:202530_AT mitogen-activated protein kinase 14 hs
HG-U133_PLUS_2:211561_X_AT mitogen-activated protein kinase 14 hs
HG-U133A:211561_X_AT mitogen-activated protein kinase 14 hs
HG-U133A_2:211561_X_AT mitogen-activated protein kinase 14 hs
HG-U95AV2:1999_S_AT mitogen-activated protein kinase 14 hs
HC-G110:1999_S_AT mitogen-activated protein kinase 14 hs
HG-U133_PLUS_2:210449_X_AT mitogen-activated protein kinase 14 hs
HG-U133A:210449_X_AT mitogen-activated protein kinase 14 hs
HG-U133A_2:210449_X_AT mitogen-activated protein kinase 14 hs
HG-U133_PLUS_2:211087_X_AT mitogen-activated protein kinase 14 hs
HG-U133A:211087_X_AT mitogen-activated protein kinase 14 hs
HG-U133A_2:211087_X_AT mitogen-activated protein kinase 14 hs
HG-U95AV2:1671_S_AT mitogen-activated protein kinase 14 hs
HC-G110:1671_S_AT mitogen-activated protein kinase 14 hs
HUGENEFL:L35253_S_AT mitogen-activated protein kinase 14 hs
HUGENEFL:L35263_AT mitogen-activated protein kinase 14 hs
U133_X3P:G7109716_3P_A_AT mitogen-activated protein kinase 14 hs
U133_X3P:G4503068_3P_AT mitogen-activated protein kinase 14 hs
U133_X3P:G405742_3P_S_AT mitogen-activated protein kinase 14 hs
U133_X3P:G405742_3P_AT mitogen-activated protein kinase 14 hs
U133_X3P:211087_3P_X_AT mitogen-activated protein kinase 14 hs
HG-U95AV2:37733_AT mitogen-activated protein kinase 14 hs
HG-U95E:78240_AT mitogen-activated protein kinase 14 hs
HG-U95C:63457_F_AT Mitogen-activated protein kinase 14 hs
HG-U95C:63458_R_AT Mitogen-activated protein kinase 14 hs
HG-U95E:68539_AT Mitogen-activated protein kinase 14 hs
HG-U95D:73032_AT Mitogen-activated protein kinase 14 hs
HU35KSUBC:RC_AA454220_AT Mitogen-activated protein kinase 14 hs
MOE430A:1426104_AT mitogen activated protein kinase 14 mm
MOUSE430A_2:1426104_AT mitogen activated protein kinase 14 mm
MOUSE430_2:1426104_AT mitogen activated protein kinase 14 mm
MOE430A:1451927_A_AT mitogen activated protein kinase 14 mm
MOUSE430A_2:1451927_A_AT mitogen activated protein kinase 14 mm
MOUSE430_2:1451927_A_AT mitogen activated protein kinase 14 mm
MU11KSUBA:U10871_S_AT mitogen activated protein kinase 14 mm
MU11KSUBB:MSA.8386.0_S_AT mitogen activated protein kinase 14 mm
MU11KSUBB:MSA.18975.0_S_AT mitogen activated protein kinase 14 mm
MG-U74AV2:99978_S_AT mitogen activated protein kinase 14 mm
MOE430A:1416703_AT mitogen activated protein kinase 14 mm
MOUSE430A_2:1416703_AT mitogen activated protein kinase 14 mm
MOUSE430_2:1416703_AT mitogen activated protein kinase 14 mm
MOE430A:1416704_AT mitogen activated protein kinase 14 mm
MOUSE430A_2:1416704_AT mitogen activated protein kinase 14 mm
MOUSE430_2:1416704_AT mitogen activated protein kinase 14 mm
MG-U74CV2:135682_AT Mitogen activated protein kinase 14, mRNA (cDNA clone MGC:18431 IMAGE:4195842) mm
MOUSE430_2:1442364_AT Mitogen activated protein kinase 14, mRNA (cDNA clone MGC:18431 IMAGE:4195842) mm
MOE430B:1442364_AT Mitogen activated protein kinase 14, mRNA (cDNA clone MGC:18431 IMAGE:4195842) mm
MOE430B:1459617_AT Mitogen activated protein kinase 14, mRNA (cDNA clone MGC:18431 IMAGE:4195842) mm
MOUSE430_2:1459617_AT Mitogen activated protein kinase 14, mRNA (cDNA clone MGC:18431 IMAGE:4195842) mm
MU19KSUBA:TC18233_S_AT Mitogen activated protein kinase 14, mRNA (cDNA clone MGC:18431 IMAGE:4195842) mm
MU19KSUBC:TC36422_S_AT Mitogen activated protein kinase 14, mRNA (cDNA clone MGC:18431 IMAGE:4195842) mm
RN-U34:RC_AI171630_S_AT mitogen activated protein kinase 14 rn
RT-U34:RC_AI171630_S_AT mitogen activated protein kinase 14 rn
RG-U34A:RC_AI171630_S_AT mitogen activated protein kinase 14 rn
RN-U34:U73142_AT mitogen activated protein kinase 14 rn
RT-U34:U73142_AT mitogen activated protein kinase 14 rn
RG-U34A:U73142_AT mitogen activated protein kinase 14 rn
RN-U34:RC_AI137862_S_AT mitogen activated protein kinase 14 rn
RT-U34:RC_AI137862_S_AT mitogen activated protein kinase 14 rn
RG-U34A:RC_AI137862_S_AT mitogen activated protein kinase 14 rn
RN-U34:U73142_G_AT mitogen activated protein kinase 14 rn
RT-U34:U73142_G_AT mitogen activated protein kinase 14 rn
RG-U34A:U73142_G_AT mitogen activated protein kinase 14 rn
RN-U34:RC_AA924542_S_AT mitogen activated protein kinase 14 rn
RT-U34:RC_AA924542_S_AT mitogen activated protein kinase 14 rn
RG-U34A:RC_AA924542_S_AT mitogen activated protein kinase 14 rn
RN-U34:U91847_S_AT mitogen activated protein kinase 14 rn
RT-U34:U91847_S_AT mitogen activated protein kinase 14 rn
RG-U34A:U91847_S_AT mitogen activated protein kinase 14 rn
RAE230A:1367697_AT mitogen activated protein kinase 14 rn
RAT230_2:1367697_AT mitogen activated protein kinase 14 rn
RAE230A:1377136_AT Mitogen activated protein kinase 14 rn
RAT230_2:1377136_AT Mitogen activated protein kinase 14 rn
RAE230B:1380238_AT Mitogen activated protein kinase 14 rn
RAT230_2:1380238_AT Mitogen activated protein kinase 14 rn
YEAST_2:1775699_AT Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
6468 protein amino acid phosphorylation inferred from direct assay QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4707 MAP kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
4672 protein kinase activity inferred from direct assay QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAB00664 P38 map kinase family protein 1 [Caenorhabditis elegans] ref|NP_501365.1| P38 Map Kinase family member (pmk-1) [Caenorhabditis elegans] sp|Q17446|PMK1_CAEEL Mitogen-activated protein kinase pmk-1 (p38 MAP kinase 1) (Stress-activated protein kinase pmk-1) 0.0
blast CAE58424 Hypothetical protein CBG01555 [Caenorhabditis briggsae] 0.0
blast 1IAN Human P38 Map Kinase Inhibitor Complex 1.0E-130
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 4.0E-75
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 1.0E-43
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 2.0E-75
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 2.0E-41
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 1.0E-75
hanks 3.1.1 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; CDC2Hs 6.0E-76
hanks 3.1.1 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; CDC2Hs 2.0E-76
hanks 3.1.1 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; CDC2Hs 1.0E-76
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 7.6E-84
Pfam IPR000719 EMBL-EBI Protein kinase 1.2E-49
Pfam IPR000719 EMBL-EBI Protein kinase 7.6E-84
Pfam IPR000719 EMBL-EBI Protein kinase 6.9E-46
Pfam IPR000719 EMBL-EBI Protein kinase 7.6E-84
Sequence
Target Sequence 
>C. ELEGANS:191432_AT
ggattggcacgtcaaactgattctgaaatgactggatacgtggcaacaagatggtacaga
gctccagagattatgctcaattggatgcattacacgcagactgttgatgtatggtcagtt
gggtgtattcttgcagaacttatcactggaaaaacattgttccctggatctgatcacatc
gatcaattgactcgtatcatgtcagtaactggaacaccagatgaagaattccttaaaaag
atctcatcagaagaagctcgtaattacattcgaaatcttccaaaaatgactcgccgtgat
ttcaaacgtctgtttgctcaagcaactcctcaagcaatcgatctccttgaaaagatgctt
caccttgatccagatcgtcgtccaactgcaaaagaagctatggagcatgaatatctggct
gcttatcacgatg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GGATTGGCACGTCAAACTGATTCTG 376 505 553 Antisense
GGATGCATTACACGCAGACTGTTGA 447 511 635 Antisense
GGTCAGTTGGGTGTATTCTTGCAGA 533 503 665 Antisense
AACATTGTTCCCTGGATCTGATCAC 238 137 705 Antisense
AAATCTTCCAAAAATGACTCGCCGT 501 117 825 Antisense
GACTCGCCGTGATTTCAAACGTCTG 409 373 840 Antisense
ACGTCTGTTTGCTCAAGCAACTCCT 485 95 858 Antisense
AAGCAACTCCTCAAGCAATCGATCT 43 153 872 Antisense
GAAAAGATGCTTCACCTTGATCCAG 103 355 901 Antisense
TCCAGATCGTCGTCCAACTGCAAAA 678 587 921 Antisense
GAATATCTGGCTGCTTATCACGATG 162 327 961 Antisense
Sequence Source Affymetrix Proprietary Database