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[191415_at] serine/threonine kinase

Description F42G10.2 /REP_DB=WormBase Gene ID /WP=CE10328 /TR=SW:Q20347 /GB=CAB08355.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=serine-threonine kinase
Cluster 6grp_highest_10_10 > 85      6grp_high1_10_10 > 57      4grp_high_8_8 > 04      6grp_highest_nonorm > 82      6grp_total > 57      4grp_total > 05      6grp_highest_sub > Cu      6grp_cgc > 28      6grp_high1_sub > Cu      6grp_cgc_sub > Cu      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 397
1 2 3 4 range
A 362.9
(-0.6)
P 		257.8
(-2.5)
P 		229.2
(-3)
P 		568.9
(3)
P 		340
B 383.9
(-0.3)
P 		232.9
(-2.8)
A 		221.5
(-3)
P 		584.7
(3)
P 		363
C 352
(-1.1)
P 		226.2
(-3)
P 		272.5
(-2.3)
P 		618.4
(3)
P 		392
avr 366.3
(-0.8) 		239
(-3) 		241.1
(-3) 		590.7
(3) 		352

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 282
1 2 3 4 5 6 range
A 366.1
(-0.7)
P 		372.5
(-0.6)
P 		274.6
(-3)
P 		324.2
(-1.8)
P 		286
(-2.7)
P 		517.6
(3)
P 		243
B 319.8
(-1.8)
P 		354.7
(-0.9)
P 		273.5
(-3)
P 		299.8
(-2.3)
P 		362.2
(-0.7)
P 		502.2
(3)
P 		229
C 418.6
(0.8)
P 		358.5
(-0.5)
P 		335.5
(-0.9)
P 		287.9
(-2)
P 		239.1
(-3)
P 		521.2
(3)
P 		282
avr 368.2
(-1) 		361.9
(-1.2) 		294.5
(-3) 		304
(-2.7) 		295.8
(-3) 		513.7
(3) 		219
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 81
1 2 3 4 range
A 132.1
(3)
P 		56
(-3)
P 		59.9
(-2.7)
P 		83.3
(-0.8)
P 		76
B 122.4
(2.8)
P 		57.5
(-2.5)
A 		51.3
(-3)
P 		124.6
(3)
P 		73
C 116.5
(3)
P 		65
(-3)
P 		95
(0.5)
P 		104.3
(1.6)
P 		52
avr 123.7
(3) 		59.5
(-3) 		68.7
(-2.1) 		104.1
(1.2) 		64

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 129
1 2 3 4 5 6 range
A 67.5
(-2.4)
P 		132.5
(3)
P 		59.8
(-3)
P 		82.2
(-1.2)
P 		86.3
(-0.8)
P 		126
(2.5)
P 		73
B 111.3
(-0.8)
P 		118.1
(-0.4)
P 		66.4
(-3)
P 		79.4
(-2.4)
P 		147.1
(1)
P 		187.3
(3)
P 		121
C 155.2
(2)
P 		109.4
(-0.3)
P 		85.4
(-1.6)
P 		57.9
(-3)
P 		77.4
(-2)
P 		174.5
(3)
P 		117
avr 111.3
(-0.3) 		120
(0.2) 		70.5
(-3) 		73.2
(-2.8) 		103.6
(-0.8) 		162.6
(3) 		92
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 191415_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.16224
Sequence Type Exemplar sequence
Representative Public ID F42G10.2 NCBI
Target Description F42G10.2 /REP_DB=WormBase Gene ID /WP=CE10328 /TR=SW:Q20347 /GB=CAB08355.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=serine-threonine kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077281(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077281 NCBI Caenorhabditis elegans MKK (MAP Kinase Kinase) homolog family member (mkk-4) (mkk-4) mRNA, complete cds. 11/11 None
F42G10.2 ENSEMBL cdna:known chromosome:CEL140:X:10027786:10030059:1 gene:F42G10.2 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000025102 7/11 Cross Hyb Matching Probes None
GENEFINDER00000025104 7/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:10027790-10029587(+) 100.0 100.0
Public Domain and Genome References
Gene Title serine/threonine kinase
Gene Symbol mkk-4
Ensembl F42G10.2
Entrez Gene 185682 Entrez gene
SwissProt Q20347 EMBL-EBI
WormBase CE10328 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1584937_AT similar to Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (JNK activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1) cfa
CANINE_2:CFA.11004.1.A1_AT similar to Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (JNK activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1) cfa
CANINE_2:CFAAFFX.27320.1.S1_AT similar to Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (JNK activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1) cfa
CANINE_2:CFAAFFX.27320.1.S1_S_AT similar to Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (JNK activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1) cfa
DROSOPHILA_2:1630916_AT MAP kinase kinase 4 dm
DROSGENOME1:142758_AT MAP kinase kinase 4 dm
CHICKEN:GGAAFFX.644.1.S1_AT similar to Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (JNK activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1) gga
CHICKEN:GGAAFFX.644.2.S1_AT similar to Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (JNK activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1) gga
CHICKEN:GGAAFFX.644.2.S1_S_AT similar to Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (JNK activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1) gga
CHICKEN:GGAAFFX.644.2.S1_X_AT similar to Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (JNK activating kinase 1) (c-Jun N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1) (SEK1) gga
HG-U95AV2:1845_AT mitogen-activated protein kinase kinase 4 hs
HC-G110:1845_AT mitogen-activated protein kinase kinase 4 hs
HU35KSUBD:RC_R43877_AT mitogen-activated protein kinase kinase 4 hs
HG-U95AV2:1712_S_AT mitogen-activated protein kinase kinase 4 hs
HC-G110:1712_S_AT mitogen-activated protein kinase kinase 4 hs
HUGENEFL:U17743_S_AT mitogen-activated protein kinase kinase 4 hs
HUGENEFL:L36870_AT mitogen-activated protein kinase kinase 4 hs
HG-U133A:203266_S_AT mitogen-activated protein kinase kinase 4 hs
HG-U133_PLUS_2:203266_S_AT mitogen-activated protein kinase kinase 4 hs
HG-FOCUS:203266_S_AT mitogen-activated protein kinase kinase 4 hs
HG-U133A_2:203266_S_AT mitogen-activated protein kinase kinase 4 hs
U133_X3P:G4506888_3P_A_AT mitogen-activated protein kinase kinase 4 hs
U133_X3P:HS.75217.0.S2_3P_A_AT mitogen-activated protein kinase kinase 4 hs
HG-U133A_2:203265_S_AT mitogen-activated protein kinase kinase 4 hs
HG-U133_PLUS_2:203265_S_AT mitogen-activated protein kinase kinase 4 hs
HG-U133A:203265_S_AT mitogen-activated protein kinase kinase 4 hs
HG-U95AV2:36910_AT mitogen-activated protein kinase kinase 4 hs
HG-U95C:61186_AT Mitogen-activated protein kinase kinase 4 hs
HG-U95D:78553_AT Mitogen-activated protein kinase kinase 4 hs
MU11KSUBA:U18310_S_AT mitogen activated protein kinase kinase 4 mm
MG-U74AV2:99960_AT mitogen activated protein kinase kinase 4 mm
MG-U74BV2:111507_AT mitogen activated protein kinase kinase 4 mm
MOE430A:1426233_AT mitogen activated protein kinase kinase 4 mm
MOUSE430A_2:1426233_AT mitogen activated protein kinase kinase 4 mm
MOUSE430_2:1426233_AT mitogen activated protein kinase kinase 4 mm
MOE430A:1451982_AT mitogen activated protein kinase kinase 4 mm
MOUSE430A_2:1451982_AT mitogen activated protein kinase kinase 4 mm
MOUSE430_2:1451982_AT mitogen activated protein kinase kinase 4 mm
MOUSE430_2:1442679_AT Mitogen activated protein kinase kinase 4 (Map2k4), mRNA mm
MOE430B:1442679_AT Mitogen activated protein kinase kinase 4 (Map2k4), mRNA mm
MU19KSUBC:TC35292_S_AT Mitogen activated protein kinase kinase 4 (Map2k4), mRNA mm
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA88264 Hypothetical protein F42G10.2 [Caenorhabditis elegans] emb|CAB08355.1| Hypothetical protein F42G10.2 [Caenorhabditis elegans] ref|NP_509682.1| MKK (MAP Kinase Kinase) homolog family member (mkk-4) [Caenorhabditis elegans] sp|Q20347|YR62_CAEEL Putative serine/threonine-protein kinase F42G10.2 0.0
blast CAE58750 Hypothetical protein CBG01940 [Caenorhabditis briggsae] 1.0E-175
blast CAB08354 Hypothetical protein VZC374L.1 [Caenorhabditis elegans] ref|NP_509683.1| VZC374L.1 [Caenorhabditis elegans] 1.0E-125
Protein Families
Method ID Description E-Value
hanks 2.1.19 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; PhKgM 2.0E-59
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 1.5E-60
Sequence
Target Sequence 
>C. ELEGANS:191415_AT
gtcgtcggacatatcacagtttgcactgtagatgcattggattatttgaagaaagaatta
aaaattattcatcgagacgtgaaaccctccaatattcttgtagacggaactggagcagtg
aaactttgcgattttggtatttgtgggcagttagaagaatcatttgcgaaaactcatgac
gccggttgtcagccgtatcttgcacccgaaaggattacaagttcagacaaatatgatgtg
agatcggatgtgtggtcattgggaataactttgtacgaaatagcaacaggaaaatttccc
taccaagaatggaattcactttttgatcagattgctacagtagtaagcggtgatcctcca
attctacatccagacagcgacgatttccattacagtttgccgcttgtcaagtttatcaat
acttgcttaactaaagacagacgccatcggcccaaatatgatactctgaagagttttgac
ttttatagaatatacgcagttgccggacccgaaattgaa

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GTCGTCGGACATATCACAGTTTGCA 93 473 517 Antisense
GAAACCCTCCAATATTCTTGTAGAC 18 357 597 Antisense
GCGAAAACTCATGACGCCGGTTGTC 80 289 682 Antisense
CCGTATCTTGCACCCGAAAGGATTA 79 263 709 Antisense
AGTAAGCGGTGATCCTCCAATTCTA 562 61 858 Antisense
TCCAATTCTACATCCAGACAGCGAC 501 587 873 Antisense
GACAGCGACGATTTCCATTACAGTT 420 367 889 Antisense
ATTACAGTTTGCCGCTTGTCAAGTT 86 13 905 Antisense
TAACTAAAGACAGACGCCATCGGCC 323 639 944 Antisense
GACGCCATCGGCCCAAATATGATAC 140 381 956 Antisense
CGCAGTTGCCGGACCCGAAATTGAA 69 255 1011 Antisense
Sequence Source Affymetrix Proprietary Database