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[191363_s_at] metalloprotease

Description ZK154.7 /REP_DB=WormBase Gene ID /WP=CE15265 /GEN=adm-4 /TR=Q94316 /GB=AAB09097.1 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=metalloprotease
Cluster 6grp_highest_10_10 > 34      6grp_high1_10_10 > 33      4grp_highest_8_8 > 10      4grp_high_8_8 > 54      6grp_highest_nonorm > 61      6grp_total > 21      4grp_total > 56      6grp_highest_sub > 02_03      6grp_cgc > 62      6grp_high1_sub > 02      6grp_cgc_sub > 02      6grp_total_sub > Hat      6grp_rule_based > S2      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 274
1 2 3 4 range
A 392.6
(-3)
P 		447.9
(1.1)
P 		474.7
(3)
P 		392
(-3)
P 		83
B 355.9
(-1.3)
P 		464.2
(1.1)
P 		551
(3)
P 		276.7
(-3)
P 		274
C 385.1
(-3)
P 		521.3
(3)
P 		506.7
(2.4)
P 		402.8
(-2.2)
P 		136
avr 377.9
(-2.2) 		477.8
(1.7) 		510.8
(3) 		357.2
(-3) 		154

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 225
1 2 3 4 5 6 range
A 397.1
(-0.3)
P 		514.3
(3)
P 		415.8
(0.3)
P 		386.1
(-0.6)
P 		423.1
(0.5)
P 		298.3
(-3)
P 		216
B 381.2
(-0.5)
P 		505.7
(3)
P 		470.7
(2)
P 		476.3
(2.2)
P 		389.6
(-0.3)
P 		294.8
(-3)
P 		211
C 421.8
(1)
P 		488.1
(3)
P 		473.6
(2.6)
P 		442.1
(1.6)
P 		289.5
(-3)
P 		331.7
(-1.7)
P 		199
avr 400
(-0.2) 		502.7
(3) 		453.4
(1.5) 		434.8
(0.9) 		367.4
(-1.2) 		308.3
(-3) 		194
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 119
1 2 3 4 range
A 142.9
(3)
P 		97.2
(-0.2)
P 		124.1
(1.7)
P 		57.4
(-3)
P 		86
B 113.5
(1.8)
P 		114.6
(1.9)
P 		127.7
(3)
P 		59
(-3)
P 		69
C 127.5
(0.3)
P 		149.9
(1.5)
P 		176.6
(3)
P 		67.9
(-3)
P 		109
avr 128
(1.9) 		120.6
(1.4) 		142.8
(3) 		61.4
(-3) 		81

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 110
1 2 3 4 5 6 range
A 73.2
(-3)
P 		182.9
(3)
P 		90.5
(-2)
P 		97.9
(-1.6)
P 		127.7
(-0)
P 		72.6
(-3)
P 		110
B 132.6
(-0.7)
P 		168.3
(3)
P 		114.3
(-2.5)
P 		126.2
(-1.3)
P 		158.3
(2)
P 		109.9
(-3)
P 		58
C 156.3
(3)
P 		148.9
(2.3)
P 		120.5
(-0.2)
P 		88.9
(-3)
P 		93.7
(-2.6)
P 		111
(-1)
P 		67
avr 120.7
(-1) 		166.7
(3) 		108.4
(-2.1) 		104.3
(-2.4) 		126.6
(-0.5) 		97.8
(-3) 		69
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 191363_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.16533
Sequence Type Exemplar sequence
Representative Public ID ZK154.7 NCBI
Target Description ZK154.7 /REP_DB=WormBase Gene ID /WP=CE15265 /GEN=adm-4 /TR=Q94316 /GB=AAB09097.1 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=metalloprotease
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_076917(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_076917 NCBI Caenorhabditis elegans ZK154.7 (metalloprotease) mRNA, complete cds. 11/11 None
SNAP00000014397 ENSEMBL cdna:SNAP chromosome:CEL140:X:7795259:7797022:-1 11/11 None
ZK154.7 ENSEMBL cdna:known chromosome:CEL140:X:7795021:7798226:-1 gene:ZK154.7 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:7795257-7798220(-) 100.0 100.0
Public Domain and Genome References
Gene Title metalloprotease
Gene Symbol adm-4
Ensembl ZK154.7
Entrez Gene 181041 Entrez gene
SwissProt Q94316 EMBL-EBI
WormBase CE15265 Wormbase
Functional Annotations
Ortholog
ID Title Organism
DROSOPHILA_2:1639144_A_AT dm
DROSGENOME1:153418_AT dm
CHICKEN:GGA.7793.1.S1_S_AT ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) gga
HG-U133A:205745_X_AT ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) hs
HG-U133_PLUS_2:205745_X_AT ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) hs
HG-U133A_2:205745_X_AT ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) hs
HG-U133_PLUS_2:205746_S_AT ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) hs
HG-U133A:205746_S_AT ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) hs
HG-FOCUS:205746_S_AT ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) hs
HG-U133A_2:205746_S_AT ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) hs
HG-U133_PLUS_2:213532_AT ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) hs
HG-U133A_2:213532_AT ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) hs
HG-U133A:213532_AT ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) hs
HG-U95AV2:1226_AT ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) hs
HC-G110:1226_AT ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) hs
HG-U95AV2:1227_G_AT ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) hs
HC-G110:1227_G_AT ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) hs
HU35KSUBA:AA434196_AT ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) hs
HUGENEFL:U86755_S_AT ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) hs
HUGENEFL:U69611_AT ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) hs
U133_X3P:G1857672_3P_A_AT ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) hs
U133_X3P:G11497003_3P_A_AT ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) hs
U133_X3P:HS.52438.1.A1_3P_AT ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) hs
HG-U133_PLUS_2:237897_AT ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) hs
HG-U133B:237897_AT ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) hs
HG-U95AV2:41601_AT ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) hs
HG-U95AV2:41786_AT ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) hs
HG-U95D:88931_AT ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) hs
U133_X3P:HS.202407.0.A1_3P_AT ADAM metallopeptidase domain 17 (tumor necrosis factor, alpha, converting enzyme) hs
MU11KSUBA:C76813_RC_S_AT a disintegrin and metallopeptidase domain 17 mm
MG-U74AV2:160241_AT a disintegrin and metallopeptidase domain 17 mm
MOE430A:1421857_AT a disintegrin and metallopeptidase domain 17 mm
MOUSE430A_2:1421857_AT a disintegrin and metallopeptidase domain 17 mm
MOUSE430_2:1421857_AT a disintegrin and metallopeptidase domain 17 mm
MOE430A:1421858_AT a disintegrin and metallopeptidase domain 17 mm
MOUSE430A_2:1421858_AT a disintegrin and metallopeptidase domain 17 mm
MOUSE430_2:1421858_AT a disintegrin and metallopeptidase domain 17 mm
MOE430A:1421859_AT a disintegrin and metallopeptidase domain 17 mm
MOUSE430A_2:1421859_AT a disintegrin and metallopeptidase domain 17 mm
MOUSE430_2:1421859_AT a disintegrin and metallopeptidase domain 17 mm
MOUSE430_2:1445500_AT A disintegrin and metallopeptidase domain 17 (Adam17), mRNA mm
MOE430B:1445500_AT A disintegrin and metallopeptidase domain 17 (Adam17), mRNA mm
MU19KSUBC:TC36728_AT A disintegrin and metallopeptidase domain 17 (Adam17), mRNA mm
MU19KSUBC:TC41989_AT A disintegrin and metallopeptidase domain 17 (Adam17), mRNA mm
RN-U34:AJ012603UTR#1_G_AT a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) rn
RG-U34A:AJ012603UTR#1_G_AT a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) rn
RN-U34:AJ012603CDS_AT a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) rn
RG-U34A:AJ012603CDS_AT a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) rn
RN-U34:AJ012603UTR#1_AT a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) rn
RG-U34A:AJ012603UTR#1_AT a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) rn
RAE230A:1367922_AT a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) rn
RAT230_2:1367922_AT a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme) rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
8237 metallopeptidase activity inferred from electronic annotation QuickGO AmiGO
8270 zinc ion binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAB09097 Adam (disintegrin plus metalloprotease) family protein 4 [Caenorhabditis elegans] ref|NP_509318.1| ZK154.7 [Caenorhabditis elegans] 0.0
blast CAE70280 Hypothetical protein CBG16796 [Caenorhabditis briggsae] 0.0
blast T16661 hypothetical protein R03G5.4 - Caenorhabditis elegans 1.0E-138
blast AAF56986 CG7908-PA, isoform A [Drosophila melanogaster] ref|NP_733334.1| CG7908-PA, isoform A [Drosophila melanogaster] gb|AAO53296.1| TNF-alpha converting enzyme/ADAM17 [Drosophila melanogaster] gb|AAO24939.1| RE65757p [Drosophila melanogaster] sp|Q9VAC5|ADA17_DROME ADAM 17-like protease precursor 6.0E-76
Protein Domains
Database ID Description E-Value
Pfam IPR001762 EMBL-EBI Disintegrin 2.0E-34
Pfam IPR001762 EMBL-EBI Disintegrin 2.0E-34
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_509318.1 1 639-658
ZK154.7 1 639-658
SNAP00000014397 1 392-411
Sequence
Target Sequence 
>C. ELEGANS:191363_S_AT
tgttggcgcaaaatgttcacccctaaaccatatttgctgcacaccaacctgtcagttcca
caactctacccatgtctgtttaccaggagattcccttttatgtaaagctgatgctgtatg
caacggtttctctggtgaatgcccatccgctcccccagtcagagatggtcaagagtgtct
tgaaggtggtgaatgcctaaatggtgtttgcttaccgttctgtgaaaaaatgagtattgg
aaagaagagctgcatttgcgaagatttggaactttcttgccgtctgtgctgtcgtgacta
caacggaacgtgtgctcctgttcctggtcatgtttaccttcgagatggtgtccgttgctc
aaaaggatcttgccgagatagaaagtgtgtaaacgaagttgtcgataatgtccgcaacta
ctttt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TGTTGGCGCAAAATGTTCACCCCTA 700 561 1452 Antisense
TTCACCCCTAAACCATATTTGCTGC 201 687 1467 Antisense
CATATTTGCTGCACACCAACCTGTC 255 215 1480 Antisense
CTCTACCCATGTCTGTTTACCAGGA 330 231 1515 Antisense
GCTCCCCCAGTCAGAGATGGTCAAG 581 297 1600 Antisense
AATGGTGTTTGCTTACCGTTCTGTG 466 161 1651 Antisense
CCGTCTGTGCTGTCGTGACTACAAC 424 265 1731 Antisense
CAACGGAACGTGTGCTCCTGTTCCT 34 189 1752 Antisense
TCCTGTTCCTGGTCATGTTTACCTT 79 593 1767 Antisense
CCTTCGAGATGGTGTCCGTTGCTCA 614 269 1788 Antisense
GTCGATAATGTCCGCAACTACTTTT 320 473 1852 Antisense
Sequence Source Affymetrix Proprietary Database