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[191344_s_at] ubiquitin activating enzyme

Description C08B6.9 /REP_DB=WormBase Gene ID /WP=CE05246 /TR=Q17820 /GB=CAA96591.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=ubiquitin activating enzyme
Cluster 6grp_highest_10_10 > 49      6grp_high1_10_10 > 94      4grp_highest_8_8 > 21      4grp_high_8_8 > 23      6grp_highest_nonorm > 65      6grp_total > 75      4grp_total > 0      6grp_highest_sub > 04_05_06      6grp_cgc > 67      6grp_high1_sub > In      6grp_cgc_sub > In      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 539
1 2 3 4 range
A 882
(-0.9)
P 		728.5
(-3)
P 		1012.9
(0.9)
P 		1164.9
(3)
P 		436
B 951.9
(-1.3)
P 		829.1
(-3)
P 		985.4
(-0.9)
P 		1267.5
(3)
P 		438
C 841.4
(-3)
P 		867.5
(-2.4)
P 		1123.8
(3)
P 		972.2
(-0.2)
P 		282
avr 891.8
(-1.5) 		808.4
(-3) 		1040.7
(1.3) 		1134.9
(3) 		327

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 706
1 2 3 4 5 6 range
A 951.9
(-3)
P 		1041.6
(-2.1)
P 		1256.3
(-0.1)
P 		1574.8
(3)
P 		1134.4
(-1.2)
P 		1327.1
(0.6)
P 		623
B 902.9
(-3)
P 		1076.1
(-0.9)
P 		1270.5
(1.4)
P 		1209.7
(0.7)
P 		1370.7
(2.6)
P 		1403.1
(3)
P 		500
C 952.7
(-3)
P 		991.1
(-2.6)
P 		1026.1
(-2.3)
P 		1496
(2)
P 		1197.7
(-0.8)
P 		1608.6
(3)
P 		656
avr 935.8
(-3) 		1036.3
(-1.8) 		1184.3
(-0.1) 		1426.8
(2.8) 		1234.3
(0.5) 		1446.3
(3) 		511
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 234
1 2 3 4 range
A 321.1
(3)
P 		158.1
(-3)
P 		264.8
(0.9)
P 		170.5
(-2.5)
P 		163
B 303.6
(3)
P 		204.8
(-3)
P 		228.4
(-1.6)
P 		270.1
(1)
P 		99
C 278.5
(0)
P 		249.4
(-0.7)
P 		391.7
(3)
P 		163.9
(-3)
P 		228
avr 301.1
(3) 		204.1
(-2.8) 		295
(2.6) 		201.5
(-3) 		100

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 381
1 2 3 4 5 6 range
A 175.5
(-3)
P 		370.4
(2.2)
P 		273.6
(-0.4)
P 		399.4
(3)
P 		342.3
(1.5)
P 		323.1
(1)
P 		224
B 314.1
(-2.9)
P 		358.2
(-1.8)
P 		308.5
(-3)
P 		320.4
(-2.7)
P 		556.9
(3)
P 		523.2
(2.2)
P 		248
C 353.1
(-1)
P 		302.4
(-2.1)
P 		261.2
(-3)
P 		300.9
(-2.1)
P 		387.5
(-0.3)
P 		538.5
(3)
P 		277
avr 280.9
(-3) 		343.7
(-0.9) 		281.1
(-3) 		340.2
(-1) 		428.9
(1.9) 		461.6
(3) 		181
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 191344_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.11410
Sequence Type Exemplar sequence
Representative Public ID C08B6.9 NCBI
Target Description C08B6.9 /REP_DB=WormBase Gene ID /WP=CE05246 /TR=Q17820 /GB=CAA96591.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=ubiquitin activating enzyme
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_073203(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_073203 NCBI Caenorhabditis elegans Activator Of Sumo (yeast AOS homolog) family member (aos-1) (aos-1) mRNA, complete cds. 11/11 None
SNAP00000004955 ENSEMBL cdna:SNAP chromosome:CEL140:V:10130261:10132875:-1 11/11 None
GENEFINDER00000004968 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:10130261:10132875:-1 11/11 None
C08B6.9 ENSEMBL cdna:known chromosome:CEL140:V:10130106:10132876:-1 gene:C08B6.9 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:10130260-10132854(-) 100.0 100.0
Public Domain and Genome References
Gene Title ubiquitin activating enzyme
Gene Symbol aos-1
Ensembl C08B6.9
Entrez Gene 179409 Entrez gene
SwissProt Q17820 EMBL-EBI
WormBase CE05246 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:248523_S_AT SUMO activating enzyme, putative at
CANINE:1604266_AT similar to Ubiquitin-like 1 activating enzyme E1A (SUMO-1 activating enzyme subunit 1) cfa
CANINE:1587639_AT similar to Ubiquitin-like 1 activating enzyme E1A (SUMO-1 activating enzyme subunit 1) cfa
CANINE_2:CFA.1997.1.S1_AT similar to Ubiquitin-like 1 activating enzyme E1A (SUMO-1 activating enzyme subunit 1) cfa
CANINE_2:CFAAFFX.7190.1.S1_AT similar to Ubiquitin-like 1 activating enzyme E1A (SUMO-1 activating enzyme subunit 1) cfa
CANINE_2:CFAAFFX.7190.1.S1_S_AT similar to Ubiquitin-like 1 activating enzyme E1A (SUMO-1 activating enzyme subunit 1) cfa
DROSOPHILA_2:1629655_AT dm
DROSGENOME1:154656_AT dm
HG-U133_PLUS_2:217946_S_AT SUMO-1 activating enzyme subunit 1 hs
HG-U133A:217946_S_AT SUMO-1 activating enzyme subunit 1 hs
HG-U133A_2:217946_S_AT SUMO-1 activating enzyme subunit 1 hs
HU35KSUBA:RC_AA490323_AT SUMO-1 activating enzyme subunit 1 hs
U133_X3P:G7705472_3P_S_AT SUMO-1 activating enzyme subunit 1 hs
U133_X3P:HS2.279868.2.S1_3P_S_AT SUMO-1 activating enzyme subunit 1 hs
HG-U133_PLUS_2:1555618_S_AT SUMO-1 activating enzyme subunit 1 hs
HG-U95B:45712_AT SUMO-1 activating enzyme subunit 1 hs
HG-U95C:51084_AT SUMO-1 activating enzyme subunit 1 hs
HG-U95D:76318_AT SUMO-1 activating enzyme subunit 1 hs
U133_X3P:HS.32748.0.S1_3P_AT SUMO-1 activating enzyme subunit 1 hs
HG-U133_PLUS_2:241185_AT SUMO-1 activating enzyme subunit 1 hs
HG-U133B:241185_AT SUMO-1 activating enzyme subunit 1 hs
HG-U95B:45900_AT SUMO-1 activating enzyme subunit 1 hs
HU35KSUBC:RC_Z40689_AT SUMO-1 activating enzyme subunit 1 hs
MOUSE430_2:1430021_A_AT ubiquitin-like 1 (sentrin) activating enzyme E1A mm
MOE430A:1430021_A_AT ubiquitin-like 1 (sentrin) activating enzyme E1A mm
MOUSE430A_2:1430021_A_AT ubiquitin-like 1 (sentrin) activating enzyme E1A mm
MOE430A:1430022_AT ubiquitin-like 1 (sentrin) activating enzyme E1A mm
MOUSE430A_2:1430022_AT ubiquitin-like 1 (sentrin) activating enzyme E1A mm
MOUSE430_2:1430022_AT ubiquitin-like 1 (sentrin) activating enzyme E1A mm
MU11KSUBA:AA592294_S_AT ubiquitin-like 1 (sentrin) activating enzyme E1A mm
MU11KSUBB:MSA.28926.0_S_AT ubiquitin-like 1 (sentrin) activating enzyme E1A mm
MG-U74AV2:95703_AT ubiquitin-like 1 (sentrin) activating enzyme E1A mm
MOE430A:1416443_A_AT ubiquitin-like 1 (sentrin) activating enzyme E1A mm
MOUSE430A_2:1416443_A_AT ubiquitin-like 1 (sentrin) activating enzyme E1A mm
MOUSE430_2:1416443_A_AT ubiquitin-like 1 (sentrin) activating enzyme E1A mm
RG-U34B:RC_AA956535_AT ubiquitin-like 1 (sentrin) activating enzyme E1A (predicted) rn
RAE230A:1371830_AT ubiquitin-like 1 (sentrin) activating enzyme E1A (predicted) rn
RAT230_2:1371830_AT ubiquitin-like 1 (sentrin) activating enzyme E1A (predicted) rn
YEAST_2:1773654_AT Nuclear protein that acts as a heterodimer with Uba2p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability Sc
Gene Ontology
GO Molecular Function (view graph)
ID Description Evidence Links
3824 catalytic activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA96591 Hypothetical protein C08B6.9 [Caenorhabditis elegans] ref|NP_505604.1| Activator Of Sumo (yeast AOS homolog) family member (aos-1) [Caenorhabditis elegans] 0.0
blast CAE64738 Hypothetical protein CBG09526 [Caenorhabditis briggsae] 1.0E-136
blast CAE64738 Hypothetical protein CBG09526 [Caenorhabditis briggsae] 1.0E-134
blast NP_001016870 SUMO-1 activating enzyme subunit 1 [Xenopus tropicalis] 4.0E-39
Protein Domains
Database ID Description E-Value
Pfam IPR000594 EMBL-EBI UBA/THIF-type NAD/FAD binding fold 1.2E-38
Pfam IPR000594 EMBL-EBI UBA/THIF-type NAD/FAD binding fold 1.2E-38
Sequence
Target Sequence 
>C. ELEGANS:191344_S_AT
gattggctacgcatttttcgatttcgatggccatgcttatttagtaaaagctaaaagccc
ggattgcttgaatgaagaagaatcggaaaccggaaagacgagcacagtggttacggtaga
tgaagaattcgtgcttgaaacgttttcatatccatcatttgtcgaaacgctcaactctga
tttcacggcgaagaaaattgtgagaaagtgcaaacggatcgttccaacatcatatttcct
cgtgaaaagtatgctccgcgcttccagcgaaaataaacttaccggagtcactgaaaacga
tattgagaaattaattccaatctggaacgaggaggtggccgctggaaatcataccatcga
tatgcaaccagttcaacccgatcgatttgatcatttgttcggaccaaactttggaccaac
agcagcatgtgtcggtggagtaattggacaagaagctattaaatcaatttcggaaggaaa
gaatccacttcgcaatttgttcatctataccggcttcgaatc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GATTGGCTACGCATTTTTCGATTTC 404 435 489 Antisense
TTTCGATTTCGATGGCCATGCTTAT 159 669 504 Antisense
AACGTTTTCATATCCATCATTTGTC 20 145 627 Antisense
AAACGCTCAACTCTGATTTCACGGC 87 127 653 Antisense
GATCGTTCCAACATCATATTTCCTC 599 417 705 Antisense
CCTCGTGAAAAGTATGCTCCGCGCT 527 265 726 Antisense
GGTGGCCGCTGGAAATCATACCATC 414 499 822 Antisense
CAACCAGTTCAACCCGATCGATTTG 285 185 853 Antisense
GGACCAACAGCAGCATGTGTCGGTG 171 523 901 Antisense
GAATCCACTTCGCAATTTGTTCATC 133 331 969 Antisense
TGTTCATCTATACCGGCTTCGAATC 591 559 986 Antisense
Sequence Source Affymetrix Proprietary Database