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[191332_at] isocitrate dehydrogenase

Description C37E2.1 /REP_DB=WormBase Gene ID /WP=CE08620 /TR=SW:Q93353 /GB=CAB02822.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=isocitrate dehydrogenase
Cluster 6grp_highest_10_10 > 31      6grp_high1_10_10 > 22      4grp_highest_8_8 > 17      4grp_high_8_8 > 60      6grp_highest_nonorm > 42      6grp_total > 23      4grp_total > 59      6grp_highest_sub > De      6grp_high1_sub > De      6grp_total_sub > Decrease      6grp_rule_based > S2      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 645
1 2 3 4 range
A 855.3
(0.9)
P 		830.1
(0.7)
P 		1050.3
(3)
P 		481.2
(-3)
P 		569
B 754
(-0.6)
P 		966.9
(1.5)
P 		1126.5
(3)
P 		501
(-3)
P 		626
C 914.1
(1.7)
P 		977.7
(2.4)
P 		1032.5
(3)
P 		506
(-3)
P 		527
avr 841.1
(0.6) 		924.9
(1.5) 		1069.8
(3) 		496.1
(-3) 		574

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 982
1 2 3 4 5 6 range
A 751.4
(0.9)
P 		955.4
(3)
P 		842.8
(1.8)
P 		590.5
(-0.7)
P 		630
(-0.3)
P 		371.3
(-3)
P 		584
B 828.5
(1.1)
P 		1026.6
(3)
P 		951.4
(2.3)
P 		820.6
(1)
P 		696
(-0.2)
P 		399.1
(-3)
P 		628
C 1353.5
(3)
P 		1008.2
(0.9)
P 		883
(0.1)
P 		625.6
(-1.5)
P 		721.4
(-0.9)
P 		384.9
(-3)
P 		969
avr 977.8
(2.8) 		996.7
(3) 		892.4
(2) 		678.9
(-0.1) 		682.5
(-0.1) 		385.1
(-3) 		612
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 289
1 2 3 4 range
A 311.4
(3)
P 		180.2
(-0.3)
P 		274.6
(2.1)
P 		70.4
(-3)
P 		241
B 240.4
(2.2)
P 		238.8
(2.1)
P 		261
(3)
P 		106.8
(-3)
P 		154
C 302.6
(1.7)
P 		281.1
(1.3)
P 		359.8
(3)
P 		85.3
(-3)
P 		275
avr 284.8
(2.6) 		233.4
(1.1) 		298.5
(3) 		87.5
(-3) 		211

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 411
1 2 3 4 5 6 range
A 138.5
(-1.8)
P 		339.8
(3)
P 		183.5
(-0.8)
P 		149.8
(-1.6)
P 		190.1
(-0.6)
P 		90.4
(-3)
P 		249
B 288.3
(1.3)
P 		341.7
(3)
P 		231
(-0.4)
P 		217.3
(-0.9)
P 		282.8
(1.2)
P 		148.8
(-3)
P 		193
C 501.7
(3)
P 		307.6
(-0.1)
P 		224.7
(-1.4)
P 		125.8
(-3)
P 		233.4
(-1.3)
P 		128.8
(-3)
P 		376
avr 309.5
(2.4) 		329.7
(3) 		213.1
(-0.4) 		164.3
(-1.8) 		235.4
(0.3) 		122.7
(-3) 		207
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 191332_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.17490
Sequence Type Exemplar sequence
Representative Public ID C37E2.1 NCBI
Target Description C37E2.1 /REP_DB=WormBase Gene ID /WP=CE08620 /TR=SW:Q93353 /GB=CAB02822.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=isocitrate dehydrogenase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_077961(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_077961 NCBI Caenorhabditis elegans C37E2.1 (C37E2.1) mRNA, complete cds. 11/11 None
SNAP00000011519 ENSEMBL cdna:SNAP chromosome:CEL140:X:14171383:14173308:-1 11/11 None
GENEFINDER00000011526 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:14171383:14173308:-1 11/11 None
C37E2.1.1 ENSEMBL cdna:known chromosome:CEL140:X:14170795:14173309:-1 gene:C37E2.1 11/11 A 
C37E2.1.2 ENSEMBL cdna:known chromosome:CEL140:X:14170795:14173983:-1 gene:C37E2.1 11/11 A 
C37E2.1.3 ENSEMBL cdna:known chromosome:CEL140:X:14170800:14173314:-1 gene:C37E2.1 11/11 None
C37E2.1.4 ENSEMBL cdna:known chromosome:CEL140:X:14170828:14173315:-1 gene:C37E2.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:14171382-14173308(-) 100.0 100.0
Public Domain and Genome References
Gene Title isocitrate dehydrogenase
Ensembl C37E2.1
Entrez Gene 181528 Entrez gene
SwissProt Q93353 EMBL-EBI
WormBase CE08620 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:12329_AT isocitrate dehydrogenase, putative / NAD+ isocitrate dehydrogenase, putative at
ATH1-121501:253149_AT isocitrate dehydrogenase, putative / NAD+ isocitrate dehydrogenase, putative at
CANINE:1584935_AT similar to isocitrate dehydrogenase 3, beta subunit isoform b precursor cfa
CANINE:1583193_S_AT similar to isocitrate dehydrogenase 3, beta subunit isoform b precursor cfa
CANINE_2:CFA.12762.1.A1_S_AT similar to isocitrate dehydrogenase 3, beta subunit isoform b precursor cfa
CANINE_2:CFA.270.2.A1_AT similar to isocitrate dehydrogenase 3, beta subunit isoform b precursor cfa
CANINE_2:CFAAFFX.10904.1.S1_S_AT similar to isocitrate dehydrogenase 3, beta subunit isoform b precursor cfa
DROSOPHILA_2:1629745_AT dm
DROSGENOME1:153008_AT dm
CHICKEN:GGA.5623.2.S1_S_AT isocitrate dehydrogenase 3 (NAD+) beta gga
CHICKEN:GGA.5668.1.S1_S_AT isocitrate dehydrogenase 3 (NAD+) beta gga
HG-U95AV2:40112_AT isocitrate dehydrogenase 3 (NAD+) beta hs
HG-U133A:201509_AT isocitrate dehydrogenase 3 (NAD+) beta hs
HG-U133_PLUS_2:201509_AT isocitrate dehydrogenase 3 (NAD+) beta hs
HG-U133A_2:201509_AT isocitrate dehydrogenase 3 (NAD+) beta hs
HG-U133_PLUS_2:210418_S_AT isocitrate dehydrogenase 3 (NAD+) beta hs
HG-U133A:210418_S_AT isocitrate dehydrogenase 3 (NAD+) beta hs
HG-FOCUS:210418_S_AT isocitrate dehydrogenase 3 (NAD+) beta hs
HG-U133A_2:210418_S_AT isocitrate dehydrogenase 3 (NAD+) beta hs
HG-U133A:210014_X_AT isocitrate dehydrogenase 3 (NAD+) beta hs
HG-U133_PLUS_2:210014_X_AT isocitrate dehydrogenase 3 (NAD+) beta hs
HG-U133A_2:210014_X_AT isocitrate dehydrogenase 3 (NAD+) beta hs
HU35KSUBA:AA166733_AT isocitrate dehydrogenase 3 (NAD+) beta hs
HU35KSUBA:RC_AA287131_AT isocitrate dehydrogenase 3 (NAD+) beta hs
U133_X3P:G4103445_3P_A_AT isocitrate dehydrogenase 3 (NAD+) beta hs
HG-U95AV2:40111_G_AT isocitrate dehydrogenase 3 (NAD+) beta hs
HG-U95AV2:40110_AT isocitrate dehydrogenase 3 (NAD+) beta hs
HUGENEFL:U87972_AT Isocitrate dehydrogenase 3 (NAD+) beta hs
MU11KSUBB:W13167_AT isocitrate dehydrogenase 3 (NAD+) beta mm
MG-U74AV2:95676_AT isocitrate dehydrogenase 3 (NAD+) beta mm
MG-U74CV2:166805_F_AT isocitrate dehydrogenase 3 (NAD+) beta mm
MOE430A:1418886_S_AT isocitrate dehydrogenase 3 (NAD+) beta mm
MOUSE430A_2:1418886_S_AT isocitrate dehydrogenase 3 (NAD+) beta mm
MOUSE430_2:1418886_S_AT isocitrate dehydrogenase 3 (NAD+) beta mm
MOE430A:1418885_A_AT isocitrate dehydrogenase 3 (NAD+) beta mm
MOUSE430A_2:1418885_A_AT isocitrate dehydrogenase 3 (NAD+) beta mm
MOUSE430_2:1418885_A_AT isocitrate dehydrogenase 3 (NAD+) beta mm
MOUSE430_2:1441271_AT Isocitrate dehydrogenase 3 (NAD+) beta (Idh3b), mRNA mm
MOE430B:1441271_AT Isocitrate dehydrogenase 3 (NAD+) beta (Idh3b), mRNA mm
MU19KSUBB:TC26981_S_AT Isocitrate dehydrogenase 3 (NAD+) beta (Idh3b), mRNA mm
MU19KSUBB:TC33162_AT Isocitrate dehydrogenase 3 (NAD+) beta (Idh3b), mRNA mm
RG-U34B:RC_AI011824_AT isocitrate dehydrogenase 3 (NAD+) beta rn
RG-U34C:RC_AI105469_AT isocitrate dehydrogenase 3 (NAD+) beta rn
RAE230A:1388160_A_AT isocitrate dehydrogenase 3 (NAD+) beta rn
RAT230_2:1388160_A_AT isocitrate dehydrogenase 3 (NAD+) beta rn
YEAST_2:1779489_AT Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6099 tricarboxylic acid cycle inferred from electronic annotation QuickGO AmiGO
8152 metabolism inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5739 mitochondrion inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4449 isocitrate dehydrogenase (NAD+) activity inferred from electronic annotation QuickGO AmiGO
16491 oxidoreductase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB02822 Hypothetical protein C37E2.1 [Caenorhabditis elegans] ref|NP_510362.1| C37E2.1 [Caenorhabditis elegans] sp|Q93353|IDH3B_CAEEL Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial precursor (Isocitric dehydrogenase) (NAD(+)-specific ICDH) 0.0
blast CAE69933 Hypothetical protein CBG16309 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001804 EMBL-EBI Isocitrate/isopropylmalate dehydrogenase 5.5E-64
Pfam IPR001804 EMBL-EBI Isocitrate/isopropylmalate dehydrogenase 8.0E-18
Sequence
Target Sequence 
>C. ELEGANS:191332_AT
cacgagctcgttccaggagtcattgaatgtctcaagatttctaccagaaccaaagccgag
cgcattgccaagtttgcctttgactacgctaccaagactggaagaaagaaggtcaccgcc
gtgcacaaggccaacattatgaagctcggagacggtttgttcttgagaacctgtgaagga
gttgccaagcagtacccgaagatccagtttgagagcatgattattgacaacacttgcatg
cagttggtgtccaagcccgagcaattcgacgtgatggtcatgccaaatctctacggaaac
atcattgataacttggctgctggactggtcggaggagccggagtcgtgccaggacaatct
gtgggacgtgactttgtcatcttcgagccaggaagtcgtcactctttccaagaggccatg
ggacgctctatcgccaacccaactgccatgattctctgcgctgccaacatgctcaatcac
ttgcatcttgatgcttggggaaattcacttcgtcaagccgtcgctgatgttgttaaggag
ggaaaagttcgcacccgtgatttgg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CACGAGCTCGTTCCAGGAGTCATTG 131 199 529 Antisense
CGAGCGCATTGCCAAGTTTGCCTTT 49 251 585 Antisense
GAAGCTCGGAGACGGTTTGTTCTTG 146 343 669 Antisense
GCAGTACCCGAAGATCCAGTTTGAG 627 307 717 Antisense
ATGGTCATGCCAAATCTCTACGGAA 186 51 802 Antisense
TGGTCGGAGGAGCCGGAGTCGTGCC 189 549 854 Antisense
GACGTGACTTTGTCATCTTCGAGCC 445 377 893 Antisense
CAGGAAGTCGTCACTCTTTCCAAGA 621 207 917 Antisense
CTGCCAACATGCTCAATCACTTGCA 356 237 989 Antisense
TCGTCAAGCCGTCGCTGATGTTGTT 362 603 1038 Antisense
GGAAAAGTTCGCACCCGTGATTTGG 420 525 1069 Antisense
Sequence Source Affymetrix Proprietary Database