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[191326_at] guanylate cyclase

Description R134.1 /REP_DB=WormBase Gene ID /WP=CE01636 /GEN=gcy-3 /TR=Q10028 /GB=CAA88052.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=guanylate cyclase
Cluster 6grp_total > 26      4grp_total > 13      6grp_cgc > 04      6grp_cgc_sub > Cu      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 223
1 2 3 4 range
A 93.7
(-0.5)
A 		13.1
(-3)
A 		39.9
(-2.2)
A 		205.8
(3)
P 		193
B 111.6
(0)
P 		51.1
(-3)
A 		50.5
(-3)
A 		171.3
(3)
P 		121
C 124.4
(0.2)
M 		57.2
(-1.6)
A 		4.2
(-3)
A 		227.3
(3)
P 		223
avr 109.9
(-0.2) 		40.5
(-2.7) 		31.5
(-3) 		201.5
(3) 		170

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 120
1 2 3 4 5 6 range
A 86.2
(1)
A 		125.4
(3)
A 		5.1
(-3)
A 		19.5
(-2.3)
A 		6.9
(-2.9)
A 		30.8
(-1.7)
A 		120
B 67.5
(3)
P 		48.7
(0.5)
A 		21.7
(-3)
A 		47.5
(0.4)
A 		35.1
(-1.2)
A 		51.5
(0.9)
A 		46
C 42.3
(2.5)
A 		27.1
(0.1)
A 		11.2
(-2.5)
A 		8
(-3)
A 		30.2
(0.6)
A 		45.5
(3)
A 		38
avr 65.3
(2.8) 		67.1
(3) 		12.7
(-3) 		25
(-1.6) 		24.1
(-1.7) 		42.6
(0.3) 		54
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 40
1 2 3 4 range
A 34.1
(3)
A 		2.9
(-3)
A 		10.4
(-1.6)
A 		30.1
(2.2)
P 		31
B 35.6
(2.8)
P 		12.6
(-2.8)
A 		11.7
(-3)
A 		36.5
(3)
P 		25
C 41.2
(3)
M 		16.4
(-0.7)
A 		1.5
(-3)
A 		38.3
(2.6)
P 		40
avr 37
(3) 		10.6
(-2.4) 		7.9
(-3) 		35
(2.6) 		29

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 44
1 2 3 4 5 6 range
A 15.9
(-1)
A 		44.6
(3)
A 		1.1
(-3)
A 		4.9
(-2.5)
A 		2.1
(-2.9)
A 		7.5
(-2.1)
A 		44
B 23.5
(3)
P 		16.2
(0.6)
A 		5.3
(-3)
A 		12.6
(-0.6)
A 		14.2
(-0.1)
A 		19.2
(1.6)
A 		18
C 15.7
(3)
A 		8.3
(-0.1)
A 		2.8
(-2.5)
A 		1.6
(-3)
A 		9.8
(0.5)
A 		15.2
(2.8)
A 		14
avr 18.4
(1.6) 		23
(3) 		3.1
(-3) 		6.4
(-2) 		8.7
(-1.3) 		14
(0.3) 		20
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 191326_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.3625
Sequence Type Exemplar sequence
Representative Public ID R134.1 NCBI
Target Description R134.1 /REP_DB=WormBase Gene ID /WP=CE01636 /GEN=gcy-3 /TR=Q10028 /GB=CAA88052.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=guanylate cyclase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_063636(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_063636 NCBI Caenorhabditis elegans Guanylyl CYclase family member (gcy-3) (gcy-3) mRNA, complete cds. 11/11 None
SNAP00000017799 ENSEMBL cdna:SNAP chromosome:CEL140:II:9502668:9509985:-1 11/11 None
R134.1 ENSEMBL cdna:known chromosome:CEL140:II:9502668:9507192:-1 gene:R134.1 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
GENEFINDER00000017801 8/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:9502664-9507189(-) 100.0 100.0
Public Domain and Genome References
Gene Title guanylate cyclase
Gene Symbol gcy-3
Ensembl R134.1
Entrez Gene 191641 Entrez gene
SwissProt Q10028 EMBL-EBI
WormBase CE01636 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4383 guanylate cyclase activity inferred from electronic annotation QuickGO AmiGO
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA88052 Hypothetical protein R134.1 [Caenorhabditis elegans] ref|NP_496037.1| Guanylyl CYclase family member (gcy-3) [Caenorhabditis elegans] 0.0
blast CAA88089 Hypothetical protein AH6.1 [Caenorhabditis elegans] emb|CAA88054.1| Hypothetical protein AH6.1 [Caenorhabditis elegans] ref|NP_496039.1| Guanylyl CYclase family member (gcy-1) [Caenorhabditis elegans] sp|Q09435|GCY1_CAEEL Guanylate cyclase receptor-type gcy-1 precursor 0.0
blast CAA88053 Hypothetical protein R134.2 [Caenorhabditis elegans] ref|NP_496038.1| Guanylyl CYclase family member (gcy-2) [Caenorhabditis elegans] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 3.6E-11
Pfam IPR000719 EMBL-EBI Protein kinase 8.0E-18
Pfam IPR001054 EMBL-EBI Guanylate cyclase 3.9E-98
Pfam IPR001054 EMBL-EBI Guanylate cyclase 1.9E-96
Pfam IPR001828 EMBL-EBI Extracellular ligand-binding receptor 2.3E-69
Pfam IPR000719 EMBL-EBI Protein kinase 8.0E-18
Pfam IPR001054 EMBL-EBI Guanylate cyclase 1.9E-96
Pfam IPR001828 EMBL-EBI Extracellular ligand-binding receptor 2.3E-69
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_496037.1 1 498-520
R134.1 1 498-520
SNAP00000017799 2 71-93,1107-1129
Sequence
Target Sequence 
>C. ELEGANS:191326_AT
tgtgtatcagggcttccgacaagaaatggtttcaatcatataaaacaaattgtcgatatg
tcactcaagtttatggattattgcaagaacttcaaaataccccatttaccaagagagcgt
gttgaactacgaattggggtgaacagtggaccctgtgttgccggagttgtcggtttatca
atgcctcgttattgcctttttggagatactgtgaatactgcatcaagaatggagagtaat
ggaaaaccatcacttattcatttaaccagtgatgctcatttgcttcttatgaagcatttt
ccacaccaatacgaaacaaactcgcgaggagaagtaattataaaggggaaaggagtcatg
gaaacgttctgggtactcggaagatctggtgatattgaaccaagcatcagtaacagatct
actcctcctgttacacaagaaaggtttacagttcgtgctccagatactccagaagcaaga
tccgtaagctcacatggttcacggccttcaagtaatcataataacaacaatgaccctctc
tacagg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TGTGTATCAGGGCTTCCGACAAGAA 466 555 2860 Antisense
AATACCCCATTTACCAAGAGAGCGT 577 149 2955 Antisense
TTAACCAGTGATGCTCATTTGCTTC 675 683 3121 Antisense
TGAAGCATTTTCCACACCAATACGA 347 573 3149 Antisense
GAAACGTTCTGGGTACTCGGAAGAT 179 347 3220 Antisense
GCATCAGTAACAGATCTACTCCTCC 17 309 3263 Antisense
TCTACTCCTCCTGTTACACAAGAAA 240 615 3277 Antisense
AAAGGTTTACAGTTCGTGCTCCAGA 523 119 3299 Antisense
AGATCCGTAAGCTCACATGGTTCAC 456 65 3337 Antisense
CATGGTTCACGGCCTTCAAGTAATC 76 201 3352 Antisense
TAACAACAATGACCCTCTCTACAGG 679 637 3381 Antisense
Sequence Source Affymetrix Proprietary Database