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[191320_s_at] beta tubulin

Description ZK154.3 /REP_DB=WormBase Gene ID /WP=CE15257 /GEN=mec-7 /TR=SW:P12456 /GB=AAB09092.1 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=beta tubulin
Cluster 6grp_highest_10_10 > 40      6grp_high1_10_10 > 16      4grp_highest_8_8 > 40      4grp_high_8_8 > 43      6grp_highest_nonorm > 11      6grp_total > 15      4grp_total > 52      6grp_highest_sub > De      6grp_cgc > 23      6grp_high1_sub > De      6grp_cgc_sub > De      6grp_total_sub > Decrease      6grp_rule_based > S1      4grp_rule_based > L2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 2733
1 2 3 4 range
A 2849.6
(2.2)
P 		3198.9
(3)
P 		1937.1
(0.2)
P 		465.9
(-3)
P 		2733
B 2968.8
(2.5)
P 		3189.7
(3)
P 		1964.3
(0.3)
P 		468.6
(-3)
P 		2721
C 2963.4
(3)
P 		2610.9
(2.1)
P 		1888.2
(0.4)
P 		477.3
(-3)
P 		2486
avr 2927.3
(2.8) 		2999.8
(3) 		1929.9
(0.5) 		470.6
(-3) 		2529

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 2372
1 2 3 4 5 6 range
A 2989.8
(3)
P 		2325.3
(1.3)
P 		1165.2
(-1.7)
P 		942.4
(-2.2)
P 		755.1
(-2.7)
P 		645.9
(-3)
P 		2344
B 2526.4
(3)
P 		2216.2
(2)
P 		1525.7
(-0.1)
P 		1085.5
(-1.5)
P 		756.7
(-2.6)
P 		617.9
(-3)
P 		1909
C 2799.6
(3)
P 		2010.3
(0.8)
P 		1595.9
(-0.4)
P 		959.2
(-2.2)
P 		918.3
(-2.3)
P 		681.2
(-3)
P 		2118
avr 2771.9
(3) 		2183.9
(1.3) 		1428.9
(-0.8) 		995.7
(-2) 		810
(-2.5) 		648.3
(-3) 		2124
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 969
1 2 3 4 range
A 1037.5
(3)
P 		694.4
(0.9)
P 		506.4
(-0.3)
P 		68.2
(-3)
P 		969
B 946.7
(3)
P 		787.8
(1.9)
P 		455.2
(-0.5)
P 		99.9
(-3)
P 		847
C 981
(3)
P 		750.6
(1.5)
P 		658.1
(0.8)
P 		80.5
(-3)
P 		901
avr 988.4
(3) 		744.3
(1.4) 		539.9
(0) 		82.9
(-3) 		906

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 881
1 2 3 4 5 6 range
A 551.1
(0.5)
P 		827
(3)
P 		253.8
(-2.1)
P 		239
(-2.3)
P 		227.8
(-2.4)
P 		157.2
(-3)
P 		670
B 879.1
(3)
P 		737.7
(1.7)
P 		370.5
(-1.7)
P 		287.5
(-2.5)
P 		307.4
(-2.3)
P 		230.4
(-3)
P 		649
C 1037.7
(3)
P 		613.4
(-0)
P 		406.2
(-1.5)
P 		192.9
(-3)
P 		297.1
(-2.3)
P 		228
(-2.8)
P 		845
avr 822.6
(3) 		726
(2.1) 		343.5
(-1.7) 		239.8
(-2.7) 		277.4
(-2.3) 		205.2
(-3) 		617
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 191320_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.17227
Sequence Type Exemplar sequence
Representative Public ID ZK154.3 NCBI
Target Description ZK154.3 /REP_DB=WormBase Gene ID /WP=CE15257 /GEN=mec-7 /TR=SW:P12456 /GB=AAB09092.1 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=beta tubulin
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_076912(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_076912 NCBI Caenorhabditis elegans MEChanosensory abnormality family member (mec-7) (mec-7) mRNA, complete cds. 11/11 None
SNAP00000014390 ENSEMBL cdna:SNAP chromosome:CEL140:X:7774910:7776505:-1 11/11 None
GENEFINDER00000014403 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:7774910:7776505:-1 11/11 None
ZK154.3 ENSEMBL cdna:known chromosome:CEL140:X:7774798:7776621:-1 gene:ZK154.3 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:7774908-7776504(-) 100.0 100.0
Public Domain and Genome References
Gene Title beta tubulin
Gene Symbol mec-7
Ensembl ZK154.3
Entrez Gene 181036 Entrez gene
SwissProt P12456 EMBL-EBI
WormBase CE15257 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:266295_AT tubulin beta-7 chain (TUB7) at
CANINE:1585654_AT similar to tubulin, beta cfa
CANINE_2:CFA.14859.1.A1_AT similar to tubulin, beta cfa
DROSOPHILA_2:1624746_AT Tubulin at 85D dm
DROSGENOME1:143393_AT Tubulin at 85D dm
CHICKEN:GGA.1815.1.S1_AT tubulin, beta 2 gga
HG-U95AV2:39332_AT tubulin, beta polypeptide paralog hs
HG-U95AV2:429_F_AT tubulin, beta polypeptide paralog hs
HC-G110:429_F_AT tubulin, beta polypeptide paralog hs
U133_X3P:HS.179661.4.S1_3P_X_AT tubulin, beta polypeptide paralog hs
U133_X3P:HS.179661.4.S1_3P_A_AT tubulin, beta polypeptide paralog hs
U133_X3P:HS.179661.3.S1_3P_X_AT tubulin, beta polypeptide paralog hs
HG-U133A_2:209372_X_AT tubulin, beta polypeptide paralog hs
HG-U133_PLUS_2:209372_X_AT tubulin, beta polypeptide paralog hs
HG-U133A:209372_X_AT tubulin, beta polypeptide paralog hs
HG-U133A_2:214023_X_AT tubulin, beta polypeptide paralog hs
HG-U133_PLUS_2:214023_X_AT tubulin, beta polypeptide paralog hs
HG-U133A:214023_X_AT tubulin, beta polypeptide paralog hs
MOUSE430A_2:1419966_AT RIKEN cDNA 2410129E14 gene mm
MOE430A:1419966_AT RIKEN cDNA 2410129E14 gene mm
MOUSE430_2:1419966_AT RIKEN cDNA 2410129E14 gene mm
MOUSE430A_2:1449682_S_AT RIKEN cDNA 2410129E14 gene mm
MOE430A:1449682_S_AT RIKEN cDNA 2410129E14 gene mm
MOUSE430_2:1449682_S_AT RIKEN cDNA 2410129E14 gene mm
MOUSE430A_2:1449683_X_AT RIKEN cDNA 2410129E14 gene mm
MOE430A:1449683_X_AT RIKEN cDNA 2410129E14 gene mm
MOUSE430_2:1449683_X_AT RIKEN cDNA 2410129E14 gene mm
MU11KSUBB:MSA.26238.0_S_AT RIKEN cDNA 2410129E14 gene mm
MU11KSUBB:MSA.12367.0_AT RIKEN cDNA 2410129E14 gene mm
MOE430A:1427347_S_AT RIKEN cDNA 2410129E14 gene mm
MOUSE430A_2:1427347_S_AT RIKEN cDNA 2410129E14 gene mm
MOUSE430_2:1427347_S_AT RIKEN cDNA 2410129E14 gene mm
MOE430A:1452679_AT RIKEN cDNA 2410129E14 gene mm
MOUSE430A_2:1452679_AT RIKEN cDNA 2410129E14 gene mm
MOUSE430_2:1452679_AT RIKEN cDNA 2410129E14 gene mm
MU19KSUBB:TC33792_AT RIKEN cDNA 2410129E14 gene (2410129E14Rik), mRNA mm
RAE230A:1388131_AT similar to tubulin, beta (predicted) rn
RAT230_2:1388131_AT similar to tubulin, beta (predicted) rn
RG-U34A:X03369_I_AT similar to tubulin, beta (predicted) rn
RG-U34A:X03369_S_AT similar to tubulin, beta (predicted) rn
RG-U34B:RC_AA899219_I_AT similar to tubulin, beta (predicted) rn
RAE230B:1379995_AT Similar to tubulin, beta 2 rn
RAT230_2:1379995_AT Similar to tubulin, beta 2 rn
RG-U34B:RC_AI060086_AT Similar to tubulin, beta 2 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
7018 microtubule-based movement inferred from electronic annotation QuickGO AmiGO
46785 microtubule polymerization inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5874 microtubule inferred from electronic annotation QuickGO AmiGO
45298 tubulin inferred from electronic annotation QuickGO AmiGO
43005 neuron projection inferred from direct assay QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
3924 GTPase activity inferred from electronic annotation QuickGO AmiGO
5198 structural molecule activity inferred from electronic annotation QuickGO AmiGO
5525 GTP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAB09092 Mechanosensory abnormality protein 7 [Caenorhabditis elegans] emb|CAA33320.1| beta-tubulin [Caenorhabditis elegans] ref|NP_509313.1| MEChanosensory abnormality family member (mec-7) [Caenorhabditis elegans] sp|P12456|TBB1_CAEEL Tubulin beta-1 chain (Beta-1 tubulin) 0.0
blast Q17299 Tubulin beta-1 chain (Beta-1 tubulin) emb|CAE70274.1| Hypothetical protein CBG16786 [Caenorhabditis briggsae] gb|AAB01983.1| beta tubulin 0.0
blast P02554 Tubulin beta chain pdb|1SA1|D Chain D, Tubulin-Podophyllotoxin: Stathmin-Like Domain Complex pdb|1SA1|B Chain B, Tubulin-Podophyllotoxin: Stathmin-Like Domain Complex pdb|1SA0|D Chain D, Tubulin-Colchicine: Stathmin-Like Domain Complex pdb|1SA0|B Chain B, Tubulin-Colchicine: Stathmin-Like Domain Complex pdb|1IA0|B Chain B, Kif1a Head-Microtubule Complex Structure In Atp-Form pdb|1JFF|B Chain B, Refined Structure Of Alpha-Beta Tubulin From Zinc-Induced Sheets Stabilized With Taxol pdb|1FFX|D Chain D, Tubulin:stathmin-Like Domain Complex pdb|1FFX|B Chain B, Tubulin:stathmin-Like Domain Complex 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR003008 EMBL-EBI Tubulin/FtsZ, GTPase 2.7E-112
Pfam IPR008280 EMBL-EBI Tubulin/FtsZ, C-terminal 1.6E-81
Sequence
Target Sequence 
>C. ELEGANS:191320_S_AT
gcggatctacgaaagttggcagtgaacatggttccattcccacgtcttcacttcttcatg
ccaggattcgcaccactgactagcagaagcaatcagcagtatcgtgccattactgtccct
gagctgacccaacaatgtttcgacgcaaagaacatgatggctgcatgcgatccaagacat
ggacgttatctcaccgctgctgccattttccgaggaagaatgagcatgaaggaggttgac
gagcagatgctcaacatccagaacaagaactcttcctacttcgtggactggattccaaac
aatgtcaagaccgcagtttgtgacattccaccaagaggattaaagatgtccgcaacattc
atcggaaactccaccgcc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GCGGATCTACGAAAGTTGGCAGTGA 274 293 754 Antisense
GTTGGCAGTGAACATGGTTCCATTC 48 435 768 Antisense
GGATTCGCACCACTGACTAGCAGAA 351 509 817 Antisense
GCAGTATCGTGCCATTACTGTCCCT 667 311 849 Antisense
CCTGAGCTGACCCAACAATGTTTCG 302 267 871 Antisense
GGCTGCATGCGATCCAAGACATGGA 677 539 912 Antisense
AAGACATGGACGTTATCTCACCGCT 464 153 927 Antisense
ACAAGAACTCTTCCTACTTCGTGGA 38 113 1016 Antisense
CTTCCTACTTCGTGGACTGGATTCC 283 1 1025 Antisense
AAGACCGCAGTTTGTGACATTCCAC 85 155 1060 Antisense
AACATTCATCGGAAACTCCACCGCC 437 137 1107 Antisense
Sequence Source Affymetrix Proprietary Database