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[191297_at] multidrug resistance protein

Description DH11.3 /REP_DB=WormBase Gene ID /WP=CE24868 /TR=Q19015 /GB=CAA88940.2 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=multidrug resistance protein
Cluster 6grp_highest_10_10 > 66      6grp_high1_10_10 > 76      4grp_high_8_8 > 05      6grp_highest_nonorm > 91      6grp_total > 66      4grp_total > 03      6grp_highest_sub > Da      6grp_cgc > 47      6grp_high1_sub > Da      4grp_rule_based > L4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 626
1 2 3 4 range
A 164.6
(-1.7)
P 		98
(-2.5)
P 		52.7
(-3)
A 		579.4
(3)
P 		527
B 145.6
(-2.1)
P 		67.5
(-2.9)
P 		53.9
(-3)
P 		678.8
(3)
P 		625
C 161.3
(-2)
P 		72.5
(-3)
P 		85.6
(-2.8)
P 		580.1
(3)
P 		508
avr 157.2
(-2) 		79.3
(-2.8) 		64.1
(-3) 		612.8
(3) 		549

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 248
1 2 3 4 5 6 range
A 135.6
(-2.7)
P 		179.9
(-1.3)
P 		219.8
(-0)
P 		165.7
(-1.8)
P 		126.9
(-3)
P 		314.9
(3)
P 		188
B 109.8
(-2.4)
P 		177
(-0.6)
P 		85.7
(-3)
P 		142
(-1.5)
P 		103.9
(-2.5)
P 		317.1
(3)
P 		231
C 158.8
(-2)
P 		184.6
(-1.3)
P 		194.9
(-1)
P 		123.7
(-3)
P 		123.6
(-3)
P 		333.6
(3)
P 		210
avr 134.7
(-2.5) 		180.5
(-1.2) 		166.8
(-1.6) 		143.8
(-2.2) 		118.1
(-3) 		321.9
(3) 		204
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 132
1 2 3 4 range
A 59.9
(0.9)
P 		21.3
(-2.4)
P 		13.8
(-3)
A 		84.8
(3)
P 		71
B 46.4
(-1.5)
P 		16.7
(-2.8)
P 		12.5
(-3)
P 		144.7
(3)
P 		132
C 53.4
(-0.5)
P 		20.8
(-3)
P 		29.8
(-2.3)
P 		97.8
(3)
P 		77
avr 53.2
(-0.7) 		19.6
(-2.9) 		18.7
(-3) 		109.1
(3) 		90

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 97
1 2 3 4 5 6 range
A 25
(-3)
P 		64
(1.5)
P 		47.9
(-0.3)
P 		42
(-1)
P 		38.3
(-1.5)
P 		76.7
(3)
P 		52
B 38.2
(-1.9)
P 		58.9
(-0.7)
P 		20.8
(-3)
P 		37.6
(-2)
P 		42.2
(-1.7)
P 		118.2
(3)
P 		97
C 58.9
(-0.6)
P 		56.3
(-0.8)
P 		49.6
(-1.3)
P 		24.9
(-3)
P 		40
(-2)
P 		111.7
(3)
P 		87
avr 40.7
(-2.5) 		59.7
(-0.8) 		39.4
(-2.6) 		34.8
(-3) 		40.2
(-2.5) 		102.2
(3) 		67
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 191297_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.3494
Sequence Type Exemplar sequence
Representative Public ID DH11.3 NCBI
Target Description DH11.3 /REP_DB=WormBase Gene ID /WP=CE24868 /TR=Q19015 /GB=CAA88940.2 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=multidrug resistance protein
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_063273(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_063273 NCBI Caenorhabditis elegans P-GlycoProtein related family member (pgp-11) (pgp-11) mRNA, complete cds. 11/11 None
SNAP00000004560 ENSEMBL cdna:SNAP chromosome:CEL140:II:7995627:8000312:-1 11/11 None
GENEFINDER00000004565 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:7995627:8000473:-1 11/11 None
DH11.3 ENSEMBL cdna:known chromosome:CEL140:II:7995509:8003074:-1 gene:DH11.3 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:7995623-8003071(-) 100.0 100.0
Public Domain and Genome References
Gene Title multidrug resistance protein
Gene Symbol pgp-11
Ensembl DH11.3
Entrez Gene 183971 Entrez gene
SwissProt Q19015 EMBL-EBI
WormBase CE34788 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6810 transport inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
16021 integral to membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
166 nucleotide binding inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA88940 Hypothetical protein DH11.3 [Caenorhabditis elegans] ref|NP_495674.2| P-GlycoProtein related family member (pgp-11) [Caenorhabditis elegans] 0.0
blast CAE67781 Hypothetical protein CBG13356 [Caenorhabditis briggsae] 0.0
blast AAD49436 P-glycoprotein [Onchocerca volvulus] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 1.4E-29
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 2.3E-9
Pfam IPR003439 EMBL-EBI ABC transporter 2.6E-62
Pfam IPR003439 EMBL-EBI ABC transporter 4.1E-67
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 1.9E-29
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 2.3E-9
Pfam IPR003439 EMBL-EBI ABC transporter 2.6E-62
Pfam IPR003439 EMBL-EBI ABC transporter 4.1E-67
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 1.9E-29
Pfam IPR001140 EMBL-EBI ABC transporter, transmembrane region 2.3E-9
Pfam IPR003439 EMBL-EBI ABC transporter 2.6E-62
Pfam IPR003439 EMBL-EBI ABC transporter 4.1E-67
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_495674.2 9 73-95,115-137,301-323,338-357,711-733,753-775,832-854,858-877,945-967
DH11.3 9 73-95,115-137,301-323,338-357,711-733,753-775,832-854,858-877,945-967
SNAP00000004560 9 38-60,75-97,261-283,298-317,671-693,713-735,792-814,818-837,905-927
GENEFINDER00000004565 9 29-51,71-93,257-279,294-313,667-689,709-731,788-810,814-833,901-923
Sequence
Target Sequence 
>C. ELEGANS:191297_AT
attagttggagcttctggatgcggaaagagcacaattatttcaatgcttgaaagattcta
tagtgccaaagctggaagaattagtgtcgatgacaacgatattgacggaattgatgtgaa
tcatcttcgaaataatatttctgttgttggacaagaacctgtactcttcaatgcaacaat
tcgagaaaatatcacaattggaatagatgaagtatcagttgaagaggttcaaaaagcatg
taaagctgcaaatgctgctggttttattgaaagtttcccattgggttacgatacaatagt
tggtgaaggaggagcttctttatctggtggacaaaaacaacgaatagccattgctagagc
aattattcgaaaaccaaaaatattacttttggacgaagcaacaagtgctcttgatactca
atcagaagaaattgtacaaaaagcacttcgatcggcaacaactggaagaacaagtataat
agtagcacatcgactgagtactgttcaacactgtgatacaatctattatatatctcgagg
agcggttgcagaatatggtacacatgctgaactagtggcaa

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
ATTAGTTGGAGCTTCTGGATGCGGA 429 11 3105 Antisense
AAAGATTCTATAGTGCCAAAGCTGG 332 111 3155 Antisense
GAACCTGTACTCTTCAATGCAACAA 211 347 3259 Antisense
GTTTCCCATTGGGTTACGATACAAT 705 449 3377 Antisense
AGGAGGAGCTTCTTTATCTGGTGGA 438 55 3411 Antisense
GCAACAAGTGCTCTTGATACTCAAT 67 319 3502 Antisense
AAAGCACTTCGATCGGCAACAACTG 685 123 3544 Antisense
GTAGCACATCGACTGAGTACTGTTC 185 457 3586 Antisense
GAGTACTGTTCAACACTGTGATACA 500 399 3600 Antisense
ATATCTCGAGGAGCGGTTGCAGAAT 638 19 3634 Antisense
GGTACACATGCTGAACTAGTGGCAA 223 505 3661 Antisense
Sequence Source Affymetrix Proprietary Database