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[191262_at] channel protein

Description F16B3.1 /REP_DB=WormBase Gene ID /WP=CE24905 /GEN=egl-2 /TR=O44164 /GB=AAB88348.2 /SUBMIT=ST.LOUIS /CHR=5 /FEA=Sanger Annotation /DEF=channel protein
Cluster 6grp_total > 04      4grp_total > 30      6grp_cgc > 51      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 104
1 2 3 4 range
A 163.4
(3)
A 		62
(-3)
A 		73.7
(-2.3)
A 		74.2
(-2.3)
A 		101
B 119.2
(1.4)
A 		88.6
(-1.5)
A 		72.9
(-3)
A 		136.4
(3)
A 		64
C 79.6
(-0.4)
A 		105.7
(3)
A 		59.3
(-3)
A 		80.5
(-0.3)
A 		46
avr 120.7
(3) 		85.4
(-1.1) 		68.6
(-3) 		97
(0.3) 		52

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 74
1 2 3 4 5 6 range
A 34.4
(-1.2)
A 		78.7
(3)
A 		17.8
(-2.8)
A 		34.3
(-1.2)
A 		51
(0.4)
A 		15.3
(-3)
A 		63
B 89.7
(3)
A 		49.2
(-2.6)
A 		50.3
(-2.5)
A 		51.4
(-2.3)
A 		65.1
(-0.4)
A 		46.6
(-3)
A 		43
C 58
(-0)
A 		53.6
(-0.7)
A 		79.4
(3)
A 		75.5
(2.4)
A 		45.2
(-1.9)
A 		37.3
(-3)
A 		42
avr 60.7
(3) 		60.5
(3) 		49.2
(0.5) 		53.7
(1.5) 		53.8
(1.5) 		33.1
(-3) 		28
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 49
1 2 3 4 range
A 59.5
(3)
A 		13.5
(-2.7)
A 		19.3
(-2)
A 		10.9
(-3)
A 		49
B 38
(3)
A 		21.9
(-1.6)
A 		16.9
(-3)
A 		29.1
(0.5)
A 		21
C 26.3
(1.5)
A 		30.4
(3)
A 		20.7
(-0.5)
A 		13.6
(-3)
A 		17
avr 41.3
(3) 		21.9
(-2) 		19
(-2.7) 		17.9
(-3) 		23

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 28
1 2 3 4 5 6 range
A 6.3
(-2.4)
A 		28
(3)
A 		3.9
(-3)
A 		8.7
(-1.8)
A 		15.4
(-0.1)
A 		3.7
(-3)
A 		24
B 31.2
(3)
A 		16.4
(-1.7)
A 		12.2
(-3)
A 		13.6
(-2.6)
A 		26.4
(1.5)
A 		17.4
(-1.4)
A 		19
C 21.5
(3)
A 		16.3
(-0.5)
A 		20.2
(2.1)
A 		15.2
(-1.2)
A 		14.6
(-1.6)
A 		12.5
(-3)
A 		9
avr 19.7
(2.7) 		20.2
(3) 		12.1
(-2.4) 		12.5
(-2.1) 		18.8
(2.1) 		11.2
(-3) 		9
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 191262_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.14859
Sequence Type Exemplar sequence
Representative Public ID F16B3.1 NCBI
Target Description F16B3.1 /REP_DB=WormBase Gene ID /WP=CE24905 /GEN=egl-2 /TR=O44164 /GB=AAB88348.2 /SUBMIT=ST.LOUIS /CHR=5 /FEA=Sanger Annotation /DEF=channel protein
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_071001(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_071001 NCBI Caenorhabditis elegans EGg Laying defective family member (egl-2) (egl-2) mRNA, complete cds. 11/11 None
SNAP00000041054 ENSEMBL cdna:SNAP chromosome:CEL140:V:1289525:1293085:-1 11/11 None
F16B3.1 ENSEMBL cdna:known chromosome:CEL140:V:1289202:1299161:-1 gene:F16B3.1 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
GENEFINDER00000041059 7/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:1289524-1299037(-) 100.0 100.0
Public Domain and Genome References
Gene Title channel protein
Gene Symbol egl-2
Ensembl F16B3.1
Entrez Gene 178624 Entrez gene
SwissProt O44164 EMBL-EBI
WormBase CE24905 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.18757.1.S1_AT similar to Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (hEAG1) (h-eag) cfa
CANINE_2:CFAAFFX.18772.1.S1_S_AT similar to Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (hEAG1) (h-eag) cfa
CANINE_2:CFAAFFX.18780.1.S1_S_AT similar to Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (hEAG1) (h-eag) cfa
DROSOPHILA_2:1635822_AT ether a go-go dm
DROSGENOME1:143138_AT ether a go-go dm
CHICKEN:GGAAFFX.6192.1.S1_AT similar to Potassium voltage-gated channel subfamily H member 1 (Voltage-gated potassium channel subunit Kv10.1) (Ether-a-go-go potassium channel 1) (hEAG1) (h-eag) gga
HG-U95AV2:33087_S_AT potassium voltage-gated channel, subfamily H (eag-related), member 1 hs
HG-U133_PLUS_2:207635_S_AT potassium voltage-gated channel, subfamily H (eag-related), member 1 hs
HG-U133A:207635_S_AT potassium voltage-gated channel, subfamily H (eag-related), member 1 hs
HG-FOCUS:207635_S_AT potassium voltage-gated channel, subfamily H (eag-related), member 1 hs
HG-U133A_2:207635_S_AT potassium voltage-gated channel, subfamily H (eag-related), member 1 hs
U133_X3P:G4504830_3P_A_AT potassium voltage-gated channel, subfamily H (eag-related), member 1 hs
HG-U95AV2:33088_AT potassium voltage-gated channel, subfamily H (eag-related), member 1 hs
HG-U95C:60717_AT Potassium voltage-gated channel, subfamily H (eag-related), member 1 hs
MU11KSUBA:U04294_S_AT potassium voltage-gated channel, subfamily H (eag-related), member 1 mm
MG-U74AV2:98380_AT potassium voltage-gated channel, subfamily H (eag-related), member 1 mm
MOE430A:1418414_AT potassium voltage-gated channel, subfamily H (eag-related), member 1 mm
MOUSE430A_2:1418414_AT potassium voltage-gated channel, subfamily H (eag-related), member 1 mm
MOUSE430_2:1418414_AT potassium voltage-gated channel, subfamily H (eag-related), member 1 mm
MG-U74CV2:138138_AT Potassium voltage-gated channel, subfamily H (eag-related), member 1 (Kcnh1), mRNA mm
MOE430B:1435994_AT Potassium voltage-gated channel, subfamily H (eag-related), member 1 (Kcnh1), mRNA mm
MOUSE430_2:1435994_AT Potassium voltage-gated channel, subfamily H (eag-related), member 1 (Kcnh1), mRNA mm
MOE430B:1446763_AT Potassium voltage-gated channel, subfamily H (eag-related), member 1 (Kcnh1), mRNA mm
MOUSE430_2:1446763_AT Potassium voltage-gated channel, subfamily H (eag-related), member 1 (Kcnh1), mRNA mm
RN-U34:Z34264_AT potassium voltage-gated channel, subfamily H (eag-related), member 1 rn
RG-U34A:Z34264_AT potassium voltage-gated channel, subfamily H (eag-related), member 1 rn
RAE230A:1368061_AT potassium voltage-gated channel, subfamily H (eag-related), member 1 rn
RAT230_2:1368061_AT potassium voltage-gated channel, subfamily H (eag-related), member 1 rn
RAE230B:1380734_AT Potassium voltage-gated channel, subfamily H (eag-related), member 1 rn
RAT230_2:1380734_AT Potassium voltage-gated channel, subfamily H (eag-related), member 1 rn
RAE230B:1391103_AT Potassium voltage-gated channel, subfamily H (eag-related), member 1 rn
RAT230_2:1391103_AT Potassium voltage-gated channel, subfamily H (eag-related), member 1 rn
RAE230B:1396147_AT Potassium voltage-gated channel, subfamily H (eag-related), member 1 rn
RAT230_2:1396147_AT Potassium voltage-gated channel, subfamily H (eag-related), member 1 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6355 regulation of transcription, DNA-dependent inferred from electronic annotation QuickGO AmiGO
6811 ion transport inferred from electronic annotation QuickGO AmiGO
6813 potassium ion transport inferred from electronic annotation QuickGO AmiGO
6979 response to oxidative stress inferred from electronic annotation QuickGO AmiGO
7165 signal transduction inferred from electronic annotation QuickGO AmiGO
6813 potassium ion transport inferred from sequence similarity QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4601 peroxidase activity inferred from electronic annotation QuickGO AmiGO
4871 signal transducer activity inferred from electronic annotation QuickGO AmiGO
5216 ion channel activity inferred from electronic annotation QuickGO AmiGO
5249 voltage-gated potassium channel activity inferred from electronic annotation QuickGO AmiGO
5267 potassium channel activity inferred from sequence similarity QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAB88348 Egg laying defective protein 2 [Caenorhabditis elegans] ref|NP_503402.3| EGg Laying defective family member (egl-2) [Caenorhabditis elegans] 0.0
blast AAD28468 EAG K+ channel EGL-2 [Caenorhabditis elegans] 0.0
blast CAE62526 Hypothetical protein CBG06635 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR005821 EMBL-EBI Ion transport protein 2.6E-25
Pfam IPR001610 EMBL-EBI PAC motif 4.8E-8
Pfam IPR000595 EMBL-EBI Cyclic nucleotide-binding domain 2.7E-22
Pfam IPR000595 EMBL-EBI Cyclic nucleotide-binding domain 2.7E-22
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_503402.3 4 218-240,365-387,435-457,464-486
F16B3.1 4 218-240,365-387,435-457,464-486
SNAP00000041054 2 41-63,70-92
Sequence
Target Sequence 
>C. ELEGANS:191262_AT
atctccaggatatcatcgctacactcgatgattgacgagaccggtggtggtggatcctcg
tacgtcaagtcgcctaggagtaaaccgaagagacctccgttaatgaaacgccaaacagtc
gacgaggacgcactatcccgtacaagttggggaatggataagaaagatcgtgaatggagt
tcactttccaatatcaaaactgagatgaagagcaagtttgacataattggagagcgtctc
acgatcatcgaacaaatcaatagtcgattggcgcttctcgagagagttctgattggaaac
aacggcggagcaaacacgccgtcaacgatgccagttggctcattttctgcgttgaatgag
tctggaaatcggctaacacttgacgcggcgcctgtcgcaaggagcgtctcgtggagtgag
caacatcaaccacattggcagagaacatccactgttccaccacttcgcgagcttgaagcc
ggcgagtgggagcctccaattcgagaaccaaccccgaatccttcaacgtcttcgtctaga
gtccct

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
ATCTCCAGGATATCATCGCTACACT 217 33 2281 Antisense
TCCTCGTACGTCAAGTCGCCTAGGA 71 591 2335 Antisense
GACGCACTATCCCGTACAAGTTGGG 490 379 2407 Antisense
TGGAGAGCGTCTCACGATCATCGAA 586 549 2508 Antisense
ACGCCGTCAACGATGCCAGTTGGCT 127 91 2596 Antisense
GAAATCGGCTAACACTTGACGCGGC 207 363 2645 Antisense
CCTGTCGCAAGGAGCGTCTCGTGGA 647 265 2671 Antisense
TTCCACCACTTCGCGAGCTTGAAGC 21 699 2735 Antisense
TTGAAGCCGGCGAGTGGGAGCCTCC 112 701 2753 Antisense
GGAGCCTCCAATTCGAGAACCAACC 97 523 2769 Antisense
TTCAACGTCTTCGTCTAGAGTCCCT 158 685 2802 Antisense
Sequence Source Affymetrix Proprietary Database