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[191257_at] guanylate cyclase

Description R134.2 /REP_DB=WormBase Gene ID /WP=CE25080 /GEN=gcy-2 /TR=Q10029 /GB=CAA88053.2 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=guanylate cyclase
Cluster 6grp_total > 90      4grp_total > 41      6grp_cgc > 86      6grp_cgc_sub > 04      6grp_rule_based > S4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 44
1 2 3 4 range
A 40.1
(1.7)
A 		25.3
(-1.1)
A 		47.3
(3)
A 		14.8
(-3)
A 		33
B 11.2
(-3)
A 		28.9
(0.8)
A 		38.8
(3)
A 		14.4
(-2.3)
A 		28
C 4.8
(-2.8)
A 		30
(0.7)
A 		3.6
(-3)
A 		46.3
(3)
A 		43
avr 18.7
(-3) 		28.1
(2) 		29.9
(3) 		25.2
(0.5) 		11

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 48
1 2 3 4 5 6 range
A 7.9
(-2.2)
A 		1.7
(-3)
A 		27.9
(0.2)
A 		50.1
(3)
A 		32.4
(0.8)
A 		26.1
(0)
A 		48
B 30
(0.2)
A 		24.2
(-0.7)
A 		8.9
(-3)
A 		48.5
(3)
A 		34.7
(0.9)
A 		32.8
(0.6)
A 		40
C 17.8
(-1.3)
A 		35.7
(2.4)
A 		9.6
(-3)
A 		38.4
(3)
A 		37.9
(2.9)
A 		23.8
(-0)
A 		29
avr 18.6
(-2.4) 		20.5
(-2) 		15.5
(-3) 		45.7
(3) 		35
(0.9) 		27.6
(-0.6) 		30
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 13
1 2 3 4 range
A 14.6
(3)
A 		5.5
(-1.4)
A 		12.4
(1.9)
A 		2.2
(-3)
A 		12
B 3.6
(-2.5)
A 		7.1
(1.1)
A 		9
(3)
A 		3.1
(-3)
A 		6
C 1.6
(-2.7)
A 		8.6
(3)
A 		1.2
(-3)
A 		7.8
(2.4)
A 		7
avr 6.6
(1.3) 		7.1
(2.2) 		7.5
(3) 		4.4
(-3) 		3

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 14
1 2 3 4 5 6 range
A 1.5
(-2.6)
A 		0.6
(-3)
A 		6.1
(-0.3)
A 		12.7
(3)
A 		9.8
(1.6)
A 		6.3
(-0.2)
A 		12
B 10.4
(1.1)
A 		8.1
(-0)
A 		2.2
(-3)
A 		12.8
(2.3)
A 		14.1
(3)
A 		12.2
(2)
A 		12
C 6.6
(-0.5)
A 		10.9
(2.2)
A 		2.4
(-3)
A 		7.7
(0.2)
A 		12.3
(3)
A 		8
(0.4)
A 		10
avr 6.2
(-1.2) 		6.5
(-1) 		3.6
(-3) 		11.1
(2.3) 		12.1
(3) 		8.8
(0.7) 		9
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 191257_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.2611
Sequence Type Exemplar sequence
Representative Public ID R134.2 NCBI
Target Description R134.2 /REP_DB=WormBase Gene ID /WP=CE25080 /GEN=gcy-2 /TR=Q10029 /GB=CAA88053.2 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=guanylate cyclase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_063637(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_063637 NCBI Caenorhabditis elegans Guanylyl CYclase family member (gcy-2) (gcy-2) mRNA, complete cds. 11/11 None
SNAP00000017799 ENSEMBL cdna:SNAP chromosome:CEL140:II:9502668:9509985:-1 11/11 None
GENEFINDER00000017801 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:9502363:9512006:-1 11/11 None
R134.2 ENSEMBL cdna:known chromosome:CEL140:II:9507515:9512006:-1 gene:R134.2 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:9507511-9512003(-) 100.0 100.0
Public Domain and Genome References
Gene Title guanylate cyclase
Gene Symbol gcy-2
Ensembl R134.2
Entrez Gene 191640 Entrez gene
SwissProt Q10029 EMBL-EBI
WormBase CE25080 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4383 guanylate cyclase activity inferred from electronic annotation QuickGO AmiGO
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA88053 Hypothetical protein R134.2 [Caenorhabditis elegans] ref|NP_496038.1| Guanylyl CYclase family member (gcy-2) [Caenorhabditis elegans] 0.0
blast CAA88089 Hypothetical protein AH6.1 [Caenorhabditis elegans] emb|CAA88054.1| Hypothetical protein AH6.1 [Caenorhabditis elegans] ref|NP_496039.1| Guanylyl CYclase family member (gcy-1) [Caenorhabditis elegans] sp|Q09435|GCY1_CAEEL Guanylate cyclase receptor-type gcy-1 precursor 0.0
blast CAA88052 Hypothetical protein R134.1 [Caenorhabditis elegans] ref|NP_496037.1| Guanylyl CYclase family member (gcy-3) [Caenorhabditis elegans] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 3.6E-11
Pfam IPR000719 EMBL-EBI Protein kinase 8.0E-18
Pfam IPR001054 EMBL-EBI Guanylate cyclase 3.9E-98
Pfam IPR001054 EMBL-EBI Guanylate cyclase 1.9E-96
Pfam IPR001828 EMBL-EBI Extracellular ligand-binding receptor 2.3E-69
Pfam IPR000719 EMBL-EBI Protein kinase 1.4E-16
Pfam IPR000719 EMBL-EBI Protein kinase 8.0E-18
Pfam IPR001054 EMBL-EBI Guanylate cyclase 3.9E-98
Pfam IPR001054 EMBL-EBI Guanylate cyclase 1.9E-96
Pfam IPR001828 EMBL-EBI Extracellular ligand-binding receptor 4.1E-56
Pfam IPR001828 EMBL-EBI Extracellular ligand-binding receptor 2.3E-69
Pfam IPR000719 EMBL-EBI Protein kinase 1.4E-16
Pfam IPR001054 EMBL-EBI Guanylate cyclase 3.9E-98
Pfam IPR001828 EMBL-EBI Extracellular ligand-binding receptor 5.6E-65
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_496038.1 1 498-520
R134.2 1 498-520
SNAP00000017799 2 71-93,1107-1129
GENEFINDER00000017801 3 445-467,566-583,1526-1548
Sequence
Target Sequence 
>C. ELEGANS:191257_AT
gtgatgctcatttacttcttctgactcactaccctaaccattacgacacgagttcccgcg
gagaagtaataataaaaggaaaaggagttatggaaacattttgggtgcacggaagaattg
atgatatagctgaaccaactgaactaagaagtatttgtaaaccgtcaacagtagcaaatg
aaagatggattacaccgccagcaccaaaaccagagattcgatcagtgagctctcatggat
cacgtcctccgagtgtgtatgatccactgcaggat

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GTGATGCTCATTTACTTCTTCTGAC 100 485 3053 Antisense
TCATTTACTTCTTCTGACTCACTAC 653 619 3060 Antisense
TACCCTAACCATTACGACACGAGTT 356 647 3082 Antisense
GACACGAGTTCCCGCGGAGAAGTAA 686 363 3097 Antisense
GATGATATAGCTGAACCAACTGAAC 388 409 3172 Antisense
GTATTTGTAAACCGTCAACAGTAGC 657 451 3203 Antisense
GAAAGATGGATTACACCGCCAGCAC 134 361 3232 Antisense
GCCAGCACCAAAACCAGAGATTCGA 368 279 3249 Antisense
GATTCGATCAGTGAGCTCTCATGGA 195 433 3267 Antisense
GATCACGTCCTCCGAGTGTGTATGA 237 421 3290 Antisense
GAGTGTGTATGATCCACTGCAGGAT 420 401 3303 Antisense
Sequence Source Affymetrix Proprietary Database