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[191243_s_at] Aspartyl-tRNA synthetase

Description B0464.1 /REP_DB=WormBase Gene ID /WP=CE00015 /TR=SW:Q03577 /GB=CAA79536.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=Aspartyl-tRNA synthetase
Cluster 6grp_highest_10_10 > 12      6grp_high1_10_10 > 20      4grp_highest_8_8 > 25      4grp_high_8_8 > 60      6grp_highest_nonorm > 47      6grp_total > 50      4grp_total > 60      6grp_cgc > 94      6grp_cgc_sub > 04      6grp_total_sub > Hat      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1867
1 2 3 4 range
A 4817.1
(1.2)
P 		5367.5
(3)
P 		5339.5
(2.9)
P 		3500.2
(-3)
P 		1867
B 5070.9
(2.3)
P 		4415.7
(-0.7)
P 		5221.2
(3)
P 		3918
(-3)
P 		1303
C 4643.6
(1.1)
P 		4821.7
(1.8)
P 		5150.8
(3)
P 		3561.2
(-3)
P 		1590
avr 4843.9
(1.5) 		4868.3
(1.6) 		5237.2
(3) 		3659.8
(-3) 		1577

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1561
1 2 3 4 5 6 range
A 3737.4
(0.7)
P 		3860.9
(1.2)
P 		2831.2
(-3)
P 		4307.3
(3)
P 		2893.4
(-2.7)
P 		3559.6
(-0)
P 		1476
B 3617.5
(1.9)
P 		3374.5
(0.5)
P 		3818.7
(3)
P 		3275.9
(-0)
P 		2746.5
(-3)
P 		2908.3
(-2.1)
P 		1072
C 3887.2
(1.3)
P 		3075.6
(-3)
P 		4209.9
(3)
P 		3936.4
(1.6)
P 		3198.7
(-2.3)
P 		3293.2
(-1.8)
P 		1134
avr 3747.4
(2.4) 		3437
(0.3) 		3619.9
(1.5) 		3839.9
(3) 		2946.2
(-3) 		3253.7
(-0.9) 		894
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 1283
1 2 3 4 range
A 1753.9
(3)
P 		1165.1
(0.2)
P 		1395.9
(1.3)
P 		512.4
(-3)
P 		1242
B 1617.1
(3)
P 		1090.6
(-1)
P 		1209.9
(-0.1)
P 		834.9
(-3)
P 		782
C 1537.2
(1.7)
P 		1386.3
(0.9)
P 		1795.2
(3)
P 		600.5
(-3)
P 		1195
avr 1636.1
(3) 		1214
(0.4) 		1467
(2) 		649.3
(-3) 		987

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 824
1 2 3 4 5 6 range
A 689
(-2.4)
P 		1373.1
(3)
P 		616.6
(-3)
P 		1092.4
(0.8)
P 		873.1
(-1)
P 		866.7
(-1)
P 		757
B 1258.7
(3)
P 		1123.2
(0.9)
P 		927.3
(-2.1)
P 		867.7
(-3)
P 		1115.9
(0.8)
P 		1084.5
(0.3)
P 		391
C 1440.8
(3)
P 		938.4
(-1.6)
P 		1071.5
(-0.4)
P 		791.6
(-3)
P 		1035
(-0.8)
P 		1102.4
(-0.1)
P 		649
avr 1129.5
(2.7) 		1144.9
(3) 		871.8
(-3) 		917.2
(-2) 		1008
(-0) 		1017.9
(0.2) 		273
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 191243_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.7086
Sequence Type Exemplar sequence
Representative Public ID B0464.1 NCBI
Target Description B0464.1 /REP_DB=WormBase Gene ID /WP=CE00015 /TR=SW:Q03577 /GB=CAA79536.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=Aspartyl-tRNA synthetase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_066688(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_066688 NCBI Caenorhabditis elegans aspartyl(D) tRNA Synthetase family member (drs-1) (drs-1) mRNA, complete cds. 11/11 None
SNAP00000014950 ENSEMBL cdna:SNAP chromosome:CEL140:III:9489217:9496927:-1 11/11 None
GENEFINDER00000014952 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:9489217:9491105:-1 11/11 None
B0464.1.1 ENSEMBL cdna:known chromosome:CEL140:III:9489072:9491111:-1 gene:B0464.1 11/11 None
B0464.1.2 ENSEMBL cdna:known chromosome:CEL140:III:9489074:9491132:-1 gene:B0464.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:9489212-9491101(-) 100.0 100.0
Public Domain and Genome References
Gene Title Aspartyl-tRNA synthetase
Gene Symbol drs-1
Ensembl B0464.1
Entrez Gene 176334 Entrez gene
SwissProt Q03577 EMBL-EBI
WormBase CE00015 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:253561_AT aspartyl-tRNA synthetase, putative / aspartate--tRNA ligase, putative at
CANINE_2:CFA.20254.1.S1_AT similar to Aspartyl-tRNA synthetase (Aspartate--tRNA ligase) (AspRS) cfa
CANINE_2:CFAAFFX.8689.1.S1_S_AT similar to Aspartyl-tRNA synthetase (Aspartate--tRNA ligase) (AspRS) cfa
DROSOPHILA_2:1629026_AT Aspartyl-tRNA synthetase dm
DROSGENOME1:153336_AT Aspartyl-tRNA synthetase dm
CHICKEN:GGAAFFX.12482.1.S1_S_AT aspartyl-tRNA synthetase gga
HG-U133A:201624_AT aspartyl-tRNA synthetase hs
HG-U133_PLUS_2:201624_AT aspartyl-tRNA synthetase hs
HG-FOCUS:201624_AT aspartyl-tRNA synthetase hs
HG-U133A_2:201624_AT aspartyl-tRNA synthetase hs
HG-U133_PLUS_2:201623_S_AT aspartyl-tRNA synthetase hs
HG-U133A:201623_S_AT aspartyl-tRNA synthetase hs
HG-U133A_2:201623_S_AT aspartyl-tRNA synthetase hs
HU35KSUBA:J05032_AT aspartyl-tRNA synthetase hs
HUGENEFL:J05032_AT aspartyl-tRNA synthetase hs
U133_X3P:G12653688_3P_A_AT aspartyl-tRNA synthetase hs
HG-U95AV2:32615_AT aspartyl-tRNA synthetase hs
U133_X3P:HS.169905.0.A1_3P_AT Aspartyl-tRNA synthetase hs
HG-U133_PLUS_2:244000_AT Aspartyl-tRNA synthetase hs
HG-U133B:244000_AT Aspartyl-tRNA synthetase hs
HG-U95D:91902_AT Aspartyl-tRNA synthetase hs
HG-U133_PLUS_2:243355_AT Aspartyl-tRNA synthetase hs
HG-U133B:243355_AT Aspartyl-tRNA synthetase hs
HG-U95B:45961_I_AT Aspartyl-tRNA synthetase hs
HG-U95B:45962_R_AT Aspartyl-tRNA synthetase hs
HG-U95C:56476_AT Aspartyl-tRNA synthetase hs
HG-U95D:90447_AT Aspartyl-tRNA synthetase hs
HU35KSUBA:RC_D59347_AT Aspartyl-tRNA synthetase hs
U133_X3P:HS.125453.0.A1_3P_AT Aspartyl-tRNA synthetase hs
MU11KSUBA:AA266759_S_AT aspartyl-tRNA synthetase mm
MU11KSUBB:MSA.22997.0_S_AT aspartyl-tRNA synthetase mm
MG-U74AV2:98940_AT aspartyl-tRNA synthetase mm
MOE430A:1423800_AT aspartyl-tRNA synthetase mm
MOUSE430A_2:1423800_AT aspartyl-tRNA synthetase mm
MOUSE430_2:1423800_AT aspartyl-tRNA synthetase mm
MU19KSUBB:TC27789_S_AT Aspartyl-tRNA synthetase (Dars), mRNA mm
MU19KSUBC:TC38074_AT Aspartyl-tRNA synthetase (Dars), mRNA mm
RG-U34A:U30485MRNA_S_AT aspartyl-tRNA synthetase rn
RG-U34A:RC_AI009682_S_AT aspartyl-tRNA synthetase rn
RAE230A:1398795_AT aspartyl-tRNA synthetase rn
RAT230_2:1398795_AT aspartyl-tRNA synthetase rn
YEAST_2:1776523_AT Cytoplasmic aspartyl-tRNA synthetase, homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6418 tRNA aminoacylation for protein translation inferred from electronic annotation QuickGO AmiGO
6422 aspartyl-tRNA aminoacylation inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5737 cytoplasm inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
3676 nucleic acid binding inferred from electronic annotation QuickGO AmiGO
4812 tRNA ligase activity inferred from electronic annotation QuickGO AmiGO
4815 aspartate-tRNA ligase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA79536 Hypothetical protein B0464.1 [Caenorhabditis elegans] ref|NP_499089.1| aspartyl(D) tRNA Synthetase family member (drs-1) [Caenorhabditis elegans] sp|Q03577|SYD_CAEEL Aspartyl-tRNA synthetase (Aspartate--tRNA ligase) (AspRS) 0.0
blast CAE65201 Hypothetical protein CBG10076 [Caenorhabditis briggsae] 0.0
blast XP_393437 PREDICTED: similar to ENSANGP00000017612 [Apis mellifera] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR004365 EMBL-EBI OB-fold nucleic acid binding domain 5.1E-16
Pfam IPR004364 EMBL-EBI tRNA synthetase, class II (D, K and N) 1.0E-126
Pfam IPR004365 EMBL-EBI OB-fold nucleic acid binding domain 5.1E-16
Pfam IPR004364 EMBL-EBI tRNA synthetase, class II (D, K and N) 1.0E-126
Sequence
Target Sequence 
>C. ELEGANS:191243_S_AT
tggccttcaacttccattatcacgaggttatggaaaccattgcagaagtgctcacccaga
tgttcaaaggtcttcaacaaaactatcaagatgagatcgcagccgttggaaatcaatatc
cagctgagccattccagttctgcgagccaccacttattttaaaatatcctgatgcaatca
ctcttctccgtgagaatggaattgaaatcggagacgaagatgatctgtcgacaccagtgg
agaagttcctcggaaaattggtgaaggagaagtatagcaccgacttctacgtgctcgaca
agttcccactgtctgttcgtccattctacaccatgccagacgctcacgatgaacgttatt
caaacagttacgacatgtttatgcgtggagaagagattctctcaggagctcaacgtattc
acgatgctgatatgcttgtcgaacgtgcgaaacatcaccaagttgatctggctaagattc
agtcttacatcgattccttcaaatacggatgtccaccacacgcaggaggaggcatcggac
ttgagcgagttaccatgctcttcctt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TGGCCTTCAACTTCCATTATCACGA 2 545 980 Antisense
GCAGAAGTGCTCACCCAGATGTTCA 287 313 1021 Antisense
AATATCCAGCTGAGCCATTCCAGTT 535 173 1094 Antisense
ATATCCTGATGCAATCACTCTTCTC 331 21 1143 Antisense
ATAGCACCGACTTCTACGTGCTCGA 532 19 1253 Antisense
CATGCCAGACGCTCACGATGAACGT 311 211 1311 Antisense
CTCTCAGGAGCTCAACGTATTCACG 267 229 1378 Antisense
GATGCTGATATGCTTGTCGAACGTG 327 413 1402 Antisense
ATTCAGTCTTACATCGATTCCTTCA 61 13 1456 Antisense
TGTCCACCACACGCAGGAGGAGGCA 105 557 1489 Antisense
TGAGCGAGTTACCATGCTCTTCCTT 630 569 1521 Antisense
Sequence Source Affymetrix Proprietary Database