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[191235_at] protein kinase

Description F22E5.3 /REP_DB=WormBase Gene ID /WP=CE09555 /GEN=gcy-21 /TR=O16715 /GB=AAB66169.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=protein kinase
Cluster 6grp_total > 37      4grp_total > 32      6grp_cgc > 25      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 54
1 2 3 4 range
A 4.8
(-3)
A 		29.8
(0.6)
A 		34.8
(1.4)
A 		46
(3)
A 		41
B 18.8
(-1.2)
A 		3.1
(-3)
A 		56.9
(3)
A 		30.1
(0)
A 		54
C 5
(-3)
A 		11.7
(-1.1)
A 		12.8
(-0.8)
A 		25.9
(3)
A 		21
avr 9.5
(-3) 		14.9
(-1.7) 		34.8
(3) 		34
(2.8) 		25

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 33
1 2 3 4 5 6 range
A 34.1
(3)
A 		20
(0.3)
A 		5.1
(-2.5)
A 		3
(-2.9)
A 		2.7
(-3)
A 		27.4
(1.7)
A 		31
B 5
(-2.2)
A 		15.1
(0.3)
A 		3.8
(-2.5)
A 		26.2
(3)
A 		2.1
(-3)
A 		1.9
(-3)
A 		24
C 7.2
(-1.8)
A 		31.1
(3)
A 		1.3
(-3)
A 		13.7
(-0.5)
A 		2.1
(-2.8)
A 		12.2
(-0.8)
A 		30
avr 15.4
(1) 		22.1
(3) 		3.4
(-2.7) 		14.3
(0.6) 		2.3
(-3) 		13.8
(0.5) 		20
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 12
1 2 3 4 range
A 1.8
(-3)
A 		6.5
(0.9)
A 		9.1
(3)
A 		6.7
(1)
A 		7
B 6
(-0.5)
A 		0.8
(-3)
A 		13.2
(3)
A 		6.4
(-0.3)
A 		12
C 1.7
(-3)
A 		3.4
(0.6)
A 		4.5
(3)
A 		4.4
(2.8)
A 		3
avr 3.2
(-3) 		3.6
(-2.6) 		8.9
(3) 		5.8
(-0.3) 		6

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 9
1 2 3 4 5 6 range
A 6.3
(2.2)
A 		7.1
(3)
A 		1.1
(-2.7)
A 		0.8
(-3)
A 		0.8
(-3)
A 		6.7
(2.6)
A 		6
B 1.7
(-2)
A 		5
(1.2)
A 		0.9
(-2.8)
A 		6.9
(3)
A 		0.9
(-2.8)
A 		0.7
(-3)
A 		6
C 2.7
(-1.4)
A 		9.5
(3)
A 		0.3
(-3)
A 		2.8
(-1.4)
A 		0.7
(-2.7)
A 		4.1
(-0.5)
A 		9
avr 3.6
(-0.4) 		7.2
(3) 		0.8
(-3) 		3.5
(-0.5) 		0.8
(-3) 		3.8
(-0.2) 		6
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 191235_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.4048
Sequence Type Exemplar sequence
Representative Public ID F22E5.3 NCBI
Target Description F22E5.3 /REP_DB=WormBase Gene ID /WP=CE09555 /GEN=gcy-21 /TR=O16715 /GB=AAB66169.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=protein kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_061923(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_061923 NCBI Caenorhabditis elegans Guanylyl CYclase family member (gcy-21) (gcy-21) mRNA, complete cds. 11/11 A 
F22E5.3 ENSEMBL cdna:known chromosome:CEL140:II:2659671:2665023:1 gene:F22E5.3 11/11 A 
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
NM_062067 1/11 Cross Hyb Matching Probes A 
SNAP00000023614 4/11 Cross Hyb Matching Probes None
SNAP00000023615 3/11 Cross Hyb Matching Probes None
GENEFINDER00000023622 4/11 Cross Hyb Matching Probes None
SNAP00000024287 1/11 Cross Hyb Matching Probes None
GENEFINDER00000024303 1/11 Cross Hyb Matching Probes None
ZC239.7 1/11 Cross Hyb Matching Probes A 
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:2659669-2665022(+) 100.0 100.0
chrII:3192004-3197262(-) 94.46 94.46
Public Domain and Genome References
Gene Title protein kinase
Gene Symbol gcy-21
Ensembl F22E5.3
Entrez Gene 191651 Entrez gene
SwissProt O16715 EMBL-EBI
WormBase CE09555 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4383 guanylate cyclase activity inferred from electronic annotation QuickGO AmiGO
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast NP_494324 Guanylyl CYclase family member (gcy-21) [Caenorhabditis elegans] gb|AAB66169.1| Guanylyl cyclase protein 21 [Caenorhabditis elegans] 0.0
blast AAB37946 Guanylyl cyclase protein 15 [Caenorhabditis elegans] ref|NP_494468.1| Guanylyl CYclase family member (gcy-15) [Caenorhabditis elegans] 0.0
blast CAE72387 Hypothetical protein CBG19543 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 6.5E-9
Pfam IPR000719 EMBL-EBI Protein kinase 6.2E-5
Pfam IPR001054 EMBL-EBI Guanylate cyclase 4.3E-85
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_494324.1 1 378-400
F22E5.3 1 378-400
Sequence
Target Sequence 
>C. ELEGANS:191235_AT
tctcttggacttgctttgctgaaagctgttgagagttttaaaattcgtcacttaccaaat
gagaaggttcgactaagaattggtatgaactcgggaccttgtgtagcaggggttgttgga
ttgaagatgccgcgatattgcttgttcggggacacagtgaacacggcaagtcgcatggag
agtaatggaattcctctccgcatcaactgctccggcaccgccaaagaaattctcgaccag
ctcggtggctatgagatcgaagaacgcggaattgtggagatgaagggaaaaggcaaacag
atgacgtattttgtgagaggcgagaattcggatatgagaagagagcggattatcagagaa
cgtgtcaagttcgcaagcttgaagaaggctcagatccaagagaagacttatgaattctca
ttgaataaattgttcattgttaaatcatttctaaaattgttgataagatatttgcaaatg
cgtagacatccaatttctaatcataatgtggtcacagtaaaaacctgtatgaggactatt
ccaccgcaagaagtttacatttccagcacattgccgtatgaagattctga

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TCTCTTGGACTTGCTTTGCTGAAAG 310 611 2743 Antisense
TGAGAGTTTTAAAATTCGTCACTTA 646 565 2772 Antisense
GAAGGTTCGACTAAGAATTGGTATG 187 321 2805 Antisense
GAGTAATGGAATTCCTCTCCGCATC 432 399 2922 Antisense
AATTGTTCATTGTTAAATCATTTCT 44 179 3170 Antisense
GCAAATGCGTAGACATCCAATTTCT 53 319 3216 Antisense
TTCTAATCATAATGTGGTCACAGTA 458 671 3237 Antisense
ACCTGTATGAGGACTATTCCACCGC 230 89 3265 Antisense
GACTATTCCACCGCAAGAAGTTTAC 59 361 3276 Antisense
AAGTTTACATTTCCAGCACATTGCC 402 157 3293 Antisense
GCACATTGCCGTATGAAGATTCTGA 9 317 3308 Antisense
Sequence Source Affymetrix Proprietary Database