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[191184_at] protein kinase

Description B0207.4 /REP_DB=WormBase Gene ID /WP=CE24761 /GEN=air-2 /TR=O01427 /GB=AAB52459.2 /SUBMIT=ST.LOUIS /CHR=1 /FEA=Sanger Annotation /DEF=protein kinase
Cluster 6grp_highest_10_10 > 87      6grp_high1_10_10 > 88      4grp_high_8_8 > 61      6grp_highest_nonorm > 93      6grp_total > 78      4grp_total > 58      6grp_highest_sub > Da      6grp_cgc > 49      6grp_high1_sub > Da      6grp_cgc_sub > Da      6grp_total_sub > Increase      6grp_rule_based > S6      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 175
1 2 3 4 range
A 170.8
(-1.6)
P 		274.2
(3)
P 		240.9
(1.5)
P 		139.3
(-3)
A 		135
B 237.4
(2.3)
P 		248.5
(2.7)
P 		255.8
(3)
P 		101.8
(-3)
P 		154
C 159
(-1.8)
P 		237.4
(1.4)
P 		276.8
(3)
P 		129.8
(-3)
P 		147
avr 189.1
(-0.1) 		253.4
(2.8) 		257.8
(3) 		123.6
(-3) 		134

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 717
1 2 3 4 5 6 range
A 222.5
(-2.4)
P 		192.1
(-2.7)
P 		159.2
(-3)
P 		246
(-2.1)
P 		434.6
(-0.2)
P 		758.4
(3)
P 		599
B 212.5
(-2.3)
P 		200.1
(-2.5)
P 		146.4
(-3)
P 		200
(-2.5)
P 		440
(-0)
P 		739.5
(3)
P 		593
C 225.7
(-2.6)
P 		180.6
(-2.9)
P 		174
(-3)
P 		182.4
(-2.9)
P 		437.8
(-0.7)
P 		863.5
(3)
P 		690
avr 220.2
(-2.4) 		190.9
(-2.7) 		159.9
(-3) 		209.5
(-2.5) 		437.5
(-0.3) 		787.1
(3) 		627
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 76
1 2 3 4 range
A 62.2
(2.9)
P 		59.5
(2.5)
P 		63
(3)
P 		20.4
(-3)
A 		43
B 75.7
(3)
P 		61.4
(1.4)
P 		59.3
(1.2)
P 		21.7
(-3)
P 		54
C 52.6
(-0.5)
P 		68.2
(0.7)
P 		96.5
(3)
P 		21.9
(-3)
P 		75
avr 63.5
(1.9) 		63
(1.8) 		72.9
(3) 		21.3
(-3) 		52

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 254
1 2 3 4 5 6 range
A 41
(-2.7)
P 		68.3
(-1.7)
P 		34.7
(-3)
P 		62.4
(-1.9)
P 		131.2
(0.9)
P 		184.6
(3)
P 		150
B 73.9
(-2)
P 		66.6
(-2.2)
P 		35.5
(-3)
P 		53
(-2.6)
P 		178.8
(0.6)
P 		275.7
(3)
P 		240
C 83.7
(-1.9)
P 		55.1
(-2.6)
P 		44.3
(-2.8)
P 		36.7
(-3)
P 		141.7
(-0.5)
P 		289.1
(3)
P 		252
avr 66.2
(-2.2) 		63.3
(-2.3) 		38.2
(-3) 		50.7
(-2.6) 		150.6
(0.2) 		249.8
(3) 		212
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 191184_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.758
Sequence Type Exemplar sequence
Representative Public ID B0207.4 NCBI
Target Description B0207.4 /REP_DB=WormBase Gene ID /WP=CE24761 /GEN=air-2 /TR=O01427 /GB=AAB52459.2 /SUBMIT=ST.LOUIS /CHR=1 /FEA=Sanger Annotation /DEF=protein kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_059313(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_059313 NCBI Caenorhabditis elegans Aurora/Ipl1 Related kinase family member (air-2) (air-2) mRNA, complete cds. 11/11 None
SNAP00000009169 ENSEMBL cdna:SNAP chromosome:CEL140:I:5945619:5946824:1 11/11 None
GENEFINDER00000009188 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:5945619:5946824:1 11/11 None
B0207.4 ENSEMBL cdna:known chromosome:CEL140:I:5945612:5947170:1 gene:B0207.4 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:5945618-5946824(+) 100.0 100.0
Public Domain and Genome References
Gene Title protein kinase
Gene Symbol air-2
Ensembl B0207.4
Entrez Gene 172268 Entrez gene
SwissProt O01427 EMBL-EBI
WormBase CE24761 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:19794_AT protein kinase, putative at
ATH1-121501:267529_AT protein kinase, putative at
CANINE:1604216_AT similar to Serine/threonine-protein kinase 6 (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase) cfa
CANINE_2:CFA.18463.1.S1_S_AT similar to Serine/threonine-protein kinase 6 (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase) cfa
CANINE_2:CFAAFFX.18502.1.S1_AT similar to Serine/threonine-protein kinase 6 (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase) cfa
DROSOPHILA_2:1627325_AT aurora dm
DROSGENOME1:153893_AT aurora dm
HG-U133_PLUS_2:208080_AT serine/threonine kinase 6 hs
HG-U133A:208080_AT serine/threonine kinase 6 hs
HG-U133A_2:208080_AT serine/threonine kinase 6 hs
HG-U133_PLUS_2:204092_S_AT serine/threonine kinase 6 hs
HG-U133A:204092_S_AT serine/threonine kinase 6 hs
HG-FOCUS:204092_S_AT serine/threonine kinase 6 hs
HG-U133A_2:204092_S_AT serine/threonine kinase 6 hs
HG-U133_PLUS_2:208079_S_AT serine/threonine kinase 6 hs
HG-U133A:208079_S_AT serine/threonine kinase 6 hs
HG-FOCUS:208079_S_AT serine/threonine kinase 6 hs
HG-U133A_2:208079_S_AT serine/threonine kinase 6 hs
HG-U95AV2:34851_AT serine/threonine kinase 6 hs
HU35KSUBA:W78726_AT serine/threonine kinase 6 hs
HU35KSUBC:RC_AA243133_AT serine/threonine kinase 6 hs
U133_X3P:G4507278_3P_AT serine/threonine kinase 6 hs
U133_X3P:G4507274_3P_S_AT serine/threonine kinase 6 hs
HG-U95AV2:34852_G_AT serine/threonine kinase 6 hs
HG-U95D:84436_AT Serine/threonine kinase 6 hs
HU35KSUBB:RC_H47106_AT Serine/threonine kinase 6 hs
MU11KSUBA:U80932_S_AT aurora kinase A mm
MU11KSUBB:MSA.12159.0_S_AT aurora kinase A mm
MG-U74AV2:92639_AT aurora kinase A mm
MOE430A:1424511_AT aurora kinase A mm
MOUSE430A_2:1424511_AT aurora kinase A mm
MOUSE430_2:1424511_AT aurora kinase A mm
MOUSE430_2:1440129_AT Aurora kinase A, mRNA (cDNA clone MGC:11471 IMAGE:3968835) mm
MOE430B:1440129_AT Aurora kinase A, mRNA (cDNA clone MGC:11471 IMAGE:3968835) mm
MU19KSUBC:TC40731_AT Aurora kinase A, mRNA (cDNA clone MGC:11471 IMAGE:3968835) mm
RAE230A:1376039_AT serine/threonine kinase 6 rn
RAT230_2:1376039_AT serine/threonine kinase 6 rn
RAE230A:1374943_AT Serine/threonine kinase 6 rn
RAT230_2:1374943_AT Serine/threonine kinase 6 rn
RG-U34C:RC_AA817849_AT Serine/threonine kinase 6 rn
RG-U34C:RC_AA817849_G_AT Serine/threonine kinase 6 rn
RG-U34C:RC_AI170809_AT Serine/threonine kinase 6 rn
YEAST_2:1779348_AT Aurora kinase involved in regulating kinetochore-microtubule attachments, associates with Sli5p, which stimulates Ipl1p kinase activity and promotes its association with the mitotic spindle, potential Cdc28p substrate Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
793 condensed chromosome inferred from direct assay QuickGO AmiGO
794 condensed nuclear chromosome inferred from direct assay QuickGO AmiGO
5819 spindle inferred from direct assay QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAB52459 Aurora/ipl1 related kinase protein 2 [Caenorhabditis elegans] ref|NP_491714.1| Aurora/Ipl1 Related kinase family member (air-2) [Caenorhabditis elegans] gb|AAC70945.1| aurora/Ipl1-related protein kinase 2 [Caenorhabditis elegans] 1.0E-179
blast CAE60424 Hypothetical protein CBG04030 [Caenorhabditis briggsae] 1.0E-148
blast XP_580561 PREDICTED: similar to Serine/threonine-protein kinase 6 (Serine/threonine kinase 15) (Aurora/IPL1-related kinase 1) (Aurora-related kinase 1) (hARK1) (Aurora-A) (Breast-tumor-amplified kinase) [Bos taurus] 4.0E-97
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 1.0E-65
hanks 2.1.8 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; DdMLCK 1.0E-73
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 3.4E-86
Sequence
Target Sequence 
>C. ELEGANS:191184_AT
tctcgttttggaatatgcccccggaggcgaaatgtacaagcaattgacagtgagcaagag
attctcagagccaacagctgcaaaatatatgtatgagatcgcagatgctttgtcatattg
ccacaggaaaaatgtgattcatcgcgacattaaaccggagaatttgcttatcggatcaca
aggagaattgaaaattggagattttggatggagtgttcatgctccttcgaataagcgcca
aacaatgtgcggaacaatggactatctccctcctgaaatggtgaatggagccgatcacag
tgacgcagttgacttatgggcaatcggcgttctctgctatgagtttctcgttggaaaacc
cccattcgagcacgaagatcagtccaagacatatgcggcaatcaaagcggcacggtttac
ttaccctgattctgtgaagaagggtgcacgagatttgattggaagattgcttgtcgttga
tcccaa

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TCTCGTTTTGGAATATGCCCCCGGA 558 609 324 Antisense
GCCCCCGGAGGCGAAATGTACAAGC 277 281 340 Antisense
GAGATTCTCAGAGCCAACAGCTGCA 527 397 381 Antisense
GCAGATGCTTTGTCATATTGCCACA 228 313 424 Antisense
GTTCATGCTCCTTCGAATAAGCGCC 213 445 538 Antisense
ACTATCTCCCTCCTGAAATGGTGAA 89 103 584 Antisense
GAATGGAGCCGATCACAGTGACGCA 368 333 606 Antisense
ACTTATGGGCAATCGGCGTTCTCTG 518 29 635 Antisense
GGCGTTCTCTGCTATGAGTTTCTCG 707 541 649 Antisense
CACGGTTTACTTACCCTGATTCTGT 566 199 734 Antisense
GAAGATTGCTTGTCGTTGATCCCAA 21 339 785 Antisense
Sequence Source Affymetrix Proprietary Database