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[191178_s_at] serine/threonine kinase

Description C41C4.4 /REP_DB=WormBase Gene ID /WP=CE01519 /TR=SW:Q09499 /GB=CAA88100.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=serine-threonine kinase
Cluster 6grp_highest_10_10 > 75      6grp_high1_10_10 > 49      4grp_highest_8_8 > 53      4grp_high_8_8 > 08      6grp_highest_nonorm > 82      6grp_total > 59      4grp_total > 23      6grp_highest_sub > Cu      6grp_cgc > 39      6grp_high1_sub > Cu      6grp_cgc_sub > Cu      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 199
1 2 3 4 range
A 342.9
(2.4)
P 		163.2
(-3)
P 		203.3
(-1.8)
P 		361.8
(3)
P 		199
B 305.7
(3)
P 		182.7
(-3)
P 		207.2
(-1.8)
P 		274.3
(1.5)
P 		123
C 319.9
(3)
P 		204.6
(-1.4)
P 		164.1
(-3)
P 		182.3
(-2.3)
P 		156
avr 322.8
(3) 		183.5
(-3) 		191.5
(-2.7) 		272.8
(0.8) 		139

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 189
1 2 3 4 5 6 range
A 356.2
(1.5)
P 		274.4
(-1.6)
P 		238
(-3)
P 		374.7
(2.2)
P 		307.5
(-0.3)
P 		394.9
(3)
P 		157
B 386.1
(3)
P 		258.5
(-3)
P 		294.9
(-1.3)
P 		297.2
(-1.2)
P 		333.2
(0.5)
P 		308.8
(-0.6)
P 		128
C 341.7
(-0.9)
P 		294.2
(-3)
P 		296.5
(-2.9)
P 		424
(2.9)
P 		294.1
(-3)
P 		427.2
(3)
P 		133
avr 361.3
(2.1) 		275.7
(-3) 		276.5
(-3) 		365.3
(2.3) 		311.6
(-0.9) 		377
(3) 		101
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 94
1 2 3 4 range
A 124.9
(3)
P 		35.4
(-3)
P 		53.1
(-1.8)
P 		53
(-1.8)
P 		90
B 97.5
(3)
P 		45.1
(-3)
P 		48
(-2.7)
P 		58.4
(-1.5)
P 		52
C 105.9
(3)
P 		58.8
(-0.8)
P 		57.2
(-0.9)
P 		30.7
(-3)
P 		75
avr 109.4
(3) 		46.4
(-3) 		52.8
(-2.4) 		47.4
(-2.9) 		63

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 91
1 2 3 4 5 6 range
A 65.7
(-1.2)
P 		97.6
(3)
P 		51.8
(-3)
P 		95
(2.7)
P 		92.8
(2.4)
P 		96.1
(2.8)
P 		46
B 134.3
(2.9)
P 		86
(-1.6)
P 		71.6
(-3)
P 		78.7
(-2.3)
P 		135.4
(3)
P 		115.1
(1.1)
P 		64
C 126.6
(1.5)
P 		89.8
(-1.7)
P 		75.5
(-3)
P 		85.3
(-2.1)
P 		95.2
(-1.2)
P 		143
(3)
P 		68
avr 108.9
(1.9) 		91.1
(-0.1) 		66.3
(-3) 		86.3
(-0.7) 		107.8
(1.8) 		118.1
(3) 		52
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 191178_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.3626
Sequence Type Exemplar sequence
Representative Public ID C41C4.4 NCBI
Target Description C41C4.4 /REP_DB=WormBase Gene ID /WP=CE01519 /TR=SW:Q09499 /GB=CAA88100.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=serine-threonine kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_063300(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_063300 NCBI Caenorhabditis elegans IRE1 kinase related family member (ire-1) (ire-1) mRNA, complete cds. 11/11 A 
SNAP00000036857 ENSEMBL cdna:SNAP chromosome:CEL140:II:8112591:8115208:-1 11/11 None
GENEFINDER00000036875 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:8112591:8115454:-1 11/11 None
C41C4.4 ENSEMBL cdna:known chromosome:CEL140:II:8112189:8124761:-1 gene:C41C4.4 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:8112587-8124758(-) 100.0 100.0
Public Domain and Genome References
Gene Title serine/threonine kinase
Gene Symbol ire-1
Ensembl C41C4.4
Entrez Gene 174305 Entrez gene
WormBase CE35836 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.18320.1.S1_AT similar to endoplasmic reticulum to nucleus signalling 1 isoform 1 cfa
DROSOPHILA_2:1641293_AT dm
DROSGENOME1:150220_AT dm
CHICKEN:GGA.10887.1.S1_S_AT similar to ER to nucleus signalling 1 gga
CHICKEN:GGAAFFX.25872.1.S1_AT similar to ER to nucleus signalling 1 gga
HG-U133_PLUS_2:207061_AT endoplasmic reticulum to nucleus signalling 1 hs
HG-U133A:207061_AT endoplasmic reticulum to nucleus signalling 1 hs
HG-FOCUS:207061_AT endoplasmic reticulum to nucleus signalling 1 hs
HG-U133A_2:207061_AT endoplasmic reticulum to nucleus signalling 1 hs
HG-U95AV2:31380_AT endoplasmic reticulum to nucleus signalling 1 hs
U133_X3P:G4557568_3P_AT endoplasmic reticulum to nucleus signalling 1 hs
U133_X3P:HS.129166.0.A1_3P_AT endoplasmic reticulum to nucleus signalling 1 hs
HG-U133_PLUS_2:235745_AT endoplasmic reticulum to nucleus signalling 1 hs
HG-U133B:235745_AT endoplasmic reticulum to nucleus signalling 1 hs
HG-U95D:69557_G_AT endoplasmic reticulum to nucleus signalling 1 hs
HG-U95E:76574_AT endoplasmic reticulum to nucleus signalling 1 hs
HG-U133_PLUS_2:239045_AT Endoplasmic reticulum to nucleus signalling 1 hs
HG-U133B:239045_AT Endoplasmic reticulum to nucleus signalling 1 hs
HG-U95B:48236_AT Endoplasmic reticulum to nucleus signalling 1 hs
HG-U95C:60109_AT Endoplasmic reticulum to nucleus signalling 1 hs
HG-U95C:60390_AT Endoplasmic reticulum to nucleus signalling 1 hs
HG-U95D:69555_AT Endoplasmic reticulum to nucleus signalling 1 hs
HG-U95E:87738_AT Endoplasmic reticulum to nucleus signalling 1 hs
HG-U95D:91417_AT Endoplasmic reticulum to nucleus signalling 1 hs
HU35KSUBA:RC_D20835_AT Endoplasmic reticulum to nucleus signalling 1 hs
HU35KSUBD:RC_AA620764_AT Endoplasmic reticulum to nucleus signalling 1 hs
U133_X3P:HS.30778.0.A1_3P_AT Endoplasmic reticulum to nucleus signalling 1 hs
MOUSE430_2:1431886_AT endoplasmic reticulum (ER) to nucleus signalling 1 mm
MOUSE430A_2:1431886_AT endoplasmic reticulum (ER) to nucleus signalling 1 mm
MOE430A:1431886_AT endoplasmic reticulum (ER) to nucleus signalling 1 mm
MOE430A:1450176_AT endoplasmic reticulum (ER) to nucleus signalling 1 mm
MOUSE430_2:1450176_AT endoplasmic reticulum (ER) to nucleus signalling 1 mm
MOUSE430A_2:1450176_AT endoplasmic reticulum (ER) to nucleus signalling 1 mm
MOUSE430_2:1421240_AT endoplasmic reticulum (ER) to nucleus signalling 1 mm
MOUSE430A_2:1421240_AT endoplasmic reticulum (ER) to nucleus signalling 1 mm
MOE430A:1421240_AT endoplasmic reticulum (ER) to nucleus signalling 1 mm
MG-U74BV2:107353_AT endoplasmic reticulum (ER) to nucleus signalling 1 mm
MG-U74BV2:164051_AT Endoplasmic reticulum (ER) to nucleus signalling 1 (Ern1), mRNA mm
MOE430B:1437119_AT Endoplasmic reticulum (ER) to nucleus signalling 1 (Ern1), mRNA mm
MOUSE430_2:1437119_AT Endoplasmic reticulum (ER) to nucleus signalling 1 (Ern1), mRNA mm
MG-U74BV2:104981_AT Endoplasmic reticulum (ER) to nucleus signalling 1 (Ern1), mRNA mm
MOUSE430_2:1438583_AT Endoplasmic reticulum (ER) to nucleus signalling 1 (Ern1), mRNA mm
MOE430B:1438583_AT Endoplasmic reticulum (ER) to nucleus signalling 1 (Ern1), mRNA mm
MOE430B:1438997_AT Endoplasmic reticulum (ER) to nucleus signalling 1 (Ern1), mRNA mm
MOUSE430_2:1438997_AT Endoplasmic reticulum (ER) to nucleus signalling 1 (Ern1), mRNA mm
RAE230A:1377213_AT Similar to protein kinase/endoribonuclease(IRE1) alpha rn
RAT230_2:1377213_AT Similar to protein kinase/endoribonuclease(IRE1) alpha rn
RG-U34A:RC_H33528_AT Similar to protein kinase/endoribonuclease(IRE1) alpha rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6118 electron transport inferred from electronic annotation QuickGO AmiGO
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5634 nucleus inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
3677 DNA binding inferred from electronic annotation QuickGO AmiGO
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA88100 Hypothetical protein C41C4.4 [Caenorhabditis elegans] ref|NP_495701.2| IRE1 kinase related family member (ire-1) [Caenorhabditis elegans] gb|AAL30828.1| Ser/Thr protein kinase [Caenorhabditis elegans] 0.0
blast Q09499 Putative serine/threonine-protein kinase C41C4.4 precursor 0.0
blast CAE67758 Hypothetical protein CBG13333 [Caenorhabditis briggsae] 0.0
Protein Families
Method ID Description E-Value
hanks 2.1.20 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; PhKgT 1.0E-26
hanks 2.1.20 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; PhKgT 7.0E-27
Protein Domains
Database ID Description E-Value
Pfam IPR010513 EMBL-EBI Ribonuclease 2-5A 1.7E-74
Pfam IPR002372 EMBL-EBI Bacterial quinoprotein 6.5E-8
Pfam IPR002372 EMBL-EBI Bacterial quinoprotein 1.4E-7
Pfam IPR000719 EMBL-EBI Protein kinase 6.0E-53
Pfam IPR010513 EMBL-EBI Ribonuclease 2-5A 1.7E-74
Pfam IPR000719 EMBL-EBI Protein kinase 6.0E-53
Pfam IPR010513 EMBL-EBI Ribonuclease 2-5A 1.7E-74
Pfam IPR000719 EMBL-EBI Protein kinase 6.0E-53
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_495701.2 1 5-27
C41C4.4 1 5-27
Sequence
Target Sequence 
>C. ELEGANS:191178_S_AT
ctgaacgtggagccattgcaccgattgaccgctgatgccgtcttgaatcatccatttttc
tggacatctgaaaagcgattagcatatttttcggatgtatctgatcgtgtagagaaagaa
gaagacaatagtccagttgtgagaagaatagaaacagatgctcgaatagttgtatgcggt
ggatggagggagaagatttgtgatgctttgaaggaagatttaagaaagttcagaacatac
aaatcattttcagttcgagatttgctaagagcaatgcgtaacaagaagcatcactataga
gaattaccagaagatgtcagacaatctcttggagacattccagatcagttcttgcattat
tttacatcacgcttccctcggctattacttcatgtttacaaagcaaccgagtattgttcc
ggagaggctgtcttcaaaagatactattccgatgatgttcgtgctcgaatgtatccaatt
gtggaagaagaagagagagtaagaaagaagattaaagaagaaatggcaaatgaggtgtgg
gcacgagcaccaaaacctgtcgagcaacgaactcctctaaa

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CTGAACGTGGAGCCATTGCACCGAT 255 239 2335 Antisense
CATTGCACCGATTGACCGCTGATGC 390 217 2348 Antisense
GCTGATGCCGTCTTGAATCATCCAT 370 295 2365 Antisense
AATCATCCATTTTTCTGGACATCTG 406 171 2380 Antisense
GAGACATTCCAGATCAGTTCTTGCA 438 393 2666 Antisense
GCATTATTTTACATCACGCTTCCCT 391 307 2688 Antisense
TCCCTCGGCTATTACTTCATGTTTA 629 597 2708 Antisense
ATTGTTCCGGAGAGGCTGTCTTCAA 350 3 2747 Antisense
GTTCGTGCTCGAATGTATCCAATTG 618 439 2791 Antisense
GGTGTGGGCACGAGCACCAAAACCT 371 497 2868 Antisense
CTGTCGAGCAACGAACTCCTCTAAA 149 239 2891 Antisense
Sequence Source Affymetrix Proprietary Database