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[191154_at] man(9)-alpha-mannosidase

Description T03G11.4 /REP_DB=WormBase Gene ID /WP=CE04872 /TR=Q22120 /GB=AAA82446.1 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=man(9)-alpha-mannosidase
Cluster 4grp_high_8_8 > 56      6grp_total > 60      4grp_total > 63      6grp_total_sub > Hat      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 178
1 2 3 4 range
A 252.1
(2.6)
P 		210.5
(-2.3)
P 		255.5
(3)
P 		204.6
(-3)
P 		51
B 310.9
(3)
P 		153.4
(-3)
P 		243.3
(0.4)
P 		271.4
(1.5)
P 		158
C 230.7
(-1.7)
P 		230
(-1.8)
A 		331.6
(3)
P 		203.3
(-3)
P 		128
avr 264.6
(2.1) 		198
(-3) 		276.8
(3) 		226.4
(-0.8) 		79

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 356
1 2 3 4 5 6 range
A 243.4
(-2.8)
P 		270
(-2)
P 		318.6
(-0.7)
P 		447.7
(3)
P 		236.5
(-3)
P 		274.6
(-1.9)
M 		211
B 360.9
(0.3)
P 		240.2
(-2.7)
P 		382.9
(0.9)
P 		468.6
(3)
P 		227.1
(-3)
P 		233.9
(-2.8)
A 		242
C 365.2
(0.5)
P 		302.4
(-0.6)
P 		398.6
(1.1)
P 		513.6
(3)
P 		158
(-3)
P 		279.3
(-1)
A 		356
avr 323.2
(-0.4) 		270.9
(-1.6) 		366.7
(0.6) 		476.6
(3) 		207.2
(-3) 		262.6
(-1.8) 		269
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 86
1 2 3 4 range
A 91.8
(3)
P 		45.7
(-1.5)
P 		66.8
(0.6)
P 		30
(-3)
P 		62
B 99.1
(3)
P 		37.9
(-3)
P 		56.4
(-1.2)
P 		57.8
(-1)
P 		61
C 76.4
(0.1)
P 		66.1
(-0.7)
A 		115.6
(3)
P 		34.3
(-3)
P 		81
avr 89.1
(3) 		49.9
(-1.9) 		79.6
(1.8) 		40.7
(-3) 		48

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 90
1 2 3 4 5 6 range
A 44.9
(-3)
P 		96
(1.5)
P 		69.4
(-0.9)
P 		113.6
(3)
P 		71.4
(-0.7)
P 		66.9
(-1.1)
M 		69
B 125.6
(3)
P 		80
(-3)
P 		93
(-1.3)
P 		124.1
(2.8)
P 		92.3
(-1.4)
P 		87.2
(-2.1)
A 		46
C 135.3
(3)
P 		92.3
(-0.1)
P 		101.4
(0.6)
P 		103.3
(0.7)
P 		51.1
(-3)
P 		93.5
(0)
A 		84
avr 101.9
(1.3) 		89.4
(-0.5) 		87.9
(-0.7) 		113.7
(3) 		71.6
(-3) 		82.5
(-1.4) 		42
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 191154_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.16520
Sequence Type Exemplar sequence
Representative Public ID T03G11.4 NCBI
Target Description T03G11.4 /REP_DB=WormBase Gene ID /WP=CE04872 /TR=Q22120 /GB=AAA82446.1 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=man(9)-alpha-mannosidase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_076476(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_076476 NCBI Caenorhabditis elegans T03G11.4 (man(9)-alpha-mannosidase) mRNA, complete cds. 11/11 None
SNAP00000028924 ENSEMBL cdna:SNAP chromosome:CEL140:X:5165378:5168481:1 11/11 None
GENEFINDER00000028939 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:5165378:5168481:1 11/11 None
T03G11.4 ENSEMBL cdna:known chromosome:CEL140:X:5165362:5168735:1 gene:T03G11.4 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:5165378-5168482(+) 99.44 100.0
Public Domain and Genome References
Gene Title man(9)-alpha-mannosidase
Ensembl T03G11.4
Entrez Gene 180787 Entrez gene
SwissProt Q22120 EMBL-EBI
WormBase CE29462 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:260029_AT glycoside hydrolase family 47 protein at
CANINE_2:CFA.21228.1.S1_AT similar to Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (ER alpha-1,2-mannosidase) (Mannosidase alpha class 1B member 1) (Man9GlcNAc2-specific processing alpha-mannosidase) cfa
CANINE_2:CFAAFFX.29828.1.S1_S_AT similar to Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (ER alpha-1,2-mannosidase) (Mannosidase alpha class 1B member 1) (Man9GlcNAc2-specific processing alpha-mannosidase) cfa
CANINE_2:CFAAFFX.29835.1.S1_AT similar to Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (ER alpha-1,2-mannosidase) (Mannosidase alpha class 1B member 1) (Man9GlcNAc2-specific processing alpha-mannosidase) cfa
DROSGENOME1:150805_AT dm
DROSOPHILA_2:1626972_AT dm
CHICKEN:GGA.3217.1.S1_AT similar to Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (ER alpha-1,2-mannosidase) (Mannosidase alpha class 1B member 1) (Man9GlcNAc2-specific processing alpha-mannosidase) (UNQ747/PRO1477) gga
HU35KSUBA:RC_AA446899_AT mannosidase, alpha, class 1B, member 1 hs
HG-U133A:218636_S_AT mannosidase, alpha, class 1B, member 1 hs
HG-U133_PLUS_2:218636_S_AT mannosidase, alpha, class 1B, member 1 hs
HG-U133A_2:218636_S_AT mannosidase, alpha, class 1B, member 1 hs
U133_X3P:G7706436_3P_S_AT mannosidase, alpha, class 1B, member 1 hs
HG-U95C:64339_S_AT mannosidase, alpha, class 1B, member 1 hs
HG-U133A_2:65884_AT mannosidase, alpha, class 1B, member 1 hs
HG-FOCUS:65884_AT mannosidase, alpha, class 1B, member 1 hs
HG-U133_PLUS_2:65884_AT mannosidase, alpha, class 1B, member 1 hs
HG-U133A:65884_AT mannosidase, alpha, class 1B, member 1 hs
HG-U95C:65884_AT mannosidase, alpha, class 1B, member 1 hs
MU11KSUBA:AA711984_S_AT mannosidase, alpha, class 1B, member 1 mm
MG-U74AV2:104677_AT mannosidase, alpha, class 1B, member 1 mm
MOE430A:1452235_AT mannosidase, alpha, class 1B, member 1 mm
MOUSE430A_2:1452235_AT mannosidase, alpha, class 1B, member 1 mm
MOUSE430_2:1452235_AT mannosidase, alpha, class 1B, member 1 mm
MU19KSUBB:TC29849_AT Mannosidase, alpha, class 1B, member 1, mRNA (cDNA clone IMAGE:5320430) mm
MU19KSUBB:TC31491_AT Mannosidase, alpha, class 1B, member 1, mRNA (cDNA clone IMAGE:5320430) mm
RG-U34C:RC_AI229831_AT similar to Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (ER alpha-1,2-mannosidase) (Mannosidase alpha class 1B member 1) (Man9GlcNAc2-specific processing alpha-mannosidase) (UNQ747/PRO1477) rn
RAE230B:1383427_AT similar to Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (ER alpha-1,2-mannosidase) (Mannosidase alpha class 1B member 1) (Man9GlcNAc2-specific processing alpha-mannosidase) (UNQ747/PRO1477) rn
RAT230_2:1383427_AT similar to Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (ER alpha-1,2-mannosidase) (Mannosidase alpha class 1B member 1) (Man9GlcNAc2-specific processing alpha-mannosidase) (UNQ747/PRO1477) rn
RAE230A:1371601_AT Similar to Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (ER alpha-1,2-mannosidase) (Mannosidase alpha class 1B member 1) (Man9GlcNAc2-specific processing alpha-mannosidase) (UNQ747/PRO1477) rn
RAT230_2:1371601_AT Similar to Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (ER alpha-1,2-mannosidase) (Mannosidase alpha class 1B member 1) (Man9GlcNAc2-specific processing alpha-mannosidase) (UNQ747/PRO1477) rn
RG-U34B:RC_AA964880_AT Similar to Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (ER alpha-1,2-mannosidase) (Mannosidase alpha class 1B member 1) (Man9GlcNAc2-specific processing alpha-mannosidase) (UNQ747/PRO1477) rn
RG-U34C:RC_AI071458_AT Similar to Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (ER alpha-1,2-mannosidase) (Mannosidase alpha class 1B member 1) (Man9GlcNAc2-specific processing alpha-mannosidase) (UNQ747/PRO1477) rn
YEAST_2:1775213_AT Alpha-1,2-mannosidase involved in ER quality control; catalyzes the removal of one mannose residue from Man9GlcNAc to produce a single isomer of Man8GlcNAc in N-linked oligosaccharide biosynthesis; integral to ER membrane Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6487 protein amino acid N-linked glycosylation inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity inferred from electronic annotation QuickGO AmiGO
5509 calcium ion binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast NP_508877 T03G11.4 [Caenorhabditis elegans] gb|AAA82446.2| Hypothetical protein T03G11.4 [Caenorhabditis elegans] 0.0
blast CAE68703 Hypothetical protein CBG14624 [Caenorhabditis briggsae] 0.0
blast CAA92567 Hypothetical protein ZC410.3 [Caenorhabditis elegans] ref|NP_501577.1| ZC410.3 [Caenorhabditis elegans] 1.0E-157
Protein Domains
Database ID Description E-Value
Pfam IPR001382 EMBL-EBI Glycoside hydrolase, family 47 1.0E-126
Pfam IPR001382 EMBL-EBI Glycoside hydrolase, family 47 1.0E-126
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_508877.1 1 43-65
T03G11.4 1 43-65
GENEFINDER00000028939 1 43-65
Sequence
Target Sequence 
>C. ELEGANS:191154_AT
gtggtcaaacgtactctcctaaaatggatcaccttgtgtgtttcattgccggtactttat
cgcaaggtagtcaacacggttttccaagaaaacatttggatatggctgaaaaaattggag
agacttgccacaatatgtatgacaatccgactggcctgggaccagaaattgcacatttta
acatgattcccgggaaggaagatttatatgtcaagccacttgatgctcactgtctacttc
gtcccgaagcaattgaagcatggttttacttatacaggttcacaggagacaaaaaatacc
aggaatggggatggtctgcattccaagcaattgaaaaatatgctagaatacccactggcg
gatactcatcaatttcaaatgtgaaacaaattaatgtacggttcagagactcaatggaat
ccttcttgct

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GTGGTCAAACGTACTCTCCTAAAAT 334 489 1064 Antisense
GGATCACCTTGTGTGTTTCATTGCC 204 511 1089 Antisense
GTTTCATTGCCGGTACTTTATCGCA 476 447 1103 Antisense
GCAAGGTAGTCAACACGGTTTTCCA 422 315 1125 Antisense
ATGTATGACAATCCGACTGGCCTGG 633 47 1198 Antisense
GCCTGGGACCAGAAATTGCACATTT 559 281 1217 Antisense
TCAAGCCACTTGATGCTCACTGTCT 559 631 1274 Antisense
ACTGTCTACTTCGTCCCGAAGCAAT 344 97 1292 Antisense
ATGGGGATGGTCTGCATTCCAAGCA 446 49 1368 Antisense
AATACCCACTGGCGGATACTCATCA 111 173 1410 Antisense
GAGACTCAATGGAATCCTTCTTGCT 284 393 1469 Antisense
Sequence Source Affymetrix Proprietary Database