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[191111_at] serine/threonine kinase

Description R03D7.5 /REP_DB=WormBase Gene ID /WP=CE01612 /TR=SW:Q09595 /GB=CAA86858.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=serine-threonine kinase
Cluster 6grp_total > 17      4grp_total > 43      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 39
1 2 3 4 range
A 39.5
(2.8)
A 		40.7
(3)
A 		3.3
(-3)
A 		37.2
(2.4)
A 		37
B 8.9
(-2.7)
A 		42.1
(3)
A 		9.4
(-2.6)
A 		6.9
(-3)
A 		35
C 7.9
(-3)
A 		41.8
(3)
A 		29.1
(0.8)
A 		11.7
(-2.3)
A 		34
avr 18.8
(-1.9) 		41.5
(3) 		13.9
(-3) 		18.6
(-2) 		28

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 39
1 2 3 4 5 6 range
A 12.4
(-0.3)
A 		23.8
(3)
A 		16.2
(0.8)
A 		9.1
(-1.2)
A 		2.9
(-3)
A 		4.2
(-2.6)
A 		21
B 41.6
(3)
A 		4.3
(-2.9)
A 		11.6
(-1.8)
A 		3.8
(-3)
A 		10.6
(-1.9)
A 		23.5
(0.1)
A 		38
C 23.7
(3)
A 		14
(-0.4)
A 		14
(-0.4)
A 		6.5
(-3)
A 		9.1
(-2.1)
A 		9.1
(-2.1)
A 		17
avr 25.9
(3) 		14
(-0.7) 		13.9
(-0.7) 		6.5
(-3) 		7.5
(-2.7) 		12.3
(-1.2) 		19
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 14
1 2 3 4 range
A 14.4
(3)
A 		8.8
(0.5)
A 		0.9
(-3)
A 		5.5
(-1)
A 		14
B 2.9
(-2.1)
A 		10.4
(3)
A 		2.2
(-2.5)
A 		1.5
(-3)
A 		9
C 2.6
(-2.6)
A 		12
(3)
A 		10.1
(1.9)
A 		2
(-3)
A 		10
avr 6.6
(-0.1) 		10.4
(3) 		4.4
(-1.9) 		3
(-3) 		7

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 14
1 2 3 4 5 6 range
A 2.3
(-1.9)
A 		8.5
(3)
A 		3.5
(-0.9)
A 		2.3
(-1.9)
A 		0.9
(-3)
A 		1
(-2.9)
A 		8
B 14.5
(3)
A 		1.4
(-2.8)
A 		2.8
(-2.2)
A 		1
(-3)
A 		4.3
(-1.5)
A 		8.8
(0.5)
A 		14
C 8.8
(3)
A 		4.3
(-0.6)
A 		3.6
(-1.2)
A 		1.3
(-3)
A 		2.9
(-1.7)
A 		3.1
(-1.6)
A 		8
avr 8.5
(3) 		4.7
(-0.3) 		3.3
(-1.5) 		1.5
(-3) 		2.7
(-2) 		4.3
(-0.6) 		7
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 191111_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.3025
Sequence Type Exemplar sequence
Representative Public ID R03D7.5 NCBI
Target Description R03D7.5 /REP_DB=WormBase Gene ID /WP=CE01612 /TR=SW:Q09595 /GB=CAA86858.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=serine-threonine kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Genome Target Overlap based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade B annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_063955
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_063955 NCBI Caenorhabditis elegans R03D7.5 (R03D7.5) mRNA, complete cds. None
R03D7.5 ENSEMBL cdna:known chromosome:CEL140:II:10947521:10949095:1 gene:R03D7.5 None
SNAP00000040570 ENSEMBL cdna:SNAP chromosome:CEL140:II:10947521:10949095:1 None
GENEFINDER00000040574 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:10947684:10949095:1 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:10947545-10949092(+) 100.0 100.0
Public Domain and Genome References
Gene Title serine/threonine kinase
Ensembl R03D7.5
Entrez Gene 187536 Entrez gene
WormBase CE35899 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA86858 Hypothetical protein R03D7.5 [Caenorhabditis elegans] ref|NP_496356.2| R03D7.5 [Caenorhabditis elegans] 0.0
blast Q09595 Putative serine/threonine-protein kinase R03D7.5 0.0
blast Q09595 Putative serine/threonine-protein kinase R03D7.5 1.0E-179
blast CAE73227 Hypothetical protein CBG20633 [Caenorhabditis briggsae] 1.0E-155
blast CAA86858 Hypothetical protein R03D7.5 [Caenorhabditis elegans] ref|NP_496356.2| R03D7.5 [Caenorhabditis elegans] 1.0E-151
blast Q09595 Putative serine/threonine-protein kinase R03D7.5 1.0E-145
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 1.0E-54
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 3.0E-61
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 1.0E-21
hanks 3.1.7 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; PCTAIRE1 1.0E-25
hanks 3.1.1 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; CDC2Hs 4.0E-53
hanks 3.1.1 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; CDC2Hs 7.0E-57
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 5.8E-48
Pfam IPR000719 EMBL-EBI Protein kinase 3.9E-42
Pfam IPR000719 EMBL-EBI Protein kinase 1.3E-46
Sequence
Target Sequence 
>C. ELEGANS:191111_AT
aaaattcaccgcgtctatcgatatttggtcagcaacttgtgtggcgtttgaacttttcgc
taatcgagttctttttaaaggaaaggacactaaagatcagattgtgttgataactggagt
tttcggatatcctacagacgatgatattaaaagcattggagtaaaaaggcctagagttgc
aagaaaagatgcgagaggaatagaaacggtaaaaattaaagaaaaaaccaataaaactaa
aaaagaagcgaaacaaagcacacttgtccacgagaagtacacacgcgcgcgcgcaatgtc
gcgctccactgaaaacaaattggcgccattcaccagcaagatgctcgactcggaaatcta
cgatttcatgaaagcaacactgaaaatcgatccgaaaaagagaaaatccgcgattgacgt
gctgaaaatgccccttttcgatattctacgatcgagtccaccgaagaagcgatcaaacgg
agttgagatgccaaatctcgcgagttatacg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AAAATTCACCGCGTCTATCGATATT 483 133 627 Antisense
TGGTCAGCAACTTGTGTGGCGTTTG 380 545 652 Antisense
GTGGCGTTTGAACTTTTCGCTAATC 703 489 667 Antisense
GGAGTTTTCGGATATCCTACAGACG 480 513 742 Antisense
TTGTCCACGAGAAGTACACACGCGC 482 705 890 Antisense
ATGTCGCGCTCCACTGAAAACAAAT 369 49 922 Antisense
AAACAAATTGGCGCCATTCACCAGC 130 127 939 Antisense
AAAATCCGCGATTGACGTGCTGAAA 522 133 1029 Antisense
AATGCCCCTTTTCGATATTCTACGA 165 167 1053 Antisense
TATTCTACGATCGAGTCCACCGAAG 447 663 1068 Antisense
GATGCCAAATCTCGCGAGTTATACG 459 415 1113 Antisense
Sequence Source Affymetrix Proprietary Database