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[191082_at] glutathione peroxidase

Description F26E4.12 /REP_DB=WormBase Gene ID /WP=CE09696 /TR=SW:O02621 /GB=CAB03004.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=glutathione peroxidase
Cluster 6grp_highest_10_10 > 73      6grp_high1_10_10 > 37      4grp_highest_8_8 > 21      4grp_high_8_8 > 15      6grp_highest_nonorm > 20      6grp_total > 07      4grp_total > 08      6grp_highest_sub > Cu      6grp_total_sub > Decrease      4grp_rule_based > L4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 2159
1 2 3 4 range
A 937.9
(-2.8)
P 		896
(-3)
P 		1213.3
(-1.6)
P 		2267.8
(3)
P 		1372
B 789.8
(-3)
P 		994.6
(-2.4)
P 		1584.3
(-0.7)
P 		2851.2
(3)
P 		2061
C 883.3
(-3)
P 		940.6
(-2.8)
P 		1256.2
(-1.9)
P 		2948.9
(3)
P 		2066
avr 870.3
(-3) 		943.7
(-2.8) 		1351.3
(-1.4) 		2689.3
(3) 		1819

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1153
1 2 3 4 5 6 range
A 1810.1
(3)
P 		1056.7
(-0.9)
P 		1381.1
(0.8)
P 		1011.9
(-1.2)
P 		657.6
(-3)
P 		1013.5
(-1.1)
P 		1153
B 1665.3
(3)
P 		1089.1
(-1.1)
P 		1348.1
(0.7)
P 		994.1
(-1.8)
P 		822.3
(-3)
P 		1017.2
(-1.6)
P 		843
C 1517.9
(3)
P 		1073.3
(-0.6)
P 		1127.1
(-0.1)
P 		796.8
(-2.8)
P 		771.7
(-3)
P 		1196.2
(0.4)
P 		746
avr 1664.4
(3) 		1073
(-0.9) 		1285.4
(0.5) 		934.3
(-1.8) 		750.5
(-3) 		1075.6
(-0.9) 		914
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 413
1 2 3 4 range
A 341.5
(3)
P 		194.5
(-3)
P 		317.2
(2)
P 		332
(2.6)
P 		147
B 251.9
(-2.9)
P 		245.6
(-3)
P 		367.1
(-1)
P 		607.6
(3)
P 		362
C 292.4
(-2.4)
P 		270.4
(-3)
P 		437.8
(1.4)
P 		497.2
(3)
P 		227
avr 295.3
(-1.6) 		236.8
(-3) 		374
(0.4) 		478.9
(3) 		242

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 419
1 2 3 4 5 6 range
A 333.7
(1.6)
P 		375.8
(3)
P 		300.8
(0.5)
P 		256.6
(-1)
P 		198.4
(-3)
P 		246.7
(-1.4)
P 		177
B 579.4
(3)
P 		362.5
(-1.1)
P 		327.3
(-1.8)
P 		263.3
(-3)
P 		334.1
(-1.7)
P 		379.3
(-0.8)
P 		316
C 562.6
(3)
P 		327.5
(-0.5)
P 		286.9
(-1.1)
P 		160.2
(-3)
P 		249.7
(-1.7)
P 		400.4
(0.6)
P 		402
avr 491.9
(3) 		355.3
(-0.1) 		305
(-1.2) 		226.7
(-3) 		260.7
(-2.2) 		342.1
(-0.4) 		265
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 191082_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.2387
Sequence Type Exemplar sequence
Representative Public ID F26E4.12 NCBI
Target Description F26E4.12 /REP_DB=WormBase Gene ID /WP=CE09696 /TR=SW:O02621 /GB=CAB03004.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=glutathione peroxidase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_060197(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_060197 NCBI Caenorhabditis elegans F26E4.12 (F26E4.12) mRNA, complete cds. 11/11 None
SNAP00000026228 ENSEMBL cdna:SNAP chromosome:CEL140:I:9788470:9793612:1 11/11 None
GENEFINDER00000026236 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:9788470:9789461:1 11/11 None
F26E4.12 ENSEMBL cdna:known chromosome:CEL140:I:9788470:9789461:1 gene:F26E4.12 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:9788400-9789392(+) 100.0 100.0
Public Domain and Genome References
Gene Title glutathione peroxidase
Ensembl F26E4.12
Entrez Gene 184981 Entrez gene
SwissProt O02621 EMBL-EBI
WormBase CE09696 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATGENOME1:15660_S_AT glutathione peroxidase, putative at
ATH1-121501:254890_AT glutathione peroxidase, putative at
DROSOPHILA_2:1628257_S_AT dm
DROSGENOME1:141815_AT dm
CHICKEN:GGA.107.1.S1_AT glutathione peroxidase 4 (phospholipid hydroperoxidase) gga
HG-U95AV2:33931_AT glutathione peroxidase 4 (phospholipid hydroperoxidase) hs
HG-U133_PLUS_2:201106_AT glutathione peroxidase 4 (phospholipid hydroperoxidase) hs
HG-U133A:201106_AT glutathione peroxidase 4 (phospholipid hydroperoxidase) hs
HG-FOCUS:201106_AT glutathione peroxidase 4 (phospholipid hydroperoxidase) hs
HG-U133A_2:201106_AT glutathione peroxidase 4 (phospholipid hydroperoxidase) hs
HUGENEFL:X71973_AT glutathione peroxidase 4 (phospholipid hydroperoxidase) hs
U133_X3P:G4504106_3P_X_AT glutathione peroxidase 4 (phospholipid hydroperoxidase) hs
U133_X3P:G4504106_3P_AT glutathione peroxidase 4 (phospholipid hydroperoxidase) hs
MOE430A:1451695_A_AT glutathione peroxidase 4 mm
MOUSE430_2:1451695_A_AT glutathione peroxidase 4 mm
MOUSE430A_2:1451695_A_AT glutathione peroxidase 4 mm
MG-U74AV2:94897_AT glutathione peroxidase 4 mm
MU11KSUBA:D87896_F_AT glutathione peroxidase 4 mm
MU11KSUBB:MSA.17332.0_F_AT glutathione peroxidase 4 mm
MU11KSUBB:MSA.3420.0_F_AT glutathione peroxidase 4 mm
MU19KSUBB:TC30547_AT Glutathione peroxidase 4 (Gpx4), mRNA mm
MU19KSUBB:TC30548_AT Glutathione peroxidase 4 (Gpx4), mRNA mm
MU19KSUBB:TC33491_F_AT Glutathione peroxidase 4 (Gpx4), mRNA mm
RT-U34:L24896_S_AT glutathione peroxidase 4 rn
RG-U34A:L24896_S_AT glutathione peroxidase 4 rn
RAE230A:1386871_AT glutathione peroxidase 4 rn
RAT230_2:1386871_AT glutathione peroxidase 4 rn
RAE230B:1391529_AT glutathione peroxidase 4 rn
RAT230_2:1391529_AT glutathione peroxidase 4 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6979 response to oxidative stress inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4602 glutathione peroxidase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB03004 Hypothetical protein F26E4.12 [Caenorhabditis elegans] ref|NP_492598.1| F26E4.12 [Caenorhabditis elegans] sp|O02621|GPX1_CAEEL Probable glutathione peroxidase F26E4.12 8.0E-91
blast CAB03004 Hypothetical protein F26E4.12 [Caenorhabditis elegans] ref|NP_492598.1| F26E4.12 [Caenorhabditis elegans] sp|O02621|GPX1_CAEEL Probable glutathione peroxidase F26E4.12 4.0E-90
blast CAE60228 Hypothetical protein CBG03799 [Caenorhabditis briggsae] 6.0E-84
blast CAE60228 Hypothetical protein CBG03799 [Caenorhabditis briggsae] 2.0E-83
blast CAE73436 Hypothetical protein CBG20879 [Caenorhabditis briggsae] 2.0E-73
Protein Domains
Database ID Description E-Value
Pfam IPR000889 EMBL-EBI Glutathione peroxidase 5.3E-55
Sequence
Target Sequence 
>C. ELEGANS:191082_AT
atgtcttcggtttacgatttcaacgtcaaaaatgctaatggtgatgacgtgtcactttcg
gattacaaaggaaaagttctcattatcgtgaacgtcgcttcacagtgtggacttaccaac
aagaattatacacaactcaaagaattgctcgatgtgtacaaaaaggatggtctcgaagtt
cttgccttcccttgcaatcaatttgccggtcaggaaccatcgtgtgaaatcgatattcaa
gcatttgtcgctgacaaatttaaattcgaaccaacacttttccagaagattgatgtgaat
ggagataaacagtcaccacttttcaaatttttgaaaaatgagaaaggtggattcatgttc
gatgcaattaaatggaatttcacaaagttcttggttggacgcgatgggaaaattatcaag
agatttggaccaacgactgatccaaaggacat

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
ATGTCTTCGGTTTACGATTTCAACG 146 47 13 Antisense
GATGACGTGTCACTTTCGGATTACA 17 411 55 Antisense
TTCTCATTATCGTGAACGTCGCTTC 296 691 89 Antisense
GTCGCTTCACAGTGTGGACTTACCA 286 475 106 Antisense
GCCTTCCCTTGCAATCAATTTGCCG 340 281 196 Antisense
TTGCCGGTCAGGAACCATCGTGTGA 626 701 215 Antisense
ATTCGAACCAACACTTTTCCAGAAG 171 9 276 Antisense
ACAGTCACCACTTTTCAAATTTTTG 612 97 321 Antisense
GGTGGATTCATGTTCGATGCAATTA 75 499 358 Antisense
AAGTTCTTGGTTGGACGCGATGGGA 276 155 397 Antisense
GACCAACGACTGATCCAAAGGACAT 498 383 440 Antisense
Sequence Source Affymetrix Proprietary Database