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[191052_at] protein kinase

Description F42G8.4 /REP_DB=WormBase Gene ID /WP=CE17063 /GEN=pmk-3 /TR=O44514 /GB=AAB92065.1 /SUBMIT=ST.LOUIS /CHR=4 /FEA=Sanger Annotation /DEF=protein kinase
Cluster 6grp_highest_10_10 > 72      6grp_high1_10_10 > 38      4grp_highest_8_8 > 36      4grp_high_8_8 > 0      6grp_highest_nonorm > 60      6grp_total > 37      4grp_total > 15      6grp_highest_sub > Cu      6grp_cgc > 15      6grp_high1_sub > Cu      6grp_cgc_sub > Cu      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 265
1 2 3 4 range
A 456.3
(3)
P 		339.3
(-2.2)
P 		321.4
(-3)
P 		361.9
(-1.2)
P 		135
B 484.7
(1.2)
P 		300.6
(-3)
P 		398
(-0.8)
P 		565.3
(3)
P 		265
C 498.8
(3)
P 		315.3
(-3)
P 		415.3
(0.3)
P 		394.6
(-0.4)
P 		184
avr 479.9
(3) 		318.4
(-3) 		378.2
(-0.8) 		440.6
(1.5) 		162

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 422
1 2 3 4 5 6 range
A 426.7
(1.3)
P 		480.7
(3)
P 		361.1
(-0.7)
P 		408.3
(0.8)
P 		285.8
(-3)
P 		449.5
(2)
P 		195
B 498.5
(3)
P 		466
(1.9)
P 		327
(-3)
P 		381.8
(-1.1)
P 		403.5
(-0.3)
P 		463.4
(1.8)
P 		172
C 707.9
(3)
P 		455.8
(-1.7)
P 		385.9
(-3)
P 		407.4
(-2.6)
P 		383.2
(-3)
P 		456
(-1.7)
P 		325
avr 544.4
(3) 		467.5
(0.5) 		358
(-3) 		399.2
(-1.7) 		357.5
(-3) 		456.3
(0.2) 		187
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 113
1 2 3 4 range
A 166.1
(3)
P 		73.7
(-1.9)
P 		84
(-1.4)
P 		53
(-3)
P 		113
B 154.6
(3)
P 		74.3
(-3)
P 		92.2
(-1.7)
P 		120.5
(0.5)
P 		80
C 165.1
(3)
P 		90.6
(-1.5)
P 		144.8
(1.8)
P 		66.5
(-3)
P 		99
avr 161.9
(3) 		79.5
(-3) 		107
(-1) 		80
(-3) 		82

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 184
1 2 3 4 5 6 range
A 78.7
(-3)
P 		171
(3)
P 		78.6
(-3)
P 		103.6
(-1.4)
P 		86.3
(-2.5)
P 		109.4
(-1)
P 		92
B 173.4
(3)
P 		155.1
(1.8)
P 		79.4
(-3)
P 		101.1
(-1.6)
P 		163.9
(2.4)
P 		172.8
(3)
P 		94
C 262.4
(3)
P 		139.1
(-1.1)
P 		98.2
(-2.5)
P 		81.9
(-3)
P 		124
(-1.6)
P 		152.7
(-0.6)
P 		181
avr 171.5
(3) 		155.1
(1.9) 		85.4
(-3) 		95.5
(-2.3) 		124.7
(-0.3) 		145
(1.2) 		86
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 191052_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.10235
Sequence Type Exemplar sequence
Representative Public ID F42G8.4 NCBI
Target Description F42G8.4 /REP_DB=WormBase Gene ID /WP=CE17063 /GEN=pmk-3 /TR=O44514 /GB=AAB92065.1 /SUBMIT=ST.LOUIS /CHR=4 /FEA=Sanger Annotation /DEF=protein kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_068962(10)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_068962 NCBI Caenorhabditis elegans P38 Map Kinase family member (pmk-3) (pmk-3) mRNA, complete cds. 10/11 None
SNAP00000028280 ENSEMBL cdna:SNAP chromosome:CEL140:IV:8140227:8142781:1 10/11 None
GENEFINDER00000028293 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:8140227:8142781:1 10/11 None
F42G8.4.1 ENSEMBL cdna:known chromosome:CEL140:IV:8139200:8143118:1 gene:F42G8.4 10/11 None
F42G8.4.2 ENSEMBL cdna:known chromosome:CEL140:IV:8139200:8143118:1 gene:F42G8.4 10/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:8140232-8142787(+) 100.0 100.0
Public Domain and Genome References
Gene Title protein kinase
Gene Symbol pmk-3
Ensembl F42G8.4
Entrez Gene 177610 Entrez gene
SwissProt O44514 EMBL-EBI
WormBase CE29318 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAB92065 P38 map kinase family protein 3 [Caenorhabditis elegans] ref|NP_501363.1| P38 Map Kinase family member (pmk-3) [Caenorhabditis elegans] sp|O44514|PMK3_CAEEL Mitogen-activated protein kinase pmk-3 (p38 MAP kinase 3) (Stress-activated protein kinase pmk-3) 0.0
blast T32642 hypothetical protein F42G8.4 - Caenorhabditis elegans 0.0
blast CAE58422 Hypothetical protein CBG01553 [Caenorhabditis briggsae] 0.0
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 9.0E-68
hanks 3.1.1 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; CDC2Hs 3.0E-69
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 2.6E-70
Sequence
Target Sequence 
>C. ELEGANS:191052_AT
atctggcagatatgtggtcacttggatgtattgctgcagaacttttaactggagaaccac
tgtttccgggtgatgagcccaatgctcaatatcaacgtattactcaattatgtggaagtc
ctgatgaagaacttttgacaaagattgaaaatgataactcgtctgcaattaaagccgtaa
ttcaatcctacacaactcacaaacgtcgaaatttccgtgatgtattttctgctcataatc
catcagaagactttattgatctacttgagaagcttttagttttggatccagagaagagga
ttacggtggaagaagctattcaacatccatatttggcagagttttcacttccagaagatg
aaccaagagctgatcatatatttgacttggatgactctcaagctagaacaagattcgagt
ggagaggtaaggctcaaagatcacgtaatagaattctgcacacctgcaaatttgaaaaac
aacaaatgcaaaaatattttattacagatgccgtctggaaggaaataatgaactacaaaa
gactcagctcatca

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
ATCTGGCAGATATGTGGTCACTTGG 38 35 935 Antisense
ACTGGAGAACCACTGTTTCCGGGTG 170 97 982 Antisense
GTTTCCGGGTGATGAGCCCAATGCT 439 449 996 Antisense
AGCCCAATGCTCAATATCAACGTAT 339 83 1010 Antisense
TAACTCGTCTGCAATTAAAGCCGTA 576 637 1089 Antisense
TAAAGCCGTAATTCAATCCTACACA 279 639 1104 Antisense
ATCCTACACAACTCACAAACGTCGA 693 35 1119 Antisense
TGTATTTTCTGCTCATAATCCATCA 388 561 1155 Antisense
GAGAAGCTTTTAGTTTTGGATCCAG 629 391 1201 Antisense
GTAATAGAATTCTGCACACCTGCAA 318 461 1379 Antisense
GAACTACAAAAGACTCAGCTCATCA 707 349 1464 Antisense
Sequence Source Affymetrix Proprietary Database