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[191013_s_at] acetly-CoA thiolase /// acetoacetyl-C0A thiolase

Description T02G5.8 /REP_DB=WormBase Gene ID /WP=CE04860 /TR=Q22100 /GB=AAA82397.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=acetoacetyl-C0A thiolase
Cluster 6grp_highest_10_10 > 35      6grp_high1_10_10 > 53      4grp_highest_8_8 > 10      4grp_high_8_8 > 54      6grp_highest_nonorm > 36      6grp_total > 30      4grp_total > 57      6grp_highest_sub > 03      6grp_cgc > 82      6grp_high1_sub > 03      6grp_cgc_sub > 03      6grp_total_sub > Hat      6grp_rule_based > S3      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 3012
1 2 3 4 range
A 2389.9
(-3)
P 		4662
(1.5)
P 		5402.1
(3)
P 		2993
(-1.8)
P 		3012
B 3781.4
(0.7)
P 		4425
(3)
P 		4162.7
(2.1)
P 		2731.8
(-3)
P 		1693
C 3072.9
(-1.1)
P 		3999.5
(3)
P 		3955.4
(2.8)
P 		2634.2
(-3)
P 		1365
avr 3081.4
(-2) 		4362.2
(2.5) 		4506.7
(3) 		2786.3
(-3) 		1720

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 2636
1 2 3 4 5 6 range
A 4346.3
(-0.8)
P 		4278.8
(-1.1)
P 		5139.1
(3)
P 		4292.2
(-1)
P 		3876.8
(-3)
P 		4101.3
(-1.9)
P 		1262
B 3147.4
(-2.7)
P 		4432.9
(1.5)
P 		4551.7
(1.9)
P 		4894.4
(3)
P 		3381.8
(-1.9)
P 		3040.5
(-3)
P 		1854
C 3337.8
(-2.5)
P 		4784.8
(0.9)
P 		5676.5
(3)
P 		4351.9
(-0.1)
P 		3107
(-3)
P 		3791.5
(-1.4)
P 		2570
avr 3610.5
(-2.4) 		4498.8
(0.8) 		5122.4
(3) 		4512.8
(0.8) 		3455.2
(-3) 		3644.4
(-2.3) 		1667
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 974
1 2 3 4 range
A 870.2
(-0.3)
P 		1012
(0.5)
P 		1412.2
(3)
P 		438.1
(-3)
P 		974
B 1205.8
(3)
P 		1092.9
(1.9)
P 		964.6
(0.7)
P 		582.1
(-3)
P 		624
C 1017.2
(0.7)
P 		1149.9
(1.5)
P 		1378.6
(3)
P 		444.2
(-3)
P 		934
avr 1031.1
(1.3) 		1084.9
(1.7) 		1251.8
(3) 		488.1
(-3) 		764

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 721
1 2 3 4 5 6 range
A 801.2
(-3)
P 		1521.7
(3)
P 		1119.2
(-0.4)
P 		1088.6
(-0.6)
P 		1169.9
(0.1)
P 		998.5
(-1.4)
P 		721
B 1095.2
(-3)
P 		1475.5
(3)
P 		1105.3
(-2.8)
P 		1296.3
(0.2)
P 		1374
(1.4)
P 		1133.8
(-2.4)
P 		380
C 1237.2
(0.7)
P 		1460
(3)
P 		1444.8
(2.8)
P 		875.2
(-3)
P 		1005.4
(-1.7)
P 		1269.2
(1)
P 		585
avr 1044.5
(-3) 		1485.7
(3) 		1223.1
(-0.6) 		1086.7
(-2.4) 		1183.1
(-1.1) 		1133.8
(-1.8) 		441
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 191013_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.5333
Sequence Type Exemplar sequence
Representative Public ID T02G5.8 NCBI
Target Description T02G5.8 /REP_DB=WormBase Gene ID /WP=CE04860 /TR=Q22100 /GB=AAA82397.1 /SUBMIT=ST.LOUIS /CHR=2 /FEA=Sanger Annotation /DEF=acetoacetyl-C0A thiolase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_063054(11), NM_063060(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_063054 NCBI Caenorhabditis elegans 3-Ketoacyl-coA Thiolase family member (kat-1) (kat-1) mRNA, complete cds. 11/11 A 
NM_063060 NCBI Caenorhabditis elegans T02G5.4 (T02G5.4) mRNA, complete cds. 11/11 A 
SNAP00000014283 ENSEMBL cdna:SNAP chromosome:CEL140:II:7073745:7075339:1 11/11 None
SNAP00000014288 ENSEMBL cdna:SNAP chromosome:CEL140:II:7082032:7084013:1 11/11 None
GENEFINDER00000014295 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:7082032:7088142:1 11/11 None
GENEFINDER00000014298 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:7073745:7075339:1 11/11 None
T02G5.8 ENSEMBL cdna:known chromosome:CEL140:II:7073744:7075481:1 gene:T02G5.8 11/11 A 
T02G5.4 ENSEMBL cdna:known chromosome:CEL140:II:7082032:7084304:1 gene:T02G5.4 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:7073740-7075335(+) 100.0 100.0
Public Domain and Genome References
Gene Title acetly-CoA thiolase
acetoacetyl-C0A thiolase
Gene Symbol kat-1
Ensembl T02G5.8
T02G5.4
Entrez Gene 174161 Entrez gene
187992 Entrez gene
SwissProt Q22106 EMBL-EBI
Q22100 EMBL-EBI
WormBase CE04856 Wormbase
CE29990 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:248690_AT acetyl-CoA C-acyltransferase, putative / 3-ketoacyl-CoA thiolase, putative at
CANINE:1605244_AT similar to Acetyl-CoA acetyltransferase, mitochondrial precursor (Acetoacetyl-CoA thiolase) (T2) cfa
CANINE:1599365_S_AT similar to Acetyl-CoA acetyltransferase, mitochondrial precursor (Acetoacetyl-CoA thiolase) (T2) cfa
CANINE:1591382_S_AT similar to Acetyl-CoA acetyltransferase, mitochondrial precursor (Acetoacetyl-CoA thiolase) (T2) cfa
CANINE_2:CFA.1502.1.S1_AT similar to Acetyl-CoA acetyltransferase, mitochondrial precursor (Acetoacetyl-CoA thiolase) (T2) cfa
CANINE_2:CFAAFFX.22496.1.S1_AT similar to Acetyl-CoA acetyltransferase, mitochondrial precursor (Acetoacetyl-CoA thiolase) (T2) cfa
CANINE_2:CFAAFFX.22504.1.S1_S_AT similar to Acetyl-CoA acetyltransferase, mitochondrial precursor (Acetoacetyl-CoA thiolase) (T2) cfa
DROSOPHILA_2:1638717_AT dm
DROSGENOME1:154229_AT dm
CHICKEN:GGA.3173.1.S1_AT acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) gga
HUGENEFL:D10511_AT acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) hs
HG-U133_PLUS_2:205412_AT acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) hs
HG-U133A:205412_AT acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) hs
HG-FOCUS:205412_AT acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) hs
HG-U133A_2:205412_AT acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) hs
U133_X3P:G4557236_3P_S_AT acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) hs
U133_X3P:HS2.37.2.S1_3P_AT acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) hs
HG-U133_PLUS_2:1554947_AT acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) hs
U133_X3P:HS2.397519.1.S1_3P_S_AT Acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) hs
HG-U133_PLUS_2:1559239_S_AT Acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) hs
HG-U95AV2:39678_AT Acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase) hs
MOE430A:1424183_AT acetyl-Coenzyme A acetyltransferase 1 mm
MOUSE430A_2:1424183_AT acetyl-Coenzyme A acetyltransferase 1 mm
MOUSE430_2:1424183_AT acetyl-Coenzyme A acetyltransferase 1 mm
MOUSE430_2:1424182_AT acetyl-Coenzyme A acetyltransferase 1 mm
MOE430A:1424182_AT acetyl-Coenzyme A acetyltransferase 1 mm
MOUSE430A_2:1424182_AT acetyl-Coenzyme A acetyltransferase 1 mm
MOUSE430A_2:1451271_A_AT acetyl-Coenzyme A acetyltransferase 1 mm
MOE430A:1451271_A_AT acetyl-Coenzyme A acetyltransferase 1 mm
MOUSE430_2:1451271_A_AT acetyl-Coenzyme A acetyltransferase 1 mm
MU11KSUBA:AA710204_S_AT acetyl-Coenzyme A acetyltransferase 1 mm
MU19KSUBB:TC30854_AT Acetyl-CoA acetyltransferase (Acat1 gene) mm
MU19KSUBB:TC32584_AT Acetyl-CoA acetyltransferase (Acat1 gene) mm
RG-U34A:D13921_S_AT acetyl-coenzyme A acetyltransferase 1 rn
RG-U34A:D00512_G_AT acetyl-coenzyme A acetyltransferase 1 rn
RG-U34A:D00512_AT acetyl-coenzyme A acetyltransferase 1 rn
RG-U34B:RC_AA899304_AT acetyl-coenzyme A acetyltransferase 1 rn
RAE230A:1367763_AT acetyl-coenzyme A acetyltransferase 1 rn
RAT230_2:1367763_AT acetyl-coenzyme A acetyltransferase 1 rn
RAE230B:1383416_AT Acetyl-coenzyme A acetyltransferase 1 rn
RAT230_2:1383416_AT Acetyl-coenzyme A acetyltransferase 1 rn
RAE230B:1395768_AT Acetyl-coenzyme A acetyltransferase 1 rn
RAT230_2:1395768_AT Acetyl-coenzyme A acetyltransferase 1 rn
YEAST_2:1775467_AT Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis Sc
Protein Similarities
Method ID Description E-Value
blast NP_495455 3-Ketoacyl-coA Thiolase family member (kat-1) [Caenorhabditis elegans] gb|AAA82397.2| 3-ketoacyl-coa thiolase protein 1 [Caenorhabditis elegans] 0.0
blast CAE56900 Hypothetical protein CBG24741 [Caenorhabditis briggsae] 0.0
blast NP_495461 T02G5.4 [Caenorhabditis elegans] gb|AAA82403.1| Hypothetical protein T02G5.4 [Caenorhabditis elegans] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR002155 EMBL-EBI Thiolase 2.9E-52
Pfam IPR002155 EMBL-EBI Thiolase 1.1E-113
Pfam IPR002155 EMBL-EBI Thiolase 4.6E-44
Pfam IPR002155 EMBL-EBI Thiolase 9.5E-51
Pfam IPR002155 EMBL-EBI Thiolase 4.6E-44
Pfam IPR002155 EMBL-EBI Thiolase 3.2E-48
Pfam IPR002155 EMBL-EBI Thiolase 2.9E-52
Pfam IPR002155 EMBL-EBI Thiolase 2.1E-118
Sequence
Target Sequence 
>C. ELEGANS:191013_S_AT
caatcagatgttgctcaatgggaagttaatgaagccttctcatgtgttccccttgctttc
atcaaaaaactaggagtcgatccatcccttgtgaacccacatggaggagctgtttcaatt
ggtcaccccatcggaatgtccggagcccgcctcatcactcatcttgtgcacacactcaaa
agtggccaaatcggagttgctgc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
CAATCAGATGTTGCTCAATGGGAAG 639 181 988 Antisense
GATGTTGCTCAATGGGAAGTTAATG 504 407 994 Antisense
TAATGAAGCCTTCTCATGTGTTCCC 635 635 1014 Antisense
TGTTCCCCTTGCTTTCATCAAAAAA 132 563 1032 Antisense
TTCCCCTTGCTTTCATCAAAAAACT 325 697 1034 Antisense
TCAAAAAACTAGGAGTCGATCCATC 44 627 1049 Antisense
TGAACCCACATGGAGGAGCTGTTTC 161 575 1079 Antisense
TTTCAATTGGTCACCCCATCGGAAT 444 671 1100 Antisense
TCACCCCATCGGAATGTCCGGAGCC 695 625 1110 Antisense
TCATCACTCATCTTGTGCACACACT 589 619 1139 Antisense
AAAGTGGCCAAATCGGAGTTGCTGC 304 121 1166 Antisense
Sequence Source Affymetrix Proprietary Database