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[190969_at] serine/threonine kinase /// ---

Description Y106G6D.4 /REP_DB=WormBase Gene ID /WP=CE19302 /TR=Q9XX60 /GB=CAA20977.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=serine-threonine kinase
Cluster 6grp_highest_10_10 > 18      6grp_high1_10_10 > 80      4grp_highest_8_8 > 01      4grp_high_8_8 > 45      6grp_highest_nonorm > 80      6grp_total > 82      4grp_total > 50      6grp_highest_sub > 04_05      6grp_high1_sub > 02_03_04_05      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 119
1 2 3 4 range
A 190.8
(-3)
P 		195.6
(-2.6)
P 		258.8
(3)
P 		222.3
(-0.2)
P 		68
B 198.9
(-0.2)
P 		247.5
(3)
P 		213.8
(0.8)
P 		156.7
(-3)
P 		91
C 170.4
(-1.2)
P 		241.4
(3)
P 		184.8
(-0.3)
P 		139.5
(-3)
P 		102
avr 186.7
(-1.5) 		228.2
(3) 		219.1
(2) 		172.8
(-3) 		55

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 106
1 2 3 4 5 6 range
A 211.7
(-0.1)
P 		177.2
(-2.1)
P 		161.1
(-3)
P 		267.3
(3)
P 		250.6
(2.1)
P 		175
(-2.2)
P 		106
B 206.5
(0.1)
P 		190.9
(-1.3)
P 		240.7
(3)
P 		197
(-0.8)
P 		217.8
(1)
P 		171
(-3)
P 		70
C 184.7
(-1.5)
P 		229.6
(2.5)
P 		235.7
(3)
P 		168.2
(-3)
P 		186.4
(-1.4)
P 		177.6
(-2.2)
P 		68
avr 201
(0.6) 		199.2
(0.4) 		212.5
(2.2) 		210.8
(2) 		218.3
(3) 		174.5
(-3) 		44
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 46
1 2 3 4 range
A 69.5
(3)
P 		42.5
(-1.4)
P 		67.7
(2.7)
P 		32.5
(-3)
P 		37
B 63.4
(3)
P 		61.1
(2.5)
P 		49.5
(0.2)
P 		33.4
(-3)
P 		30
C 56.4
(1.3)
P 		69.4
(3)
P 		64.4
(2.3)
P 		23.5
(-3)
P 		46
avr 63.1
(3) 		57.7
(2) 		60.5
(2.5) 		29.8
(-3) 		33

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 55
1 2 3 4 5 6 range
A 39
(-2.4)
P 		63
(1.1)
P 		35.1
(-3)
P 		67.8
(1.8)
P 		75.6
(3)
P 		42.6
(-1.9)
P 		41
B 71.9
(0.3)
P 		63.5
(-1.1)
P 		58.5
(-2)
P 		52.2
(-3)
P 		88.5
(3)
P 		63.7
(-1.1)
P 		36
C 68.5
(2.8)
P 		70
(3)
P 		60
(1.3)
P 		33.8
(-3)
P 		60.3
(1.4)
P 		59.5
(1.3)
P 		36
avr 59.8
(-0.8) 		65.5
(0.6) 		51.2
(-3) 		51.3
(-3) 		74.8
(3) 		55.3
(-2) 		24
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 190969_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.2477
Sequence Type Exemplar sequence
Representative Public ID Y106G6D.4 NCBI
Target Description Y106G6D.4 /REP_DB=WormBase Gene ID /WP=CE19302 /TR=Q9XX60 /GB=CAA20977.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=serine-threonine kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Genome Target Overlap based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade B annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_001026535, NM_060267
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
SNAP00000020350 ENSEMBL cdna:SNAP chromosome:CEL140:I:10122913:10124678:1 None
GENEFINDER00000020356 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:10122913:10126199:1 None
NM_060267 NCBI Caenorhabditis elegans Y106G6D.4 (Y106G6D.4) mRNA, complete cds. A 
NM_001026535 NCBI Caenorhabditis elegans Y106G6D.8 (Y106G6D.8) mRNA, complete cds. None
Y106G6D.4 ENSEMBL cdna:known chromosome:CEL140:I:10122913:10124678:1 gene:Y106G6D.4 None
Y106G6D.8.1 ENSEMBL cdna:known chromosome:CEL140:I:10125182:10126261:1 gene:Y106G6D.8 None
Y106G6D.8.2 ENSEMBL cdna:known chromosome:CEL140:I:10125280:10126199:1 gene:Y106G6D.8 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:10122843-10126130(+) 100.0 100.0
Public Domain and Genome References
Gene Title serine/threonine kinase

Ensembl Y106G6D.4
Y106G6D.8
Entrez Gene 172876 Entrez gene
3565292 Entrez gene
SwissProt Q9XX60 EMBL-EBI
Q7K7C1 EMBL-EBI
WormBase CE36225 Wormbase
CE36226 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA20977 Hypothetical protein Y106G6D.4 [Caenorhabditis elegans] ref|NP_492668.2| Y106G6D.4 [Caenorhabditis elegans] 0.0
blast CAE66689 Hypothetical protein CBG12029 [Caenorhabditis briggsae] 1.0E-160
blast CAE64384 Hypothetical protein CBG09071 [Caenorhabditis briggsae] 2.0E-79
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 7.0E-20
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 2.0E-20
hanks 3.1.5 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; Cdk6 9.0E-51
hanks 3.1.5 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; Cdk6 1.0E-51
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 1.9E-47
Sequence
Target Sequence 
>C. ELEGANS:190969_AT
atggtccaaaacttctttctcatccatttttcgatctcattttcacgccaaaatgcacac
tttccaatgggcttctcgtctcacaagtgatcactctcgacgattacaaaactgctcaga
aaaatgatagtacttctggtaaacagtatgctgccgcaattctacggcatgagatcagat
tttcgttgaaagcgccaattgttcaccctccagctccgcctgctccaccagttgtgccca
tgattgatatgatttcctgtcgtttcctgatatttctgtcgttgctggttactgtatttt
c

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
ATGGTCCAAAACTTCTTTCTCATCC 458 51 929 Antisense
CATTTTTCGATCTCATTTTCACGCC 27 215 953 Antisense
ATGCACACTTTCCAATGGGCTTCTC 358 43 981 Antisense
GGCTTCTCGTCTCACAAGTGATCAC 261 537 998 Antisense
CAAGTGATCACTCTCGACGATTACA 373 183 1012 Antisense
AACAGTATGCTGCCGCAATTCTACG 681 131 1070 Antisense
TTGAAAGCGCCAATTGTTCACCCTC 356 705 1114 Antisense
CTCCACCAGTTGTGCCCATGATTGA 198 235 1151 Antisense
TGATATGATTTCCTGTCGTTTCCTG 166 565 1173 Antisense
GTTTCCTGATATTTCTGTCGTTGCT 338 451 1190 Antisense
TGTCGTTGCTGGTTACTGTATTTTC 316 557 1205 Antisense
Sequence Source Affymetrix Proprietary Database