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[190956_at] Glutathione reductase

Description ZK637.10 /REP_DB=WormBase Gene ID /WP=CE15373 /TR=SW:P30635 /GB=CAA77459.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=Glutathione reductase
Cluster 6grp_highest_10_10 > 47      6grp_high1_10_10 > 63      4grp_high_8_8 > 56      6grp_highest_nonorm > 82      6grp_total > 64      4grp_total > 63      6grp_cgc > 66      6grp_high1_sub > 03      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 270
1 2 3 4 range
A 356.5
(3)
P 		106.4
(-2.6)
P 		235.2
(0.3)
P 		86.2
(-3)
M 		270
B 241.2
(3)
P 		165.5
(-0.8)
P 		203
(1.1)
P 		122.6
(-3)
P 		119
C 285.8
(3)
P 		140.2
(-3)
P 		279.5
(2.7)
P 		191
(-0.9)
P 		146
avr 294.5
(3) 		137.4
(-2.8) 		239.2
(0.9) 		133.3
(-3) 		161

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 427
1 2 3 4 5 6 range
A 213.5
(-3)
P 		353.1
(0.4)
P 		422.4
(2.2)
P 		456.7
(3)
P 		220.2
(-2.8)
P 		267.2
(-1.7)
P 		243
B 309.8
(-3)
P 		333.2
(-2.6)
P 		640.6
(3)
P 		399.5
(-1.4)
P 		417.1
(-1.1)
P 		446
(-0.5)
P 		331
C 276.1
(-2.6)
P 		264.7
(-3)
P 		383
(0.6)
P 		323.1
(-1.2)
P 		330.9
(-1)
P 		459.5
(3)
P 		195
avr 266.5
(-3) 		317
(-1.6) 		482
(3) 		393.1
(0.5) 		322.7
(-1.4) 		390.9
(0.5) 		216
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 117
1 2 3 4 range
A 129.8
(3)
P 		23.1
(-2.5)
P 		61.5
(-0.5)
P 		12.6
(-3)
M 		117
B 76.9
(3)
P 		40.9
(-1.3)
P 		47
(-0.5)
P 		26.1
(-3)
P 		51
C 94.6
(2.7)
P 		40.3
(-2.3)
P 		97.4
(3)
P 		32.2
(-3)
P 		65
avr 100.4
(3) 		34.8
(-2.1) 		68.6
(0.5) 		23.6
(-3) 		77

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 130
1 2 3 4 5 6 range
A 39.4
(-3)
P 		125.6
(3)
P 		92
(0.7)
P 		115.8
(2.3)
P 		66.5
(-1.1)
P 		65.1
(-1.2)
P 		86
B 107.8
(-2.8)
P 		110.9
(-2.5)
P 		155.6
(1.7)
P 		105.8
(-3)
P 		169.5
(3)
P 		166.3
(2.7)
P 		64
C 102.4
(-0.5)
P 		80.8
(-1.9)
P 		97.5
(-0.8)
P 		65
(-3)
P 		107.1
(-0.2)
P 		153.8
(3)
P 		89
avr 83.2
(-3) 		105.8
(-0) 		115
(1.2) 		95.5
(-1.4) 		114.4
(1.1) 		128.4
(3) 		45
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 190956_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.7921
Sequence Type Exemplar sequence
Representative Public ID ZK637.10 NCBI
Target Description ZK637.10 /REP_DB=WormBase Gene ID /WP=CE15373 /TR=SW:P30635 /GB=CAA77459.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=Glutathione reductase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_066570(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_066570 NCBI Caenorhabditis elegans ThioRedoXin Reductase family member (trxr-2) (trxr-2) mRNA, complete cds. 11/11 None
SNAP00000013209 ENSEMBL cdna:SNAP chromosome:CEL140:III:8913684:8916257:1 11/11 None
GENEFINDER00000013238 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:8913684:8916257:1 11/11 None
ZK637.10 ENSEMBL cdna:known chromosome:CEL140:III:8913672:8916349:1 gene:ZK637.10 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:8913679-8916253(+) 100.0 100.0
Public Domain and Genome References
Gene Title Glutathione reductase
Gene Symbol trxr-2
Ensembl ZK637.10
Entrez Gene 176259 Entrez gene
SwissProt P30635 EMBL-EBI
WormBase CE15373 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1602339_AT similar to thioredoxin reductase 2 isoform 1 precursor cfa
CANINE_2:CFA.14565.1.S1_AT similar to thioredoxin reductase 2 isoform 1 precursor cfa
CANINE_2:CFAAFFX.22329.1.S1_AT similar to thioredoxin reductase 2 isoform 1 precursor cfa
CANINE_2:CFAAFFX.22364.1.S1_AT similar to thioredoxin reductase 2 isoform 1 precursor cfa
CANINE_2:CFAAFFX.22364.1.S1_S_AT similar to thioredoxin reductase 2 isoform 1 precursor cfa
DROSOPHILA_2:1631152_AT thioredoxin reductase 2 dm
DROSGENOME1:149237_AT thioredoxin reductase 2 dm
CHICKEN:GGAAFFX.1316.1.S1_AT similar to Txnrd2-prov protein gga
CHICKEN:GGAAFFX.25362.1.S1_AT similar to Txnrd2-prov protein gga
HG-U133_PLUS_2:210803_AT thioredoxin reductase 2 hs
HG-U133A:210803_AT thioredoxin reductase 2 hs
HG-FOCUS:210803_AT thioredoxin reductase 2 hs
HG-U133A_2:210803_AT thioredoxin reductase 2 hs
HG-U133_PLUS_2:211177_S_AT thioredoxin reductase 2 hs
HG-U133A:211177_S_AT thioredoxin reductase 2 hs
HG-U133A_2:211177_S_AT thioredoxin reductase 2 hs
HG-U95AV2:41711_AT thioredoxin reductase 2 hs
HU35KSUBA:RC_AA431318_AT thioredoxin reductase 2 hs
U133_X3P:G4827178_3P_A_AT thioredoxin reductase 2 hs
U133_X3P:G12043737_3P_X_AT thioredoxin reductase 2 hs
U133_X3P:1560671_3P_AT Thioredoxin reductase 2 hs
U133_X3P:HS2.300152.1.A1_3P_AT Thioredoxin reductase 2 hs
U133_X3P:HS2.300152.1.A1_3P_X_AT Thioredoxin reductase 2 hs
MOUSE430_2:1451936_A_AT thioredoxin reductase 2 mm
MOE430A:1451936_A_AT thioredoxin reductase 2 mm
MOUSE430A_2:1451936_A_AT thioredoxin reductase 2 mm
MG-U74AV2:160437_AT thioredoxin reductase 2 mm
MOE430A:1449097_AT thioredoxin reductase 2 mm
MOUSE430A_2:1449097_AT thioredoxin reductase 2 mm
MOUSE430_2:1449097_AT thioredoxin reductase 2 mm
MOE430B:1429972_S_AT thioredoxin reductase 2 mm
MOUSE430_2:1429972_S_AT thioredoxin reductase 2 mm
MOE430B:1429971_AT thioredoxin reductase 2 mm
MOUSE430_2:1429971_AT thioredoxin reductase 2 mm
MU19KSUBC:TC36200_AT Thioredoxin reductase 2, mRNA (cDNA clone MGC:5671 IMAGE:3584154) mm
RT-U34:AF072865_G_AT thioredoxin reductase 2 rn
RG-U34A:AF072865_G_AT thioredoxin reductase 2 rn
RT-U34:AF072865_AT thioredoxin reductase 2 rn
RG-U34A:AF072865_AT thioredoxin reductase 2 rn
RAE230A:1368309_AT thioredoxin reductase 2 rn
RAT230_2:1368309_AT thioredoxin reductase 2 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6118 electron transport inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5737 cytoplasm inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
15036 disulfide oxidoreductase activity inferred from electronic annotation QuickGO AmiGO
16491 oxidoreductase activity inferred from electronic annotation QuickGO AmiGO
16654 oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor inferred from electronic annotation QuickGO AmiGO
46872 metal ion binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA77459 Hypothetical protein ZK637.10 [Caenorhabditis elegans] ref|NP_498971.1| ThioRedoXin Reductase family member (trxr-2) [Caenorhabditis elegans] sp|P30635|GSHR_CAEEL Probable glutathione reductase (GR) (GRase) 0.0
blast S15798 glutathione reductase homolog - Caenorhabditis elegans 0.0
blast CAE62724 Hypothetical protein CBG06883 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR004099 EMBL-EBI Pyridine nucleotide-disulphide oxidoreductase dimerisation domain 9.7E-45
Pfam IPR001327 EMBL-EBI FAD-dependent pyridine nucleotide-disulphide oxidoreductase 1.3E-85
Pfam IPR004099 EMBL-EBI Pyridine nucleotide-disulphide oxidoreductase dimerisation domain 9.7E-45
Pfam IPR001327 EMBL-EBI FAD-dependent pyridine nucleotide-disulphide oxidoreductase 4.3E-81
Sequence
Target Sequence 
>C. ELEGANS:190956_AT
gaatttgatagagcttcctgtaatggtgtatatgccgttggagatattgttcaggatcgc
caagagctcacgccacttgctattcaatccggaaaacttctagctgatcgtcttttttca
aattccaaacaaatagttcgattcgatggagttgccactacagtattcacgcctcttgaa
ctctcaaccgtcgggttaactgaggaagaagccattcagaaacatggagaagattcgatc
gaagtgtttcattctcattttactccgtttgagtatgttgtgccacagaataaggatagc
ggtttttgttatgtgaaagccgtgtgtacaagagatgaatcgcagaaaattcttggtctt
cattttgttggaccaaatgccgcagaagtaattcaaggctacgcagtagcattccgtgtt
ggaatttcaatgtctgatcttcaaaacacaattgccattcatccatgttcttctgaagag
ttcgtgaagcttcacattacaaaacgatct

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GAATTTGATAGAGCTTCCTGTAATG 504 325 979 Antisense
TGTTCAGGATCGCCAAGAGCTCACG 661 561 1026 Antisense
CGCCACTTGCTATTCAATCCGGAAA 684 255 1049 Antisense
AACTTCTAGCTGATCGTCTTTTTTC 386 139 1073 Antisense
GAGTTGCCACTACAGTATTCACGCC 546 397 1127 Antisense
TACAGTATTCACGCCTCTTGAACTC 323 643 1137 Antisense
GAACTCTCAACCGTCGGGTTAACTG 530 303 1156 Antisense
GATTCGATCGAAGTGTTTCATTCTC 342 433 1210 Antisense
TTTCATTCTCATTTTACTCCGTTTG 694 671 1225 Antisense
CTCCGTTTGAGTATGTTGTGCCACA 682 233 1241 Antisense
GAAGCTTCACATTACAAAACGATCT 676 341 1464 Antisense
Sequence Source Affymetrix Proprietary Database