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[190943_at] lipoamide acyltransferase

Description ZK669.4 /REP_DB=WormBase Gene ID /WP=CE01115 /TR=Q23571 /GB=CAA85465.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=lipoamide acyltransferase
Cluster 6grp_highest_10_10 > 23      6grp_high1_10_10 > 21      4grp_highest_8_8 > 25      4grp_high_8_8 > 60      6grp_highest_nonorm > 22      6grp_total > 32      4grp_total > 60      6grp_highest_sub > 01_02_03      6grp_high1_sub > 03      6grp_total_sub > Hat      6grp_rule_based > S3      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 2239
1 2 3 4 range
A 2158.9
(1.5)
P 		2144.9
(1.5)
P 		2711.6
(3)
P 		507.1
(-3)
P 		2205
B 2429.4
(2.4)
P 		2297.8
(2)
P 		2635.3
(3)
P 		584.8
(-3)
P 		2051
C 2080.6
(1.6)
P 		2221.4
(2)
P 		2557.8
(3)
P 		473.1
(-3)
P 		2085
avr 2223
(1.8) 		2221.4
(1.8) 		2634.9
(3) 		521.7
(-3) 		2113

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1152
1 2 3 4 5 6 range
A 2171.7
(3)
P 		2054.8
(2.3)
P 		2064.6
(2.4)
P 		1636.6
(-0.1)
P 		1466
(-1)
P 		1119.1
(-3)
P 		1053
B 1897.7
(1.4)
P 		2010.4
(2.1)
P 		2165.5
(3)
P 		1650.5
(-0.1)
P 		1571.3
(-0.5)
P 		1153.2
(-3)
P 		1012
C 1932.7
(1.2)
P 		2032.2
(1.7)
P 		2271.3
(3)
P 		1850.8
(0.8)
P 		1149.7
(-3)
P 		1151.7
(-3)
P 		1122
avr 2000.7
(2) 		2032.5
(2.2) 		2167.1
(3) 		1712.6
(0.3) 		1395.7
(-1.5) 		1141.3
(-3) 		1026
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 817
1 2 3 4 range
A 786
(3)
P 		465.6
(0.3)
P 		708.9
(2.4)
P 		74.2
(-3)
P 		712
B 774.7
(3)
P 		567.5
(1.1)
P 		610.7
(1.5)
P 		124.6
(-3)
P 		650
C 688.7
(1.5)
P 		638.7
(1.1)
P 		891.5
(3)
P 		79.8
(-3)
P 		812
avr 749.8
(3) 		557.3
(1.2) 		737
(2.9) 		92.9
(-3) 		657

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 458
1 2 3 4 5 6 range
A 400.3
(-1.3)
P 		730.8
(3)
P 		449.6
(-0.7)
P 		415.1
(-1.1)
P 		442.4
(-0.8)
P 		272.5
(-3)
P 		458
B 660.3
(2.8)
P 		669.2
(3)
P 		525.9
(-0.6)
P 		437.2
(-2.8)
P 		638.4
(2.2)
P 		430
(-3)
P 		239
C 716.4
(3)
P 		620.1
(1.3)
P 		578.1
(0.6)
P 		372.2
(-3)
P 		372
(-3)
P 		385.5
(-2.8)
P 		344
avr 592.3
(1.4) 		673.4
(3) 		517.9
(-0) 		408.2
(-2.1) 		484.3
(-0.7) 		362.7
(-3) 		311
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 190943_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.4495
Sequence Type Exemplar sequence
Representative Public ID ZK669.4 NCBI
Target Description ZK669.4 /REP_DB=WormBase Gene ID /WP=CE01115 /TR=Q23571 /GB=CAA85465.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=lipoamide acyltransferase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_063269(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_063269 NCBI Caenorhabditis elegans ZK669.4 (ZK669.4) mRNA, complete cds. 11/11 None
SNAP00000000893 ENSEMBL cdna:SNAP chromosome:CEL140:II:7942800:7945097:-1 11/11 None
GENEFINDER00000000900 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:7942800:7945097:-1 11/11 None
ZK669.4.1 ENSEMBL cdna:known chromosome:CEL140:II:7942535:7945128:-1 gene:ZK669.4 11/11 None
ZK669.4.2 ENSEMBL cdna:known chromosome:CEL140:II:7942535:7945130:-1 gene:ZK669.4 11/11 None
ZK669.4.3 ENSEMBL cdna:known chromosome:CEL140:II:7942535:7945130:-1 gene:ZK669.4 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:7942796-7945094(-) 100.0 100.0
Public Domain and Genome References
Gene Title lipoamide acyltransferase
Ensembl ZK669.4
Entrez Gene 174279 Entrez gene
SwissProt Q23571 EMBL-EBI
WormBase CE01115 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:258527_AT branched chain alpha-keto acid dehydrogenase E2 subunit (din3) at
CANINE_2:CFAAFFX.30636.1.S1_AT similar to Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) (E2) (Dihydrolipoamide branched chain transacylase) (BCKAD ... cfa
CANINE_2:CFAAFFX.30638.1.S1_S_AT similar to Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) (E2) (Dihydrolipoamide branched chain transacylase) (BCKAD ... cfa
DROSOPHILA_2:1625125_AT dm
DROSGENOME1:155026_AT dm
CHICKEN:GGA.187.1.S1_AT dihydrolipoamide branched chain transacylase E2 gga
CHICKEN:GGA.187.2.S1_A_AT dihydrolipoamide branched chain transacylase E2 gga
HG-U133_PLUS_2:205369_X_AT dihydrolipoamide branched chain transacylase E2 hs
HG-U133A:205369_X_AT dihydrolipoamide branched chain transacylase E2 hs
HG-U133A_2:205369_X_AT dihydrolipoamide branched chain transacylase E2 hs
HG-U133_PLUS_2:211196_AT dihydrolipoamide branched chain transacylase E2 hs
HG-U133A:211196_AT dihydrolipoamide branched chain transacylase E2 hs
HG-U133A_2:211196_AT dihydrolipoamide branched chain transacylase E2 hs
HG-U133_PLUS_2:205370_X_AT dihydrolipoamide branched chain transacylase E2 hs
HG-U133A_2:205370_X_AT dihydrolipoamide branched chain transacylase E2 hs
HG-U133A:205370_X_AT dihydrolipoamide branched chain transacylase E2 hs
HG-U133_PLUS_2:205371_S_AT dihydrolipoamide branched chain transacylase E2 hs
HG-FOCUS:205371_S_AT dihydrolipoamide branched chain transacylase E2 hs
HG-U133A_2:205371_S_AT dihydrolipoamide branched chain transacylase E2 hs
HG-U133A:205371_S_AT dihydrolipoamide branched chain transacylase E2 hs
HU35KSUBA:X66785_F_AT dihydrolipoamide branched chain transacylase E2 hs
HU35KSUBA:X66785_I_AT dihydrolipoamide branched chain transacylase E2 hs
HU35KSUBA:HUM_ALU_AT dihydrolipoamide branched chain transacylase E2 hs
HU35KSUBB:HUM_ALU_AT dihydrolipoamide branched chain transacylase E2 hs
HU35KSUBC:HUM_ALU_AT dihydrolipoamide branched chain transacylase E2 hs
HU35KSUBD:HUM_ALU_AT dihydrolipoamide branched chain transacylase E2 hs
HUGENEFL:HUM_ALU_AT dihydrolipoamide branched chain transacylase E2 hs
HC-G110:HUM_ALU_AT dihydrolipoamide branched chain transacylase E2 hs
HUGENEFL:X66785_AT dihydrolipoamide branched chain transacylase E2 hs
HUGENEFL:M27093_S_AT dihydrolipoamide branched chain transacylase E2 hs
HUGENEFL:M19301_AT dihydrolipoamide branched chain transacylase E2 hs
U133_X3P:G736674_3P_A_AT dihydrolipoamide branched chain transacylase E2 hs
U133_X3P:G4503264_3P_AT dihydrolipoamide branched chain transacylase E2 hs
U133_X3P:G186635_3P_X_AT dihydrolipoamide branched chain transacylase E2 hs
U133_X3P:G186635_3P_AT dihydrolipoamide branched chain transacylase E2 hs
U133_X3P:G186635_3P_A_AT dihydrolipoamide branched chain transacylase E2 hs
U133_X3P:G179353_3P_X_AT dihydrolipoamide branched chain transacylase E2 hs
U133_X3P:G179353_3P_A_AT dihydrolipoamide branched chain transacylase E2 hs
U133_X3P:211196_3P_AT dihydrolipoamide branched chain transacylase E2 hs
U133_X3P:205369_3P_X_AT dihydrolipoamide branched chain transacylase E2 hs
HG-U95AV2:37862_AT dihydrolipoamide branched chain transacylase E2 hs
HG-U95D:70202_AT Dihydrolipoamide branched chain transacylase E2 hs
MU11KSUBA:L42996_S_AT dihydrolipoamide branched chain transacylase E2 mm
MG-U74AV2:98966_AT dihydrolipoamide branched chain transacylase E2 mm
MOE430A:1449118_AT dihydrolipoamide branched chain transacylase E2 mm
MOUSE430A_2:1449118_AT dihydrolipoamide branched chain transacylase E2 mm
MOUSE430_2:1449118_AT dihydrolipoamide branched chain transacylase E2 mm
MOUSE430_2:1440016_AT Dihydrolipoamide branched chain transacylase E2 (Dbt), mRNA mm
MOE430B:1440016_AT Dihydrolipoamide branched chain transacylase E2 (Dbt), mRNA mm
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
8152 metabolism inferred from electronic annotation QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
5576 extracellular region inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
5179 hormone activity inferred from electronic annotation QuickGO AmiGO
5515 protein binding inferred from electronic annotation QuickGO AmiGO
8415 acyltransferase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA85465 Hypothetical protein ZK669.4 [Caenorhabditis elegans] ref|NP_495670.1| ZK669.4 [Caenorhabditis elegans] 0.0
blast CAE59815 Hypothetical protein CBG03281 [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR004167 EMBL-EBI E3 binding 6.1E-23
Pfam IPR001078 EMBL-EBI Catalytic domain of components of various dehydrogenase complexes 7.4E-111
Pfam IPR000089 EMBL-EBI Biotin/lipoyl attachment 2.1E-19
Sequence
Target Sequence 
>C. ELEGANS:190943_AT
ttgagctacatgccattcttcatcaaagctgcttctttagctcttctcgaatacccatct
ttgaattctacaactgatgagaaaatggaaaatgttatacataaggcttctcacaatatt
tgtctcgccatggacacaccaggagggcttgttgtaccgaatatcaaaaactgtgagcaa
agaagtatctttgaaattgctcaagagctcaatcgtcttctggaggctggaaagaaacag
caaattaagagagaagatttgattgatggaactttctcattgagcaatattggaaatatc
ggtggaacctacgcctctccagttgtcttcccaccacaagtggctattggagcaattgga
aaaatcgaaaaactcccacgattcgataaacatgacaatgtcatccctgtgaacatcatg
aaagtttcgtggtgcgcagatcaccgagttgtggacggagctacaatggctcgcttcagc
aatcgctggaag

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TTGAGCTACATGCCATTCTTCATCA 39 705 823 Antisense
CAAAGCTGCTTCTTTAGCTCTTCTC 250 193 846 Antisense
CTCTTCTCGAATACCCATCTTTGAA 102 231 863 Antisense
GGCTTCTCACAATATTTGTCTCGCC 432 537 927 Antisense
TATTTGTCTCGCCATGGACACACCA 435 661 939 Antisense
GACACACCAGGAGGGCTTGTTGTAC 633 365 955 Antisense
AAATATCGGTGGAACCTACGCCTCT 178 115 1116 Antisense
GTCTTCCCACCACAAGTGGCTATTG 526 445 1147 Antisense
GTGCGCAGATCACCGAGTTGTGGAC 415 479 1254 Antisense
GGACGGAGCTACAATGGCTCGCTTC 237 523 1275 Antisense
GGCTCGCTTCAGCAATCGCTGGAAG 425 539 1290 Antisense
Sequence Source Affymetrix Proprietary Database