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[190918_at] Bacterial mutT protein

Description Y37H9A.6 /REP_DB=WormBase Gene ID /WP=CE20230 /TR=Q9U2M7 /GB=CAB63351.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=Bacterial mutT protein
Cluster 6grp_highest_10_10 > 58      6grp_high1_10_10 > 84      4grp_highest_8_8 > 14      4grp_high_8_8 > 22      6grp_highest_nonorm > 64      6grp_total > 75      4grp_total > 09      6grp_cgc > 67      6grp_cgc_sub > In      4grp_rule_based > L4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 733
1 2 3 4 range
A 571.2
(-3)
P 		743.9
(-1.5)
P 		688.3
(-2)
P 		1247
(3)
P 		676
B 633.8
(-3)
P 		704.4
(-2.2)
P 		887.2
(-0)
P 		1145.9
(3)
P 		512
C 545.3
(-3)
P 		702.7
(-1.7)
P 		694.1
(-1.8)
P 		1278.3
(3)
P 		733
avr 583.4
(-3) 		717
(-1.7) 		756.5
(-1.4) 		1223.7
(3) 		640

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 471
1 2 3 4 5 6 range
A 704.3
(-2.2)
P 		665.6
(-3)
P 		838.7
(0.6)
P 		950.6
(3)
P 		873.9
(1.4)
P 		912
(2.2)
P 		285
B 706.3
(-1.2)
P 		613.1
(-3)
P 		918.1
(3)
P 		852.3
(1.7)
P 		811.2
(0.9)
P 		904.2
(2.7)
P 		305
C 635.5
(-3)
P 		716.1
(-1.9)
P 		775.6
(-1.1)
P 		971.2
(1.5)
P 		865.6
(0.1)
P 		1083.6
(3)
P 		448
avr 682
(-2.7) 		664.9
(-3) 		844.1
(0.6) 		924.7
(2.2) 		850.2
(0.7) 		966.6
(3) 		302
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 83
1 2 3 4 range
A 208
(3)
P 		161.5
(-3)
P 		179.9
(-0.6)
P 		182.5
(-0.3)
P 		47
B 202.1
(-0.6)
P 		174
(-3)
P 		205.6
(-0.3)
P 		244.2
(3)
P 		70
C 180.5
(-3)
P 		202
(-0.9)
P 		241.9
(3)
P 		215.5
(0.4)
P 		61
avr 196.9
(0) 		179.2
(-3) 		209.1
(2.1) 		214.1
(3) 		35

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 233
1 2 3 4 5 6 range
A 129.8
(-3)
P 		236.7
(1.8)
P 		182.6
(-0.6)
P 		241.1
(2)
P 		263.7
(3)
P 		222
(1.1)
P 		134
B 245.8
(-1.1)
P 		204.1
(-3)
P 		222.9
(-2.2)
P 		225.8
(-2)
P 		329.6
(2.7)
P 		337.2
(3)
P 		133
C 235.5
(-1.6)
P 		218.5
(-2.2)
P 		197.4
(-2.9)
P 		195.3
(-3)
P 		280.1
(0)
P 		362.7
(3)
P 		167
avr 203.7
(-2.8) 		219.8
(-1.9) 		201
(-3) 		220.7
(-1.9) 		291.1
(2.1) 		307.3
(3) 		106
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 190918_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.2364
Sequence Type Exemplar sequence
Representative Public ID Y37H9A.6 NCBI
Target Description Y37H9A.6 /REP_DB=WormBase Gene ID /WP=CE20230 /TR=Q9U2M7 /GB=CAB63351.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=Bacterial mutT protein
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_061012(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_061012 NCBI Caenorhabditis elegans NuDiX family member (ndx-4) (ndx-4) mRNA, complete cds. 11/11 None
GENEFINDER00000010053 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:13800857:13805709:-1 11/11 None
Y37H9A.6.1 ENSEMBL cdna:known chromosome:CEL140:I:13800763:13802270:-1 gene:Y37H9A.6 11/11 None
Y37H9A.6.2 ENSEMBL cdna:known chromosome:CEL140:I:13800776:13802272:-1 gene:Y37H9A.6 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000010048 6/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:13800787-13802189(-) 100.0 100.0
Public Domain and Genome References
Gene Title Bacterial mutT protein
Gene Symbol ndx-4
Ensembl Y37H9A.6
Entrez Gene 189639 Entrez gene
SwissProt Q9U2M7 EMBL-EBI
WormBase CE20230 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1585352_S_AT similar to Bis(5-nucleosyl)-tetraphosphatase [Asymmetrical] (Diadenosine 5,5-P1,P4-tetraphosphate asymmetrical hydrolase) (Diadenosine tetraphosphatase) (Ap4A hydrolase) (Ap4Aase) (Nucleoside diphosphate-linked moiety X motif 2) (Nudix motif 2)... cfa
CANINE_2:CFA.11231.1.A1_AT similar to Bis(5-nucleosyl)-tetraphosphatase [Asymmetrical] (Diadenosine 5,5-P1,P4-tetraphosphate asymmetrical hydrolase) (Diadenosine tetraphosphatase) (Ap4A hydrolase) (Ap4Aase) (Nucleoside diphosphate-linked moiety X motif 2) (Nudix motif 2)... cfa
CANINE_2:CFAAFFX.3791.1.S1_AT similar to Bis(5-nucleosyl)-tetraphosphatase [Asymmetrical] (Diadenosine 5,5-P1,P4-tetraphosphate asymmetrical hydrolase) (Diadenosine tetraphosphatase) (Ap4A hydrolase) (Ap4Aase) (Nucleoside diphosphate-linked moiety X motif 2) (Nudix motif 2)... cfa
CANINE_2:CFAAFFX.3791.1.S1_S_AT similar to Bis(5-nucleosyl)-tetraphosphatase [Asymmetrical] (Diadenosine 5,5-P1,P4-tetraphosphate asymmetrical hydrolase) (Diadenosine tetraphosphatase) (Ap4A hydrolase) (Ap4Aase) (Nucleoside diphosphate-linked moiety X motif 2) (Nudix motif 2)... cfa
CHICKEN:GGA.12541.1.S1_AT nudix (nucleoside diphosphate linked moiety X)-type motif 2 gga
HG-U133_PLUS_2:218609_S_AT nudix (nucleoside diphosphate linked moiety X)-type motif 2 hs
HG-U133A:218609_S_AT nudix (nucleoside diphosphate linked moiety X)-type motif 2 hs
HG-FOCUS:218609_S_AT nudix (nucleoside diphosphate linked moiety X)-type motif 2 hs
HG-U133A_2:218609_S_AT nudix (nucleoside diphosphate linked moiety X)-type motif 2 hs
HUGENEFL:U30313_AT nudix (nucleoside diphosphate linked moiety X)-type motif 2 hs
U133_X3P:G4502124_3P_S_AT nudix (nucleoside diphosphate linked moiety X)-type motif 2 hs
HG-U95E:78494_AT nudix (nucleoside diphosphate linked moiety X)-type motif 2 hs
MG-U74BV2:108551_AT nudix (nucleoside diphosphate linked moiety X)-type motif 2 mm
MOE430A:1418737_AT nudix (nucleoside diphosphate linked moiety X)-type motif 2 mm
MOUSE430A_2:1418737_AT nudix (nucleoside diphosphate linked moiety X)-type motif 2 mm
MOUSE430_2:1418737_AT nudix (nucleoside diphosphate linked moiety X)-type motif 2 mm
MU19KSUBB:TC30850_AT Nudix (nucleoside diphosphate linked moiety X)-type motif 2, mRNA (cDNA clone MGC:35745 IMAGE:4236805) mm
RG-U34B:RC_AA924072_AT nudix (nucleoside diphosphate linked moiety X)-type motif 2 rn
RAE230B:1377602_AT nudix (nucleoside diphosphate linked moiety X)-type motif 2 rn
RAT230_2:1377602_AT nudix (nucleoside diphosphate linked moiety X)-type motif 2 rn
RG-U34C:RC_AI236901_AT Nudix (nucleoside diphosphate linked moiety X)-type motif 2 rn
Gene Ontology
GO Molecular Function (view graph)
ID Description Evidence Links
8796 bis(5'-nucleosyl)-tetraphosphatase activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB63351 Hypothetical protein Y37H9A.6 [Caenorhabditis elegans] ref|NP_493413.1| NuDiX family member (ndx-4) [Caenorhabditis elegans] sp|Q9U2M7|AP4A_CAEEL Bis(5'-nucleosyl)-tetraphosphatase [Asymmetrical] (Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase) (Diadenosine tetraphosphatase) (Ap4A hydrolase) (Ap4Aase) pdb|1KTG|B Chain B, Crystal Structure Of A C. Elegans Ap4a Hydrolase Binary Complex pdb|1KTG|A Chain A, Crystal Structure Of A C. Elegans Ap4a Hydrolase Binary Complex pdb|1KT9|A Chain A, Crystal Structure Of C. Elegans Ap4a Hydrolase 7.0E-79
blast CAB63351 Hypothetical protein Y37H9A.6 [Caenorhabditis elegans] ref|NP_493413.1| NuDiX family member (ndx-4) [Caenorhabditis elegans] sp|Q9U2M7|AP4A_CAEEL Bis(5'-nucleosyl)-tetraphosphatase [Asymmetrical] (Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase) (Diadenosine tetraphosphatase) (Ap4A hydrolase) (Ap4Aase) pdb|1KTG|B Chain B, Crystal Structure Of A C. Elegans Ap4a Hydrolase Binary Complex pdb|1KTG|A Chain A, Crystal Structure Of A C. Elegans Ap4a Hydrolase Binary Complex pdb|1KT9|A Chain A, Crystal Structure Of C. Elegans Ap4a Hydrolase 8.0E-78
blast CAE68019 Hypothetical protein CBG13634 [Caenorhabditis briggsae] 5.0E-70
blast CAE68019 Hypothetical protein CBG13634 [Caenorhabditis briggsae] 5.0E-69
blast AAK73892 Hypothetical protein T06A10.2 [Caenorhabditis elegans] ref|NP_503001.3| T06A10.2 [Caenorhabditis elegans] 2.0E-60
blast EAA12242 ENSANGP00000019921 [Anopheles gambiae str. PEST] ref|XP_316948.2| ENSANGP00000019921 [Anopheles gambiae str. PEST] 4.0E-34
Protein Domains
Database ID Description E-Value
Pfam IPR002673 EMBL-EBI Ribosomal L29e protein 5.1E-11
Pfam IPR000086 EMBL-EBI NUDIX hydrolase 2.1E-25
Pfam IPR000086 EMBL-EBI NUDIX hydrolase 2.1E-25
Trans Membrane
ID Number Of Domains Domain Boundaries
GENEFINDER00000010053 2 72-94,101-123
Sequence
Target Sequence 
>C. ELEGANS:190918_AT
aaaagccgcgggacttgtgatctaccggaagttggcgggaaaaatcgagtttctcctgct
tcaagcctcctatccaccacatcactggaccccaccaaaaggtcacgtggatccaggaga
agatgaatggcaggcggcaattcgtgagactaaggaagaagctaatattacaaaagagca
actgacaattcatgaagattgtcatgaaacactcttttatgaggcaaaagggaagccaaa
atcagtgaaatattggctcgccaagctcaacaatccagacgacgttcaactatctcatga
acatcaaaattggaaatggtgtgaattggaagatgctatcaaaattgccgattacgctga
aatgggcagccttctccgc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AAAAGCCGCGGGACTTGTGATCTAC 239 131 21 Antisense
GTGATCTACCGGAAGTTGGCGGGAA 189 485 37 Antisense
AAAATCGAGTTTCTCCTGCTTCAAG 106 133 61 Antisense
CACTGGACCCCACCAAAAGGTCACG 369 197 103 Antisense
AAAGGTCACGTGGATCCAGGAGAAG 516 121 118 Antisense
ATGGCAGGCGGCAATTCGTGAGACT 266 53 147 Antisense
AATCAGTGAAATATTGGCTCGCCAA 306 169 260 Antisense
CTCGCCAAGCTCAACAATCCAGACG 209 233 277 Antisense
TCCAGACGACGTTCAACTATCTCAT 708 589 294 Antisense
CAAAATTGCCGATTACGCTGAAATG 483 189 360 Antisense
CGCTGAAATGGGCAGCCTTCTCCGC 535 253 375 Antisense
Sequence Source Affymetrix Proprietary Database