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[190861_at] zinc metalloprotease

Description C05D11.6 /REP_DB=WormBase Gene ID /WP=CE01136 /TR=SW:P55112 /GB=AAB53827.1 /SUBMIT=ST.LOUIS /CHR=3 /FEA=Sanger Annotation /DEF=zinc metalloprotease
Cluster 6grp_highest_10_10 > 08      6grp_high1_10_10 > 80      4grp_highest_8_8 > 01      4grp_high_8_8 > 45      6grp_highest_nonorm > 71      6grp_total > 82      4grp_total > 50      6grp_cgc > 74      6grp_high1_sub > 02_03_04_05      6grp_cgc_sub > 02_03_04_05      4grp_rule_based > L2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 674
1 2 3 4 range
A 66.9
(-3)
P 		740.5
(3)
P 		469.4
(0.6)
P 		98.2
(-2.7)
P 		674
B 134.1
(-2.6)
P 		676.9
(3)
P 		547.8
(1.7)
P 		90.9
(-3)
P 		586
C 94.1
(-2.8)
P 		728.7
(3)
P 		572.2
(1.6)
P 		69.9
(-3)
P 		659
avr 98.4
(-2.9) 		715.4
(3) 		529.8
(1.2) 		86.3
(-3) 		629

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 366
1 2 3 4 5 6 range
A 230.4
(-1.9)
P 		462
(2.7)
P 		378.6
(1)
P 		458.6
(2.6)
P 		478.9
(3)
P 		172.9
(-3)
P 		306
B 249.9
(-1)
P 		466.1
(2.9)
P 		357.4
(0.9)
P 		351.5
(0.8)
P 		474.2
(3)
P 		134.4
(-3)
P 		340
C 228.5
(-2.1)
P 		473
(2.5)
P 		315.2
(-0.5)
P 		500.7
(3)
P 		423.9
(1.6)
P 		182.3
(-3)
P 		318
avr 236.3
(-1.6) 		467
(3) 		350.4
(0.7) 		436.9
(2.4) 		459
(2.8) 		163.2
(-3) 		304
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 198
1 2 3 4 range
A 24.4
(-2.6)
P 		160.7
(3)
P 		122.7
(1.4)
P 		14.4
(-3)
P 		146
B 42.8
(-2.1)
P 		167.2
(3)
P 		126.9
(1.4)
P 		19.4
(-3)
P 		148
C 31.2
(-2.4)
P 		209.5
(3)
P 		199.4
(2.7)
P 		11.8
(-3)
P 		198
avr 32.8
(-2.4) 		179.1
(3) 		149.7
(1.9) 		15.2
(-3) 		164

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 151
1 2 3 4 5 6 range
A 42.5
(-3)
P 		164.3
(3)
P 		82.5
(-1)
P 		116.3
(0.6)
P 		144.5
(2)
P 		42.1
(-3)
P 		122
B 87
(-1.4)
P 		155.1
(1.4)
P 		86.8
(-1.5)
P 		93.1
(-1.2)
P 		192.6
(3)
P 		50.1
(-3)
P 		143
C 84.7
(-1.3)
P 		144.3
(3)
P 		80.2
(-1.6)
P 		100.7
(-0.1)
P 		137.2
(2.5)
P 		61
(-3)
P 		83
avr 71.4
(-1.9) 		154.6
(2.8) 		83.2
(-1.2) 		103.4
(-0.1) 		158.1
(3) 		51.1
(-3) 		107
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 190861_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.6788
Sequence Type Exemplar sequence
Representative Public ID C05D11.6 NCBI
Target Description C05D11.6 /REP_DB=WormBase Gene ID /WP=CE01136 /TR=SW:P55112 /GB=AAB53827.1 /SUBMIT=ST.LOUIS /CHR=3 /FEA=Sanger Annotation /DEF=zinc metalloprotease
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_066004(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_066004 NCBI Caenorhabditis elegans Nematode AStacin protease family member (nas-4) (nas-4) mRNA, complete cds. 11/11 None
GENEFINDER00000019461 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:6412699:6414481:-1 11/11 None
C05D11.6 ENSEMBL cdna:known chromosome:CEL140:III:6411536:6414929:-1 gene:C05D11.6 11/11 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
SNAP00000019450 7/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:6412697-6414792(-) 100.0 100.0
Public Domain and Genome References
Gene Title zinc metalloprotease
Gene Symbol nas-4
Ensembl C05D11.6
Entrez Gene 182259 Entrez gene
SwissProt P55112 EMBL-EBI
WormBase CE37080 Wormbase
Functional Annotations
Ortholog
ID Title Organism
DROSOPHILA_2:1625104_AT dm
DROSGENOME1:150438_AT dm
CHICKEN:GGAAFFX.5056.1.S1_AT similar to astacin like metalloendopeptidase gga
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
8237 metallopeptidase activity inferred from electronic annotation QuickGO AmiGO
8270 zinc ion binding inferred from electronic annotation QuickGO AmiGO
8533 astacin activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAB53827 Nematode astacin protease protein 4 [Caenorhabditis elegans] ref|NP_498405.2| Nematode AStacin protease family member (nas-4) [Caenorhabditis elegans] sp|P55112|NAS4_CAEEL Zinc metalloproteinase nas-4 precursor (Nematode astacin 4) 1.0E-173
blast AAB53827 Nematode astacin protease protein 4 [Caenorhabditis elegans] ref|NP_498405.2| Nematode AStacin protease family member (nas-4) [Caenorhabditis elegans] sp|P55112|NAS4_CAEEL Zinc metalloproteinase nas-4 precursor (Nematode astacin 4) 1.0E-150
blast CAE72486 Hypothetical protein CBG19665 [Caenorhabditis briggsae] 1.0E-147
blast CAE72486 Hypothetical protein CBG19665 [Caenorhabditis briggsae] 1.0E-145
blast CAD99204 NAS-4 protein [Caenorhabditis elegans] 1.0E-124
blast CAD99204 NAS-4 protein [Caenorhabditis elegans] 1.0E-118
Protein Domains
Database ID Description E-Value
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 1.7E-118
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 1.7E-118
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_498405.2 1 7-24
C05D11.6 1 7-24
Sequence
Target Sequence 
>C. ELEGANS:190861_AT
acaccctgtcttcacaatacggttcctatgcaagaagtgtgattgccaacgcaatgaacg
aatatcatacaaaaacatgtgtcaaattcgttgccagagatccatcgaagcatcacgatt
atctatggattcatccagacgaaggatgttacagtttggttggaaaaaccggaggaaagc
agccagtgtctttggattctggatgtattcaagttggaacaattgttcacgagctgatgc
atgctgttgggttcttccatgagcagagcagacaagaccgtgacagttatatcgacgtag
tctggcagaatgtgatgaacggcgctgatgatcaatttgagaaatacaacttgaatgtga
tttcccatttggatgaaccatatgactacgcttccattatgcattacggaccatacgcat
tcagtggatccggaaagaagacattggtgccaaagaagtctgggtccgaacgtatgggtc
agcgtgtcaagttttctgacattgacgttagaaagatcaataagctatacaattgtccag
gagtctccggta

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
ACACCCTGTCTTCACAATACGGTTC 13 111 401 Antisense
TCAAATTCGTTGCCAGAGATCCATC 333 629 482 Antisense
AAGCAGCCAGTGTCTTTGGATTCTG 107 147 577 Antisense
GTTCACGAGCTGATGCATGCTGTTG 415 443 625 Antisense
GCTGTTGGGTTCTTCCATGAGCAGA 458 295 643 Antisense
GCAGAGCAGACAAGACCGTGACAGT 585 311 663 Antisense
GACTACGCTTCCATTATGCATTACG 450 373 784 Antisense
GCATTACGGACCATACGCATTCAGT 136 307 801 Antisense
GAAGTCTGGGTCCGAACGTATGGGT 159 331 855 Antisense
GTATGGGTCAGCGTGTCAAGTTTTC 487 455 872 Antisense
TACAATTGTCCAGGAGTCTCCGGTA 535 641 928 Antisense
Sequence Source Affymetrix Proprietary Database