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[190811_at] Probable rabGAP domains

Description Y48E1C.3 /REP_DB=WormBase Gene ID /WP=CE14882 /TR=O18207 /GB=CAB07701.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=Probable rabGAP domains
Cluster 6grp_highest_10_10 > 20      6grp_high1_10_10 > 14      4grp_highest_8_8 > 16      4grp_high_8_8 > 60      6grp_highest_nonorm > 71      6grp_total > 04      4grp_total > 59      6grp_highest_sub > De      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 204
1 2 3 4 range
A 360.1
(-0.2)
P 		404.3
(3)
P 		376.7
(1)
P 		320.6
(-3)
P 		84
B 363.1
(3)
P 		257.7
(-1.5)
P 		328.8
(1.5)
P 		222.6
(-3)
P 		141
C 317.8
(-2.5)
P 		426.4
(3)
P 		409.8
(2.2)
P 		307.1
(-3)
P 		119
avr 347
(1.3) 		362.8
(2.4) 		371.8
(3) 		283.4
(-3) 		88

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 311
1 2 3 4 5 6 range
A 532.6
(3)
P 		292.2
(-1.8)
P 		250.1
(-2.6)
P 		315.5
(-1.3)
P 		297.6
(-1.6)
P 		229
(-3)
P 		304
B 305
(-2.5)
P 		540.4
(3)
P 		359.1
(-1.3)
P 		285.3
(-3)
P 		412
(-0)
P 		312.3
(-2.4)
P 		255
C 407.9
(3)
P 		342.9
(0.8)
P 		287.8
(-1.1)
P 		358.6
(1.3)
P 		300.7
(-0.6)
P 		230.7
(-3)
P 		177
avr 415.2
(3) 		391.8
(2.1) 		299
(-1.4) 		319.8
(-0.6) 		336.8
(0) 		257.3
(-3) 		158
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 96
1 2 3 4 range
A 131.1
(3)
P 		87.8
(-0.1)
P 		98.5
(0.7)
P 		46.9
(-3)
P 		84
B 115.8
(3)
P 		63.6
(-1.6)
P 		76.2
(-0.5)
P 		47.4
(-3)
P 		68
C 105.2
(0.5)
P 		122.6
(1.7)
P 		142.8
(3)
P 		51.8
(-3)
P 		91
avr 117.4
(3) 		91.3
(0.7) 		105.8
(2) 		48.7
(-3) 		69

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 125
1 2 3 4 5 6 range
A 98.2
(2.3)
P 		103.9
(3)
P 		54.5
(-3)
P 		80
(0.1)
P 		89.8
(1.3)
P 		55.8
(-2.8)
P 		49
B 106.1
(-1.2)
P 		179.9
(3)
P 		87.2
(-2.3)
P 		75.6
(-3)
P 		167.4
(2.3)
P 		116.4
(-0.7)
P 		104
C 151.2
(3)
P 		104.6
(-0.5)
P 		73.3
(-2.9)
P 		72.1
(-3)
P 		97.3
(-1.1)
P 		77.2
(-2.6)
P 		79
avr 118.5
(1.9) 		129.5
(3) 		71.7
(-3) 		75.9
(-2.6) 		118.2
(1.8) 		83.1
(-1.8) 		58
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 190811_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.3040
Sequence Type Exemplar sequence
Representative Public ID Y48E1C.3 NCBI
Target Description Y48E1C.3 /REP_DB=WormBase Gene ID /WP=CE14882 /TR=O18207 /GB=CAB07701.1 /SUBMIT=HINXTON /CHR=2 /FEA=Sanger Annotation /DEF=Probable rabGAP domains
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Genome Target Overlap based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade B annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_182167
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_182167 NCBI Caenorhabditis elegans Y48E1C.3 (Y48E1C.3) mRNA, complete cds. None
GENEFINDER00000029074 ENSEMBL cdna:GeneFinder chromosome:CEL140:II:13437232:13440805:-1 None
Y48E1C.3 ENSEMBL cdna:known chromosome:CEL140:II:13437494:13441302:-1 gene:Y48E1C.3 None
Annotation Notes
Cross Hybridizing mRNA Matched Probes Nature of Assignment Related Probesets by Grade
NM_182206 6/11 Cross Hyb Matching Probes None
NM_064429 7/11 Cross Hyb Matching Probes None
GENEFINDER00000029076 8/11 Cross Hyb Matching Probes None
Y48E1C.4b 8/11 Cross Hyb Matching Probes None
Y48E1C.4a 8/11 Cross Hyb Matching Probes None
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrII:13433640-13441299(-) 98.49 100.0
Public Domain and Genome References
Gene Title Probable rabGAP domains
Ensembl Y48E1C.3
Entrez Gene 3565412 Entrez gene
SwissProt O18207 EMBL-EBI
WormBase CE32976 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:248313_AT RabGAP/TBC domain-containing protein at
CANINE:1588981_AT similar to TBC1 domain family, member 15 cfa
CANINE_2:CFA.9163.1.S1_S_AT similar to TBC1 domain family, member 15 cfa
CANINE_2:CFAAFFX.1657.1.S1_AT similar to TBC1 domain family, member 15 cfa
DROSOPHILA_2:1627598_AT dm
DROSGENOME1:154389_AT dm
CHICKEN:GGA.17199.1.S1_S_AT TBC1 domain family, member 15 gga
HG-U133_PLUS_2:218268_AT TBC1 domain family, member 15 hs
HG-U133A:218268_AT TBC1 domain family, member 15 hs
HG-U133A_2:218268_AT TBC1 domain family, member 15 hs
HU35KSUBA:RC_AA608723_AT TBC1 domain family, member 15 hs
HU35KSUBC:RC_AA398158_AT TBC1 domain family, member 15 hs
HU35KSUBD:RC_AA424814_AT TBC1 domain family, member 15 hs
U133_X3P:G12232450_3P_AT TBC1 domain family, member 15 hs
HG-U95B:46955_AT TBC1 domain family, member 15 hs
HG-U95C:64420_AT TBC1 domain family, member 15 hs
HG-U95E:76716_AT TBC1 domain family, member 15 hs
HG-U133_PLUS_2:230072_AT TBC1 domain family, member 15 hs
HG-U133B:230072_AT TBC1 domain family, member 15 hs
HG-U95C:66209_R_AT TBC1 domain family, member 15 hs
HG-U95E:70482_AT TBC1 domain family, member 15 hs
HG-U95E:82931_AT TBC1 domain family, member 15 hs
HU35KSUBB:RC_AA056258_AT TBC1 domain family, member 15 hs
U133_X3P:HS.146220.0.A1_3P_AT TBC1 domain family, member 15 hs
MU11KSUBA:AA426777_AT TBC1 domain family, member 15 mm
MG-U74AV2:104283_AT TBC1 domain family, member 15 mm
MG-U74AV2:103471_AT TBC1 domain family, member 15 mm
MOE430A:1416061_AT TBC1 domain family, member 15 mm
MOUSE430A_2:1416061_AT TBC1 domain family, member 15 mm
MOUSE430_2:1416061_AT TBC1 domain family, member 15 mm
MOE430A:1416062_AT TBC1 domain family, member 15 mm
MOUSE430A_2:1416062_AT TBC1 domain family, member 15 mm
MOUSE430_2:1416062_AT TBC1 domain family, member 15 mm
MOE430A:1416060_AT TBC1 domain family, member 15 mm
MOUSE430A_2:1416060_AT TBC1 domain family, member 15 mm
MOUSE430_2:1416060_AT TBC1 domain family, member 15 mm
MG-U74CV2:131116_AT TBC1 domain family, member 15 (Tbc1d15), mRNA mm
MU19KSUBC:TC41359_AT TBC1 domain family, member 15 (Tbc1d15), mRNA mm
MU19KSUBC:TC41359_G_AT TBC1 domain family, member 15 (Tbc1d15), mRNA mm
RG-U34C:RC_AI171795_AT TBC1 domain family, member 15 (predicted) rn
RAE230B:1382045_AT TBC1 domain family, member 15 (predicted) rn
RAT230_2:1382045_AT TBC1 domain family, member 15 (predicted) rn
RAE230B:1385596_AT TBC1 domain family, member 15 (predicted) rn
RAT230_2:1385596_AT TBC1 domain family, member 15 (predicted) rn
Protein Similarities
Method ID Description E-Value
blast CAB07701 Hypothetical protein Y48E1C.3 [Caenorhabditis elegans] ref|NP_871967.1| Y48E1C.3 [Caenorhabditis elegans] 1.0E-136
blast CAB07701 Hypothetical protein Y48E1C.3 [Caenorhabditis elegans] ref|NP_871967.1| Y48E1C.3 [Caenorhabditis elegans] 1.0E-101
blast XP_624756 PREDICTED: similar to CG11490-PA [Apis mellifera] 7.0E-69
blast EAA12884 ENSANGP00000009947 [Anopheles gambiae str. PEST] ref|XP_317575.2| ENSANGP00000009947 [Anopheles gambiae str. PEST] 2.0E-66
blast EAA12884 ENSANGP00000009947 [Anopheles gambiae str. PEST] ref|XP_317575.2| ENSANGP00000009947 [Anopheles gambiae str. PEST] 3.0E-60
blast AAF51531 CG11490-PA [Drosophila melanogaster] gb|AAK93170.1| LD27216p [Drosophila melanogaster] ref|NP_608503.1| CG11490-PA [Drosophila melanogaster] 4.0E-59
Protein Domains
Database ID Description E-Value
Pfam IPR000195 EMBL-EBI RabGAP/TBC domain 2.8E-9
Pfam IPR000195 EMBL-EBI RabGAP/TBC domain 9.7E-9
Sequence
Target Sequence 
>C. ELEGANS:190811_AT
gactccgctagttctcaaatcaaacgttcgagattttatggacatttgcaaggacgacgt
tcaattcgacgatcgcattttttcgaaaaagttgggtggccggacacagctgatgtcaca
tatcgcgaaagttcgcattggatcggctcgtgcgtgtacgaaaacgaagacgttatcgtt
gtaatgtggcgcctcacaacactcgactcgagcttcatgtcctatttcccgtcgtttatc
accaaaaaagagaacaaaatgattgtaaaggaaggcgcgttggatgttcaaatcgatcga
gaaggacacgtgttgagaattgttaatcgaccgatcactgcatcggatcgagaaggcgcg
aaatcgctggcgaagatgaaagaagagcaacatcaggaatacgtccaggctgaggaaaag
gaaatgcggaaggagtttgatcgacaatatcataccatcttcagccagccatcagactgc
ccttttttttggg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GACTCCGCTAGTTCTCAAATCAAAC 274 375 1333 Antisense
GGACGACGTTCAATTCGACGATCGC 5 525 1384 Antisense
TGGCCGGACACAGCTGATGTCACAT 140 545 1429 Antisense
GAAAGTTCGCATTGGATCGGCTCGT 585 359 1459 Antisense
GATCGGCTCGTGCGTGTACGAAAAC 244 407 1473 Antisense
TTATCGTTGTAATGTGGCGCCTCAC 134 679 1505 Antisense
CGACTCGAGCTTCATGTCCTATTTC 306 251 1536 Antisense
GAAGGCGCGTTGGATGTTCAAATCG 411 333 1603 Antisense
TCGACCGATCACTGCATCGGATCGA 528 601 1659 Antisense
CGACAATATCATACCATCTTCAGCC 241 253 1774 Antisense
CCATCAGACTGCCCTTTTTTTTGGG 449 271 1801 Antisense
Sequence Source Affymetrix Proprietary Database