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[190789_s_at] Disintegrin

Description Y37D8A.13 /REP_DB=WormBase Gene ID /WP=CE20217 /GEN=adm-1 /TR=P90974 /GB=CAA21545.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=Disintegrin
Cluster 6grp_highest_10_10 > 83      6grp_high1_10_10 > 38      6grp_highest_nonorm > 90      6grp_total > 37      4grp_total > 52      6grp_highest_sub > Cu      6grp_cgc > 16      6grp_high1_sub > Cu      6grp_cgc_sub > Cu      6grp_total_sub > Cup      4grp_rule_based > L2      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 218
1 2 3 4 range
A 154.8
(0.9)
P 		231.9
(3)
P 		135.5
(0.3)
A 		14.1
(-3)
A 		218
B 88.1
(1.3)
P 		96.8
(3)
M 		73.4
(-1.6)
P 		66.3
(-3)
A 		31
C 123.6
(0.6)
P 		190.9
(3)
P 		89.1
(-0.6)
P 		21.5
(-3)
A 		169
avr 122.2
(0.8) 		173.2
(3) 		99.3
(-0.2) 		34
(-3) 		139

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 155
1 2 3 4 5 6 range
A 193.6
(2.9)
P 		130.8
(-0.2)
P 		84.6
(-2.5)
P 		105.5
(-1.4)
P 		74
(-3)
P 		195.9
(3)
P 		122
B 183.7
(3)
P 		158.7
(1.6)
P 		94.2
(-2.1)
P 		78.2
(-3)
P 		130
(-0.1)
P 		179
(2.7)
P 		106
C 229.4
(3)
P 		165.6
(0.2)
P 		103.9
(-2.5)
P 		113
(-2.1)
P 		91.9
(-3)
P 		144.2
(-0.7)
P 		138
avr 202.2
(3) 		151.7
(0.2) 		94.2
(-3) 		98.9
(-2.7) 		98.6
(-2.8) 		173
(1.4) 		108
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 54
1 2 3 4 range
A 56.4
(3)
P 		50.3
(2.3)
P 		35.4
(0.7)
A 		2.1
(-3)
A 		54
B 28.1
(3)
P 		23.9
(1.2)
M 		17
(-1.8)
P 		14.1
(-3)
A 		14
C 40.9
(1.4)
P 		54.9
(3)
P 		31.1
(0.2)
P 		3.6
(-3)
A 		51
avr 41.8
(2.8) 		43
(3) 		27.8
(0.5) 		6.6
(-3) 		36

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 67
1 2 3 4 5 6 range
A 35.7
(0.5)
P 		46.5
(2.8)
P 		18.4
(-3)
P 		26.8
(-1.3)
P 		22.3
(-2.2)
P 		47.7
(3)
P 		29
B 63.9
(2.6)
P 		52.8
(1.2)
P 		22.9
(-2.7)
P 		20.7
(-3)
P 		52.8
(1.2)
P 		66.7
(3)
P 		46
C 85
(3)
P 		50.5
(-0.3)
P 		26.5
(-2.6)
P 		22.7
(-3)
P 		29.7
(-2.3)
P 		48.3
(-0.5)
P 		62
avr 61.5
(3) 		49.9
(1.2) 		22.6
(-3) 		23.4
(-2.9) 		34.9
(-1.1) 		54.2
(1.9) 		39
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 190789_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.6912
Sequence Type Exemplar sequence
Representative Public ID Y37D8A.13 NCBI
Target Description Y37D8A.13 /REP_DB=WormBase Gene ID /WP=CE20217 /GEN=adm-1 /TR=P90974 /GB=CAA21545.1 /SUBMIT=HINXTON /CHR=3 /FEA=Sanger Annotation /DEF=Disintegrin
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_067279(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_067279 NCBI Caenorhabditis elegans Y37D8A.13 (Disintegrin) mRNA, complete cds. 11/11 A 
SNAP00000028781 ENSEMBL cdna:SNAP chromosome:CEL140:III:12881066:12885552:-1 10/11 None
GENEFINDER00000028801 ENSEMBL cdna:GeneFinder chromosome:CEL140:III:12881066:12886833:-1 11/11 None
Y37D8A.13 ENSEMBL cdna:known chromosome:CEL140:III:12880914:12891611:-1 gene:Y37D8A.13 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIII:12881061-12891476(-) 100.0 100.0
Public Domain and Genome References
Gene Title Disintegrin
Gene Symbol unc-71
Ensembl Y37D8A.13
Entrez Gene 176706 Entrez gene
SwissProt P90974 EMBL-EBI
WormBase CE20217 Wormbase
Functional Annotations
Ortholog
ID Title Organism
DROSOPHILA_2:1630103_AT mind-meld dm
DROSGENOME1:145166_AT mind-meld dm
CHICKEN:GGAAFFX.8074.1.S1_AT similar to ADAM 12 gga
CHICKEN:GGAAFFX.8074.2.S1_AT similar to ADAM 12 gga
CHICKEN:GGAAFFX.8074.2.S1_S_AT similar to ADAM 12 gga
CHICKEN:GGAAFFX.8079.1.S1_AT similar to ADAM 12 gga
CHICKEN:GGAAFFX.8079.2.S1_S_AT similar to ADAM 12 gga
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
6508 proteolysis inferred from sequence similarity QuickGO AmiGO
GO Cellular Component (view graph)
ID Description Evidence Links
16020 membrane inferred from direct assay QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4197 cysteine-type endopeptidase activity inferred from electronic annotation QuickGO AmiGO
4222 metalloendopeptidase activity inferred from electronic annotation QuickGO AmiGO
8237 metallopeptidase activity inferred from sequence similarity QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA21545 Hypothetical protein Y37D8A.13 [Caenorhabditis elegans] ref|NP_499680.1| Y37D8A.13 [Caenorhabditis elegans] gb|AAC47444.1| ADM-1 preproprotein [Caenorhabditis elegans] 0.0
blast CAE69554 Hypothetical protein CBG15766 [Caenorhabditis briggsae] 0.0
blast XP_624055 PREDICTED: similar to CG9163-PA, isoform A [Apis mellifera] 2.0E-94
Protein Domains
Database ID Description E-Value
Pfam IPR001762 EMBL-EBI Disintegrin 4.2E-29
Pfam IPR001590 EMBL-EBI Peptidase M12B, ADAM/reprolysin 1.8E-58
Pfam IPR001762 EMBL-EBI Disintegrin 4.2E-29
Pfam IPR001590 EMBL-EBI Peptidase M12B, ADAM/reprolysin 7.4E-64
Pfam IPR002870 EMBL-EBI Peptidase M12B, propeptide 1.2E-38
Pfam IPR001762 EMBL-EBI Disintegrin 4.2E-29
Pfam IPR001590 EMBL-EBI Peptidase M12B, ADAM/reprolysin 9.2E-74
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_499680.1 1 747-769
Y37D8A.13 1 747-769
SNAP00000028781 1 484-506
GENEFINDER00000028801 1 508-530
Sequence
Target Sequence 
>C. ELEGANS:190789_S_AT
gttggggggatacgcgatccctacgccggagagcacatctacgcagagtcctcctcaaat
catctgactcgtcaattccgtggaatcaactccgatggctcatatcctctccgatctttc
ggttcatggcgatcttcggctccaatcagtccggcttcttcctcaggccaactgactgat
gtgagcactgcgacaactccgctgaggcttaacaagattggaaaattcctgaaaacactg
caatccgacgatgaatcgccatctccgttctctgatcatcaaagtttcaccactggaatt
ggaatcggagcccgcctggagcagatgcagtttggaggcggaggagacgaagagctatcc
gcagttga

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GTTGGGGGGATACGCGATCCCTACG 533 433 2575 Antisense
GAGAGCACATCTACGCAGAGTCCTC 306 395 2603 Antisense
AGTCCTCCTCAAATCATCTGACTCG 308 61 2621 Antisense
ATCTGACTCGTCAATTCCGTGGAAT 64 35 2636 Antisense
TCCGTGGAATCAACTCCGATGGCTC 209 595 2651 Antisense
TCCTCTCCGATCTTTCGGTTCATGG 33 593 2679 Antisense
TTCTTCCTCAGGCCAACTGACTGAT 703 689 2730 Antisense
GATGTGAGCACTGCGACAACTCCGC 414 409 2752 Antisense
AACTCCGCTGAGGCTTAACAAGATT 612 141 2769 Antisense
ATCTCCGTTCTCTGATCATCAAAGT 650 33 2835 Antisense
GAGACGAAGAGCTATCCGCAGTTGA 224 393 2918 Antisense
Sequence Source Affymetrix Proprietary Database