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[190760_at] Sterol O-acyltransferase

Description B0395.2 /REP_DB=WormBase Gene ID /WP=CE02943 /TR=Q17498 /GB=CAA92217.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=Sterol O-acyltransferase
Cluster 6grp_highest_10_10 > 08      6grp_high1_10_10 > 80      4grp_highest_8_8 > 12      4grp_high_8_8 > 39      6grp_highest_nonorm > 80      6grp_total > 82      4grp_total > 41      6grp_high1_sub > 02_03_04_05      4grp_rule_based > L3      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 418
1 2 3 4 range
A 138.9
(-3)
P 		347.1
(0.9)
P 		456.8
(3)
P 		350.5
(1)
P 		318
B 96
(-3)
P 		372.5
(2)
P 		427
(3)
P 		344.1
(1.5)
P 		331
C 77.6
(-3)
P 		495.6
(3)
P 		468.2
(2.6)
P 		323.1
(0.5)
P 		418
avr 104.2
(-3) 		405.1
(2.2) 		450.7
(3) 		339.2
(1.1) 		347

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 171
1 2 3 4 5 6 range
A 121.5
(-3)
P 		226.4
(1)
P 		277.2
(3)
P 		244.4
(1.7)
P 		229.6
(1.2)
P 		132.9
(-2.6)
P 		156
B 135.2
(-2.8)
P 		262.5
(2.2)
P 		166.4
(-1.5)
P 		256.2
(2)
P 		281.9
(3)
P 		129.2
(-3)
P 		153
C 135.2
(-2.1)
P 		272.4
(3)
P 		176.4
(-0.6)
P 		260.5
(2.6)
P 		233.1
(1.5)
P 		110.5
(-3)
P 		162
avr 130.6
(-2.7) 		253.8
(3) 		206.7
(0.8) 		253.7
(3) 		248.2
(2.7) 		124.2
(-3) 		130
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 138
1 2 3 4 range
A 50.6
(-3)
P 		75.3
(-0.8)
P 		119.4
(3)
P 		51.3
(-2.9)
P 		69
B 30.6
(-3)
P 		92
(2.4)
P 		98.9
(3)
P 		73.3
(0.8)
P 		68
C 25.7
(-3)
P 		142.5
(2.1)
P 		163.2
(3)
P 		54.5
(-1.7)
P 		138
avr 35.6
(-3) 		103.3
(1.4) 		127.2
(3) 		59.7
(-1.4) 		92

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 92
1 2 3 4 5 6 range
A 22.4
(-3)
P 		80.5
(3)
P 		60.4
(0.9)
P 		62
(1.1)
P 		69.3
(1.8)
P 		32.3
(-2)
P 		58
B 47
(-2.5)
P 		87.4
(0.8)
P 		40.4
(-3)
P 		67.9
(-0.8)
P 		114.5
(3)
P 		48.2
(-2.4)
P 		74
C 50.1
(-1.3)
P 		83.1
(3)
P 		44.9
(-2)
P 		52.4
(-1)
P 		75.4
(2)
P 		37
(-3)
P 		46
avr 39.8
(-2.9) 		83.7
(2.7) 		48.6
(-1.8) 		60.8
(-0.3) 		86.4
(3) 		39.2
(-3) 		47
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 190760_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.17876
Sequence Type Exemplar sequence
Representative Public ID B0395.2 NCBI
Target Description B0395.2 /REP_DB=WormBase Gene ID /WP=CE02943 /TR=Q17498 /GB=CAA92217.1 /SUBMIT=HINXTON /CHR=X /FEA=Sanger Annotation /DEF=Sterol O-acyltransferase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_078222(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_078222 NCBI Caenorhabditis elegans B0395.2 (B0395.2) mRNA, complete cds. 11/11 None
SNAP00000033250 ENSEMBL cdna:SNAP chromosome:CEL140:X:16030736:16034591:1 11/11 None
GENEFINDER00000033252 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:16030736:16034591:1 11/11 None
B0395.2 ENSEMBL cdna:known chromosome:CEL140:X:16030720:16034713:1 gene:B0395.2 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:16030735-16034591(+) 100.0 100.0
Public Domain and Genome References
Gene Title Sterol O-acyltransferase
Ensembl B0395.2
Entrez Gene 181681 Entrez gene
SwissProt Q17498 EMBL-EBI
WormBase CE02943 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.21458.1.S1_AT similar to Sterol O-acyltransferase 1 (Cholesterol acyltransferase 1) (Acyl coenzyme A:cholesterol acyltransferase 1) (ACAT-1) cfa
DROSOPHILA_2:1636353_S_AT dm
DROSGENOME1:149518_AT dm
CHICKEN:GGAAFFX.2598.1.S1_AT similar to Sterol O-acyltransferase 1 (Cholesterol acyltransferase 1) (Acyl coenzyme A:cholesterol acyltransferase 1) (ACAT-1) gga
HG-FOCUS:221561_AT sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 hs
HG-U133A:221561_AT sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 hs
HG-U133_PLUS_2:221561_AT sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 hs
HG-U133A_2:221561_AT sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 hs
HUGENEFL:L21934_AT sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 hs
U133_X3P:G4878021_3P_AT sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 hs
HG-U95D:90190_AT sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 hs
HG-U95E:90505_R_AT sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 hs
HG-U133_PLUS_2:244661_AT Sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 hs
HG-U133B:244661_AT Sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 hs
HG-U95C:62428_AT Sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 hs
U133_X3P:HS.148376.0.A1_3P_AT Sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1 hs
MOUSE430A_2:1448068_AT sterol O-acyltransferase 1 mm
MOE430A:1448068_AT sterol O-acyltransferase 1 mm
MOUSE430_2:1448068_AT sterol O-acyltransferase 1 mm
MU11KSUBA:L42293_S_AT sterol O-acyltransferase 1 mm
MU11KSUBA:AA177204_AT sterol O-acyltransferase 1 mm
MG-U74AV2:95887_AT sterol O-acyltransferase 1 mm
MG-U74AV2:160767_AT sterol O-acyltransferase 1 mm
MG-U74CV2:167785_R_AT sterol O-acyltransferase 1 mm
MOE430A:1417695_A_AT sterol O-acyltransferase 1 mm
MOUSE430A_2:1417695_A_AT sterol O-acyltransferase 1 mm
MOUSE430_2:1417695_A_AT sterol O-acyltransferase 1 mm
MOE430A:1417697_AT sterol O-acyltransferase 1 mm
MOUSE430A_2:1417697_AT sterol O-acyltransferase 1 mm
MOUSE430_2:1417697_AT sterol O-acyltransferase 1 mm
MOE430A:1417696_AT sterol O-acyltransferase 1 mm
MOUSE430A_2:1417696_AT sterol O-acyltransferase 1 mm
MOUSE430_2:1417696_AT sterol O-acyltransferase 1 mm
MU19KSUBA:TC23903_AT Sterol O-acyltransferase 1, mRNA (cDNA clone IMAGE:4007277) mm
RG-U34A:D86373_S_AT sterol O-acyltransferase 1 rn
RAE230A:1373869_AT sterol O-acyltransferase 1 rn
RAT230_2:1373869_AT sterol O-acyltransferase 1 rn
RAE230A:1369002_AT sterol O-acyltransferase 1 rn
RAT230_2:1369002_AT sterol O-acyltransferase 1 rn
RAT230_2:1374976_A_AT Sterol O-acyltransferase 1 rn
RAE230A:1374976_A_AT Sterol O-acyltransferase 1 rn
RAE230B:1379835_AT Sterol O-acyltransferase 1 rn
RAT230_2:1379835_AT Sterol O-acyltransferase 1 rn
RG-U34B:RC_AA957535_AT Sterol O-acyltransferase 1 rn
RG-U34B:RC_AI012418_AT Sterol O-acyltransferase 1 rn
RG-U34B:RC_AI059242_AT Sterol O-acyltransferase 1 rn
RG-U34C:RC_AI103060_AT Sterol O-acyltransferase 1 rn
RG-U34C:RC_AI235919_AT Sterol O-acyltransferase 1 rn
RG-U34C:RC_AI236009_AT Sterol O-acyltransferase 1 rn
Protein Similarities
Method ID Description E-Value
blast CAA92217 Hypothetical protein B0395.2 [Caenorhabditis elegans] ref|NP_510623.1| B0395.2 [Caenorhabditis elegans] 0.0
blast CAE70002 Hypothetical protein CBG16409 [Caenorhabditis briggsae] 0.0
blast AAH83092 Sterol O-acyltransferase 1 [Mus musculus] dbj|BAE25081.1| unnamed protein product [Mus musculus] dbj|BAE35047.1| unnamed protein product [Mus musculus] dbj|BAE35563.1| unnamed protein product [Mus musculus] dbj|BAE35158.1| unnamed protein product [Mus musculus] gb|AAB36050.1| acyl-coenzyme A:cholesterol acyltransferase; ACAT [Mus sp.] 5.0E-74
Protein Domains
Database ID Description E-Value
Pfam IPR004299 EMBL-EBI Membrane bound O-acyl transferase, MBOAT 4.8E-62
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_510623.1 9 58-76,98-120,133-155,165-187,238-260,280-302,365-382,386-408,417-439
B0395.2 9 58-76,98-120,133-155,165-187,238-260,280-302,365-382,386-408,417-439
SNAP00000033250 9 58-76,98-120,133-155,165-187,238-260,280-302,365-382,386-408,417-439
GENEFINDER00000033252 9 58-76,98-120,133-155,165-187,238-260,280-302,365-382,386-408,417-439
Sequence
Target Sequence 
>C. ELEGANS:190760_AT
tacactagcctgagcttttccacaattgctctttctctgttcactggaattatccctggg
atcatttgcatgacgtcacttttctatggacttttgcactgctggttgaattgtttctct
gaaatgatgcagtttgctgataggcaattttatttgaactggtggcactcttccaacatg
gcagaatactatcgaaactggaacctggttgttcacgactggctgtacgcttacgtcttc
cgggacctggcagcttataatccaggacgaaaaggtcaacgtgccgctcaaatggcagtg
tttttcctttcggccgtattccatgaatactggtttggagtcgcattcagatgtttctac
cctgttatgttcgtactgtacttcattttcggcggaaccttctttgcagtttcccgtctt
attacaaaccgttccgcgtggaacactgctttatggtttaacttgttaattggaaccgga
atgttcattgctttctacggccaagaatggtacgcgagacgtggacactgtgccc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TACACTAGCCTGAGCTTTTCCACAA 372 643 814 Antisense
TTCTATGGACTTTTGCACTGCTGGT 294 691 895 Antisense
TTGAACTGGTGGCACTCTTCCAACA 367 703 967 Antisense
CAAATGGCAGTGTTTTTCCTTTCGG 50 193 1102 Antisense
TCCTTTCGGCCGTATTCCATGAATA 618 575 1118 Antisense
GAGTCGCATTCAGATGTTTCTACCC 328 399 1151 Antisense
GTTTCTACCCTGTTATGTTCGTACT 295 449 1166 Antisense
CGTACTGTACTTCATTTTCGGCGGA 346 239 1185 Antisense
TTTGCAGTTTCCCGTCTTATTACAA 242 669 1216 Antisense
GGAATGTTCATTGCTTTCTACGGCC 353 531 1291 Antisense
TACGCGAGACGTGGACACTGTGCCC 479 649 1324 Antisense
Sequence Source Affymetrix Proprietary Database