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[190759_at] protein-tyrosine kinase

Description C25A8.5 /REP_DB=WormBase Gene ID /WP=CE08385 /TR=Q18142 /GB=AAB03183.1 /SUBMIT=ST.LOUIS /CHR=4 /FEA=Sanger Annotation /DEF=protein-tyrosine kinase
Cluster 6grp_total > 78      4grp_total > 02      6grp_total_sub > Increase      6grp_rule_based > S6      4grp_rule_based > L4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 217
1 2 3 4 range
A 13.7
(-2.6)
A 		4.6
(-2.9)
A 		2.6
(-3)
A 		174.1
(3)
P 		172
B 3.2
(-3)
A 		9.9
(-2.8)
A 		8.6
(-2.9)
A 		219.6
(3)
P 		216
C 9.7
(-2.9)
A 		6.2
(-3)
A 		10.8
(-2.8)
A 		189.9
(3)
P 		184
avr 8.9
(-2.9) 		6.9
(-3) 		7.3
(-3) 		194.5
(3) 		188

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 73
1 2 3 4 5 6 range
A 15.8
(-1.7)
A 		9.7
(-2.2)
A 		1.4
(-3)
A 		14.1
(-1.8)
A 		18.5
(-1.4)
A 		67.2
(3)
A 		66
B 2
(-2.9)
A 		1.2
(-3)
A 		7.6
(-2.5)
A 		4.9
(-2.7)
A 		45.4
(0.6)
A 		74.1
(3)
P 		73
C 8.4
(-2.4)
A 		20.5
(-1)
A 		5.6
(-2.7)
A 		3.2
(-3)
A 		17
(-1.4)
A 		56
(3)
A 		53
avr 8.7
(-2.6) 		10.5
(-2.4) 		4.9
(-3) 		7.4
(-2.8) 		27
(-0.8) 		65.8
(3) 		61
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 46
1 2 3 4 range
A 5
(-2)
A 		1
(-2.9)
A 		0.7
(-3)
A 		25.5
(3)
P 		25
B 1
(-3)
A 		2.5
(-2.8)
A 		2
(-2.9)
A 		46.8
(3)
P 		46
C 3.2
(-2.7)
A 		1.8
(-3)
A 		3.8
(-2.6)
A 		32
(3)
P 		30
avr 3.1
(-2.8) 		1.8
(-3) 		2.2
(-2.9) 		34.8
(3) 		33

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 27
1 2 3 4 5 6 range
A 2.9
(-2)
A 		3.4
(-1.8)
A 		0.3
(-3)
A 		3.6
(-1.8)
A 		5.6
(-1)
A 		16.4
(3)
A 		16
B 0.7
(-2.9)
A 		0.4
(-3)
A 		1.8
(-2.7)
A 		1.3
(-2.8)
A 		18.5
(1)
A 		27.6
(3)
P 		27
C 3.1
(-2.2)
A 		6.3
(-1.1)
A 		1.4
(-2.7)
A 		0.6
(-3)
A 		5.5
(-1.4)
A 		18.8
(3)
A 		18
avr 2.2
(-2.7) 		3.4
(-2.3) 		1.2
(-3) 		1.8
(-2.8) 		9.9
(-0.4) 		20.9
(3) 		20
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 190759_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.9589
Sequence Type Exemplar sequence
Representative Public ID C25A8.5 NCBI
Target Description C25A8.5 /REP_DB=WormBase Gene ID /WP=CE08385 /TR=Q18142 /GB=AAB03183.1 /SUBMIT=ST.LOUIS /CHR=4 /FEA=Sanger Annotation /DEF=protein-tyrosine kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_068680(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_068680 NCBI Caenorhabditis elegans C25A8.5 (C25A8.5) mRNA, complete cds. 11/11 None
SNAP00000010522 ENSEMBL cdna:SNAP chromosome:CEL140:IV:6999583:7001477:1 11/11 None
GENEFINDER00000010528 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:6999583:7001477:1 11/11 None
C25A8.5 ENSEMBL cdna:known chromosome:CEL140:IV:6999583:7001477:1 gene:C25A8.5 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:6999588-7001483(+) 100.0 100.0
Public Domain and Genome References
Gene Title protein-tyrosine kinase
Ensembl C25A8.5
Entrez Gene 182879 Entrez gene
SwissProt Q18142 EMBL-EBI
WormBase CE08385 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAB03183 Hypothetical protein C25A8.5 [Caenorhabditis elegans] ref|NP_501081.1| C25A8.5 [Caenorhabditis elegans] 0.0
blast AAD03135 Hypothetical protein F23C8.7 [Caenorhabditis elegans] ref|NP_490975.1| F23C8.7 [Caenorhabditis elegans] 0.0
blast CAE67394 Hypothetical protein CBG12879 [Caenorhabditis briggsae] 0.0
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 3.0E-14
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 2.0E-14
hanks 2.1.8 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; DdMLCK 2.0E-66
hanks 2.1.8 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; DdMLCK 1.0E-66
Protein Domains
Database ID Description E-Value
Pfam IPR000980 EMBL-EBI SH2 motif 1.5E-17
Pfam IPR000719 EMBL-EBI Protein kinase 1.6E-65
Pfam IPR000980 EMBL-EBI SH2 motif 7.3E-13
Pfam IPR000719 EMBL-EBI Protein kinase 1.6E-65
Sequence
Target Sequence 
>C. ELEGANS:190759_AT
gcagcttgtggaatcgcgtacatgcacgagaagaagcttctgcatcgagacattgctgcg
agaaactgtctgtacggagagggccaggtgaagattgcggatttcgggttatcccgtgag
ggaaactcgtatgtcatggatcttacgaagaaggttccgattcgttggttggcaccggaa
accttgaaggcggggatttatagtccgaagtctgatgtgtttgcgtttggaataatggct
tgggagatcactgagaatgggaaggagccatatccagatatgagagtttctgaggtagtc
ggatatgtccgtagtggacaccgcatgcggtttgatccggtttttgtggatttcagattc
ggagaatatgttacgaagcactgctgggccgagaatccggatgatcgcgtgaacatgtcg
gatgttctccgctatcttcagacaacttttgggatgaagccagtgattctttcacttcgc
aatcgcacgacgactgatgatgagatgaagacgatgaaaccgccaatgttctcgatg

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GCAGCTTGTGGAATCGCGTACATGC 583 313 697 Antisense
TTCTGCATCGAGACATTGCTGCGAG 343 689 734 Antisense
GAAACTGTCTGTACGGAGAGGGCCA 505 357 758 Antisense
GTTGGCACCGGAAACCTTGAAGGCG 451 433 864 Antisense
TCCGTAGTGGACACCGCATGCGGTT 212 593 1004 Antisense
CACTGCTGGGCCGAGAATCCGGATG 630 197 1075 Antisense
GAATCCGGATGATCGCGTGAACATG 83 331 1089 Antisense
CATGTCGGATGTTCTCCGCTATCTT 564 209 1110 Antisense
AAGCCAGTGATTCTTTCACTTCGCA 369 149 1153 Antisense
ACTTCGCAATCGCACGACGACTGAT 591 103 1170 Antisense
GATGAAACCGCCAATGTTCTCGATG 204 413 1209 Antisense
Sequence Source Affymetrix Proprietary Database