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[190746_at] protein tyrosine kinase

Description F38E9.5 /REP_DB=WormBase Gene ID /WP=CE28307 /TR=Q20173 /GB=AAA93345.1 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=protein tyrosine kinase
Cluster 6grp_highest_10_10 > 50      6grp_high1_10_10 > 02      4grp_highest_8_8 > 32      4grp_high_8_8 > 51      6grp_highest_nonorm > 50      6grp_total > 24      4grp_total > 52      6grp_highest_sub > De      6grp_high1_sub > De      6grp_total_sub > Decrease      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 372
1 2 3 4 range
A 505.1
(3)
P 		352.6
(-1.6)
P 		377.1
(-0.8)
P 		304.4
(-3)
P 		201
B 476.2
(2.3)
P 		498.6
(3)
P 		456.4
(1.7)
P 		299
(-3)
P 		200
C 481.1
(-0.3)
P 		671.1
(3)
P 		543.5
(0.8)
P 		320.6
(-3)
P 		351
avr 487.5
(2.4) 		507.4
(3) 		459
(1.5) 		308
(-3) 		199

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 565
1 2 3 4 5 6 range
A 815.8
(3)
P 		408.4
(-1.3)
P 		619.6
(0.9)
P 		250.7
(-3)
P 		421.4
(-1.2)
P 		307.9
(-2.4)
P 		565
B 743.1
(3)
P 		616.2
(1.2)
P 		471.2
(-0.9)
P 		536.1
(0.1)
P 		319.6
(-3)
P 		442.7
(-1.3)
P 		424
C 403.7
(-0.9)
P 		563.5
(3)
P 		365.6
(-1.9)
P 		467.9
(0.7)
P 		319.3
(-3)
P 		351.8
(-2.2)
P 		244
avr 654.2
(3) 		529.4
(0.5) 		485.5
(-0.4) 		418.2
(-1.7) 		353.4
(-3) 		367.5
(-2.7) 		301
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 148
1 2 3 4 range
A 183.9
(3)
P 		76.5
(-1.6)
P 		98.6
(-0.7)
P 		44.6
(-3)
P 		139
B 151.9
(3)
P 		123.1
(1)
P 		105.8
(-0.1)
P 		63.7
(-3)
P 		88
C 159.3
(1.5)
P 		193
(3)
P 		189.4
(2.8)
P 		54.1
(-3)
P 		139
avr 165
(3) 		130.9
(1.2) 		131.3
(1.2) 		54.1
(-3) 		111

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 195
1 2 3 4 5 6 range
A 150.4
(3)
P 		145.2
(2.6)
P 		134.9
(1.9)
P 		63.6
(-3)
P 		127.2
(1.4)
P 		75
(-2.2)
P 		87
B 258.6
(3)
P 		205.1
(0.8)
P 		114.4
(-3)
P 		142
(-1.9)
P 		129.8
(-2.4)
P 		165.1
(-0.9)
P 		144
C 149.6
(1.3)
P 		172
(3)
P 		93.1
(-3)
P 		94.1
(-2.9)
P 		103.3
(-2.2)
P 		117.8
(-1.1)
P 		79
avr 186.2
(3) 		174.1
(2.2) 		114.1
(-2) 		99.9
(-3) 		120.1
(-1.6) 		119.3
(-1.7) 		86
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 190746_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.17521
Sequence Type Exemplar sequence
Representative Public ID F38E9.5 NCBI
Target Description F38E9.5 /REP_DB=WormBase Gene ID /WP=CE28307 /TR=Q20173 /GB=AAA93345.1 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=protein tyrosine kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_078268(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_078268 NCBI Caenorhabditis elegans F38E9.5 (F38E9.5) mRNA, complete cds. 11/11 A 
GENEFINDER00000030346 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:16446400:16450804:1 11/11 None
SNAP00000030335 ENSEMBL cdna:SNAP chromosome:CEL140:X:16447775:16450804:1 11/11 None
F38E9.5.2 ENSEMBL cdna:known chromosome:CEL140:X:16446115:16451250:1 gene:F38E9.5 11/11 A 
F38E9.5.1 ENSEMBL cdna:known chromosome:CEL140:X:16446115:16451248:1 gene:F38E9.5 11/11 A 
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:16446231-16450804(+) 100.0 100.0
Public Domain and Genome References
Gene Title protein tyrosine kinase
Ensembl F38E9.5
Entrez Gene 181711 Entrez gene
SwissProt Q20173 EMBL-EBI
WormBase CE28307 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFA.20762.1.S1_S_AT similar to twinfilin isoform 1 cfa
CANINE_2:CFAAFFX.15169.1.S1_AT similar to twinfilin isoform 1 cfa
DROSOPHILA_2:1627488_AT twinfilin dm
DROSGENOME1:154805_AT twinfilin dm
CHICKEN:GGAAFFX.11804.1.S1_AT PTK9 protein tyrosine kinase 9 gga
CHICKEN:GGAAFFX.6023.1.S1_AT PTK9 protein tyrosine kinase 9 gga
HG-U95AV2:1064_AT PTK9 protein tyrosine kinase 9 hs
HC-G110:1064_AT PTK9 protein tyrosine kinase 9 hs
HG-U133_PLUS_2:201745_AT PTK9 protein tyrosine kinase 9 hs
HG-U133A:201745_AT PTK9 protein tyrosine kinase 9 hs
HG-FOCUS:201745_AT PTK9 protein tyrosine kinase 9 hs
HG-U133A_2:201745_AT PTK9 protein tyrosine kinase 9 hs
HG-U133_PLUS_2:214007_S_AT PTK9 protein tyrosine kinase 9 hs
HG-U133A_2:214007_S_AT PTK9 protein tyrosine kinase 9 hs
HG-U133A:214007_S_AT PTK9 protein tyrosine kinase 9 hs
HUGENEFL:U02680_AT PTK9 protein tyrosine kinase 9 hs
U133_X3P:G4506274_3P_AT PTK9 protein tyrosine kinase 9 hs
U133_X3P:HS.82643.1.S1_3P_A_AT PTK9 protein tyrosine kinase 9 hs
HG-U133_PLUS_2:214008_AT PTK9 protein tyrosine kinase 9 hs
HG-U133A_2:214008_AT PTK9 protein tyrosine kinase 9 hs
HG-U133A:214008_AT PTK9 protein tyrosine kinase 9 hs
HG-U133_PLUS_2:243033_AT PTK9 protein tyrosine kinase 9 hs
HG-U133B:243033_AT PTK9 protein tyrosine kinase 9 hs
HG-U133_PLUS_2:244199_AT PTK9 protein tyrosine kinase 9 hs
HG-U133B:244199_AT PTK9 protein tyrosine kinase 9 hs
HG-U95E:68000_AT PTK9 protein tyrosine kinase 9 hs
HG-U95E:69999_R_AT PTK9 protein tyrosine kinase 9 hs
HG-U95E:70002_F_AT PTK9 protein tyrosine kinase 9 hs
U133_X3P:HS.189075.0.S1_3P_AT PTK9 protein tyrosine kinase 9 hs
U133_X3P:HS.202492.0.A1_3P_AT PTK9 protein tyrosine kinase 9 hs
U133_X3P:HS.202492.0.A1_3P_X_AT PTK9 protein tyrosine kinase 9 hs
U133_X3P:HS.82643.1.A1_3P_AT PTK9 protein tyrosine kinase 9 hs
MG-U74AV2:93646_AT protein tyrosine kinase 9 mm
MG-U74BV2:162915_AT protein tyrosine kinase 9 mm
MOE430A:1420873_AT protein tyrosine kinase 9 mm
MOUSE430A_2:1420873_AT protein tyrosine kinase 9 mm
MOUSE430_2:1420873_AT protein tyrosine kinase 9 mm
MOE430A:1420875_AT protein tyrosine kinase 9 mm
MOUSE430A_2:1420875_AT protein tyrosine kinase 9 mm
MOUSE430_2:1420875_AT protein tyrosine kinase 9 mm
MOE430A:1420874_AT protein tyrosine kinase 9 mm
MOUSE430A_2:1420874_AT protein tyrosine kinase 9 mm
MOUSE430_2:1420874_AT protein tyrosine kinase 9 mm
MU19KSUBC:TC40025_AT Protein tyrosine kinase 9, mRNA (cDNA clone MGC:13938 IMAGE:3979221) mm
MU19KSUBC:TC40025_G_AT Protein tyrosine kinase 9, mRNA (cDNA clone MGC:13938 IMAGE:3979221) mm
RG-U34A:RC_AA892851_AT protein tyrosine kinase 9 (predicted) rn
RG-U34A:RC_AA892851_G_AT protein tyrosine kinase 9 (predicted) rn
RG-U34C:RC_AI171354_AT protein tyrosine kinase 9 (predicted) rn
RAE230A:1376365_AT protein tyrosine kinase 9 (predicted) rn
RAT230_2:1376365_AT protein tyrosine kinase 9 (predicted) rn
RAE230A:1371644_AT protein tyrosine kinase 9 (predicted) rn
RAT230_2:1371644_AT protein tyrosine kinase 9 (predicted) rn
RG-U34B:RC_AI043716_AT Protein tyrosine kinase 9 (predicted) rn
YEAST_2:1769481_AT Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly Sc
Gene Ontology
GO Cellular Component (view graph)
ID Description Evidence Links
5622 intracellular inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
3779 actin binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAA93345 Hypothetical protein F38E9.5 [Caenorhabditis elegans] ref|NP_510669.1| F38E9.5 [Caenorhabditis elegans] 1.0E-176
blast AAA93345 Hypothetical protein F38E9.5 [Caenorhabditis elegans] ref|NP_510669.1| F38E9.5 [Caenorhabditis elegans] 1.0E-173
blast CAE69968 Hypothetical protein CBG16364 [Caenorhabditis briggsae] 1.0E-169
blast CAE69968 Hypothetical protein CBG16364 [Caenorhabditis briggsae] 1.0E-166
Protein Domains
Database ID Description E-Value
Pfam IPR002108 EMBL-EBI Actin-binding, cofilin/tropomyosin type 1.5E-6
Pfam IPR002108 EMBL-EBI Actin-binding, cofilin/tropomyosin type 2.2E-5
Pfam IPR002108 EMBL-EBI Actin-binding, cofilin/tropomyosin type 1.5E-6
Pfam IPR002108 EMBL-EBI Actin-binding, cofilin/tropomyosin type 2.2E-5
Sequence
Target Sequence 
>C. ELEGANS:190746_AT
agagctgcaattgcacatgccggaccacaacatatgaagggtgtcgcgttcccagtggat
cgtaatgctgaggaagccctccggcagttggctagccagaagctcagttttgttcagctc
tcggtcgataccctcaatgaagccatcaaattggagggaaccctcgaatcattggaacca
tcgcagcttgcatcaaaagtgccacgtgacaagccacgatacaccttctacaattttgat
cacacgtgggaaggtgttccgcaacaatgtactttgtttatctactcgttgccatcatct
ggaagctc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
AGAGCTGCAATTGCACATGCCGGAC 63 71 481 Antisense
TATGAAGGGTGTCGCGTTCCCAGTG 471 655 513 Antisense
CGTAATGCTGAGGAAGCCCTCCGGC 552 245 541 Antisense
CCTCCGGCAGTTGGCTAGCCAGAAG 250 265 558 Antisense
AGCTCAGTTTTGTTCAGCTCTCGGT 653 77 581 Antisense
TCGGTCGATACCCTCAATGAAGCCA 442 603 601 Antisense
GGAACCCTCGAATCATTGGAACCAT 135 529 637 Antisense
TTGGAACCATCGCAGCTTGCATCAA 416 709 652 Antisense
CCACGATACACCTTCTACAATTTTG 512 273 694 Antisense
TACTTTGTTTATCTACTCGTTGCCA 558 643 750 Antisense
ACTCGTTGCCATCATCTGGAAGCTC 239 99 764 Antisense
Sequence Source Affymetrix Proprietary Database