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[190715_at] tyrosine-protein kinase

Description T21G5.1 /REP_DB=WormBase Gene ID /WP=CE13888 /TR=O02064 /GB=AAB52900.1 /SUBMIT=ST.LOUIS /CHR=1 /FEA=Sanger Annotation /DEF=tyrosine-protein kinase
Cluster 6grp_total > 77      4grp_total > 02      6grp_total_sub > Increase      6grp_rule_based > S6      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 98
1 2 3 4 range
A 6.6
(-2.2)
A 		2.6
(-3)
A 		3.4
(-2.8)
A 		34.3
(3)
A 		32
B 5
(2.8)
A 		2.7
(-3)
A 		2.8
(-2.8)
A 		5.1
(3)
A 		2
C 3.4
(-3)
A 		3.7
(-3)
A 		4
(-3)
A 		100.9
(3)
P 		98
avr 5
(-2.7) 		3
(-3) 		3.4
(-2.9) 		46.8
(3) 		44

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 77
1 2 3 4 5 6 range
A 4
(-2.8)
A 		1.5
(-3)
A 		2.3
(-2.9)
A 		3.7
(-2.8)
A 		7.5
(-2.5)
A 		67.5
(3)
P 		66
B 2.6
(-2.9)
A 		6.1
(-2.7)
A 		1.7
(-3)
A 		18.6
(-1.7)
A 		47.4
(0.6)
A 		78.4
(3)
P 		77
C 1.9
(-3)
A 		17
(-1.6)
A 		31.5
(-0.2)
A 		25.1
(-0.8)
A 		27.1
(-0.6)
A 		64.8
(3)
A 		63
avr 2.8
(-3) 		8.2
(-2.5) 		11.8
(-2.2) 		15.8
(-1.8) 		27.3
(-0.8) 		70.2
(3) 		67
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 16
1 2 3 4 range
A 2.4
(-0.5)
A 		0.6
(-3)
A 		0.9
(-2.6)
A 		5
(3)
A 		4
B 1.6
(3)
A 		0.7
(-2.4)
A 		0.6
(-3)
A 		1.1
(0)
A 		1
C 1.1
(-3)
A 		1.1
(-3)
A 		1.4
(-2.9)
A 		17
(3)
P 		16
avr 1.7
(-2.2) 		0.8
(-3) 		1
(-2.8) 		7.7
(3) 		7

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 29
1 2 3 4 5 6 range
A 0.7
(-2.9)
A 		0.5
(-3)
A 		0.5
(-3)
A 		0.9
(-2.8)
A 		2.3
(-2.3)
A 		16.4
(3)
P 		16
B 0.9
(-2.9)
A 		2
(-2.7)
A 		0.4
(-3)
A 		4.9
(-2.1)
A 		19.2
(0.9)
A 		29.2
(3)
P 		29
C 0.7
(-3)
A 		5.2
(-1.7)
A 		8
(-0.9)
A 		5
(-1.8)
A 		8.8
(-0.7)
A 		21.7
(3)
A 		21
avr 0.8
(-3) 		2.6
(-2.5) 		3
(-2.4) 		3.6
(-2.2) 		10.1
(-0.4) 		22.4
(3) 		22
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 190715_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.1663
Sequence Type Exemplar sequence
Representative Public ID T21G5.1 NCBI
Target Description T21G5.1 /REP_DB=WormBase Gene ID /WP=CE13888 /TR=O02064 /GB=AAB52900.1 /SUBMIT=ST.LOUIS /CHR=1 /FEA=Sanger Annotation /DEF=tyrosine-protein kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_059565(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_059565 NCBI Caenorhabditis elegans T21G5.1 (T21G5.1) mRNA, complete cds. 11/11 None
SNAP00000016513 ENSEMBL cdna:SNAP chromosome:CEL140:I:6883972:6885060:1 11/11 None
GENEFINDER00000016518 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:6883972:6885060:1 11/11 None
T21G5.1 ENSEMBL cdna:known chromosome:CEL140:I:6882436:6885060:1 gene:T21G5.1 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:6882440-6884991(+) 100.0 100.0
Public Domain and Genome References
Gene Title tyrosine-protein kinase
Ensembl T21G5.1
Entrez Gene 266839 Entrez gene
SwissProt O02064 EMBL-EBI
WormBase CE13888 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAB52900 Hypothetical protein T21G5.1 [Caenorhabditis elegans] ref|NP_491966.3| T21G5.1 [Caenorhabditis elegans] 0.0
blast AAB52900 Hypothetical protein T21G5.1 [Caenorhabditis elegans] ref|NP_491966.3| T21G5.1 [Caenorhabditis elegans] 1.0E-161
blast CAE67898 Hypothetical protein CBG13495 [Caenorhabditis briggsae] 1.0E-113
blast CAE67898 Hypothetical protein CBG13495 [Caenorhabditis briggsae] 1.0E-112
blast CAA92609 Hypothetical protein T04B2.2 [Caenorhabditis elegans] ref|NP_501818.1| Fer oncogene Related Kinase family member (frk-1) [Caenorhabditis elegans] 2.0E-74
Protein Domains
Database ID Description E-Value
Pfam IPR000980 EMBL-EBI SH2 motif 1.5E-9
Pfam IPR000719 EMBL-EBI Protein kinase 3.9E-5
Pfam IPR000719 EMBL-EBI Protein kinase 5.5E-49
Pfam IPR000719 EMBL-EBI Protein kinase 5.5E-49
Trans Membrane
ID Number Of Domains Domain Boundaries
SNAP00000016513 1 21-43
GENEFINDER00000016518 1 21-43
Sequence
Target Sequence 
>C. ELEGANS:190715_AT
ggtgatgaaccatatccaggactcaataatacacaggctcgtgccaaaatagttgttctc
gactatcgaatgaaatttccggatgaagctccaactgaactagttcaagtaattgataca
tgttggaaaaaggatccagatatgagacagacaatggttttacattcatctgcacttcaa
ttactttatgagaataagcttccattattatttgctcaaacaattcaagcaacatcactt
ccaccgggaacaattgctcaatcatcaactccaattccaattccaatatctggtgtatct
ggtgctccagctgttgtaactgcaaatggtgttgaacaattcactccaccgt

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GGTGATGAACCATATCCAGGACTCA 372 501 1366 Antisense
GGACTCAATAATACACAGGCTCGTG 414 525 1384 Antisense
GGCTCGTGCCAAAATAGTTGTTCTC 219 539 1401 Antisense
GGTTTTACATTCATCTGCACTTCAA 157 507 1521 Antisense
GCTTCCATTATTATTTGCTCAAACA 67 307 1563 Antisense
CAATTCAAGCAACATCACTTCCACC 13 181 1586 Antisense
TTCCACCGGGAACAATTGCTCAATC 393 699 1604 Antisense
ACTCCAATTCCAATTCCAATATCTG 448 99 1633 Antisense
CAATATCTGGTGTATCTGGTGCTCC 442 181 1649 Antisense
TGGTGCTCCAGCTGTTGTAACTGCA 131 553 1665 Antisense
GGTGTTGAACAATTCACTCCACCGT 518 499 1693 Antisense
Sequence Source Affymetrix Proprietary Database