[Home] | [Total List]

[190709_at] serine/threonine kinase

Description F39H11.3 /REP_DB=WormBase Gene ID /WP=CE17815 /TR=P90866 /GB=CAB03083.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=serine-threonine kinase
Cluster 6grp_high1_10_10 > 66      6grp_total > 66      4grp_total > 23      6grp_cgc > 47      6grp_high1_sub > Da      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 497
1 2 3 4 range
A 365.1
(3)
P 		182
(-2.1)
A 		149.1
(-3)
A 		366.4
(3)
P 		217
B 486
(3)
P 		124.8
(-2)
A 		51.9
(-3)
A 		322.7
(0.7)
P 		434
C 549.2
(3)
P 		122.5
(-3)
A 		225.1
(-1.6)
A 		498
(2.3)
P 		427
avr 466.8
(3) 		143.1
(-3) 		142
(-3) 		395.7
(1.7) 		325

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 378
1 2 3 4 5 6 range
A 504.5
(1.9)
P 		391.2
(-0.4)
M 		397
(-0.3)
P 		454.4
(0.9)
P 		263
(-3)
P 		560.9
(3)
P 		298
B 340.3
(-1.6)
P 		275
(-3)
P 		412.3
(-0.1)
P 		351.2
(-1.4)
P 		344.8
(-1.5)
P 		558.2
(3)
P 		283
C 235.5
(-3)
M 		420.9
(-0.1)
P 		467.9
(0.7)
P 		449.7
(0.4)
P 		345.1
(-1.3)
P 		613.2
(3)
P 		378
avr 360.1
(-2) 		362.4
(-2) 		425.7
(-0.5) 		418.4
(-0.7) 		317.6
(-3) 		577.4
(3) 		260
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 170
1 2 3 4 range
A 132.9
(3)
P 		39.5
(-3)
A 		39
(-3)
A 		53.6
(-2.1)
P 		94
B 155
(3)
P 		30.8
(-2.2)
A 		12
(-3)
A 		68.8
(-0.6)
P 		143
C 181.8
(3)
P 		35.2
(-3)
A 		78.4
(-1.2)
A 		84
(-1)
P 		147
avr 156.6
(3) 		35.2
(-3) 		43.1
(-2.6) 		68.8
(-1.3) 		121

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 129
1 2 3 4 5 6 range
A 93
(-1.6)
P 		139.1
(3)
M 		86.5
(-2.3)
P 		115.2
(0.6)
P 		79.4
(-3)
P 		136.6
(2.7)
P 		60
B 118.4
(-1.6)
P 		91.5
(-3)
P 		100.1
(-2.6)
P 		93
(-2.9)
P 		140.1
(-0.5)
P 		208.2
(3)
P 		117
C 87.3
(-3)
M 		128.4
(-0.9)
P 		119.1
(-1.4)
P 		90.4
(-2.8)
P 		111.7
(-1.8)
P 		205.3
(3)
P 		118
avr 99.6
(-3) 		119.7
(-1.6) 		101.9
(-2.8) 		99.5
(-3) 		110.4
(-2.2) 		183.4
(3) 		84
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 190709_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.1191
Sequence Type Exemplar sequence
Representative Public ID F39H11.3 NCBI
Target Description F39H11.3 /REP_DB=WormBase Gene ID /WP=CE17815 /TR=P90866 /GB=CAB03083.1 /SUBMIT=HINXTON /CHR=1 /FEA=Sanger Annotation /DEF=serine-threonine kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_059956(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_059956 NCBI Caenorhabditis elegans Cyclin-Dependent Kinase family member (cdk-8) (cdk-8) mRNA, complete cds. 11/11 None
SNAP00000035954 ENSEMBL cdna:SNAP chromosome:CEL140:I:8710687:8713803:1 11/11 None
GENEFINDER00000035961 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:8710745:8713818:1 11/11 None
F39H11.3 ENSEMBL cdna:known chromosome:CEL140:I:8710603:8713920:1 gene:F39H11.3 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:8710617-8713734(+) 94.33 100.0
Public Domain and Genome References
Gene Title serine/threonine kinase
Gene Symbol cdk-8
Ensembl F39H11.3
Entrez Gene 172677 Entrez gene
SwissProt P90866 EMBL-EBI
WormBase CE32409 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.11224.1.S1_AT similar to Cell division protein kinase 8 (Protein kinase K35) cfa
DROSOPHILA_2:1630579_AT Cyclin-dependent kinase 8 dm
DROSGENOME1:142743_AT Cyclin-dependent kinase 8 dm
CHICKEN:GGA.18915.1.S1_AT similar to Cell division protein kinase 8 (Protein kinase K35) gga
HG-U95AV2:1189_AT cyclin-dependent kinase 8 hs
HC-G110:1189_AT cyclin-dependent kinase 8 hs
HUGENEFL:X85753_AT cyclin-dependent kinase 8 hs
U133_X3P:HS2.397734.1.S1_3P_S_AT cyclin-dependent kinase 8 hs
HG-U133_PLUS_2:1553112_S_AT cyclin-dependent kinase 8 hs
HG-U95AV2:35140_AT Cyclin-dependent kinase 8 hs
HG-U133_PLUS_2:1569917_AT Cyclin-dependent kinase 8 hs
U133_X3P:HS2.397734.1.S2_3P_S_AT Cyclin-dependent kinase 8 hs
U133_X3P:HS2.382306.1.S1_3P_AT Cyclin-dependent kinase 8 hs
U133_X3P:HS.25283.0.S2_3P_AT Cyclin-dependent kinase 8 hs
HG-U133_PLUS_2:1553113_S_AT Cyclin-dependent kinase 8 hs
HG-U133A_2:204831_AT Cyclin-dependent kinase 8 hs
HG-FOCUS:204831_AT Cyclin-dependent kinase 8 hs
HG-U133_PLUS_2:204831_AT Cyclin-dependent kinase 8 hs
HG-U133A:204831_AT Cyclin-dependent kinase 8 hs
MU11KSUBB:MSA.32102.0_S_AT cyclin-dependent kinase 8 mm
MG-U74AV2:96726_AT cyclin-dependent kinase 8 mm
MOE430A:1460389_AT cyclin-dependent kinase 8 mm
MOUSE430A_2:1460389_AT cyclin-dependent kinase 8 mm
MOUSE430_2:1460389_AT cyclin-dependent kinase 8 mm
MU19KSUBC:TC40855_AT Cyclin-dependent kinase 8 (Cdk8), transcript variant 1, mRNA mm
MU19KSUBC:TC40855_G_AT Cyclin-dependent kinase 8 (Cdk8), transcript variant 1, mRNA mm
YEAST_2:1772868_AT Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAB03083 Hypothetical protein F39H11.3 [Caenorhabditis elegans] ref|NP_492357.2| Cyclin-Dependent Kinase family member (cdk-8) [Caenorhabditis elegans] 0.0
blast CAE66954 Hypothetical protein CBG12346 [Caenorhabditis briggsae] 0.0
blast AAI07602 Cyclin-dependent kinase 8 [Homo sapiens] gb|AAI05951.1| Unknown (protein for MGC:126074) [Homo sapiens] gb|AAH69634.1| Cyclin-dependent kinase 8 [Homo sapiens] 1.0E-131
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 2.0E-62
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 8.0E-63
hanks 3.1.6 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; Cdk5 2.0E-62
hanks 3.1.6 CMCG Group; CMGC I Cyclin-dependent (CDKs) and close relatives; Cdk5 8.0E-63
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 8.6E-71
Pfam IPR000719 EMBL-EBI Protein kinase 8.6E-71
Sequence
Target Sequence 
>C. ELEGANS:190709_AT
gtacaacctcagatgggacaaccaccaatgggtggagcacatcccggagttgttgctcca
gatggacatccacatcaaatgatgcagcaacaacagcatccacaacagcatcatgtcagt
tttctaaatattcagaatgaaaagttaactttttctgttcagatgcaatatcaaggaatg
catgatccaatgcaaggtggaatggatgaaggaccacaagcaaaaatgatgagaatggga
aatgttcctgttggaagatatgcaccgatgcctcctccatacggtgctccacaagactat
cacccgcaacaaggtccaccaatggtgcaaatgatgcaacaaccgggaccatccggctac
tatccacaacgaccaggacaaccaacaggagcagttcctggaccaggacctcaaggatat
atgaatccacaaatgggaatgcaaatgggcatgcgtgctccaggagttccaccacaagga
tatatgcctggtcgtggaatggctccccctcaaatgggacaaca

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GTACAACCTCAGATGGGACAACCAC 331 461 1300 Antisense
AGCACATCCCGGAGTTGTTGCTCCA 265 77 1335 Antisense
GTTGCTCCAGATGGACATCCACATC 64 441 1351 Antisense
TGGAAGATATGCACCGATGCCTCCT 368 547 1551 Antisense
CAAGACTATCACCCGCAACAAGGTC 671 183 1591 Antisense
GATGCAACAACCGGGACCATCCGGC 599 411 1632 Antisense
GCTACTATCCACAACGACCAGGACA 84 303 1655 Antisense
GGAGCAGTTCCTGGACCAGGACCTC 256 519 1687 Antisense
CTCCAGGAGTTCCACCACAAGGATA 649 233 1757 Antisense
TATGCCTGGTCGTGGAATGGCTCCC 194 655 1782 Antisense
TGGCTCCCCCTCAAATGGGACAACA 172 543 1799 Antisense
Sequence Source Affymetrix Proprietary Database