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[190708_at] Protein tyrosine kinase

Description C25F6.4 /REP_DB=WormBase Gene ID /WP=CE27088 /TR=Q18163 /GB=AAK39199.1 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=Protein tyrosine kinase
Cluster 4grp_highest_8_8 > 54      4grp_high_8_8 > 10      6grp_total > 47      4grp_total > 22      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 132
1 2 3 4 range
A 158.2
(3)
P 		56.7
(-2.6)
P 		49.9
(-3)
P 		154.9
(2.8)
P 		108
B 163.1
(2)
P 		101.5
(-1.1)
P 		64.4
(-3)
P 		181.9
(3)
P 		118
C 160.5
(3)
P 		88.3
(-3)
P 		89.7
(-2.9)
P 		145.3
(1.7)
P 		72
avr 160.6
(3) 		82.2
(-2.1) 		68
(-3) 		160.7
(3) 		93

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 48
1 2 3 4 5 6 range
A 56.5
(0.1)
P 		48.8
(-1.5)
P 		49.5
(-1.3)
P 		54.3
(-0.3)
A 		41.7
(-3)
A 		70
(3)
P 		28
B 48
(-1.2)
P 		49.4
(-1)
P 		46.6
(-1.4)
A 		36
(-2.8)
A 		34.1
(-3)
A 		80.3
(3)
P 		46
C 62.6
(2.4)
P 		65.9
(3)
P 		39.1
(-1.7)
A 		55.4
(1.1)
A 		32
(-3)
A 		54.3
(0.9)
P 		34
avr 55.7
(0.7) 		54.7
(0.5) 		45.1
(-1.3) 		48.6
(-0.6) 		35.9
(-3) 		68.2
(3) 		32
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 45
1 2 3 4 range
A 57.6
(3)
P 		12.3
(-3)
P 		13.1
(-2.9)
P 		22.7
(-1.6)
P 		45
B 52
(3)
P 		25.1
(-1.4)
P 		14.9
(-3)
P 		38.8
(0.9)
P 		37
C 53.1
(3)
P 		25.4
(-2.8)
P 		31.3
(-1.6)
P 		24.5
(-3)
P 		29
avr 54.2
(3) 		20.9
(-2.8) 		19.8
(-3) 		28.7
(-1.4) 		34

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 20
1 2 3 4 5 6 range
A 10.4
(-3)
P 		17.4
(3)
P 		10.8
(-2.7)
P 		13.8
(-0.1)
A 		12.6
(-1.1)
A 		17
(2.7)
P 		7
B 16.7
(-0.9)
P 		16.5
(-0.9)
P 		11.3
(-2.5)
A 		9.5
(-3)
A 		13.9
(-1.7)
A 		29.9
(3)
P 		20
C 23.2
(3)
P 		20.1
(1.6)
P 		9.9
(-3)
A 		11.1
(-2.5)
A 		10.3
(-2.8)
A 		18.2
(0.7)
P 		13
avr 16.8
(0.3) 		18
(1) 		10.7
(-3) 		11.5
(-2.6) 		12.3
(-2.1) 		21.7
(3) 		11
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 190708_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.16982
Sequence Type Exemplar sequence
Representative Public ID C25F6.4 NCBI
Target Description C25F6.4 /REP_DB=WormBase Gene ID /WP=CE27088 /TR=Q18163 /GB=AAK39199.1 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=Protein tyrosine kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_076525(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_076525 NCBI Caenorhabditis elegans C25F6.4 (C25F6.4) mRNA, complete cds. 11/11 None
GENEFINDER00000000873 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:5461221:5466027:1 11/11 None
SNAP00000000864 ENSEMBL cdna:SNAP chromosome:CEL140:X:5462852:5466027:1 11/11 None
C25F6.4 ENSEMBL cdna:known chromosome:CEL140:X:5461221:5466027:1 gene:C25F6.4 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:5461375-5466028(+) 100.0 100.0
Public Domain and Genome References
Gene Title Protein tyrosine kinase
Ensembl C25F6.4
Entrez Gene 180817 Entrez gene
SwissProt Q18163 EMBL-EBI
WormBase CE27088 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7155 cell adhesion inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAK39199 Hypothetical protein C25F6.4 [Caenorhabditis elegans] ref|NP_508926.1| C25F6.4 [Caenorhabditis elegans] 0.0
blast CAE68755 Hypothetical protein CBG14688 [Caenorhabditis briggsae] 0.0
blast AAA98703 Similar to receptor tyrosine kinase. [Caenorhabditis briggsae] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR000421 EMBL-EBI Coagulation factor 5/8 type C domain (FA58C) 1.2E-71
Pfam IPR000719 EMBL-EBI Protein kinase 1.1E-9
Pfam IPR000719 EMBL-EBI Protein kinase 4.7E-13
Pfam IPR000719 EMBL-EBI Protein kinase 1.1E-9
Pfam IPR000719 EMBL-EBI Protein kinase 4.7E-13
Trans Membrane
ID Number Of Domains Domain Boundaries
NP_508926.1 1 372-394
C25F6.4 1 372-394
GENEFINDER00000000873 1 372-394
SNAP00000000864 1 88-110
Sequence
Target Sequence 
>C. ELEGANS:190708_AT
tgagtcatacaacttgctcctcgagcatgtagaatatggttgcatcagaaacttttggat
ggcttccgaagcgccattagataccgaatttcttgtccgaatttgcaaagacatatattc
tgcaatggcatacttggaaagtattcggatagttcacggacatttcaccccaaacaacat
actcatggacggtgaattccatgcaaaagtgtgctcgccccgagggccatcacatcatgc
tcaacttcgttattctgctccagaatcaattgtgaataacgaattcactcataaatctga
tgcttgggccgttgctacaacggtgtacgagatggcttatcagtgccgacagcgtccata
cgaagaactcaccaatgagcagatagttgataacgcgtgtgctctgctggatcaccaacc
aaatgcggttgtaccgttgatgccaacagtttttaactatgaaatcttacaacttttgac
gcgatgtttccgggtggac

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TGAGTCATACAACTTGCTCCTCGAG 107 569 1677 Antisense
GCTTCCGAAGCGCCATTAGATACCG 101 307 1738 Antisense
GGATAGTTCACGGACATTTCACCCC 193 509 1823 Antisense
TTTCACCCCAAACAACATACTCATG 281 673 1839 Antisense
TTCCATGCAAAAGTGTGCTCGCCCC 456 699 1873 Antisense
ATCACATCATGCTCAACTTCGTTAT 54 29 1905 Antisense
AAATCTGATGCTTGGGCCGTTGCTA 125 119 1969 Antisense
GAGATGGCTTATCAGTGCCGACAGC 49 397 2005 Antisense
AGCGTCCATACGAAGAACTCACCAA 71 83 2027 Antisense
TGCTCTGCTGGATCACCAACCAAAT 442 579 2076 Antisense
TTTGACGCGATGTTTCCGGGTGGAC 53 643 2151 Antisense
Sequence Source Affymetrix Proprietary Database