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[190704_s_at] protein-tyrosine kinase

Description ZC581.7 /REP_DB=WormBase Gene ID /WP=CE28168 /TR=O01774 /GB=AAB54145.2 /SUBMIT=ST.LOUIS /CHR=1 /FEA=Sanger Annotation /DEF=protein-tyrosine kinase
Cluster 6grp_total > 96      4grp_total > 27      6grp_total_sub > Increase      6grp_rule_based > S6      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 59
1 2 3 4 range
A 78.6
(-1)
A 		69
(-3)
A 		75.8
(-1.6)
A 		97.6
(3)
A 		29
B 63.5
(-2.7)
A 		96.6
(3)
A 		61.9
(-3)
A 		82.4
(0.5)
A 		35
C 69.1
(0.5)
A 		87.5
(2.6)
A 		38.2
(-3)
A 		90.8
(3)
A 		53
avr 70.4
(-0.8) 		84.4
(1.9) 		58.6
(-3) 		90.3
(3) 		32

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 175
1 2 3 4 5 6 range
A 48.7
(-3)
A 		72.3
(-1.9)
P 		56.1
(-2.7)
A 		109.1
(-0.3)
P 		173.8
(2.6)
P 		181.8
(3)
P 		133
B 48.2
(-2.3)
A 		62.5
(-1.8)
A 		28.7
(-3)
A 		52.2
(-2.2)
A 		121
(0.2)
P 		203.3
(3)
P 		175
C 70.3
(-2.6)
A 		85.4
(-1.9)
P 		62.8
(-3)
P 		152.7
(1.4)
P 		123.5
(-0)
P 		185.3
(3)
P 		123
avr 55.7
(-2.7) 		73.4
(-2) 		49.2
(-3) 		104.7
(-0.6) 		139.4
(0.8) 		190.1
(3) 		141
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 15
1 2 3 4 range
A 28.6
(3)
A 		15
(-2.7)
A 		19.8
(-0.7)
A 		14.3
(-3)
A 		14
B 20.3
(0.8)
A 		23.9
(3)
A 		14.3
(-3)
A 		17.6
(-0.9)
A 		10
C 22.9
(1.8)
A 		25.2
(3)
A 		13.3
(-3)
A 		15.3
(-2)
A 		12
avr 23.9
(3) 		21.4
(1.2) 		15.8
(-2.9) 		15.7
(-3) 		8

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 69
1 2 3 4 5 6 range
A 9
(-3)
A 		25.7
(-0.7)
P 		12.2
(-2.6)
A 		27.7
(-0.4)
P 		52.4
(3)
P 		44.3
(1.9)
P 		43
B 16.8
(-2.1)
A 		20.8
(-1.8)
A 		7
(-3)
A 		13.8
(-2.4)
A 		49.2
(0.7)
P 		75.8
(3)
P 		69
C 26.1
(-1.7)
A 		26.1
(-1.7)
P 		16
(-3)
P 		30.7
(-1.1)
P 		40
(0.1)
P 		62
(3)
P 		46
avr 17.3
(-2.3) 		24.2
(-1.5) 		11.7
(-3) 		24.1
(-1.5) 		47.2
(1.3) 		60.7
(3) 		49
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 190704_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.1679
Sequence Type Exemplar sequence
Representative Public ID ZC581.7 NCBI
Target Description ZC581.7 /REP_DB=WormBase Gene ID /WP=CE28168 /TR=O01774 /GB=AAB54145.2 /SUBMIT=ST.LOUIS /CHR=1 /FEA=Sanger Annotation /DEF=protein-tyrosine kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_059512(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_059512 NCBI Caenorhabditis elegans ZC581.7 (ZC581.7) mRNA, complete cds. 11/11 None
SNAP00000015885 ENSEMBL cdna:SNAP chromosome:CEL140:I:6668621:6670421:-1 11/11 None
GENEFINDER00000015894 ENSEMBL cdna:GeneFinder chromosome:CEL140:I:6668621:6670899:-1 11/11 None
ZC581.7 ENSEMBL cdna:known chromosome:CEL140:I:6668621:6670421:-1 gene:ZC581.7 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrI:6668549-6670350(-) 100.0 100.0
Public Domain and Genome References
Gene Title protein-tyrosine kinase
Ensembl ZC581.7
Entrez Gene 266838 Entrez gene
SwissProt O01774 EMBL-EBI
WormBase CE28168 Wormbase
Functional Annotations
Ortholog
ID Title Organism
ATH1-121501:257618_AT protein kinase family protein at
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAB54145 Hypothetical protein ZC581.7 [Caenorhabditis elegans] ref|NP_491913.1| ZC581.7 [Caenorhabditis elegans] 0.0
blast CAE59293 Hypothetical protein CBG02628 [Caenorhabditis briggsae] 1.0E-158
blast AAF98610 Hypothetical protein C18H7.4 [Caenorhabditis elegans] ref|NP_499953.1| C18H7.4 [Caenorhabditis elegans] 1.0E-158
blast AAF98610 Hypothetical protein C18H7.4 [Caenorhabditis elegans] ref|NP_499953.1| C18H7.4 [Caenorhabditis elegans] 1.0E-157
Protein Families
Method ID Description E-Value
hanks 2.1.11 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; CMKI 5.0E-63
hanks 2.1.11 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; CMKI 4.0E-63
hanks 2.1.11 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; CMKI 3.0E-63
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 2.5E-59
Pfam IPR000719 EMBL-EBI Protein kinase 2.5E-59
Pfam IPR000719 EMBL-EBI Protein kinase 2.5E-59
Sequence
Target Sequence 
>C. ELEGANS:190704_S_AT
gatattccatacttgctggttctggagctttgtaacggtggatcggtagaggataaacta
gtggaaaagggagccaagttgagcacaaagacaaggatcatgtacacttatcacgctgca
tgtgggatagagtacttgcacaagaagaaatgcatccaccgcgacattgccgctcgaaac
tgtctcattcacaaggaaatcgtcaaaattgctgactttggaatgtgccgtgccacgtca
atctacaaagtcgacttgaacaaaccaaccaatacccgttggttggcaccagaagtttgg
gataatggagagacacgtgacaatacggacatcttcgcgtttgcaataactatgtgggag
ttctttgaagtgccatatgattccccttatagtgagtggaaaggttatatggtgaagcaa
aaaactcgggctggctatcggcttccgactccaaaaggaatgccatgggatattgaagaa
ataatgaaactgtgctggcacgtggatccaaatcaacgcccgacggcttccgaattgaga
gagaagattgaggagacaatggccaaacccgaatcatcagc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GATATTCCATACTTGCTGGTTCTGG 578 425 643 Antisense
GGATCATGTACACTTATCACGCTGC 305 511 737 Antisense
CGACATTGCCGCTCGAAACTGTCTC 181 253 804 Antisense
TGGAATGTGCCGTGCCACGTCAATC 18 547 861 Antisense
AATACCCGTTGGTTGGCACCAGAAG 309 163 913 Antisense
AATACGGACATCTTCGCGTTTGCAA 357 173 964 Antisense
TGAAGTGCCATATGATTCCCCTTAT 119 575 1008 Antisense
AAAAAACTCGGGCTGGCTATCGGCT 94 129 1061 Antisense
GGCACGTGGATCCAAATCAACGCCC 660 535 1139 Antisense
GCCCGACGGCTTCCGAATTGAGAGA 46 287 1160 Antisense
CAATGGCCAAACCCGAATCATCAGC 545 183 1199 Antisense
Sequence Source Affymetrix Proprietary Database