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[190662_s_at] serine/threonine kinase

Description ZC404.9 /REP_DB=WormBase Gene ID /WP=CE07599 /TR=Q23290 /GB=AAA97966.1 /SUBMIT=ST.LOUIS /CHR=5 /FEA=Sanger Annotation /DEF=serine-threonine kinase
Cluster 6grp_highest_10_10 > 97      6grp_high1_10_10 > 49      4grp_highest_8_8 > 53      4grp_high_8_8 > 09      6grp_highest_nonorm > 72      6grp_total > 59      4grp_total > 23      6grp_highest_sub > Cu      6grp_cgc > 09      6grp_high1_sub > Cu      6grp_cgc_sub > Cu      6grp_total_sub > Cup      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 216
1 2 3 4 range
A 382.1
(3)
P 		226.7
(-2.4)
P 		208.2
(-3)
P 		255.2
(-1.4)
P 		174
B 324.1
(2.8)
P 		187.1
(-2.2)
P 		165.7
(-3)
P 		329.2
(3)
P 		164
C 336
(2)
P 		220.5
(-3)
P 		257.1
(-1.4)
P 		358.8
(3)
P 		138
avr 347.4
(3) 		211.4
(-3) 		210.3
(-3) 		314.4
(1.6) 		137

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 227
1 2 3 4 5 6 range
A 425.5
(2.2)
P 		342.8
(-0.6)
P 		348.7
(-0.4)
P 		272.3
(-3)
P 		449.4
(3)
P 		425.6
(2.2)
P 		177
B 458.3
(1.2)
P 		400.1
(-1.3)
P 		360
(-3)
P 		443
(0.6)
P 		394.6
(-1.5)
P 		498.9
(3)
P 		139
C 409.4
(0.8)
P 		372
(-0.6)
P 		307.1
(-3)
P 		430.8
(1.6)
P 		419.7
(1.2)
P 		467.8
(3)
P 		161
avr 431.1
(1.4) 		371.6
(-1.4) 		338.6
(-3) 		382
(-0.9) 		421.2
(0.9) 		464.1
(3) 		126
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 102
1 2 3 4 range
A 139.1
(3)
P 		49.2
(-2.3)
P 		54.4
(-2)
P 		37.4
(-3)
P 		102
B 103.3
(3)
P 		46.2
(-2.3)
P 		38.4
(-3)
P 		70.2
(-0.1)
P 		65
C 111.2
(3)
P 		63.4
(-2.7)
P 		89.6
(0.4)
P 		60.5
(-3)
P 		51
avr 117.9
(3) 		52.9
(-3) 		60.8
(-2.3) 		56
(-2.7) 		65

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 117
1 2 3 4 5 6 range
A 78.4
(-2.2)
P 		121.9
(1.8)
P 		75.9
(-2.4)
P 		69.1
(-3)
P 		135.6
(3)
P 		103.6
(0.1)
P 		67
B 159.5
(1.4)
P 		133.2
(-0.2)
P 		87.4
(-3)
P 		117.3
(-1.2)
P 		160.3
(1.4)
P 		186
(3)
P 		99
C 151.7
(2.6)
P 		113.5
(-0.3)
P 		78.2
(-3)
P 		86.6
(-2.4)
P 		135.8
(1.4)
P 		156.6
(3)
P 		78
avr 129.9
(1.3) 		122.9
(0.7) 		80.5
(-3) 		91
(-2.1) 		143.9
(2.6) 		148.7
(3) 		68
NetAffx Links Cluster Members
Consensus/Exemplar
Group Members
GeneChip Array Information
Probe Set ID 190662_s_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.11904
Sequence Type Exemplar sequence
Representative Public ID ZC404.9 NCBI
Target Description ZC404.9 /REP_DB=WormBase Gene ID /WP=CE07599 /TR=Q23290 /GB=AAA97966.1 /SUBMIT=ST.LOUIS /CHR=5 /FEA=Sanger Annotation /DEF=serine-threonine kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_072320(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_072320 NCBI Caenorhabditis elegans Germinal Center Kinase family member (gck-2) (gck-2) mRNA, complete cds. 11/11 None
SNAP00000042518 ENSEMBL cdna:SNAP chromosome:CEL140:V:6791483:6795254:-1 11/11 None
GENEFINDER00000042523 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:6791483:6795254:-1 11/11 None
ZC404.9 ENSEMBL cdna:known chromosome:CEL140:V:6791044:6795259:-1 gene:ZC404.9 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:6791483-6795255(-) 100.0 100.0
Public Domain and Genome References
Gene Title serine/threonine kinase
Gene Symbol gck-2
Ensembl ZC404.9
Entrez Gene 179072 Entrez gene
SwissProt Q23290 EMBL-EBI
WormBase CE07599 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE:1604481_AT similar to mitogen-activated protein kinase kinase kinase kinase 3 cfa
CANINE_2:CFAAFFX.10633.1.S1_S_AT similar to mitogen-activated protein kinase kinase kinase kinase 3 cfa
DROSOPHILA_2:1640266_A_AT dm
DROSGENOME1:147480_AT dm
HG-U133_PLUS_2:218311_AT mitogen-activated protein kinase kinase kinase kinase 3 hs
HG-U133A:218311_AT mitogen-activated protein kinase kinase kinase kinase 3 hs
HG-FOCUS:218311_AT mitogen-activated protein kinase kinase kinase kinase 3 hs
HG-U133A_2:218311_AT mitogen-activated protein kinase kinase kinase kinase 3 hs
U133_X3P:G4506376_3P_AT mitogen-activated protein kinase kinase kinase kinase 3 hs
HG-U95E:91521_AT mitogen-activated protein kinase kinase kinase kinase 3 hs
U133_X3P:HS.131929.0.A1_3P_AT Mitogen-activated protein kinase kinase kinase kinase 3 hs
HG-U133_PLUS_2:242448_AT Mitogen-activated protein kinase kinase kinase kinase 3 hs
HG-U133B:242448_AT Mitogen-activated protein kinase kinase kinase kinase 3 hs
HG-U95E:82188_AT Mitogen-activated protein kinase kinase kinase kinase 3 hs
HG-U95B:48671_AT Mitogen-activated protein kinase kinase kinase kinase 3 hs
HG-U95B:49119_AT Mitogen-activated protein kinase kinase kinase kinase 3 hs
HG-U95C:64636_AT Mitogen-activated protein kinase kinase kinase kinase 3 hs
HG-U95E:87589_AT Mitogen-activated protein kinase kinase kinase kinase 3 hs
HU35KSUBB:RC_AA059472_AT Mitogen-activated protein kinase kinase kinase kinase 3 hs
HU35KSUBD:RC_AA250828_AT Mitogen-activated protein kinase kinase kinase kinase 3 hs
HU35KSUBD:RC_AA446022_AT Mitogen-activated protein kinase kinase kinase kinase 3 hs
MU11KSUBA:AA462551_AT mitogen-activated protein kinase kinase kinase kinase 3 mm
MU11KSUBB:MSA.9915.0_S_AT mitogen-activated protein kinase kinase kinase kinase 3 mm
MG-U74AV2:95675_AT mitogen-activated protein kinase kinase kinase kinase 3 mm
MOE430A:1426759_AT mitogen-activated protein kinase kinase kinase kinase 3 mm
MOUSE430A_2:1426759_AT mitogen-activated protein kinase kinase kinase kinase 3 mm
MOUSE430_2:1426759_AT mitogen-activated protein kinase kinase kinase kinase 3 mm
MG-U74CV2:134600_AT Mitogen-activated protein kinase kinase kinase kinase 3, mRNA (cDNA clone IMAGE:3603090) mm
MOUSE430_2:1444406_AT Mitogen-activated protein kinase kinase kinase kinase 3, mRNA (cDNA clone IMAGE:3603090) mm
MOE430B:1444406_AT Mitogen-activated protein kinase kinase kinase kinase 3, mRNA (cDNA clone IMAGE:3603090) mm
MOE430B:1446798_AT Mitogen-activated protein kinase kinase kinase kinase 3, mRNA (cDNA clone IMAGE:3603090) mm
MOUSE430_2:1446798_AT Mitogen-activated protein kinase kinase kinase kinase 3, mRNA (cDNA clone IMAGE:3603090) mm
MG-U74AV2:93848_AT Mitogen-activated protein kinase kinase kinase kinase 3, mRNA (cDNA clone IMAGE:3603090) mm
MU19KSUBB:TC34731_AT Mitogen-activated protein kinase kinase kinase kinase 3, mRNA (cDNA clone IMAGE:3603090) mm
RG-U34C:RC_AA819812_AT mitogen-activated protein kinase kinase kinase kinase 3 rn
RAE230A:1373719_AT mitogen-activated protein kinase kinase kinase kinase 3 rn
RAT230_2:1373719_AT mitogen-activated protein kinase kinase kinase kinase 3 rn
RAE230A:1371042_AT mitogen-activated protein kinase kinase kinase kinase 3 rn
RAT230_2:1371042_AT mitogen-activated protein kinase kinase kinase kinase 3 rn
RG-U34C:RC_AI230742_AT Mitogen-activated protein kinase kinase kinase kinase 3 rn
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5083 small GTPase regulator activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAA97966 Germinal center kinase family protein 2 [Caenorhabditis elegans] ref|NP_504721.1| Germinal Center Kinase family member (gck-2) [Caenorhabditis elegans] 0.0
blast CAE71951 Hypothetical protein CBG19019 [Caenorhabditis briggsae] 0.0
blast AAB48435 KHS1 [Homo sapiens] sp|Q9Y4K4|M4K5_HUMAN Mitogen-activated protein kinase kinase kinase kinase 5 (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) (Kinase homologous to SPS1/STE20) (KHS) 1.0E-174
Protein Families
Method ID Description E-Value
ec A2S7_HUMAN (Q96Q40) Serine/threonine-protein kinase ALS2CR7 (EC 2.7.1.37) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene protein 7) 3.0E-65
hanks 2.1.8 CaMK Group; CaMK I Regulated by Ca2+/CaM and close relatives; DdMLCK 1.0E-69
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 8.4E-85
Pfam IPR001180 EMBL-EBI Citron-like 7.1E-105
Sequence
Target Sequence 
>C. ELEGANS:190662_S_AT
attcacgaacatcagacttcccagaattatgcattggagttggtcaaatgtctggatcaa
atgaatatcaattcaatatgatcaatttctgctcatcaactaataactctgagctcagtg
gagatttaaactcatcatacggaagtcttgccgatgacgaaatgcttgaagttggaagta
tgcatcaaattgatagagatacattatgcttttcattccgcaataaagtagtgttgactg
atctacagggattcgaacgcccgaagccgtcgatcttcactttcaattttcacattgaat
atctacacgtcgtcgatggaacgattctcgcttttcatgcaaatggagttcaaggcagag
atttgaaaagtaatctgaatactcaggatttgtgcgatgtatctcgattatatcgtgtga
tcggtgatgatagagtaataatcctccgatcgcaaccaatgtcaccccgaaactctggcg
atacttgtgacgtcagcttactta

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
ATTCACGAACATCAGACTTCCCAGA 173 11 1967 Antisense
TATGATCAATTTCTGCTCATCAACT 27 657 2043 Antisense
ATCATACGGAAGTCTTGCCGATGAC 167 31 2100 Antisense
GATACATTATGCTTTTCATTCCGCA 447 423 2164 Antisense
TACAGGGATTCGAACGCCCGAAGCC 356 643 2210 Antisense
GTCGATCTTCACTTTCAATTTTCAC 615 473 2235 Antisense
ACATTGAATATCTACACGTCGTCGA 288 105 2258 Antisense
GGAACGATTCTCGCTTTTCATGCAA 192 531 2284 Antisense
GAGTAATAATCCTCCGATCGCAACC 699 393 2399 Antisense
CCCCGAAACTCTGGCGATACTTGTG 495 261 2431 Antisense
GATACTTGTGACGTCAGCTTACTTA 694 423 2446 Antisense
Sequence Source Affymetrix Proprietary Database