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[190605_at] tyrosine-protein kinase

Description F22B3.8 /REP_DB=WormBase Gene ID /WP=CE03259 /TR=Q19704 /GB=CAA92740.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=tyrosine-protein kinase
Cluster 6grp_total > 96      4grp_total > 32      6grp_total_sub > Increase      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 39
1 2 3 4 range
A 4.9
(-2.8)
A 		3.8
(-3)
A 		41.5
(2.8)
A 		42.6
(3)
A 		39
B 34.5
(0.5)
A 		32.3
(-0.7)
A 		27.8
(-3)
A 		39.4
(3)
A 		12
C 7.9
(-3)
A 		34.5
(3)
A 		20.3
(-0.2)
A 		9.1
(-2.7)
A 		27
avr 15.8
(-3) 		23.5
(0.2) 		29.9
(2.8) 		30.4
(3) 		15

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 63
1 2 3 4 5 6 range
A 21.5
(-0.8)
A 		7.2
(-3)
A 		29.2
(0.3)
A 		46.9
(3)
A 		23.2
(-0.6)
A 		41
(2.1)
A 		40
B 44.5
(2.8)
A 		2.4
(-3)
A 		9
(-2.1)
A 		33.1
(1.3)
A 		45.7
(3)
A 		28.5
(0.6)
A 		43
C 2.7
(-3)
A 		65.8
(3)
A 		16.3
(-1.7)
A 		7.4
(-2.6)
A 		36.4
(0.2)
A 		48.3
(1.3)
A 		63
avr 22.9
(-1.7) 		25.1
(-1) 		18.2
(-3) 		29.1
(0.1) 		35.1
(1.8) 		39.3
(3) 		21
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 10
1 2 3 4 range
A 1.8
(-2.4)
A 		0.8
(-3)
A 		10.8
(3)
A 		6.2
(0.2)
A 		10
B 11
(3)
A 		8
(-0.9)
A 		6.4
(-3)
A 		8.4
(-0.4)
A 		5
C 2.6
(-2.2)
A 		9.9
(3)
A 		7.1
(1)
A 		1.5
(-3)
A 		8
avr 5.1
(-3) 		6.2
(-0.8) 		8.1
(3) 		5.4
(-2.4) 		3

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 19
1 2 3 4 5 6 range
A 4
(-2)
A 		2.5
(-3)
A 		6.4
(-0.5)
A 		11.9
(3)
A 		7
(-0.1)
A 		10
(1.8)
A 		9
B 15.5
(2)
A 		0.8
(-3)
A 		2.2
(-2.5)
A 		8.8
(-0.3)
A 		18.6
(3)
A 		10.6
(0.3)
A 		18
C 1
(-3)
A 		20.1
(3)
A 		4.1
(-2)
A 		1.5
(-2.8)
A 		11.8
(0.4)
A 		16.2
(1.8)
A 		19
avr 6.8
(-1.1) 		7.8
(-0.4) 		4.2
(-3) 		7.4
(-0.7) 		12.5
(3) 		12.3
(2.9) 		8
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 190605_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.10060
Sequence Type Exemplar sequence
Representative Public ID F22B3.8 NCBI
Target Description F22B3.8 /REP_DB=WormBase Gene ID /WP=CE03259 /TR=Q19704 /GB=CAA92740.1 /SUBMIT=HINXTON /CHR=4 /FEA=Sanger Annotation /DEF=tyrosine-protein kinase
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_069759(10)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_069759 NCBI Caenorhabditis elegans F22B3.8 (F22B3.8) mRNA, complete cds. 10/11 None
SNAP00000028593 ENSEMBL cdna:SNAP chromosome:CEL140:IV:11422692:11424584:-1 10/11 None
GENEFINDER00000028601 ENSEMBL cdna:GeneFinder chromosome:CEL140:IV:11422692:11425847:-1 10/11 None
F22B3.8 ENSEMBL cdna:known chromosome:CEL140:IV:11422682:11424462:-1 gene:F22B3.8 10/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrIV:11422656-11424468(-) 100.0 100.0
Public Domain and Genome References
Gene Title tyrosine-protein kinase
Ensembl F22B3.8
Entrez Gene 184809 Entrez gene
SwissProt Q19704 EMBL-EBI
WormBase CE35502 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6468 protein amino acid phosphorylation inferred from electronic annotation QuickGO AmiGO
7242 intracellular signaling cascade inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
4672 protein kinase activity inferred from electronic annotation QuickGO AmiGO
4674 protein serine/threonine kinase activity inferred from electronic annotation QuickGO AmiGO
4713 protein-tyrosine kinase activity inferred from electronic annotation QuickGO AmiGO
5524 ATP binding inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA92740 Hypothetical protein F22B3.8 [Caenorhabditis elegans] ref|NP_502160.3| F22B3.8 [Caenorhabditis elegans] 0.0
blast CAE59699 Hypothetical protein CBG03127 [Caenorhabditis briggsae] 0.0
blast CAA92623 Hypothetical protein W01B6.5 [Caenorhabditis elegans] ref|NP_501826.2| W01B6.5 [Caenorhabditis elegans] 1.0E-67
blast CAA92623 Hypothetical protein W01B6.5 [Caenorhabditis elegans] ref|NP_501826.2| W01B6.5 [Caenorhabditis elegans] 1.0E-64
Protein Domains
Database ID Description E-Value
Pfam IPR000719 EMBL-EBI Protein kinase 4.5E-48
Pfam IPR000719 EMBL-EBI Protein kinase 4.5E-48
Pfam IPR000719 EMBL-EBI Protein kinase 2.7E-55
Sequence
Target Sequence 
>C. ELEGANS:190605_AT
gtgtgggctcgagtacattcacttcaaagggctcattcaccgtgacttggcgactcggaa
cattttggtttcagcggataagacgccaaagattgccgatttcggtttggcaaagcacgc
gagctcctacaaaatgcgaaaagccacgaagatccctgtcaggtaccttgctccagagac
gttgagctcattcgtctattccaccaaaaccgatgtctacacgtttggtcttgtcatctg
ggaaatatttgcaaacggacaggagccatatatgaaagctcaaccacaccaagaatgtgt
tgctccaaaaaatacgcaactcagaggacgtcatattaaggagctgatcaggaaggagct
gttcgtgaaattcaaccaagaggcaccagttgctcttcaacaatatgtggctgcaaagct
gttcgtagttgatgataagaaaagacccgatatgcccgaggtaggtgtaacttctaatag
tagtgcaccatatgatgtttcaggtatcaacgttcctgggcgacatgttgaag

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GTGTGGGCTCGAGTACATTCACTTC 258 487 855 Antisense
TCACTTCAAAGGGCTCATTCACCGT 418 619 873 Antisense
TTCACCGTGACTTGGCGACTCGGAA 580 685 890 Antisense
GACGCCAAAGATTGCCGATTTCGGT 403 381 936 Antisense
AAGCACGCGAGCTCCTACAAAATGC 461 149 967 Antisense
AAGATCCCTGTCAGGTACCTTGCTC 605 153 1003 Antisense
ACGTTGAGCTCATTCGTCTATTCCA 229 95 1033 Antisense
GTCTATTCCACCAAAACCGATGTCT 609 467 1048 Antisense
GATGTCTACACGTTTGGTCTTGTCA 614 409 1066 Antisense
AAGACCCGATATGCCCGAGGTAGGT 115 153 1296 Antisense
AACGTTCCTGGGCGACATGTTGAAG 706 139 1363 Antisense
Sequence Source Affymetrix Proprietary Database