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[190591_at] GTP cyclohydrolase I

Description F32G8.6 /REP_DB=WormBase Gene ID /WP=CE05795 /TR=SW:Q19980 /GB=CAA96650.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=GTP cyclohydrolase I
Cluster 6grp_highest_10_10 > 38      6grp_high1_10_10 > 72      4grp_highest_8_8 > 39      4grp_high_8_8 > 12      6grp_highest_nonorm > 36      6grp_total > 73      4grp_total > 12      6grp_highest_sub > 04      6grp_cgc > 75      6grp_high1_sub > 04      6grp_cgc_sub > 03_04      6grp_total_sub > Hat      6grp_rule_based > S4      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 872
1 2 3 4 range
A 1969
(-1.1)
P 		1695.9
(-3)
P 		1936.4
(-1.3)
P 		2567.7
(3)
P 		872
B 2173.4
(0.3)
P 		2113.3
(-0.4)
P 		1897.6
(-3)
P 		2400.8
(3)
P 		503
C 2139.7
(-0)
P 		2061.7
(-0.9)
P 		1863.3
(-3)
P 		2422.2
(3)
P 		559
avr 2094
(-0.9) 		1957
(-2.4) 		1899.1
(-3) 		2463.6
(3) 		565

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 2952
1 2 3 4 5 6 range
A 2327.8
(-3)
P 		4055.4
(0.5)
P 		4979.7
(2.4)
P 		5279.5
(3)
P 		4062.4
(0.5)
P 		3460.3
(-0.7)
P 		2952
B 2427.8
(-3)
P 		4067.6
(1.2)
P 		4149
(1.4)
P 		4454.8
(2.2)
P 		4780.2
(3)
P 		3741.7
(0.4)
P 		2352
C 2330.3
(-3)
P 		4330.5
(3)
P 		3750.3
(1.3)
P 		3691.6
(1.1)
P 		4110.6
(2.3)
P 		4028.4
(2.1)
P 		2000
avr 2362
(-3) 		4151.2
(2.1) 		4293
(2.5) 		4475.3
(3) 		4317.7
(2.6) 		3743.5
(0.9) 		2113
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 349
1 2 3 4 range
A 716.9
(3)
P 		368.1
(-3)
P 		506.2
(-0.6)
P 		375.9
(-2.9)
P 		349
B 693.1
(3)
P 		521.9
(-1.1)
P 		439.7
(-3)
P 		511.6
(-1.3)
P 		253
C 708.3
(3)
P 		592.8
(0.7)
P 		649.4
(1.8)
P 		408.4
(-3)
P 		300
avr 706.1
(3) 		494.3
(-1.6) 		531.8
(-0.8) 		432
(-3) 		274

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 1513
1 2 3 4 5 6 range
A 429.1
(-3)
P 		1442.3
(3)
P 		1084.5
(0.9)
P 		1339
(2.4)
P 		1225.9
(1.7)
P 		842.5
(-0.6)
P 		1013
B 844.7
(-3)
P 		1353.9
(-0.2)
P 		1007.5
(-2.1)
P 		1179.9
(-1.2)
P 		1942.1
(3)
P 		1395.3
(0)
P 		1097
C 863.7
(-1.8)
P 		1321.4
(2.7)
P 		954.5
(-0.9)
P 		742.4
(-3)
P 		1330.1
(2.8)
P 		1348.5
(3)
P 		606
avr 712.5
(-3) 		1372.5
(2) 		1015.5
(-0.7) 		1087.1
(-0.1) 		1499.4
(3) 		1195.4
(0.7) 		787
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 190591_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.12076
Sequence Type Exemplar sequence
Representative Public ID F32G8.6 NCBI
Target Description F32G8.6 /REP_DB=WormBase Gene ID /WP=CE05795 /TR=SW:Q19980 /GB=CAA96650.1 /SUBMIT=HINXTON /CHR=5 /FEA=Sanger Annotation /DEF=GTP cyclohydrolase I
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_073309(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_073309 NCBI Caenorhabditis elegans abnormal CATecholamine distribution family member (cat-4) (cat-4) mRNA, complete cds. 11/11 None
GENEFINDER00000017278 ENSEMBL cdna:GeneFinder chromosome:CEL140:V:10563503:10568772:1 9/11 None
F32G8.6 ENSEMBL cdna:known chromosome:CEL140:V:10567460:10568839:1 gene:F32G8.6 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrV:10567495-10568839(+) 100.0 100.0
Public Domain and Genome References
Gene Title GTP cyclohydrolase I
Gene Symbol cat-4
Ensembl F32G8.6
Entrez Gene 179472 Entrez gene
SwissProt Q19980 EMBL-EBI
WormBase CE05795 Wormbase
Functional Annotations
Ortholog
ID Title Organism
CANINE_2:CFAAFFX.23022.1.S1_AT similar to GTP cyclohydrolase I (GTP-CH-I) cfa
CANINE_2:CFAAFFX.23022.1.S1_S_AT similar to GTP cyclohydrolase I (GTP-CH-I) cfa
CANINE_2:CFAAFFX.23033.1.S1_AT similar to GTP cyclohydrolase I (GTP-CH-I) cfa
DROSOPHILA_2:1639469_A_AT Punch dm
DROSGENOME1:154812_AT Punch dm
CHICKEN:GGA.674.1.S1_AT GTP cyclohydrolase 1 (dopa-responsive dystonia) gga
HG-U133A:204224_S_AT GTP cyclohydrolase 1 (dopa-responsive dystonia) hs
HG-U133_PLUS_2:204224_S_AT GTP cyclohydrolase 1 (dopa-responsive dystonia) hs
HG-FOCUS:204224_S_AT GTP cyclohydrolase 1 (dopa-responsive dystonia) hs
HG-U133A_2:204224_S_AT GTP cyclohydrolase 1 (dopa-responsive dystonia) hs
HUGENEFL:U19523_AT GTP cyclohydrolase 1 (dopa-responsive dystonia) hs
U133_X3P:G4503948_3P_A_AT GTP cyclohydrolase 1 (dopa-responsive dystonia) hs
HG-U95AV2:37944_AT GTP cyclohydrolase 1 (dopa-responsive dystonia) hs
MU11KSUBB:MSA.30623.0_S_AT GTP cyclohydrolase 1 mm
MU11KSUBB:MSA.21616.0_F_AT GTP cyclohydrolase 1 mm
MG-U74AV2:102313_AT GTP cyclohydrolase 1 mm
MG-U74BV2:105414_AT GTP cyclohydrolase 1 mm
MOE430A:1420499_AT GTP cyclohydrolase 1 mm
MOUSE430A_2:1420499_AT GTP cyclohydrolase 1 mm
MOUSE430_2:1420499_AT GTP cyclohydrolase 1 mm
MOE430A:1429692_S_AT GTP cyclohydrolase 1 mm
MOUSE430A_2:1429692_S_AT GTP cyclohydrolase 1 mm
MOUSE430_2:1429692_S_AT GTP cyclohydrolase 1 mm
MU11KSUBB:MSA.731.0_S_AT GTP cyclohydrolase 1 mm
MU19KSUBA:TC19251_F_AT GTP cyclohydrolase 1, mRNA (cDNA clone MGC:12095 IMAGE:3709238) mm
MU19KSUBA:TC19251_I_AT GTP cyclohydrolase 1, mRNA (cDNA clone MGC:12095 IMAGE:3709238) mm
MU19KSUBA:TC23728_AT GTP cyclohydrolase 1, mRNA (cDNA clone MGC:12095 IMAGE:3709238) mm
RG-U34A:E03424CDS_S_AT GTP cyclohydrolase 1 rn
RG-U34A:M58364_AT GTP cyclohydrolase 1 rn
RAE230A:1368503_AT GTP cyclohydrolase 1 rn
RAT230_2:1368503_AT GTP cyclohydrolase 1 rn
RAE230A:1387221_AT GTP cyclohydrolase 1 rn
RAT230_2:1387221_AT GTP cyclohydrolase 1 rn
RAE230A:1373513_AT GTP cyclohydrolase 1 rn
RAT230_2:1373513_AT GTP cyclohydrolase 1 rn
RAE230A:1380230_AT GTP cyclohydrolase 1 rn
RAT230_2:1380230_AT GTP cyclohydrolase 1 rn
RG-U34A:RC_AA875467_AT GTP cyclohydrolase 1 rn
RG-U34B:RC_AI044726_AT GTP cyclohydrolase 1 rn
RG-U34C:RC_AI231494_AT GTP cyclohydrolase 1 rn
RG-U34A:RC_AA943102_S_AT GTP cyclohydrolase 1 rn
RG-U34A:RC_AI043643_AT GTP cyclohydrolase 1 rn
RG-U34A:RC_AI639457_AT GTP cyclohydrolase 1 rn
RG-U34A:RC_AI639457_G_AT GTP cyclohydrolase 1 rn
YEAST_2:1769371_AT GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway Sc
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
9058 biosynthesis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
3934 GTP cyclohydrolase I activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast CAA96650 Hypothetical protein F32G8.6 [Caenorhabditis elegans] ref|NP_505710.1| abnormal CATecholamine distribution family member (cat-4) [Caenorhabditis elegans] sp|Q19980|GCH1_CAEEL GTP cyclohydrolase I (GTP-CH-I) 1.0E-122
blast CAA96649 Hypothetical protein F32G8.5 [Caenorhabditis elegans] ref|NP_505709.1| F32G8.5 [Caenorhabditis elegans] 1.0E-122
blast CAE64846 Hypothetical protein CBG09642 [Caenorhabditis briggsae] 1.0E-115
blast CAA96650 Hypothetical protein F32G8.6 [Caenorhabditis elegans] ref|NP_505710.1| abnormal CATecholamine distribution family member (cat-4) [Caenorhabditis elegans] sp|Q19980|GCH1_CAEEL GTP cyclohydrolase I (GTP-CH-I) 1.0E-109
blast CAE64846 Hypothetical protein CBG09642 [Caenorhabditis briggsae] 1.0E-101
blast AAC06296 GTP-cyclohydrolase [Ostertagia ostertagi] sp|O61573|GCH1_OSTOS GTP cyclohydrolase I (GTP-CH-I) 8.0E-92
Protein Domains
Database ID Description E-Value
Pfam IPR001474 EMBL-EBI GTP cyclohydrolase I 5.3E-69
Pfam IPR002486 EMBL-EBI Nematode cuticle collagen, N-terminal 3.2E-21
Pfam IPR001474 EMBL-EBI GTP cyclohydrolase I 1.8E-65
Pfam IPR008160 EMBL-EBI Collagen triple helix repeat 1.3E-10
Pfam IPR008160 EMBL-EBI Collagen triple helix repeat 1.9E-11
Trans Membrane
ID Number Of Domains Domain Boundaries
GENEFINDER00000017278 1 7-29
Sequence
Target Sequence 
>C. ELEGANS:190591_AT
gccgcaagtgttggatccgaagacgataaagttgagatgaagaaaagaaacggaacgatt
ccaaaggaagatcatttgaaatcaatgtgcaatgcctatcagagcatcattcaacatgtc
ggagaagacatcaatcgtcagggacttctgaaaactccagaacgtgctgccaaagcaatg
atggcattcacaaagggatacgatgatcaacttgatgagctcctcaacgaggcagtattc
gacgaggatcacgatgagatggttattgtgaaagatattgaaatgttctccctttgtgag
catcatttagttccatttatgggaaaagttcatattggatacattccaaacaagaaggtt
cttggtctgtccaagttggcaagaatagtcgagatgttcagcagaagacttcaagtccaa
gaacgtcttacaaagcaaattgccaccgcaatggttcaagctgtacaaccatccggagtt
gcagttgttattgaagctagtcacatgtgtatggtaatgagaggagttcaaaagatcaat
gcttccaccacaacatcctgcatgttgggagtattccgtgacgatcca

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
GCCGCAAGTGTTGGATCCGAAGACG 498 285 55 Antisense
GAAAACTCCAGAACGTGCTGCCAAA 306 355 204 Antisense
GATGAGCTCCTCAACGAGGCAGTAT 443 411 268 Antisense
GAAATGTTCTCCCTTTGTGAGCATC 518 361 334 Antisense
GTGAGCATCATTTAGTTCCATTTAT 401 483 350 Antisense
GACTTCAAGTCCAAGAACGTCTTAC 495 371 461 Antisense
TTGCCACCGCAATGGTTCAAGCTGT 277 699 494 Antisense
TCAAGCTGTACAACCATCCGGAGTT 705 631 510 Antisense
CAAAAGATCAATGCTTCCACCACAA 649 189 583 Antisense
TCCACCACAACATCCTGCATGTTGG 489 587 598 Antisense
GTTGGGAGTATTCCGTGACGATCCA 52 437 618 Antisense
Sequence Source Affymetrix Proprietary Database