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[190586_at] zinc metallprotease

Description K04E7.3 /REP_DB=WormBase Gene ID /WP=CE02798 /TR=SW:P55114 /GB=AAA80412.1 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=zinc metallprotease
Cluster 6grp_total > 15      4grp_total > 21      6grp_cgc > 21      6grp_cgc_sub > De      6grp_total_sub > Decrease      6grp_rule_based > S1      

Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 164
1 2 3 4 range
A 126.3
(1.9)
M 		109.5
(0.7)
A 		54.3
(-3)
A 		142.9
(3)
P 		89
B 132.5
(3)
P 		82.6
(-3)
A 		94.6
(-1.6)
A 		90.1
(-2.1)
A 		50
C 135.7
(0.2)
P 		89.3
(-1.5)
A 		47.8
(-3)
A 		211.4
(3)
P 		164
avr 131.5
(1.8) 		93.8
(-0.9) 		65.6
(-3) 		148.1
(3) 		83

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 212
1 2 3 4 5 6 range
A 251.7
(3)
P 		176.1
(0.7)
M 		101
(-1.6)
A 		80.8
(-2.2)
A 		86.7
(-2)
A 		53.5
(-3)
A 		198
B 155.9
(3)
P 		93.2
(-0.2)
M 		95.1
(-0.1)
P 		79.3
(-1)
P 		79.8
(-0.9)
A 		39.9
(-3)
A 		116
C 222.2
(3)
P 		146.1
(0.3)
P 		157.7
(0.7)
P 		82.9
(-1.9)
A 		56.7
(-2.8)
P 		52.2
(-3)
A 		170
avr 209.9
(3) 		138.5
(0.3) 		117.9
(-0.4) 		81
(-1.8) 		74.4
(-2) 		48.5
(-3) 		161
No Scale
G range Absolute graph Relative graph Expression Table Dauer Comp.
4 32
1 2 3 4 range
A 46
(3)
M 		23.8
(-1.2)
A 		14.2
(-3)
A 		20.9
(-1.7)
P 		32
B 42.3
(3)
P 		20.4
(-2.7)
A 		21.9
(-2.3)
A 		19.2
(-3)
A 		23
C 44.9
(3)
P 		25.7
(-1.1)
A 		16.6
(-3)
A 		35.6
(1)
P 		28
avr 44.4
(3) 		23.3
(-1.7) 		17.6
(-3) 		25.2
(-1.3) 		27

1 : 1 state (S1, L1)
2 : dauer (ST, LT)
6 69
1 2 3 4 5 6 range
A 46.4
(1)
P 		62.6
(3)
M 		22
(-1.9)
A 		20.5
(-2.1)
A 		26.2
(-1.4)
A 		13
(-3)
A 		50
B 54.2
(3)
P 		31
(-0.5)
M 		23.1
(-1.7)
P 		21
(-2.1)
P 		32.4
(-0.3)
A 		14.9
(-3)
A 		39
C 82.3
(3)
P 		44.6
(-0.4)
P 		40.1
(-0.9)
P 		16.7
(-3)
A 		18.3
(-2.9)
P 		17.5
(-2.9)
A 		66
avr 61
(3) 		46.1
(1.1) 		28.4
(-1.3) 		19.4
(-2.4) 		25.6
(-1.6) 		15.1
(-3) 		46
NetAffx Links Cluster Members
Consensus/Exemplar
GeneChip Array Information
Probe Set ID 190586_at
GeneChip Array C. elegans Genome Array
Organism Common Name Nematode
Probe Design Information
Transcript ID(Array Design) affy.Ce.16939
Sequence Type Exemplar sequence
Representative Public ID K04E7.3 NCBI
Target Description K04E7.3 /REP_DB=WormBase Gene ID /WP=CE02798 /TR=SW:P55114 /GB=AAA80412.1 /SUBMIT=ST.LOUIS /CHR=X /FEA=Sanger Annotation /DEF=zinc metallprotease
Cluster Evidence This cluster is supported by a Sanger Annotation.
Annotation Method Description
Annotation Description This probe set was annotated using the Matching Probes based pipeline to a RefSeq identifier using 1 transcript(s).
Annotation Grade This is a grade A annotation.
Annotation Transcript Cluster (# of Matching Probes) NM_076685(11)
Transcript Assignments
Representative
Transcript		 Description Matching Probes Related Probesets by Grade
NM_076685 NCBI Caenorhabditis elegans Nematode AStacin protease family member (nas-33) (nas-33) mRNA, complete cds. 11/11 None
GENEFINDER00000025387 ENSEMBL cdna:GeneFinder chromosome:CEL140:X:6451908:6455089:-1 11/11 None
SNAP00000025383 ENSEMBL cdna:SNAP chromosome:CEL140:X:6451919:6454701:-1 10/11 None
K04E7.3 ENSEMBL cdna:known chromosome:CEL140:X:6451908:6454577:-1 gene:K04E7.3 11/11 None
Annotation Notes
There are no noteworthy cross hybridizing mRNAs found for this probe set.
Genomic Alignment of Consensus/Exemplar Sequence
Assembly Wormbase March 2004
Alignment(s)
Position Identity Coverage Cytoband
chrX:6451907-6454577(-) 100.0 100.0
Public Domain and Genome References
Gene Title zinc metallprotease
Gene Symbol nas-33
Ensembl K04E7.3
Entrez Gene 186987 Entrez gene
SwissProt P55114 EMBL-EBI
WormBase CE02798 Wormbase
Functional Annotations
Gene Ontology
GO Biological Process (view graph)
ID Description Evidence Links
6508 proteolysis inferred from electronic annotation QuickGO AmiGO
GO Molecular Function (view graph)
ID Description Evidence Links
8237 metallopeptidase activity inferred from electronic annotation QuickGO AmiGO
8270 zinc ion binding inferred from electronic annotation QuickGO AmiGO
8533 astacin activity inferred from electronic annotation QuickGO AmiGO
Protein Similarities
Method ID Description E-Value
blast AAA80412 Nematode astacin protease protein 33 [Caenorhabditis elegans] ref|NP_509086.1| Nematode AStacin protease family member (nas-33) [Caenorhabditis elegans] sp|P55114|NAS33_CAEEL Zinc metalloproteinase nas-33 precursor (Nematode astacin 33) 0.0
blast CAE61261 Hypothetical protein CBG05067 [Caenorhabditis briggsae] 0.0
blast CAD99221 NAS-33 protein [Caenorhabditis elegans] 0.0
Protein Domains
Database ID Description E-Value
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 3.4E-108
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 3.4E-108
Pfam IPR001506 EMBL-EBI Peptidase M12A, astacin 3.4E-108
Sequence
Target Sequence 
>C. ELEGANS:190586_AT
tgtgggcaatgtacgtgtccgacaggactggaaggaacatattgtgaacgactgcaaact
tctaattgcggtgtggaacttccacgggcagattactcatggagaaatatttcctattcg
ggatcatctgactgttattggagaattgtttcggcaaacggcggcaatgtacgttttgag
ctcacctatgtgatgtatagatgttctccagtatgtgaagagtttgttgagatgaaagca
gaatatagtcatgaagcaaccggataccggcagtgttgcaaagccgtccttggtgaacga
attagcaaaggaaacagtgttctgattatttcaaaagctactcagaactcacaatttgta
ctcagatatagagaagatggtacagctcccactcaaagaccaccccctgtcagggttgct
gctccaagaagttattctttactgtggtccggttggacaagatgctctgaaaattgtggt
tcttgtggtactcagtatagagaaagatgtacaagtacaacgaattgcttaagatcagct
aaacaaacaagagtctgtaatactcagccatgtgcacaaggaacc

BLASTn GenBank NR
Probe Info
Probe Sequence(5'-3') Probe X Probe Y Probe Interrogation
Position 		Strandedness
TGTGGGCAATGTACGTGTCCGACAG 325 555 1039 Antisense
GGAACTTCCACGGGCAGATTACTCA 67 529 1113 Antisense
TCCTATTCGGGATCATCTGACTGTT 474 591 1150 Antisense
GTTTCGGCAAACGGCGGCAATGTAC 38 451 1186 Antisense
GTACGTTTTGAGCTCACCTATGTGA 312 457 1207 Antisense
GTTGCAAAGCCGTCCTTGGTGAACG 681 437 1313 Antisense
AGAGAAGATGGTACAGCTCCCACTC 642 69 1408 Antisense
CTGTCAGGGTTGCTGCTCCAAGAAG 37 239 1445 Antisense
TTATTCTTTACTGTGGTCCGGTTGG 241 665 1470 Antisense
AATTGTGGTTCTTGTGGTACTCAGT 256 179 1510 Antisense
TACTCAGCCATGTGCACAAGGAACC 578 643 1599 Antisense
Sequence Source Affymetrix Proprietary Database